Abstract 956: Acid-Sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus...
The molecular mechanism of pH sensing by chemoreceptors is not clear, although it had been proposed to be mediated by a drop in ... Extracellular acidosis evoked transient inward currents in glomus cells that were evident at pH 7.0 and half-activated (pH 50) ... Recently, pH-sensitive ion channels have been described in glomus cells that respond directly to extracellular acidosis. In ... by recording the responses of glomus cells isolated from rat carotid body to rapid changes in extracellular pH using whole-cell ...http://circ.ahajournals.org/content/116/Suppl_16/II_189.1
Sleep-Disordered Breathing and Cardiovascular Disease | Circulation
Chemoreceptor resetting and tonic chemoreceptor activation may also contribute to daytime increases in sympathetic activity and ... Consistent with this hypothesis, elevated plasma levels and cell expression of several adhesion molecules, as well as evidence ...http://circ.ahajournals.org/content/108/1/9
Sleep Apnea and Heart Failure | Circulation
Monocytes from OSA patients adhere more avidly to vascular endothelial cells in culture than those from control subjects.52 ... The ensuing hypoxia and hypercapnia further augment sympathetic activity by stimulating peripheral and central chemoreceptors. ... vascular cell adhesion molecule-1 (VCAM-1) and E-selectin.51 Increased expression of the adhesion molecules CD15 and CD11c in ... and decreases leukocyte adherence to human endothelial cells in culture.50 Activated leukocytes play an important role in the ...http://circ.ahajournals.org/content/107/12/1671.long