... monophosphate dehydrogenase and triggers post-G1 arrest apoptosis in human leukemia cell lines. ... The cytotoxic and anti-proliferative effects of 3-hydrogenkwadaphnin in K562 and jurkat cells is reduced by guanosine. ... 1. Study of association between MRP1 gene and multidrug resistance in leukemic patients. Theisi by Masoud Golalipour for Phd ... monophosphate dehydrogenase and triggers post-G1 arrest apoptosis in human leukemia cell lines. ...

... in different cell lines and performed immunoblot, co-immunoprecipitation, gene expression microarray, quantitative RT-PCR, cell ... Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 ... The expression of RUNX1 mutant in ASXL1-mutated myeloid cells augmented proliferation, blocked differentiation, and increased ... and bone marrow cells. Bone marrow samples from CMML showed that ID1 overexpressed in coexisted mutations of RUNX1 and ASXL1 ...

Intro Cell alternative therapies in human beings require the creation of large-scale tradition of viable, working cells. ... Apoptosis price and cell routine distribution were discovered by annexinV-FITC/PI staining assay and cell routine analysis. It ... The progenitor cells bring about GFP+ leukemic blasts with an atypical Compact disc4+Compact disc8+ phenotype in peripheral ... To generate clinically-sufficient numbers of genetically altered T cells we use K562-derived artificial Anethole trithione ...

AID 594378 - Cell cycle arrest in human K562 cells assessed as accumulation at G0-G1 phase at IC100 after 24 hrs using.... ... A number of the compounds were markedly cytotoxic toward murine P388 and L1210 leukemic cells and also to human Molt 4/C8 and ... The cell apoptosis was detected using flow cytometry. The mRNA expression of genes associated with NF-E2-related factor 2 (Nrf2 ... Pro was cytotoxic to human tumor cell lines in vitro (IC50,50 μM for 48 h). Four human tumor cell lines (SCG-7901, K562, A549 ...

Chen, Guo Qiang 2002: PML gene, arsenic and apoptosis of leukemic cells. Cell Research 12(3-4): 288-289 ... prevents infection of T cells in trans by dendritic cell-associated virus. Journal of Human Virology 5(1): 90 ... PMA induced changes in the expression of phosphotyrosine phosphatases during the differentiation of the CML cell line K562. ... PPARgamma-mediated apoptotic cell death in human and rat glioma cell lines A new therapeutic strategy?. Neurology 56(8 Suppl 3 ...

it has been shown that CD25 serves as a negative growth regulator of Chronic myeloid leukemia leukemic stem cells. PMID: ... Jak-STAT signaling pathway PI3K-Akt signaling pathway Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell ... Western Blot analysis of K562 cells using IL-2Rα Polyclonal Antibody ... Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) ( Mammalian cell-CSB-MP011649HU3 ) ...

Endothelial Cells Promote Osteogenesis by Establishing a Functional and Metabolic Coupling With Human Mesenchymal Stem Cells ... Furthermore, AML-EVs dose-dependently reduced NK cell lysis of third-party K-562 leukemia targets. This emphasizes the peculiar ... While in most patient samples the presence of NLC in co-cultures guarantees high viability of leukemic cells in vitro, in some ... Thus, melatonin not only protects normal neurons from damage by neutralizing the agents that initiate apoptosis, e.g., free ...

... non-small cell lung cancer and other solid tumors), treatment (e.g., receiving vs having received chemotherapy), exercise modes ... This effect would be of relevance in the context of cancer given the prominent role of these cells in antitumor immunity. In ... Current evidence does not support a significant effect of exercise training intervention on NK cells in blood or on their ... we aimed to summarize current evidence on the effects of exercise training on the levels and function of NK cells in cancer ...

Time-course of butyric acid-induced differentiation in human K562 leukemic cell line: rapid increase in g-globin, ... Effect of Lumican on the Migration of Human Mesenchymal Stem Cells and Endothelial Progenitor Cells: Involvement of Matrix ... A role for peroxisome proliferator-activated receptor gamma in resveratrol-induced colon cancer cell apoptosis.. Virginie Aires ... Mesenchymal stem cells as a promising source for endothelial cells in vascular tissue engineering. H. Rammal , C. Harmoush , M ...

... leukemic line K562, and an approved human embryonic cell line H1-hESC. The analysis was rapidly expanded to another 140 cell ... activation of STAT3 that occurs in a high proportion of many human cancers contributes to blocking apoptosis in cancer cells. ... cell research. Induced pluripotent stem cells are powerful cells which can be made from skin or blood cells, and … ... Human, human genome, Human Genome Project, National Human Genome Research Institute, Notch propteins, Posttranslational ...

Abnormal mutations in stem cells were found accompanying with the occurrence of MPN. It has been shown that MPL mutations (MPL ... We also observed differential effects of the four mutants on progenitors, myeloid cells and megakaryocytes. Our studies have ... are a group of blood cancers that boost normal blood cell production in the bone marrow. ... combinatory application of JAK2 inhibitor and PI3K/AKT inhibitor had synergistic effect on causing apoptosis in leukemic cells ...

... and the pharmacological intervention through inhibition of the deregulated target was able to restore normal cell function. ... enhances imatinib-induced apoptosis of Bcr-Abl‚ positive human acute leukemia cells. Blood. 2003;101(8):3236-9. ... than mycophenolic acid in the growth inhibition of K562 cell lines. In the same way, other drugs containing carboxylic acids or ... DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med. ...

CellCells,Cells;ChainCultured;DiesterDisease;ExpressionGeneHematopoieticHumans;Hydrolases,Indoles,Inhibitors,K562KinaseLeukemia ... AntibodyArrayBCR-ABLCellCells,Cells;ChainChronic,Differentiation;ExpressionFluorescentGeneHematopoieticHumans;Leukemia,Leukemic ... Adhesion,Antigens,Apoptosis,BCR-ABLCD34,CellCells,Chronic,Chronic-Phase,Complementary,DNA,Differentiation,Division,Expression ... Biology;CellCells,ComputationalCultured;CycleCycle,Cytometry;ExpressionFlowGeneGenetic,Genome,Health;Human,Humans;Neoplasms, ...

Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad ... "γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. ... However, it is ectopically overexpressed in tumor drug-resistant cells, especially in a human leukemia cell line (K562) and ... Third, γδ T cells induce target cell apoptosis via the CD95/CD95L (Fas/FasL pathway) and TNF-related apoptosis-inducing ligand ...

Induction of Resistance to the Abelson Inhibitor STI571 in human leukemic cells through gene amplification. Blood, 2000, 95(5 ... Ferrao, P.T.; Frost, M.J.; Siah, S.P.; Ashman, L.K. Overexpression of P-Glycoprotein in K562 cells does not confer resistance ... Jørgensen, H.G.; Holyoake, T.L. A comparison of normal and leukemic stem cell biology in chronic myeloid leukemia. Hematol. ... CNS & Neurological Disorders - Drug Targets Ceramide and Apoptosis: Exploring the Enigmatic Connections between Sphingolipid ...

... cell line from human pluripotent stem cells GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell ... learning model of human cancer cells Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells ... derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis Chemical pumps ... interferometric sensor arrays for high-performance label-free biomolecular detection Single-cell analysis of K562 cells: An ...

Plasma Cell, Pulmonary C23.550.382.875.750 (Replaced for 2008 by Plasma Cell Granuloma, Pulmonary) Granulosa Cells A11.436.300 ... Human G14.162.520.300 G5.360.162.520.300 Chromosomes, Human, 1-3 G14.162.520.300.235 G5.360.162.520.300.235 Chromosomes, Human ... G1.60.249.730.700.412 K562 Cells A11.443.250.480 A11.443.240.497.480 Kallikrein-Kinin System G6.184.963.500 G2.111.917.500 ... Leukemic G5.315.370.500 G5.355.315.370.500 Gene Expression Regulation, Neoplastic G5.315.370 G5.355.315.370 Gene Expression ...

Over 80% of human cancers express these ligands on the surface of tumour cells and/or associated stromal elements. In mice, ... Consequently, the prognostic impact of NKG2DL expression in human cancer is variable. In this review, we consider the ... The family of human NKG2D ligands (NKG2DL) consists of eight stress-induced molecules. ... STAT3 contributes to NK cell recognition by modulating expression of NKG2D ligands in adriamycin-resistant K562/AO2 cells. Int ...

K562, K562 IMR, K562 lenti-AHI-1, and SIB 1757 BV173) and murine cell lines (BaF3, BCR-ABLCinducible BaF3, and BaF3 cells ... Immunoprecipitation and European Blot Analysis Human being cell lines (K562, K562 IMR, K562 lenti-AHI-1, and BV173) and murine ... p27 binds with the CBG site of cyclin A to arrest the malignant cell proliferation that induces apoptosis. In the present study ... We as well as others have shown that leukemic stem cells (LSCs) possess multiple unique features expected to promote both their ...

... and BCL-2 in the Human K562 Cancer Cell Line. Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A Hamza, Gomaa Mostafa-Hedeab, ... and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells ... and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by ... Chitosan-Farnesol Nanocomposites and Assessment of Their Anticancer Potential in Human Leukemic MOLT-4 Cell Line ...

Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes ... Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability, Creating ... Effects of GM3 on Proliferation, Apoptosis and VEGF Expression in Human Lung Adenocarcinoma Cell Line A549 Cells] Zhonghua ... Id1 is a Common Downstream Target of Oncogenic Tyrosine Kinases in Leukemic Cells Blood. Sep, 2008 , Pubmed ID: 18559972 ...

... was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and ... Effects of Turkish pollen and propolis extracts on respiratory burst for K-562 cell lines.. Aliyazicioglu Y, Deger O, Ovali E, ... of tumor cells was clearly inhibited. The artepillin C was found to cause significant damage to solid tumor and leukemic cells ... Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells.. Scifo C, Cardile V, Russo A, ...

... cell line from human pluripotent stem cells GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell ... learning model of human cancer cells Kindlin-3 loss curbs chronic myeloid leukemia in mice by mobilizing leukemic stem cells ... derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis Chemical pumps ... interferometric sensor arrays for high-performance label-free biomolecular detection Single-cell analysis of K562 cells: An ...

Effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells.. ... K-562 cell cultures and mononuclear cell (MNC) cultures prepared from a peripheral blood sample to serve as control cells were ... TP3 and TP7 could induce apoptosis in human melanoma cells and there is a marked loss of cells from the G2/M phase of the cell ... The aim of this study was to investigate the mechanism of CAPE-induced apoptosis in human leukemic HL-60 cells. It was found ...