Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and ... Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and ... Study on the pharmacodynamic effect of Rhizoma Dioscoreae polysaccharides on cerebral ischemia-reperfusion injury in rats and ... The primary ischemia/hypoxia injury and secondary reperfusion injury are mainly caused by oxidative stress, which caused by ...

OM-MSC inhibits pyroptotic and apoptotic death of microglial cell in response to cerebral ischemia/reperfusion insult by ... A traditional oxygen-glucose deprivation/reperfusion (OGD/R) model, analogous to I/R, was established. Results showed that OGD/ ... been directed at developing treatments that modulate inflammatory responses and protect against cell death caused by cerebral I ... Microglial cells are the first line immune cells that initiate inflammatory responses following cerebral ischemia/reperfusion(I ...

Find the latest published documents for cerebral ischemia reperfusion, Related hot topics, top authors, the most cited ... Cerebral ischemia-reperfusion injury (CIRI) refers to the phenomenon that the ischemic injury of brain leads to the injury of ... Cerebral ischemia-reperfusion injury (CIRI) caused by ischemic stroke seriously affects the prognosis of stroke patients. The ... Celastrol Protects against Cerebral Ischemia/Reperfusion Injury in Mice by Inhibiting Glycolysis through Targeting HIF-1α/PDK1 ...

Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct ... The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats Neuropharmacology. ... Keywords: Focal cerebral ischemia; IB; MCAO; MMP; MPT; Mitochondrial membrane potential; OGD; Propofol; ROS; Reactive oxygen ... dysfunction by studying the mitochondria isolated from rat brains subjected to focal cerebral ischemia-reperfusion. The ...

Ischemic stroke is characterised by ischemia-reperfusion damage, which happens when blood flow is restored after a period of ... Ischemia causes inflammation by causing the production of Nf-kb, adhesion molecules, and the upregulation of toll-like ... ischemia. Thrombolysis with thrombolytic reagents such tissue plasminogen activator (tPA) or mechanical removal can be used to ... receptors, whereas reperfusion causes the production of reactive oxygen species (ROS), the opening of the mitochondrial pore, ...

... and middle cerebral artery occlusion was used to make cerebral ischemia/reperfusion model. Pathologically, tissues from rats in ... Inhalation of hydrogen ameliorates cerebral ischemia-reperfusion injury. In Animal studies, Nervous system by CHESS. July 5, ... Former researches proved that low-concentration of hydrogen can be used to ameliorating cerebral ischemia/reperfusion injury. ... Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats: a possible new ...

... gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with ... Global cerebral ischemia/reperfusion injury (GCIRI) occurs in patients who are successfully resuscitated from various clinical ... PPAR-alpha and PPAR-beta expression changes in the hippocampus of rats undergoing global cerebral ischemia/reperfusion due to ... PPAR-alpha and PPAR-beta expression changes in the hippocampus of rats undergoing global cerebral ischemia/reperfusion due to ...

Evaluation of P2X7/NLRP3/Inflammosome Pathway in Ischemia/Reperfusion induced Cerebral Injury. ...

COX-2/PGE2 Pathway Inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion. Yunfei Xu, Ying Liu, Kexin Li, Dun Yuan, ... Cerebral ischemia reperfusion injury induces the secretion of PGE2. After the inhibition of ferroptosis by Fer-1, the ... Cerebral ischemia reperfusion (I/R) injury easily develops in ischemic stroke, resulting in more serious injury. Ferroptosis is ... In conclusion, after cerebral ischemia reperfusion injury, the inhibition of ferroptosis inactivates the COX-2/PGE2 pathway. © ...

Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion. In: Frontiers in ... Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion. / Buscemi, Lara; ... Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion.. ... title = "Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion.", ...

Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK Sanpian decoction ameliorates ... Apoptosis; Cerebral ischemia-reperfusion injury; HIF-1 signaling pathway; MAPK signaling pathway; Network pharmacology; Sanpian ... ETHNOPHARMACOLOGICAL RELEVANCE Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process involving ... cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental ...

... cerebral ischemia. It is useful to think of an ischemic lesion as a densely ischemic core surrounded by better perfused ... Reperfusion plays an important role in the pathophysiology of cerebral ischemia. Magnetic resonance imaging (MRI) and ... Pathophysiology and treatment of cerebral ischemia J Med Invest. 1998 Aug;45(1-4):57-70. ... This article describes the pathophysiology of, and treatment strategy for, cerebral ischemia. It is useful to think of an ...

Conference Paper: Neuropeptide role of α-Melanocyte-stimulating hormone against cerebral ischemia/reperfusion injury in type 1 ... Neuropeptide role of α-Melanocyte-stimulating hormone against cerebral ischemia/reperfusion injury in type 1 diabetes. - ... Neuropeptide role of α-Melanocyte-stimulating hormone against cerebral ischemia/reperfusion injury in type 1 diabetes. ... I/R injury was induced by blocking the right middle cerebral artery for 2 hours with reperfusion for 2 hours and 22 hours, ...

Cerebral ischemia-reperfusion injury is a major public health concern that causes high rates of disability and mortality in ... Cerebral ischemia-reperfusion injury is a major public health concern that causes high rates of disability and mortality in ... Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury. ... Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury. ...

... in Sprague-Dawley rats with cerebral ischemia-reperfusion (I/R). The rat model of cerebral artery ischemia was established by ... the suture-occluded method with ischemia for 2 h and reperfusion for 72 h. Thirty-four male rats were randomly divided into ... Atorvastatin could inhibit neuronal apoptosis and alleviate the cerebral I/R injury. The mechanism may be related to the ... in Sprague-Dawley rats with cerebral ischemia-reperfusion (I/R). The rat model of cerebral artery ischemia was established by ...

... is a serious complication often associated with cerebral ischemia. The purpose of this study was to explore the therapeutic ...

Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion. ...

Targeting PFKFB3 alleviates Cerebral ischemia-reperfusion injury in mice. Exposing a potential treatment to prevent neural ... "Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice". Scientific Reports. 9 (1): 11670. Bibcode:2019NatSR ... the summer school of the International Society of Neurochemistry and the Journal of Neurochemistry under the theme of Cerebral ... death, which can be used in cases of traumatic brain injury, brain ischemia, amyotrophic lateral sclerosis, Alzheimers disease ...

d Cerebral ischemia-reperfusion induces mitophagy in a DRP1-dependent manner with subsequent neuronal cell death. e Chronic ... Inhibition of peroxynitrite-induced mitophagy activation attenuates cerebral ischemia-reperfusion injury. Mol. Neurobiol. 55, ... activates mitophagy via the PINK1/PARKIN pathway to mediate cerebral ischemia-reperfusion injury (Fig. 1d)62. Increased ... prevented mitophagy-induced cell death in the ischemia-reperfusion injured brain.. In hippocampal neuronal cell death caused by ...

The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia-reperfusion injury (CIRI). RAGs ... The model used in this study was established by middle cerebral artery occlusion (MCAO) and reperfusion. Twenty-seven adult ... The rats were fed by gavage immediately after reperfusion. Blood was collected from the orbital venous plexus, and the RAGs and ... Yu XH, Zhu YQ, Wang YJ, Xu YP, Guo Y. Effects of rhubarb anthraquinone glycoside on cerebral ischemia-reperfusion injury and ...

It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix ... "Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion". Neuroscience. 262 (3): ... and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema". Neurochem. Int. 58 (8 ...

The Alterations in Mitochondrial Dynamics Following Cerebral Ischemia/Reperfusion Injury. Previous Article in Special Issue. ...

Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow ... Hyperglycemia and the vascular effects of cerebral ischemia. Stroke. 1997 Jan. 28(1):149-54. [QxMD MEDLINE Link]. ... Cortical blindness and cerebral infarction associated with severe hypoglycemia. Diabetes Care. 1996 Sep. 19(9):1001-3. [QxMD ... Cerebral ischemic damage in diabetes: an inflammatory perspective. J Neuroinflammation. 2017 Jan 23. 14 (1):21. [QxMD MEDLINE ...

... the area of cerebral avascular necrosis, and neuronal necrosis while increasing the levels of IL-6 and APP proteins (,span ... and the pharmacodynamics and key targets were verified using the rat middle cerebral artery occlusion (MCAO) model. ,i,Methods ... 2.7.6. Effect of SHD on the Pathomorphology of Cerebral Ischemia-Reperfusion Rats. The brain tissue was fixed in 4% ... in the cerebral hemisphere after staining. . ... on blood brain barrier injury in cerebral ischemia-reperfusion ...

... exerts a neuroprotective effect and normalises redox homeostasis in a rat model of cerebral ischemia/reperfusion *E. D. ...

Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the ... Global cerebral ischemia followed by reperfusion, which leads to extensive neuronal damage, particularly the neurons in the ... Xu X, Chua CC, Gao J et al (2008) Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a ... Apoptosis is one of the major mechanisms that lead to neuronal death after cerebral ischemia and reperfusion. The ...

Protein Aggregation and Inflammatory Response Following Cerebral Ischemia and. Reperfusion Injury. Eur J Pharmacol. 2019; 853: ... ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase.. Pharmacol Res. 2011; 64(3): 195-202.. ... Administration Attenuates Focal Cerebral Ischemic Reperfusion Injury through. Inhibition of HMGB1 and Inflammation Signals. Exp ... Thalamic Degeneration in Rats with Focal Cerebral Ischemia. J. Stroke Cerebrovasc.. Dis. 1998; 7: 1-9. DOI: 10.1016/s1052-3057( ...

on cerebral ischemia and reperfusion injury in a middle cerebral artery occlusion model in mice in a dose-dependent ... and provides neuroprotection in focal cerebral ischemia/reperfusion injury in mice [56]. Researchers declare for its ... focal cerebral ischemia/reperfusion injury in mice. Eur J Pharmacol. 2016; 775: 113-9. ... olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury. J Leukoc Biol. 2013; ...

Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow ... of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in ... Molecular pathophysiology of cerebral edema. J Cereb Blood Flow Metab. (2016) 36:513-8. doi: 10.1177/0271678X15617172 ... Predictors for cerebral edema in acute ischemic stroke treated with intravenous thrombolysis. Stroke. (2017) 48:2464-71. doi: ...

Establishment of a cerebral ischemia-reperfusion model in rats through MCAO. The cerebral ischemia-reperfusion model was ... A model of cerebral ischemia‑reperfusion was established using the MCAO method. Lentivirus construction and injection were used ... The purpose of the present study was to clarify the changes in HSP90β expression in a rat cerebral ischemia-reperfusion model ... However, after cerebral ischemia-reperfusion in rats, HSP90β expression coincided with astrocyte markers in the ischemic ...