MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions.. Backx E, Wauters E, Baldan ... ADM8 is an antigen of TKI-resistant CML cells identified by patient-derived induced pluripotent stem cells.. Stem Cell Reports ... CD62L expression level determines the cell fate of myeloid progenitors.. Ito Y, Nakahara F, Kagoya Y, Kurokawa M.. Stem Cell ... Small cell variant of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma of the dura mimicking tentorial ...
The importance of cell-cell junction proteins (including armadillo proteins) in tumor biology is known, but limited with regard ... PKP-positive cells were reported as a percentage of the total number of carcinoma cells. Based on the extent of cell labeling, ... Alterations of intercellular adhesion are associated with tumor dedifferentiation and invasion [2]. Armadillo-related proteins ... The importance of cell-cell junction proteins (including armadillo proteins) in tumor biology is known, but limited with regard ...
Genome variability in plant somatic cells. 4. Variability in the process of dedifferentiation and callus formation in vitro. ... Biopolym Cell. 1995; 11(6):5-40. [100] Shimada T. Chromosome constitution of tobacco and wheat callus cells. Jpn J Genet. 1971; ... Biopolym Cell. 1998; 14(4):298-319. [3] Kunakh VA. Genome variability in plant somatic cells. 5. Growth and mitotic regime ... Biopolym Cell. 1990; 6(1):103-6. [137] Solovyan VT, Spiridonova EV, Kunakh VA. Genome rearrangements in cell culture of ...
Sugar beet is known to be recalcitrant for dedifferentiation and plant regeneration. These difficulties were major obstacles ... Obtaining dedifferentiated cells (callus) that can regenerate into whole plants is not always feasible for many plant species. ... The transformed cells are subsequently induced to regenerate whole plants.. Sugar beet (Beta vulgaris L.) is generally ... Obtaining dedifferentiated cells (callus) that can regenerate into whole plants is not always feasible for many plant species. ...
Implications of bioenergetics and mitochondrial respiration on smooth muscle cell dedifferentiation and early atherogenesis ... in smooth muscle cells, dedifferentiation markers. My program of research is guided by three main pillars:. ... My primary research interest lies in the area of vascular physiology and particularly in smooth muscle cell (SMC) proliferation ... The aim is to further the understanding of these organ systems with respect to cell signaling, contractility and, ...
Article: Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation... ... It mainly affects how nerve cells form and grow. It causes tumors to grow on nerves. You can get neurofibromatosis from your ...
cells. Reduced insulin transcription and dedifferentiation have been implicated in type 2 diabetes, making drugs that could ... Neural crest cells are in close contact with endocrine cells early in development. We find these cells give rise to neurons ... Neural crest cells are in close contact with endocrine cells early in development. We find these cells give rise to neurons ... Journal of Cell Science. Abstract:. Multi-parameter, single-cell, kinetic analysis reveals multiple modes of cell death in ...
Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in ... Epithelial-mesenchymal transition (EMT) is a reversible dedifferentiation process. In this process, the tumor microenvironment ... of most cells (including T cells, platelets, and cancer cells), with a diameter of about 50-150 nm [10]. Exosomes were first ... van Niel G, DAngelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nature reviews Molecular cell ...
... which initiates apoptosis and cell death [4]. As their main target is cell division, they affect all rapidly dividing cells, ... dedifferentiation and loss of function, invasiveness, and ability to metastasise [2]. These characteristics are caused by ... They are most effective in the G2 phase of the cell cycle and mitosis, but are also active against non-dividing cells, that is ... However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous ...
Simulation results on the composition of the functional stem cell pool of MSC populations suggest that most of the cells that ... we calculated the average transition times of individual cells into stem cell and differentiated states. We predict that at low ... Individual cell-based models are well-suited to provide quantitative predictions on essential features of the spatio-temporal ... Here, we study MSC plasticity on the level of individual cells applying a multi-scale computer model that is based on the ...
N2 - Cellular reprogramming is a dedifferentiation process during which cells continuously undergo phenotypical remodeling. ... AB - Cellular reprogramming is a dedifferentiation process during which cells continuously undergo phenotypical remodeling. ... Cellular reprogramming is a dedifferentiation process during which cells continuously undergo phenotypical remodeling. Although ... abstract = "Cellular reprogramming is a dedifferentiation process during which cells continuously undergo phenotypical ...
Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. Oncogene. 2013 May 16; 32(20): ... Ovarian steroid hormones: whats hot in the stem cell pool? Breast Cancer Res. 2010; 12(4):309. View in: PubMed ... Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of ...
Enteroendocrine cells (EEs) inside the intestinal epithelium undergo dedifferentiation into intestinal stem cells (ISCs) in ... in which cells with defined roles become less specialized, undifferentiated cells, such as stem cells. ... Massive stem cell ablation was used in earlier research using mice to cause dedifferentiation. However, in the current study, ... Posted in: Molecular & Structural Biology , Cell Biology. Tags: Cancer, Cell, Exercise, Fasting, Fruit, Genetic, Glucose, in ...
Dedifferentiation: The process where a cell might reverse its otherwise fixed differentiation status. ... The least-differentiated cells are the totipotent embryonic stem cells which can develop into any cell in the body. The most ... Cell lineage: The family tree history of a cell through all of its divisions. ... How does your entire body form from a single cell? The process of development is perhaps one of the most complicated events in ...
... that starch and sucrose metabolism pathway responsible for cell wall was only significantly enriched in asexual embryonic cell ... in which somatic cells of gametophytes go through dedifferentiation and then differentiate into haploid sporophytes bypassing ... The cell division is an important phenomenon for somatic cells dedifferentiation in apogamy. The auxin regulates cell division ... Referring to somatic cells of gametophytes were triggered into asexual embryonic cells and then changed the cell shape and ...
A variable proportion of cells with granular eosinophilic cytoplasm may be present. ... is a renal cortical tumor typically characterized by malignant epithelial cells with clear cytoplasm and a compact-alveolar ( ... Delahunt B. Sarcomatoid renal carcinoma: the final common dedifferentiation pathway of renal epithelial malignancies. Pathology ... T2 clear cell renal cell carcinoma is a rare entity: a study of 120 clear cell renal cell carcinomas. J Urol. 2005 Oct. 174(4 ...
Mesenchymal stem cells (from rat bone marrow. *Cellular analysis (Western-blot, proteolytic activity, ELISA, qRT-PCR, ARN ... Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular ... Indeed, studies suggest that OA structural progression may result from altered communication between subchondral bone cells (e. ... Identify novel soluble mediators secreted by activated bone cells and acting on chondrocytes. ...
Multiple Myeloma (MM) is an incurable malignancy of plasma cells characterized by wide and remarkable genetic heterogeneity. ... through de-differentiation of plasma cells (Leung-Hagesteijn et al, Cancer Cell 2013). Among patients who received Bortezomib- ... 1C). siRNA meditated knockdown of ADAR increased sensitivity to Bortezomib in MM cell lines with 1q amplification and high ADAR ... Multiple Myeloma (MM) is an incurable malignancy of plasma cells characterized by wide and remarkable genetic heterogeneity. ...
Materials and Methods: Human umbilical vein endothelial cells (HUVECs) were incubated with Met, Lira, or their combination in ... Conclusion: This study showed that combination therapy with Lira and Met could effectively reduce cell proliferation, induce ... apoptosis, and inhibit cell migration in the HUVECs. This study provides evidence to support using Met in combination with Lira ... Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. ...
This suggests that MSCs are inducing loss of the mature β -cell phenotype/ a mild dedifferentiation which we predict may be ... To investigate this, we aimed to induce dedifferentiation in β-cells through several methods: FGF2 treatment, inhibition of ... 8 distinct cell populations that have previously been described in islet single cell studies were identified: β, α, δ, PP, ... Mesenchymal stromal cells (MSCs) are a multipotent and multifunctional adult progenitor cell which have been extensively shown ...
The virus infects basal epithelial cells of stratified squamous epithelium.. Neuroendocrine cancer causes Google Scholar The ... dedifferentiation of neuroendocrine tumor metastases: myth or reality? PubMed Google Scholar Octreotide for the treatment of ... Head and Neck Squamous Cell Carcinoma, în literatura engleză includ neoplazii ale cavităţii orale, orofaringelui, ...
... are highly specialized endothelials that form a barrier between the blood and other liver ... Capillarization: Also known as dedifferentiation, this early event occurs in LSECs following liver injury. LSECs maintain ... Liver sinusoidal endothelial cells (LSECs) are highly specialized liver endothelial cells that form a physical barrier between ... In the presence of antigens, LSECs can induce the differentiation of T cells into regulatory T cells (Treg). This was proven in ...
Both cell types showed similar cell morphology and characteristics of dedifferentiation known for cultured disc cells ... The impact of the different media itself on disc cells behaviour in vitro was low. However, AF and NP cells were only robust, ... Human AF and NP cells were isolated from cervical discs. Cells were expanded in monolayer until passage P2 using six different ... However, proceeding culture in Hams F-12 impeded cell growth of both AF and NP cells. Furthermore, the keratin 18 gene ...
Abstract 975: Glioma cell of origin: Reprogramming and cancer stem cells Cancer Research. 71: 975-975. DOI: 10.1158/1538-7445. ... Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science (New York, N.Y.). 338: 1080-4. ... Cell. 166: 1295-1307.e21. PMID 27565350 DOI: 10.1016/J.Cell.2016.07.041 0.527. ... Cell. 164: 896-910. PMID 26919428 DOI: 10.1016/J.Cell.2015.12.057 0.627. ...
This process is similar to cellular dedifferentiation, and results in the generation of progenitor cells, which, in turn, ... We found that hairy-related 6 (her6) negatively regulates of PR production by regulating the rate of cell divisions in the MG- ... In this study, we tested whether factors involved in dedifferentiation of Drosophila CNS are implicated in the regenerative ... However, SS8-coral fragments exhibited faster growth and recovered cell density and photochemical efficiency more quickly ...
Cancer cells differ radically from healthy cells in the fine architecture of their "cell surfaces". Think in terms of a healthy ... Carcinoma dedifferentiation leading to predominance of Tn over T epitopes is described, as is the role of Tn and T epitopes in ... the ability for the cancer cell to stick to other cells including healthy cells. This process of adhesion is a critically ... The difference between the yards is largely because a cancer cell is unable to completely assemble a normal, healthy cell ...
... and 60 small cell lung carcinomas (SCLC). Carcinoids were smaller in size and had higher synaptophysin and chromogranin A, but ... The multicentre cohort included 58 typical carcinoids (TC), 42 atypical carcinoids (AC), 32 large cell neuroendocrine ... As observed in the carcinoids as well, these results are best interpreted as tumor dedifferentiation being associated with loss ... Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell ...
Tanaka et al. A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts. ... hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell ... Primary Antibodies Secondary Antibodies Blood Products Proteins & Peptides Reagents Cell Lines & Lysates TrueBlot® Kits ... Keller F et al. A Scaffold-Free 3-D Co-Culture Mimics the Major Features of the Reverse Warburg Effect In Vitro. Cells. (2020) ...
LetPub整理了最新的Journal of Molecular Cell Biology 期刊投稿经验, 期刊官方投稿网址,影响因子,审稿周期 ... MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis.. ... Journal of Molecular Cell Biology. J MOL CELL BIOL (此期刊被最新的JCR期刊SCIE收录) LetPub评分 7.5 ... 经LetPub语言功底雄
... some of these cells may derive from de-differentiation of stump cells [5]. Reserve stem cells (muscle satellite cells) are also ... The basal cells of the WT AEC had become noticeably columnar. These cells are believed to be important in signalling to the ... Columnar basal epithelial cells (be) can be seen. Hypertrophic epithelial cells (h) can be seen in the AEC. (D, D) 5 days ... there is thought to be a de-differentiation step, which occurs following wound healing and provides cells to the blastema. ...