Cellular Senescence / genetics * Humans * Hypersensitivity, Delayed * Immediate-Early Proteins / genetics* * Immediate-Early ...
involved_in cellular senescence IMP Inferred from Mutant Phenotype. more info. PubMed ...
involved_in cellular senescence ISO Inferred from Sequence Orthology. more info. acts_upstream_of_or_within chromosome ...
Cellular Senescence / genetics * Dyskeratosis Congenita / genetics * Heart Diseases / genetics * Humans * Liver Diseases / ...
... it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically ... Cellular Senescence / genetics* * Heat-Shock Proteins / metabolism * Molecular Chaperones / metabolism* * Mutation * Protein ... Transcription errors induce proteotoxic stress and shorten cellular lifespan Nat Commun. 2015 Aug 25:6:8065. doi: 10.1038/ ... Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this ...
Cellular Senescence / genetics* * CpG Islands / genetics * Cyclic Nucleotide Phosphodiesterases, Type 4 / genetics ...
Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, ... Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, ... Using this senescence panel, we are able to characterize senescent cells at the single cell level and identify key ... A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues Nat Commun. 2022 Aug 16;13 ...
... which are emerging as a link between cellular transformation and lifespan. ... Cellular Senescence / genetics* * DNA Methylation * Epigenesis, Genetic* * Gene Silencing * Histones / metabolism * Humans ...
... parameters providing evidence of the potential involvement of WPS in the pathogenesis of COPD through impairing cellular growth ... The data reported here represent the first in vitro demonstration of the effect of waterpipe smoke on cellular ... However, WSC induced cell cycle arrest and cellular senescence mediated by the p53-p21 pathway. Also our study indicated that ... Conclusion: The data reported here represent the first in vitro demonstration of the effect of waterpipe smoke on cellular ...
Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. Cancer, type 2 diabetes ... thus reducing cell proliferation and causing cellular senescence. Among the polyphenolic phytochemicals, resveratrol is ... Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. Cancer, type 2 diabetes ... and cellular organelles such as mitochondria. Aging causes multiple alterations in biological processes including energy ...
Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in ... involved_in negative regulation of cellular senescence IDA Inferred from Direct Assay. more info ... involved_in negative regulation of cellular senescence IMP Inferred from Mutant Phenotype. more info ... involved_in cellular response to hypoxia IMP Inferred from Mutant Phenotype. more info ...
Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in ... involved_in negative regulation of cellular senescence IMP Inferred from Mutant Phenotype. more info ... involved_in cellular response to hypoxia IMP Inferred from Mutant Phenotype. more info ... component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence ...
Iron accumulation during cellular senescence. Killilea DW, Wong SL, Cahaya HS, Atamna H, Ames BN. Killilea DW, et al. Among ...
... in the sense that they result from a sequence of cellular and molecular events designed by natural selection to produce a given ... The decay of senescence is not due to natural selections designing hand, but to its absence. The empirical difference between ... Development and morphogenesis may easily be thought of as programed, in the sense that they result from a sequence of cellular ... 1 Department of Cellular & Structural Biology, University of Texas Health Science Center, STCBM Bldg., Room 3.100, Barshop ...
Hallmarks of Cellular Senescence. Hernandez-Segura A, Nehme J, Demaria M. Hernandez-Segura A, et al. Among authors: demaria m. ... Cellular Senescence: Aging, Cancer, and Injury. Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A. ... Cellular Senescence: Defining a Path Forward. Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, ... The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions. Secomandi L, ...
Finally, cellular senescence was investigated by using a newly established staining procedure for lipofuscin, based on a Sudan ... Keywords: DNA damage; cell cycle; cellular senescence; clonogenic assay; gold nanoparticles (AuNPs); ionizing radiation (IR); ...
Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in ... involved_in negative regulation of cellular senescence IMP Inferred from Mutant Phenotype. more info ... involved_in cellular response to hypoxia IMP Inferred from Mutant Phenotype. more info ... component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence ...
Cellular senescence in skeletal disease: mechanisms and treatment. He X, Hu W, Zhang Y, Chen M, Ding Y, Yang H, He F, Gu Q, Shi ...
Cellular senescence in skeletal disease: mechanisms and treatment. He X, Hu W, Zhang Y, Chen M, Ding Y, Yang H, He F, Gu Q, Shi ...
Cellular Senescence: A Troy Horse in Pulmonary Fibrosis. Wan R, Wang L, Zhu M, Li W, Duan Y, Yu G. Wan R, et al. Among authors ...
The heterogeneity of cellular senescence: insights at the single-cell level. Cohn RL, Gasek NS, Kuchel GA, Xu M. Cohn RL, et al ...
involved_in negative regulation of cellular senescence ISO Inferred from Sequence Orthology. more info ...
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis. Wiley CD, Sharma R, Davis SS, Lopez- ...
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. Wang W, Zheng Y, Sun S, Li W, Song M, Ji ... Resurrection of endogenous retroviruses during aging reinforces senescence. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu ...
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts. ...
Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Yamamoto- ...
... rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence. ... Kir2.2 knockdown induces senescence of cancer cells by a mechanism involving reactive oxygen species accumulation. Title: ... Cellular electrophysiology assays of mouse Kir2.1 and human Kir2.2 indicated that, consistent with simulations, the Leu residue ... rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence. ...
Nuclear barrier induction as a new modality of cellular senescence. GSE113155. Transcriptome analysis by microarray of human ... A cellular model reflecting the phenotypic heterogeneity of squamous cell carcinoma. GSE69060. Gene expression profiles from ... Transcriptomic profiling reveals differential cellular response of copper oxide nanoparticles and polystyrene nanoplastics in ...
At the cellular level, fibroblasts from Hat1 haploinsufficient embryos undergo early senescence and accumulate high levels of ...
span,,i,BRCA1,/i, gene mutations impair homologous recombination (HR) DNA repair, resulting in cellular senescence and ... BRCA1 gene mutations impair homologous recombination (HR) DNA repair, resulting in cellular senescence and embryonic lethality ...