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*  Cell Transformation, Viral | ISHAR Online
On rare occasions a clone of cells emerges from the population in crisis and gives rise to an immortalized cell line. The ... cells continue proliferating for a limited number of population doublings beyond the point at which normal cells undergo ... the growth curve of these transformed cells changed to that of normal young cells. ... Normal human diploid cells, TIG-1, ceased to proliferate at about the 62 population doubling level (PDL). Transformed clones ...
http://isharonline.org/tags/cell-transformation-viral
*  Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA...
Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA ... To determine the requirements for the individual Ad2 E1B proteins during the transformation of rodent cells, viral mutants were ... It was completely defective for transformation of CREF cells in virion- and DNA-mediated assays. In HeLa cells, pm1722 ... was also extremely defective for the transformation of CREF cells in virion- and viral DNA-mediated assays. This result is in ...
https://www.ncbi.nlm.nih.gov/pubmed/2949421?dopt=Abstract
*  Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape. | JCB
Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape.. C ... Identification of new actin-associated polypeptides that are modified by viral transformation and changes in cell shape. ... C4h is not found in cells such as lymphocytes and oncogenically transformed mesenchymal cells where actin stress fiber bundles ... The Journal of Cell Biology Jul 1988, 107 (1) 153-161; DOI: 10.1083/jcb.107.1.153 ...
http://jcb.rupress.org/content/107/1/153
*  Oncogenicity And Cell Transformat... preview & related info | Mendeley
Oncogenicity And Cell Transformation By Papovavirus SV40: The Role Of The Viral Genome. *Butel J ... Oncogenicity And Cell Transformation By Papovavirus SV40: The Role Of The Viral Genome. Advances in Cancer Research, 15(C), 1- ... The extent of the transcription of the viral genome seems to vary from one transformed cell line to the next. No relationships ... Fusion or cocultivation of the transformed cell with normal susceptible cells may sometimes succeed in the rescue of infectious ...
https://www.mendeley.com/papers/oncogenicity-cell-transformation-papovavirus-sv40-role-viral-genome/
*  People | Steitz Lab | Molecular Biophysics and Biochemistry | Yale School of Medicine
Autoantibodies; Biochemistry; Biophysics; Cell Transformation, Viral; RNA Processing, Post-Transcriptional; Gene Expression; ...
https://medicine.yale.edu/lab/steitz/people/?page=4&
*  Joan A Steitz, PhD > Yale Stem Cell Center | Yale School of...
Autoantibodies; Biochemistry; Biophysics; Cell Transformation, Viral; RNA Processing, Post-Transcriptional; Gene Expression; ... Lee N, Moss WN, Yario TA, Steitz JA: EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA. Cell. 2015 Feb 12; ... Cazalla D, Xie M, Steitz JA: A primate herpesvirus uses the integrator complex to generate viral microRNAs. Mol Cell. 2011 Sep ... Stem Cell Center, Yale: Transcriptional Regulation of Stem and Progenitor Cells. Yale Cancer Center: Virus and Other Infection- ...
http://medicine.yale.edu/stemcell/people/joan_steitz-2.profile
*  Interaction between activin-A and follistatin-288 on Ac | Open-i
Cells were incubated for 6 hours in the presence or absence of activin-A (10 ng/ml) ... Cell Transformation, Viral. *Dose-Response Relationship, Drug. *Female. *Follistatin/pharmacology. *Gene Expression Regulation/ ... Cells were incubated for 6 hours in the presence or absence of activin-A (10 ng/ml) alone, or activin-A(10 ng/ml) incombination ... Cells were incubated for 6 hours in the presence or absence of activin-A (10 ng/ml) alone, or activin-A(10 ng/ml) incombination ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC153493_1477-7827-1-29-5&req=4
*  Latent gene expression profiles of B cells transformed | Open-i
Latent gene expression profiles of B cells transformed byΔ123 virus.(A) and (B) EBV latent gene transcription and translation ... Cell Transformation, Viral*. *Epstein-Barr Virus Infections/genetics*/virology. *Herpesvirus 4, Human/genetics*/pathogenicity* ... The viral latent proteins are necessary for permanent B cell growth, but it is unknown whether they are sufficient. EBV was ... The viral latent proteins are necessary for permanent B cell growth, but it is unknown whether they are sufficient. EBV was ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3040666_ppat.1001294.g005&req=4
*  myelodysplastic syndromes; Dysmyelopoietic Syndromes
Cell Transformation, Viral. 1. + + +. 63. Leukocytosis. 1. + + +. 64. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. 1. + + ...
https://lookfordiagnosis.com/results.php?symptoms=myelodysplastic+syndromes%3B%20Dysmyelopoietic%20Syndromes&lang=1&parent=%2F&mode=F
*  Viruses | Free Full-Text | Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles | HTML
It has been known for many years that viruses have the ability to replicate in and lyse cancer cells. Although encouraging ... Blackford, A.N.; Grand, R.J. Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J ... tumor cells [161-163], T cells [164-166], and dendritic cells (DCs) [165]. Ong et al. [167] showed that MV-infected T cells ... Cells that have been tested include mesenchymal stem cells [157-159], monocytes [160], outgrowth endothelial cells [160], ...
https://www.mdpi.com/1999-4915/2/1/78/htm
*  Middle tumor antigen - Wikipedia
... role in viral life cycle and cell transformation". Journal of cellular physiology. 215 (2): 309-19. doi:10.1002/jcp.21326. PMC ... It has the ability to induce neoplastic transformation in a variety of cell types and can immortalize cells in culture. Its ... In MPyV, MTag is an efficient oncoprotein that can be sufficient to induce neoplastic transformation in some cells. The genes ... MTag is also required for viral persistence. However, MTag's best-studied functions center on its interaction with host cell ...
https://en.wikipedia.org/wiki/Middle_tumor_antigen
*  Small tumor antigen - Wikipedia
... role in viral life cycle and cell transformation". Journal of cellular physiology. 215 (2): 309-19. doi:10.1002/jcp.21326. PMC ... the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to ... Viral proteins therefore promote dysregulation of the cell cycle and entry into S phase. This function is usually primarily ... In SV40, STag has a similar role in cellular transformation. In Merkel cell polyomavirus, it appears to play a significant role ...
https://en.wikipedia.org/wiki/Small_tumor_antigen
*  Infectious Disease
... pathogenesis of Epstein-Barr virus-mediated cell transformation, viral subversion of host growth, survival, and epigenetic ... and viral infections; antibiotic susceptibility testing; and serology tests for infectious agents. ...
http://www.brighamandwomens.org/Departments_and_Services/medicine/services/infectiousdisease/Research/default.aspx?sub=3
*  Viruses | Free Full-Text | MicroRNA and Pathogenesis of Enterovirus Infection
MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human ... shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising ... a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. ... Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the ...
http://www.mdpi.com/1999-4915/8/1/11
*  "Accumulation of human immunodeficiency virus type 1 DNA in T cells: re" by Harriet L. Robinson and Donna M. Zinkus
... whereas those grown in the absence of the antibody contained approximately 80 copies of viral DNA per cell. Most of the viral ... In cultures grown in the presence or absence of the antibody, the 9.6-kilobase linear duplex of viral DNA appeared to undergo ... These results demonstrate that T cells accumulate unintegrated human immunodeficiency virus type 1 DNA as a result of multiple ... DNA in cultures grown in the absence of the antibody was present in a broad smear of apparently incomplete viral sequences. ...
https://escholarship.umassmed.edu/oapubs/1576/
*  Activated Macrophage Mediated Cytotoxicity for Transformed Target Cells | Springer for Research & Development
... natural killer cells, natural cytotoxicity cells, antibody dependent cell... ... The biochemical mechanisms that induce target cell lysis in cell mediated cytotoxicity systems-cytotoxic T-lymphocytes, ... Oncogenicity and cell transformation by papovavirus SV40: The role the viral genome. Adv. in Cancer Res. 15:1 (1972).CrossRef ... natural killer cells, natural cytotoxicity cells, antibody dependent cell mediated cytotoxicity systems, and cytotoxic ...
https://rd.springer.com/chapter/10.1007/978-1-4684-8959-0_17
*  Joshua C. Munger, Ph.D. - University of Rochester Medical Center
Increased understanding of these mechanisms and the roles they play during viral infection and cancer-cell transformation will ... viral infection or oncogenic transformation. We measure metabolic flux by feeding cells with stable-isotope-labeled nutrient, e ... Another major focus in my laboratory is to elucidate novel metabolic activities induced by the transformation of cells from ... Both cancerous cells and viruses depend on the metabolic resources provided by the host to supply the energy and biochemical ...
https://www.urmc.rochester.edu/people/27153154-joshua-c-munger
*  Virus | Encyclopedia.com
Virus A virus is a parasite that must infect a living cell to reproduce. Although viruses share several features with living ... Viral Cancers. Infection with certain viruses can also result in cell transformation, stable genetic changes in the cell that ... Latently infected cells may express a limited number of viral products, including those that result in cell transformation. ... viral RNA is used to make new viral DNA. The viral DNA is then incorporated into host cell DNA, where it is used to direct the ...
https://www.encyclopedia.com/plants-and-animals/microbes-algae-and-fungi/moneran-and-protistan/virus
*  Human cytotoxic T-cell responses against Epstein-Barr virus nuclear antigens demonstrated by using recombinant vaccinia viruses.
Antigens, Viral. dc.subject.mesh. Cell Transformation, Viral. dc.subject.mesh. Cytotoxicity, Immunologic. ... Viral Proteins. dc.title. Human cytotoxic T-cell responses against Epstein-Barr virus nuclear antigens demonstrated by using ... Human cytotoxic T-cell responses against Epstein-Barr virus nuclear antigens demonstrated by using recombinant vaccinia viruses ... Human cytotoxic T-cell responses against Epstein-Barr virus nuclear antigens demonstrated by using recombinant vaccinia viruses ...
https://christie.openrepository.com/handle/10541/109763?show=full
*  ASH1L | Cancer Genetics Web
The virus was further modified with a cell-penetrating peptide (Tat-PTD) in the viral capsid, which we have previously shown ... the migration of lung cancer cells was reduced. In neuroendocrine cells expressing hASH1, such as a pulmonary carcinoid cell ... Cell Transformation, Viral. *Sequence Analysis, RNA. *Prolactinoma. *rac1 GTP-Binding Protein. *Adenosine Triphosphatases ... Twenty lung cancer cell lines out of 33 were positive for hASH1 mRNA by reverse transcription PCR, including 6/6 small cell ...
http://cancer-genetics.org/ASH1L.htm
*  Proteins encoded by v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal...
Amino Acid Sequence; Animals; Avian Leukosis/analysis; Avian leukosis virus; Cell Line; Cell Transformation, Viral; Coturnix; ... identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell, 34 (3). pp. 789-798 ... In uninfected quail cells, anti-v-myc 12C also recognizes a candidate c-myc protein of 60 kd, which does not appear to be ... The serum also recognizes comigrating 62 kd proteins from three chicken bursal lymphoma cell lines and from the products of in ...
http://authors.fhcrc.org/113/
*  Travel Award Recipients | College of Veterinary Medicine
Amanda Panfil, "PRMT5 is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene ... "Mechanisms of SAMHD1-mediated Anti-Proliferation in Cutaneous T-cell Lymphoma and Acute Monocytic Leukemia Cells." His mentor ... Joelle Fenger, "Dissecting the Role of MIR-9 in Normal and Malignant Mast Cell Biology." Her mentors are Drs. Cheryl London, ... Molecular and Cellular Biology: Lauren Himmel, for her poster presentation, "Suppression of Breast Cancer Stem Cells in the ...
https://vet.osu.edu/research/2010-2013-travel-award-recipients
*  Medical Xpress - green fluorescent protein
... or cell transformation. To date, the GFP gene has been introduced and expressed in many bacteria, yeast and other fungi, fish ( ... The GFP gene can be introduced into organisms and maintained in their genome through breeding, injection with a viral vector, ... Stem cells used to reattach teeth with new technique. A new approach to anchor teeth back in the jaw using stem cells has been ... In cell and molecular biology, the GFP gene is frequently used as a reporter of expression. In modified forms it has been used ...
https://medicalxpress.com/tags/green+fluorescent+protein/sort/rank/all/
*  Cell Cycle Regulation During Viral Infection | SpringerLink
... viruses typically require factors provided by the cells that they have infected. Subversion of the cellular machinery that ... To replicate their genomes in cells and generate new progeny, ... including cell transformation and cancer progression and ... Cell cycle arrest may inhibit early cell death of infected cells, allow the cells to evade immune defenses, or help promote ... Zhao RY, Elder RT (2005) Viral infections and cell cycle G2/M regulation. Cell Res 15(3):143-149PubMedGoogle Scholar ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-0888-2_10
*  Salk Institute for Biological Studies - Wikipedia
Renato Dulbecco (deceased), Nobel laureate (for viral transformation of cells).. See also[edit]. *San Diego Historical ... Pollack, Andrew (8 May 2008). "$271 Million for Research on Stem Cells in California". The New York Times.. ... The institute appointed genome biologist Eric Lander and stem cell biologist Irving Weissman as non-resident fellows in ...
https://en.wikipedia.org/wiki/Salk_Institute