PER1 also interacts with proteins ATM and Chk2. These proteins are key checkpoint proteins in the cell cycle. Cancer patients ... Period circadian protein homolog 1 is a protein in humans that is encoded by the PER1 gene. The PER1 protein is important to ... "The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells". Mol. Cell. 22 (3 ... Therefore, a cells circadian clock may play a large role in its likelihood of developing into a cancer cell. PER1 is a gene ...

DNA-damage; mice; identification; phosphorylation; gene; localization; arrest; checkpoint; mitosis; transcription factor p120( ... The E4F protein is required for mitotic progression during embryonic cell cycles. Le Cam, L.; Lacroix, M.; Ciemerych, M. A.; ... The E4F protein is required for mitotic progression during embryonic cell cycles. ... Our results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in ...

Learn more about the cell cycle and the proteins that regulate its progression. ... the ordered sequence of events that occur in a cell in preparation for cell division. The cell cycle is a four-stage process in ... which the cell increases in size, copies its DNA, prepares to divide, and divides. ... However, the cell cycle and its checkpoint systems can be sabotaged by defective proteins or genes that cause malignant ...

p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. The protein product of the ... The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. In response to ... p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. The protein product of the ... p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. ...

Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents ... We show that loss of the DNA repair protein XPA markedly augments the synthetic lethality between MK2 and p53, enhancing anti- ... Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity to ... These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of ...

A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for ... It regulates a gene expression program in which genes involved in cell cycle arrest, such as the Cip/Kip family of CDKIs are ... Percentage of cells in each phase of the cell cycle as well as that of apoptotic cells with sub-G1 DNA content under different ... Percentage of cells in each phase of the cell cycle as well as that of apoptotic cells with sub-G1 DNA content under different ...

... in correlation with an augmented expression of the cell cycle inhibitory proteins p53, p27, p21, necrosis, exacerbated ... In this study, we report the cell-autonomous antiproliferative and cytotoxic activities exhibited by the spider peptide gomesin ... the cytotoxic potential of the gomesin analogues in DFTD cells lies on specific arginine substitutions in the eight and nine ... AgGom) and gomesin-like homologue (HiGom) in DFTD cells. Mechanistically, both peptides caused a significant reduction at G0/G1 ...

... cell cycle arrest, apoptosis and senescence. In the context of DNA damage, … ... Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in ... Cell Cycle Checkpoints / genetics * DNA Damage / genetics * Gene Expression Regulation / genetics * Humans ... Tumor Suppressor Protein p53 Grants and funding * R01 GM083303/GM/NIGMS NIH HHS/United States ...

A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation ... We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. ... ovarian cancer cell lines as a target gene leading to a sequential reaction which stops the cell cycle at the G1/S checkpoint [ ... In addition to the effect of vitamin D on the proteins of the cell cycle signaling pathway, epidermal growth factor receptor ( ...

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle ... a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is ... Protein Name. Cell cycle checkpoint control protein RAD9A. Description of Target. RAD9A is highly similar to ... It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of ...

... by each cell strain at the protein level was detected by indirect immunofluorescence and western blot for cell cycle checkpoint ... gene expression was studied in four strains of primary normal human mammary epithelial cells. The cell strains were derived ... Morphology; Cell-alteration; Cell-biology; Cell-differentiation; Cell-morphology; Cellular-reactions; Pesticide-residues; ... Pesticides-and-agricultural-chemicals; Pesticide-industry; Tissue-culture; Gene-mutation; Genetic-disorders; Cancer; Cell- ...

The Paul Andreassen Lab focuses on the relationship of DNA repair and cell cycle checkpoints to the genetic instability that ... including cell cycle checkpoint signaling and DNA repair by homologous recombination (HR), that maintain genome stability and ... genes/proteins is of particular interest, along with identifying FA-BRCA interacting proteins and understanding how FA-BRCA ... Additional related interests include applying insights into FA-BRCA genes/proteins to improve therapeutic approaches to cancer ...

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell ... Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response ... This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also ... FDA approves Berkeleys test of CRISPR CAS cloning for sickle cell diseaseYes, the safe cloning of hu ...

... hormone and androgen catabolism and cell cycle checkpoint control. In PBMCs hgh administration led to increased cell ... Hgh treatment caused anabolic effects mainly by diversion of energy to protein synthesis. More genes were found to be up- ... Genes of groups similar to those detected as repressed in H9 cells were also down-regulated in the RA-1 cell line along with ... Genes for non-apoptotic cell death and regulation of osmotic pressure were down-regulated. The B lymphocyte cell line RA-1 ...

... the chorion gene loci in follicle cells (21 22 In pre-RC development the effective launching of multiple MCM complexes is ... The SNF2H protein was then synthesized by transcription-translation with rabbit reticulocyte lysate (TnT T7 quick coupled ... necessary for the toleration of replication strains and activation of checkpoint pathways (23-25). Generally chromatin- ... For cell cycle synchronization T98G cells were rendered quiescent by serum starvation for 48 h and then released into the cell ...

... and NS5B proteins (Figure 5). To promote cell cycling and evasion of the G1/S checkpoint, NS5B binds to tumor suppressor Rb to ... to prevent its role in activating TP53 responsive genes that aid in cell-cycle control[186]. Loss of p53 function aids cell ... The tumor suppressor protein P53 is a critical protein commonly mutated in cancer, that is involved in cell-cycle arrest at the ... The core protein upregulates cyclin E/CDK 2 to promote cell cycle transition from G1 to S phase with checkpoint evasion, genome ...

Declined enrichment score of cell cycle checkpoints and transition gene sets. *Induced G2/M arrest of cell cycle ... Substantially downregulated MYC target genes in medulloblastoma cells. *Notable reduction of c-MYC protein abundance in ... Significant enhancement in both cell lines G2M checkpoint, mitotic spindle, MYC targets, P53 pathway, and apoptosis gene sets ... Cell cycle and DNA replication are top signaling hubs for medulloblastoma cell growth. ...

Ku70/80 protein inhibitors reduce the repair of DNA double-strand breaks via the Ku70/80 pathway, so they can be used to treat ... Checkpoint kinase 2 (CHEK2), a cell cycle checkpoint regulator gene, codes for a kinase protein activated in response to ... A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol 1990; 10: 6460-6471. ... of cells stained at intensity category 1  1) + (% of cells stained at intensity category 2  2) + (% of cells stained at ...

... and in activating cell cycle checkpoints to reduce the progress of cells harbouring damaged DNA through the cell cycle. Like ... which is highly conserved among ATM related proteins and is believed to be involved in cell cycle regulation and in the ... 13 It is now known that ATM is required for cell cycle checkpoint control at the G1/S border, S phase, and G2/M checkpoints ... 29 Primary cells derived from the Atm−/− mice also show cell cycle checkpoint defects in common with AT, including ...

... the cancer stem cell theory argues that only a few cells (cancer stem cells or CSCs) within the tumour possess this ability to ... contains mutations that differ from that of other cells in the tumour. The clonal evolution and cancer stem cell theories of ... The theories both point to the existence of cells within a tumour that are capable of initiating the tumour in a different ... This was foiled by tumour cell plasticity, a phenomenon whereby a non-CSC spontaneously de-differentiates into a CSC. ...

The maize homologue of the cell cycle checkpoint protein MAD2 reveals kinetochore substructure and contrasting mitotic and ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... Cell Biol. (2001) [Pubmed]. *Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle ... Cell Biol. (2005) [Pubmed]. *Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein. ...

... cell cycle checkpoint, was found to be extensive in adenoid cystic carcinoma (ACC). The methylation of genes that control ... The other target gene is HMGA2, which encodes a nonhistone chromosomal high mobility group protein that is involved in ... the excretory duct reserve cell or the intercalated duct reserve cell. Excretory stem cells give rise to squamous cell and ... Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, ...

Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle ... HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell ... Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). May repress the promoter of p53, and ... Ruggieri A, Murdolo M, Rapicetta M. Induction of FAS ligand expression in a human hepatoblastoma cell line by HCV core protein ...

... that Bcl-2 family proteins interact with regulators of caspases and regulators of cell cycle check point activation (Molecular ... 94: 690-694, 1997), that cellular anti-death genes can alter the pathogenesis of virus infections (Nature Med. 5:832-835, 1999 ... Billions of cells die per day in the human body. Like cell division and differentiation, cell death is also critical for normal ... Cell Biology Research in the Wilson Lab focuses on three components of nuclear lamina structure: lamins, LEM...-domain proteins ...

GO:0007094 mitotic cell cycle spindle assembly checkpoint. GO:0051987 positive regulation of attachment of spindle microtubules ... GO:0007049 cell cycle. GO:0000775 chromosome, centromeric region. GO:0005515 protein binding. GO:0007088 regulation of mitosis ... kinesin-like protein b [Bombyx mori] (4e-176). GeneOntology terms. GO:0005737 cytoplasm. GO:0007275 multicellular organismal ... GO:0051301 cell division. GO:0005874 microtubule. GO:0000776 kinetochore. GO:0007018 microtubule-based movement. GO:0005694 ...

There is resurgent interest in cancer cell metabolism as researchers seek to understand how metabolic pathways are altered in ... which regulate pathways that control cell division. The constitutive activation of the cell cycle and the loss of checkpoints, ... The most commonly mutated gene in cancers is KRAS. The KRAS protein, a GTPase, normally functions as a molecular switch, ... Her work focuses on cell cycle control of B cell immunity and malignancies, particularly reprogramming cancer cells by cell ...

Figure 2. Orderly progression through the cell cycle involves passage through sequential checkpoints. Full holoenzyme activity ... predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is ... Cells have a protein on their surface called PD-1 (in orange above). When PD-1 binds to PD-L1 (yellow) on another cell, the T ... PD-1 blocks cell cycle progression in the G1 phase. PD-1 suppressed the transcription of SKP2, the substrate recognition ...

... which block proteins that help control the cell cycle. *drugs that help treat people with BRCA gene mutations ... but breast cancer cells can use these checkpoints to hide.. Immune checkpoint inhibitors target checkpoint proteins to turn the ... PD-1 is a protein on T cells that keeps them from attacking other cells. A PD-1 inhibitor called "pembrolizumab (Keytruda)" can ... Immune checkpoint inhibitors. are a type of immunotherapy.. The immune systems checkpoints are turned on and off to start and ...

Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism ... Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction ... signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. ... The major event of MBT was the activation of a large group of histones and other genes that modify chromatin structure ...

These findings indicate that the DPE could inhibit colonic epithelial cells proliferation through p53 pathway independently. ... each cycle consisted of seven days of 5 % DSS in the drinking water and followed by seven days of regular water. This ... Colonic epithelial cells proliferation of group IV (DPE 250 mg/kgBW) were significantly lower than III and V groups. There ... mg/kg BW was able to increase the percentage of cells in S phase. The expression of mRNA p53 was up regulated in mice received ...