DeCS 2008 - Novos termos
Platelet Factor 4 | Profiles RNS
Ciliary neurotrophic factor - wikidoc
A recombinant version of human CNTF (rhCNTF), trade name Axokine, is a modified version with a 15 amino acid truncation of the C-terminus and two amino acid substitutions. It is three to five times more potent than CNTF in in vitro and in vivo assays and has improved stability properties.[6] Like CNTF it is a neurotrophic factor, and may stimulate nerve cells to survive. It was tested in the 1990s as a treatment for amyotrophic lateral sclerosis. It did not improve muscle control as much as expected, but trial participants did report a loss of appetite. Phase III clinical trials for the drug against obesity were conducted in 2003 by Axokines maker, Regeneron, demonstrating a small positive effect in some patients, but the drug was not commercialized. A major problem with the treatment was that in nearly 70% of the subjects tested, antibodies against Axokine were produced after approximately three months of treatment.[7] In the minority of subjects who did not develop the antibodies, weight loss ...
Interleukin - wikidoc
Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of bodily cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. ...
Interferon - wikidoc
In a study of the blocking of interferon (IFN) by the Japanese Encephalitis Virus (JEV), a group of researchers infected human recombinant IFN-alpha with JEV, DEN-2, and PL406, which are all viruses, and found that some viruses have manifested methods that give them a way around the IFN-alpha/beta response. The viruses need to master these methods so they can have the ability to carry on viral replication and production of new viruses.[4] The ways that viruses find a way around the IFN response is through the inhibition of interferon signaling, production, and the blocking of the functions of IFN-induced proteins.[4] It is not unusual to find viruses encoding for a multiple number of mechanisms to allow them to elude the IFN response at many different levels.[4] While doing the study with JEV, Lin and his coworkers found that with IFN-alphas inability to block JEV means that JEV may be able to block IFN-alpha signaling which in turn would prevent IFN from having STAT1, STAT2, ISGF3, and IRF-9 ...
Semi-Quantitative Arrays
CXCL6, GCSF, G-CSF R / CD 114, GDF1, GDF11, GDF-15, GDF3, GDF5, GDF8, GDF9, GDNF, Gelsolin, GFR alpha-1, GFR alpha-2, GFR alpha ... CXCL6), GCSF, G-CSFR(CD114), GCSH , GDA, GDF1, GDF11, GDF-15, GDF3, GDF5, GDF7, GDF8, GDF9, GDI1, GDI2, GDNF, Gelsolin, ... Chemokine Arrays. * - Cytokine Arrays - Human. * - Cytokine Arrays - Mouse. * - Inflammation Arrays. * - Interleukin Arrays ...
GNA15 and CXCR1 - Wiki-MPM
Host Response - Canopy Biosciences
PPBP and CELF1 - Wiki-MPM
Tumor Angiogenesis: Pericytes and Maturation Are Not to Be Ignored
CXCR1 - Wiki-MPM
CAR-T Characterization - Canopy Biosciences
CXCL6.CXCL8.CXCL9.CXCR3.CXCR4.CXCR5.CXCR6.CYBB.DAP3.DDIT4.DECR1.DGLUCY.DHFR2.DHRS4.DIABLO.DLL1.DOCK2.DUSP1.DVL2.EBI3.EGF.EGR1. ... Chemokine Signaling, Costimulatory Molecules, Interleukin Signaling, TCR signaling, JAK-STAT, MAPK and PI3K Signaling, Myc ... Downstream of the TCR, multiple pathways induce transcriptional changes that lead to the production of chemokines and cytokines ... Toxicity is correlated with certain cytokine and chemokine profiles. These signals can induce a pro-inflammatory environment in ...