CXCR3 as a molecular target in breast cancer metastasis: inhibition of tumor cell migration and promotion of host anti-tumor ... Knockdown (KD) of CXCR3 in metastatic tumor cells suppressed tumor cell migration and metastasis. Importantly, CXCR3 expression ... and Arg-1 in myeloid cells and an increased T cell response. IFN-γ neutralization diminished the metastasis inhibition in the ... Here we report that targeting CXCR3 decreased tumor cell migration and at the same time improved host anti-tumor immunity. We ...

EOPK significantly decreased HCT116 cell proliferation and migration, and induced G1 arrest without affecting normal cells. ... To assess the effects of EOPK on cell migration, we performed a wound-healing assay. Further, the contribution of PAK1 to EOPK- ... Our studies indicate that EOPK significantly reduced proliferation and migration of colorectal cancer cells. Furthermore, EOPK ... Our findings suggest that EOPK exerts its anticancer activity via the inhibition of PAK1 expression, suggesting it may be a ...

Subsequently, the cells were treated with realgar (1/2IC50, IC50, 2IC50). Cell migration was measured using the scratch assay, ... Moreover, the scratch assay was used to detect the cell migration ability, and the transwell assay was used to detect the cell ... Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes the Inhibition of Esophageal Cancer Cell Proliferation, ... The CCK-8 method was used to measure the cell inhibition rate, and the clone formation assay was used to measure the clone ...

... CHEN Guo-yan ...

... we identify that KBU2046 inhibits cell motility and cell invasion in vitro. Across three different murine models of human ... We use the unique characteristics of small molecules to probe and selectively modulate cell motility. By coupling efficient ... We identify a unique cell motility regulatory mechanism and synthesize a targeted therapeutic, providing a platform to pursue ... In this study, the authors identify and validate a halogen-substituted isoflavanone able to inhibit prostate cancer cell ...

Ultimately, complete inhibition of cell migration toward CXCL12 and alkyl-OMPT was only achieved in the presence of both CXCR4 ... enhanced CXCL12-induced Gαi/o signaling and cell migration in the parental MDA-MB-231 cells but not in LPA1-deficient cells. ... LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express both CXCR4 and LPA1. ... The presence and impact of CXCR4-LPA1 heteromers on CXCL12-induced signaling and cell migration have been evidenced across ...

Contact inhibition of proliferation (CIP) is the inhibition of cell division with increasing percent of confluency. CIP and CIL ... Collective cell migration describes the movements of group of cells and the emergence of collective behavior from cell- ... While single-cell migration has been extensively studied, collective cell migration is a relatively new field with applications ... Collective cell migration is studied over many model species. Border cells in flies (Drosophila melanogaster): the border cells ...

Cell migration and invasion in SHSY-5Y cells were both reduced remarkably by maslinic acid. Finally, the activity of proteins ... To assess the anti-metastatic effects of maslinic acid on neuroblastoma cells, transwell chambers assays for migration as well ... The effects of maslinic acid on cellular apoptosis, ROS generation, cell migration and invasion, caspase activation and ... It induced dose as well as time reliant anti-proliferative effects against SHSY-5Y cells selectively. The underlying mechanism ...

Lung cells; Dusts; Immune reaction; Nitric oxide; Chemical inhibition; Laboratory animals; Laboratory testing; Cell migration; ... Cellular effects; Cellular reactions; Enzyme inhibitors; Cell culture techniques; Cell cultures; Cell type; Cell signaling ... we have reported that bronchial epithelial cell exposure to swine CAFO dust significantly blunts normative cell migration and ... Results: Migration of epithelial cell monolayers from wild type mice significantly promoted repair of the ECIS-standardized ...

Inhibition of the initial cytokine release and Langerhans cell migration. * Targeting of activated T cells, prevention of ... cell subset producing IL-17. These cells, which are designated Th17, are distinct from Th1 and Th2 populations. Th17 cells are ... Boniface K, Blom B, Liu YJ, de Waal Malefyt R. From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation ... In this model, antigen-presenting cells in the skin, such as Langerhans cells, are believed to migrate from the skin to ...

Cell Physiological Phenomena [G04] * Cell Movement [G04.198] * Cell Aggregation [G04.198.251] * Cell Migration Inhibition [ ... Cell Migration Inhibition Preferred Concept UI. M0003761. Scope Note. Phenomenon of cell-mediated immunity measured by in vitro ... CELL MIGRATION INHIB. Entry Term(s). Chemotaxis Inhibition Previous Indexing. Cell Movement (1968-1970). Hypersensitivity, ... Cell Migration Assays. Leukocyte Migration-Inhibitory Factors. Macrophage Migration-Inhibitory Factors. Public MeSH Note. 72. ...

Both SALPs showed a low cytotoxicity in all investigated cell types. Furthermore, SALPs markedly promoted cell migration via ... In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, ... downregulated expression of maturation markers and inhibited dendritic cell migration. ... Peptide-induced keratinocyte migration was mediated by purinergic receptors and metalloproteases. In contrast, SALPs did not ...

Cell Migration Inhibition / drug effects * Cell Migration Inhibition / immunology * Chemokine CCL20 / metabolism* ... In the chemotaxis migration assay, pretreatment with fluvastatin and simvastatin inhibited the migration of human CD4+ T cells ... However, the level of CCR6 surface expression in memory CD4+ T cells was not affected. Our results suggest that not all, but ... We demonstrated that IL-1β, TNF-α, and IL-17A significantly increased CCL20 production from HaCaT cells. However, these ...

FGFR inhibition disrupts tumor cell proliferation, survival, migration, and angiogenesis. Approval was supported by the FIGHT- ... and thereby decreases cell viability in cancer cell lines with activating FGFR amplifications and fusions. ...

... and CCL20 in migration assays inhibited MAIT cell migration toward placenta conditioned medium. Finally, MAIT cells showed ... and CCL20 in migration assays inhibited MAIT cell migration towards placenta conditioned medium. Finally, MAIT cells showed ... Migration assays showed that MAIT cells and EM T cells migrated toward conditioned medium from placental explants. A ... Migration assays showed that MAIT cells and EM T cells migrated towards conditioned medium from placental explants. A ...

CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D. ... PKClambda/iota inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Title: PKCλ/ι inhibition ... Title: CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated ... involved_in cell-cell junction organization IMP Inferred from Mutant Phenotype. more info ...

... and immune cell infiltration levels. Finally, the interaction between HNK and two HNK-targets regulating the cell cycle was ... such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. ... However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. This ... BCSCs are mostly dormant, and therefore, activating them and modulating the cell cycle are important for successful therapy ...

The extract exhibits anti-inflammatory activity through the inhibition of the cell migration. The mixture of extract ... Conclusions: The extract exhibits anti-inflammatory activity through the inhibition of the cell migration. The mixture of ... The extract also inhibited the inflammatory process induced by subcutaneous carrageenan injection by reducing cell migration, ...

Design and affinity screening of tetraspanin-targeting peptides for imaging and migration inhibition of cancer cells ... Detection and cell imaging of a prostate cancer biomarker. 20:12 CST / 14:14 CEST. Youth Forum. Ying Li. Rational development ... Molecularly imprinted artificial inhibitor for regulation of cell behaviors. 16:15 CST / 10:15 CEST. Keynote. Junqiu Liu. ... MIPs for biomedical applications (-omics, life science studies, disease diagnosis, cancer therapy, viral inhibition, and so on) ...

Explore their impact on proliferation and migration of tracheal cells. Uncover the inhibitory properties of R-albuterol on cell ... R-albuterol showed significant inhibition on migration of smooth muscel cells and the relative migration ratio decreased to 50 ... Cell Proliferation Assay. Cell proliferation was measured with CyQUANT® Cell Proliferation Assay Kit (invitrogen). Cells were ... of the control cells. S-albuterol showed on significant inhibition of cell migration, compared with contro. Black arrows ...

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on ... the cell metabolism... , Find, read and cite all the research you need on ResearchGate ... In human cancer cells, the inhibition of migration by NecroX-5 is cell type-dependent. We observed that the effect of NecroX-5 ... NecroX-5 decreased intracellular calcium concentration by blocking Ca2+ influx, which mediated the inhibition of cell migration ...

Primary endothelial cells from transgenic mouse embedded in 3D collagen gels of ~ 100 Pa Youngs modulus are exposed to 10 ... cell extracellular matrix Biological Context Biological Process. cell migration Molecular Function. myosin II ATPase inhibition ... Cell Type. blood vessel endothelial cell primary cell line cell Cellular Component. ... Robert S. Fischer, Clare M. Waterman (2010) CIL:7428, Mus musculus, blood vessel endothelial cell, primary cell line cell. CIL ...

Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer. Surgery, , ... Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling. ... Cell stem cell, , Crowther, Rebecca R; Schmidt, Stephanie M; Lange, Shannon M; McKell, Melanie C; Robillard, Michelle C; Zhao, ... Cell reports, 36 4, 109420. Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and ...

Inhibition of YAP blocks the BPS-triggered cell migration and up-regulation of fibronectin (FN) and vimentin (Vim). BPS rapidly ... Targeted inhibition of GPER/YAP inhibits BPS-induced migration of TNBC cells. Collectively, we reveal that GPER/Hippo-YAP ... thereby inhibiting HCC cell migration; the Hippo pathway was not noticeably involved in SPON2-mediated HCC cell migration. In ... NTRK1 inhibition decreased YAP-driven transcription, cancer cell proliferation and migration. Furthermore, using a ...

Inhibition of tumor cell migration was examined by wound healing assay. Finally, the effect of treatments on gene expression of ... Keywords: Cellular senescence, Endothelial progenitor cells, Induced pluripotent stem cells, Melatonin, Mesenchymal stem cells ... mesenchymal stem cells, adipose-derived stem cells, and a few others were about less-discussed types of stem cells such as ... Quercetin enhances the suppressory effect of 5-fluorouracil on migration of BC cells. The combination of Quercetin and 5- ...

Brown HO, Levine ML, Lipkin M. Inhibition of intestinal cell renewal and migration induced by starvation. Am J Physiol 1963;205 ... For instance, bloody diarrhea or the presence of white blood cells on methylene blue stain of the stool specimen suggests a ... However, fasting can reduce enterocyte renewal (72). Enteral nutrition stimulates intestinal cell renewal in several ways. In ...

Thus, BTK inhibition could lead to a defect in host innate immune response or proliferation and function of myeloid cells. ... For example, ibrutinibs disruption of chemokine-controlled B cell migration, trafficking, and homing to lymphoid organs might ... ibrutinibs off-target inhibition of interleukin 2-inducible T-cell kinase could weaken the adaptive response against H. ... perivascular/interstitial inflammatory infiltrates composed of eosinophilic and lymphocytic cells without atypical cells, ...

A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation ... We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. ... It also caused an inhibition of SKOV-3 cell migration and inhibited TGF-β1 induced EMT [28]. In addition, in vivo and in vitro ... The net effect of these actions was inhibition of migration and invasion of SKOV-3 cells [28]. Furthermore, calcitriol has been ...

Research group Laboratory for Neurogenesis and Stem Cell Research ... inhibition decreases adult neural progenitor cell migration and ... Cell road - biomaterials for neural stem cell migration Nina Hellström, Carl Zandén, R. Mottaleb, A. Osman, E. Berns, S. I. ... In vivo migration of endogenous brain progenitor cells guided by an injectable peptide amphiphile biomaterial ... Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice ...