Activated Yes-Associated Protein Accelerates Cell Cycle, Inhibits Apoptosis, and Delays Senescence in Human Periodontal...
... cellular senescence was delayed (P,0.01); the expression of P-MEK, P-ERK, P-P90RSK and P-Msk increased, while the expression of ... Keywords: Yap, Cell Cycle, Apoptosis, Senescence, Human Periodontal Ligament Stem Cells Citation styles. APA Copy. Jia, L., Gu ... Cell senescence was detected by β-galactosidase staining. Proteins in ERK, Bcl-2, and p53 signaling pathways were detected by ... Conclusions: Activated YAP promotes proliferation, inhibits apoptosis, and delays senescence of h-PDLSCs. The Hippo-YAP ...
Biblio | Page 4 | Linus Pauling Institute | Oregon State University
PDF) Pseudoephedrine-Benefits and Risks
A cellular senescence model was established by challenging airway epithelial cells with cigarette smoke extract (CSE) and ... TSG4 was isolated from TSGs using macroporous resin and found to significantly suppress cellular senescence in CSE/LPS-induced ... Tong Sai granules improves AECOPD via regulation of MAPK-SIRT1-NF-κB pathway and cellular senescence alleviation ... critical regulators of senescence such as p21 and p53, and the apoptotic marker γH2AX, all of which are factors in cellular ...
Biblio | Page 4 | Linus Pauling Institute | Oregon State University
Green Tea Compound EGCG Extends Lifespan and Healthspan by Fighting Ce - ProHealth.com
EGCG in green tea extends lifespan in aging mice by fighting back on cellular senescence, which could be why some of the ... which they measured via markers of senescence. They found that the rates of cellular senescence were tissue-dependent, with the ... EGCG Extends Lifespan and Fights Cellular Senescence. This study looked at the effects of EGCG consumption in mice aged 6, 10, ... Further, gut dysbiosis is directly linked to the induction of cellular senescence, and microbiome modulators have exhibited ...
September 2021 Director's Status Report | National Institute on Aging
Does cellular senescence hold secrets for healthier aging? (7/13/2021). *Four studies explore womens brain and heart health ... Cellular adaptation is a critical aspect of the cellular response to both intra- and extracellular challenges. This pre-meeting ... Herman will lead the newly established Translational Senescence Unit (TSU) within the RNA Regulation Section (RRS) of LGG. As ... Herman earned her Ph.D. in Molecular and Cellular Biosciences from Temple University in Philadelphia, PA in 2019. Upon ...
Frontiers | Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults
... senescence-associated secretory phenotype (SASP). The main goal of SASP production is to activate innate immune cells, such as ... differentiation and susceptibility to complications following respiratory infections such as COVID-19 and influenza.Senescence ... Cellular senescence is characterized by a state of essentially irreversible proliferative arrest caused by potentially ... Senescence. Cellular senescence is characterized by a state of essentially irreversible proliferative arrest caused by ...
Burmese ferret-badger (Melogale personata) longevity, ageing, and life history
Lung - Emphysema - Nonneoplastic Lesion Atlas
Caveolin-1, cellular senescence and pulmonary emphysema. Aging (Albany NY) 1:831-835. ... Chief, Cellular and Molecular Pathology Branch. National Toxicology Program. National Institute of Environmental Health ...
Human SNF5 arming of double-deleted vaccinia virus shows oncolytic and cytostatic activity against central nervous system...
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. J Biol Chem. ... Loss of the hSNF5 gene concomitantly inactivates p21CIP/WAF1 and p16INK4a activity associated with replicative senescence in ...
Biology | Free Full-Text | The Role and Regulation of the NKG2D/NKG2D Ligand System in Cancer
A further broad stimulus to NKG2DL expression is cellular senescence [79], which is considered to be an emerging hallmark of ... Domen, A.; Deben, C.; Verswyvel, J.; Flieswasser, T.; Prenen, H.; Peeters, M.; Lardon, F.; Wouters, A. Cellular senescence in ... Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G. PLoS ONE 2009, 4, e4503. [Google Scholar ... Zhang, Y.; Hu, R.; Xi, B.; Nie, D.; Xu, H.; Liu, A. Mechanisms of Senescence-Related NKG2D Ligands Release and Immune Escape ...
PROTEIN RPPA LIST
... positive regulation of cellular senescence; positive regulation of macrophage apoptosis; replicative senescence; cellular ... apoptotic process; cellular response to lithium ion; cellular response to indole-3-methanol; cellular component disassembly ... cellular response to epidermal growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to cell- ... cellular senescence; positive regulation of DNA replication; MAPK cascade; activation of MAPKK activity; positive regulation of ...
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Search | The Embryo Project Encyclopedia
Telomeres and Telomerase in Cellular Aging (Senescence). Telomeres are sequences of DNA on the ends of chromosomes that protect ... As cells replicate, telomeres shorten at the end of chromosomes, which correlates to senescence or cellular aging. Integral to ... mechanisms behind cellular aging. The concept states that a normal human. cell can only replicate and divide forty to sixty ... Carrels ideas about cellular immortality convinced his many contemporaries that cells could be maintained indefinitely. In the ...
Biomarkers Search
Rapamycin decelerates cellular senescence.. Demidenko ZN; Zubova SG; Bukreeva EI; Pospelov VA; Pospelova TV; Blagosklonny MV. ... 3. Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.. Brookes S; Gagrica S; Sanij E; Rowe ... Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.. Leontieva OV; Blagosklonny MV. ... Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.. Demidenko ZN; ...
Frédéric Joliot Institute for Life Sciences - Science news
Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence | eLife
... could promote further senescence phenomena in non-injured cells thus impairing tissues homeostasis. ... The authors implicitly point to the induction of senescence using the galactosidase assay. Cellular senescence is a ... The authors implicitly point to the induction of senescence using the galactosidase assay. Cellular senescence is a ... 2007) Cellular senescence: when bad things happen to good cells Nature Reviews Molecular Cell Biology 8:729-740. ...
Health and Aging Trajectories: Shared and Competing Risks and Resiliencies for Chronic Diseases Associated with Aging | NHLBI,...
Senescence: Cellular senescence is a cardinal feature of aging whereby anti-apoptotic mutations drive cells to survive but not ... cellular senescence can contribute to structural (brain) and functional (cognitive) aging, while in other tissues senescence ... Cellular senescence is also associated with decreased resilience and shorter lifespan in individuals, as exemplified by ... Molecular and cellular mechanisms of chronic age-related diseases.. *Identifying and managing shared and competing disease ...
A stress-induced cellular aging model with postnatal neural stem cells - White Rose Research Online
... and effectively induced postnatal subventricle NSCs to undergo cellular senescence as determined by augmented senescence- ... have successfully established a cellular model that will be of broad utilities to the molecular exploration of NSC senescence ... 12 more authors) (2014) A stress-induced cellular aging model with postnatal neural stem cells. Cell Death and Disease, 5. 1116 ... Accumulating evidence implicates that the senescence of neural stem cells (NSCs) is of paramount importance to the aging of ...
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ALSF Childhood Cancer Research Grants | Page 2 | Alex's Lemonade Stand Foundation for Childhood Cancer
Naftali Kaminski, MD | Directory of Faculty Research Interests
Aging Biology and Cellular Senescence In Chronic Lung Disease - Chicken Or The Egg; Mythbuster 2: IPF and Cellular Senescence ... From the Kaminski Lab Diaries: Non-coding RNAs that link senescence and pulmonary fibrosis and hormones that may cure it ... Improving Our Understanding and Treatment of Lung Diseases Using Detailed Atlas of Cellular Changes ...
ALSF Childhood Cancer Research Grants | Alex's Lemonade Stand Foundation for Childhood Cancer
2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 6 - National Institute of Mental...
Testicular Cancer Workup: Approach Considerations, Imaging Studies, Procedures
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act. Crit Rev Oncol Hematol. 2020 ... Cellular Classification. Approximately 95% of testicular tumors are germ cell tumors. These are divided into two types: pure ... LDH has independent prognostic significance: increased levels reflect tumor burden, growth rate, and cellular proliferation ...
Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
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Publications - Dr Koralia Paschalaki
Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonarydisease (COPD) and cardiovascular ... BOEC from smokers and COPD patients showed increased DNA double‐strand breaks and senescence compared to nonsmokers. Senescence ... a protein deacetylase that protects against DNA damage and cellular senescence. Inhibition of DNA damage response by silencing ... exhibited significantly reduced senescence(Senescence-associated-beta galactosidase activity, p21CIP1), markers of DNA ...
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