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*  Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase...
Measurement of cholesterol 7 alpha-hydroxylase activity in homogenates of hepatocytes, incubated with 1 microM-dexamethasone, ... As with bile acid synthesis from [14C]cholesterol, no change in enzyme activity was found in hepatocytes cultured in the ... Addition of inhibitors of protein and mRNA synthesis lowered bile acid production and cholesterol 7 alpha-hydroxylase activity ... We conclude that glucocorticoids regulate bile acid synthesis in rat hepatocytes by induction of enzyme activity of cholesterol ...
http://www.biochemj.org/content/262/1/341
*  Cholesterol 7 alpha-hydroxylase - Wikipedia
Davis RA, Miyake JH, Hui TY, Spann NJ (Apr 2002). "Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP". Journal ... Li T, Chanda D, Zhang Y, Choi HS, Chiang JY (Apr 2010). "Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription ... Li T, Chanda D, Zhang Y, Choi HS, Chiang JY (Apr 2010). "Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription ... Gbaguidi GF, Agellon LB (2004-01-01). "The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by ...
https://en.wikipedia.org/wiki/Cholesterol_7_alpha-hydroxylase
*  Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. - Semantic Scholar
5 alpha-cholestan-3 beta, 6 alpha-diol; cholestan-3 beta, 5 alpha,6 beta-triol; 5-(25R)-cholesten-3 beta,26-diol, all at 50 ... Addition of cholesterol, delivered in beta-cyclodextrin, to squalestatin-treated cells restored cholesterol 7 alpha-hydroxylase ... Previous in vivo studies suggest that cholesterol may up-regulate cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in ... These experiments provide evidence that cholesterol rather than 'oxysterols' regulate cholesterol 7 alpha-hydroxylase gene ...
https://www.semanticscholar.org/paper/Regulation-of-cholesterol-7-alpha-hydroxylase-by-in-D%C3%B6rner-Gurley/2f14fb3bf56221b48150e3e8c0235b276f9b3763
*  lecture 16 Flashcards by Molly Fowler | Brainscape
cholesterol Storage - glycogen, triglycerides, lipid soluble vitamins, Fe, Cu Catabolic - endogenous substances - hormones and ... higher in hepatitis B and C, hereditary haemochromatosis, alpha-1-antitrypsin deficiency ... cholesterol 7 alpha-hydroxylase: - vs ++ - bile formation:. -- bile-salt dependent: ++ vs -. -- non-bile-salt dependent: - vs ... bile formation and excretion into the gut - bilirubin, IgA, bile acids, cholesterol, elimination of environmental toxins, ...
https://www.brainscape.com/flashcards/lecture-16-2271432/packs/3676829
*  In Vivo Lipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed Rats
Cholesterol 7a-hydroxylase (CYP7A) is the first and rate-limiting enzyme in bile acid synthesis pathway and is expressed only ... C. Juree, N. Kasem, B. William et al., "Induction of human cholesterol 7a-hydroxylase in HepG2 cells by 2, 4, 6 - ... Lack of CYP7A results in high levels of plasma cholesterol, whereas induction of CYP7A prevents elevation of blood cholesterol ... HMGCR activity directly affects the speed of cholesterol synthesis and the level of cholesterol [12]. Clinical results confirm ...
https://www.hindawi.com/journals/ecam/2014/642058/
*  Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR...
Bile acids are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile ... Cholesterol 7-alpha-Hydroxylase / genetics, metabolism. Feedback, Physiological / drug effects. Fibroblast Growth Factors / ... Next Document: Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons.... ... Importantly, we identified tauro-conjugated beta- and alpha-muricholic acids as FXR antagonists. These studies suggest that the ...
http://www.biomedsearch.com/nih/Gut-Microbiota-Regulates-Bile-Acid/23395169.html
*  Lipidos Diferencias de Emulsiones-Nutr Clin Pract Octubre2016-Anez-Bustillos-596-609 | Lipoprotein | Low Density Lipoprotein
cholesterol. and septic (n = 20) (50/50. energy intake/energy No difference in energy expenditure or energy intake/ et al130 ( ... Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholester- The ideal emulsion would be one ... Cotter R. and cholesterol levels in serum of neo- matory lipid mediators: a new pharmacologic genus. trapping antioxidant ... incompat- cholesterol than those who received the 10% SOFE. a tetraenoic acid.63 Unfortunately.74 previously discussed. and the ...
https://www.scribd.com/document/343228933/Lipidos-Diferencias-de-Emulsiones-Nutr-Clin-Pract-Octubre2016-Anez-Bustillos-596-609
*  Environmental Health Perspectives - Association between Exposure to p,p′-DDT and Its Metabolite p,p′-DDE with Obesity:...
Effects of 3-methylcholanthrene and DDT on cholesterol 7 alpha-hydroxylase in rats. Durg-Nutr Interact 1(1):15-21, PMID: ... We defined abnormal lipids as elevated lipids (cholesterol, triglycerides, or fatty acids) in blood or liver, increased liver ... Abbreviations: CBA, conjugated bile acids; CHO, cholesterol; DPC, day post-coitus; F, females; FAs, fatty acids; GD, ... ratio of pollutant levels by the triglyceride and cholesterol content), b) include the blood lipid content as a covariate in ...
https://ehp.niehs.nih.gov/ehp527/
*  Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome
... these extracts may also inhibit carbohydrate metabolizing enzymes like alpha-amylase, alpha-glucosidase, and pancreatic lipase ... D. J. Peet, S. D. Turley, W. Ma et al., "Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear ... Freeze-dried bitter melon juice (1.5%) with diet normalized plasma TAG, cholesterol, and NEFA in female C57BL/6 mice fed a HF ... LXR also plays an important role in lipid and cholesterol metabolism. LXRα knockout mice develop enlarged fatty livers, ...
https://www.hindawi.com/journals/jl/2015/496169/
*  Induction of phase I, II and III drug metabolism/transport by xenobiotics | SpringerLink
del Castillo-Olivares, A. and Gil, G., Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase ... Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.Proc. Natl. Acad. Sci. U.S.A., 97, 12097- ... Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.Cell, 93, 693-704 ( ... A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). ...
https://link.springer.com/article/10.1007%2FBF02977789
*  De Fabiani E[au] - PubMed - NCBI
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene ... The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins ... Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis. ... Suppression of bile acid synthesis, but not of hepatic cholesterol 7alpha-hydroxylase expression, by obstructive cholestasis in ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=De+Fabiani+E%5Bau%5D&dispmax=50
*  Medical bioremediation of age-related diseases | Microbial Cell Factories | Full Text
Carter CJ: Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, ... Zhu Y, Li X, McVie-Wylie A, Jiang C, Thurberg B, Raben N, Mattaliano R, Cheng S: Carbohydrate-remodelled acid alpha-glucosidase ... Bjorkhem I, Andersson O, Diczfalusy U, Sevastik B, Xiu RJ, Duan C, Lund E: Atherosclerosis and sterol 27-hydroxylase: evidence ... cholesterol acyltransferase (ACAT) re-esterification in the cytosol and cholesterol efflux. In atherosclerosis, however, ...
https://microbialcellfactories.biomedcentral.com/articles/10.1186/1475-2859-8-21
*  NR5A2 + LRH1 ELISA Kits | www.antibodies-online.com
Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of ... alpha-1-fetoprotein transcription factor , b1-binding factor, hepatocyte transcription factor which activates enhancer II of ... hepatitis B virus , fetoprotein-alpha 1 (AFP) transcription factor , hepatocytic transcription factor , liver nuclear receptor ...
https://www.antibodies-online.com/nuclear-receptor-transcription-pathway-pathway-23/nr5a2-lrh1-elisa-kit-9091/
*  Tamaru T[au] - PubMed - NCBI
Structural aspects of bile acids involved in the regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase. ... A new synthetic route to stereoisomeric 3,6-dihydroxy- and 6-hydroxy-5 alpha-cholanoic acids. ... Synthesis of stereoisomeric 3,6,12 alpha-trihydroxy-5 beta-cholanoic acids. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Tamaru+T%5Bau%5D&dispmax=50
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cholesterol and lipoprotein dynamics in a hibernating mammal.. Jessica P Otis, Daisy Sahoo, Victor A Drover, Chi-Liang Eric Yen ... Two novel glycosylation sites on N513 of uromodulin and N470 of lysosomal alpha-glucosidase which have not yet been reported ... Cholesterol levels in total plasma, HDL and LDL particles were elevated in hibernators compared with spring or summer squirrels ... Expression of cholesterol 7 alpha-hydroxylase was 13-fold lower in hibernators than in active season squirrels. Plasma ...
https://www.jove.com/visualize?author=Chi%20Liang%20
*  SEURAT-1 liver gold reference compounds: a mechanism-based review | SpringerLink
Lund EG, Peterson LB, Adams AD et al (2006) Different roles of liver X receptor alpha and beta in lipid metabolism: effects of ... Zhao C, Dahlman-Wright K (2010) Liver X receptor in cholesterol metabolism. J Endocrinol 204(3):233-240. doi: 10.1677/JOE-09- ... Lefebvre P, Chinetti G, Fruchart JC, Staels B (2006) Sorting out the roles of PPAR alpha in energy metabolism and vascular ... Ory DS (2004) Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home? Circ Res 95( ...
https://link.springer.com/article/10.1007/s00204-014-1410-8?sa_campaign=email/event/articleAuthor/onlineFirst
*  Turmeric | St. David's HealthCare
The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J ... Effect of curcumin on serum and liver cholesterol levels in the rat. J Nutr. 1970;100: 1307-1316. ... After 7 days, 87% percent of the curcumin group experienced full or partial symptom relief from dyspepsia as compared to 53% of ... 7 Kositchaiwat C, Kositchaiwat S, Havanondha J. Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid ...
https://stdavids.com/hl/?/21874/turmeric
*  Turmeric - Health Library
The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J ... Effect of curcumin on serum and liver cholesterol levels in the rat. J Nutr. 1970;100: 1307-1316. ... Front Biosci. 2002;7:784-792. 20. Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol ... 7. Kositchaiwat C, Kositchaiwat S, Havanondha J. Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid ...
https://healthlibrary.epnet.com/GetContent.aspx?token=c5987b1e-add7-403a-b817-b3efe6109265&chunkiid=21874
*  TURMERIC: Uses, Side Effects, Interactions and Warnings - WebMD
High cholesterol. Research suggests that taking turmeric extract by mouth twice daily for 3 months reduces total cholesterol, ... Nan, B., Lin, P., Lumsden, A. B., Yao, Q., and Chen, C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin ... low-density lipoprotein (LDL or "bad") cholesterol, and triglycerides in overweight people with high cholesterol. ... For high cholesterol: 1.4 grams of turmeric extract in two divided doses daily for 3 months has been used in children at least ...
https://www.webmd.com/vitamins-supplements/ingredientmono-662-turmeric.aspx?activeingredientid=662
*  Cholesterol 7alpha-monooxygenase - Wikipedia
Boyd GS, Grimwade AM, Lawson ME (1973). "Studies on rat-liver microsomal cholesterol 7alpha-hydroxylase". Eur. J. Biochem. 37 ( ... In enzymology, a cholesterol 7alpha-monooxygenase (EC 1.14.13.17) is an enzyme that catalyzes the chemical reaction cholesterol ... Mitton JR, Scholan NA, Boyd GS (1971). "The oxidation of cholesterol in rat liver sub-cellular particles The cholesterol-7- ... alpha-Hydroxylase enzyme system". Eur. J. Biochem. 20 (4): 569-79. doi:10.1111/j.1432-1033.1971.tb01429.x. PMID 4397276. ...
https://en.wikipedia.org/wiki/Cholesterol_7alpha-monooxygenase
*  Unit 6 - Cholesterol Metabolism I; Synthesis of Cholesterol, Bile Salts, and Acids Flashcards by Annette Liem | Brainscape
Synthesis of Cholesterol, Bile Salts, and Acids flashcards from Annette Liem ... OH groups are below plane of sterol ring (alpha); methyl groups are above (beta) so have polar and nonpolar faces ... most cholesterol in plasma is esterified to FA at C3, and this cholesteryl ester is even more hydrophobic than cholesterol ... Unit 6 - Cholesterol Metabolism I; Synthesis of Cholesterol, Bile Salts, and Acids Flashcards Preview Molecular and Cellular ...
https://www.brainscape.com/flashcards/unit-6-cholesterol-metabolism-i-synthesis-2038707/packs/2719068
*  Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling
Alpha-ketoglutarate is often the α-keto acid acceptor for these transaminase reactions, generating glutamate as a product. ... Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha- ... hydroxylase. J Clin Invest. 1986;78:1064-1071. [PMC free article] [PubMed] ... alpha-ketoglutarate, and D3-citrate. In addition to mass, analytes are identified on the basis of the particular MS/MS ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2265422/
*  Plus it
Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated ... Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression. Hepatology 37: 622-631, 2003. ... Cholesterol cholelithiasis. Having previously identified the Nr1h4 gene as a candidate gene for the cholesterol gallstone ... Bile acids are the end products of hepatic cholesterol catabolism, thus providing a major pathway of excess cholesterol ...
http://physiologyonline.physiology.org/content/23/5/286
*  Anti-Bile Acid Receptor NR1H4 antibody (ab58559) | Abcam
Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 ...
http://www.abcam.com/bile-acid-receptor-nr1h4-antibody-ab58559.html
*  Turmeric, Curcumin (Curcuma longa) | Plant Profiler | China-Mainland | Sigma-Aldrich
... possibly by enhancing the activity of hepatic cholesterol-7a-hydroxylase and increasing cholesterol catabolism.91,17,16 The ... Gupta, B. and Ghosh, B. Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein ... 92 In rabbits fed a high cholesterol diet, oral turmeric (1.6-3.2mg/kg) was associated with lower levels of plasma cholesterol ... Hussain, M. S. and Chandrasekhara, N. Effect on curcumin on cholesterol gall-stone induction in mice. Indian J Med.Res 1992;96: ...
https://www.sigmaaldrich.com/china-mainland/zh/life-science/nutrition-research/learning-center/plant-profiler/curcuma-longa.html