InsulinomaApoptosisAdenoma, Islet CellPancreatic NeoplasmsCaspase 3CaspasesApoptosis Regulatory ProteinsProto-Oncogene Proteins c-bcl-2Cell Line, TumorIn Situ Nick-End LabelingIslets of LangerhansInhibitor of Apoptosis ProteinsDNA Fragmentationbcl-2-Associated X ProteinCell SurvivalTumor Cells, CulturedSignal TransductionFas Ligand ProteinInsulinMitochondriaCaspase 9Cells, CulturedCaspase InhibitorsCell ProliferationInsulin-Secreting CellsNesidioblastosisX-Linked Inhibitor of Apoptosis ProteinHypoglycemiaCaspase 8Enzyme ActivationCell LineBlotting, WesternCytochromes cCASP8 and FADD-Like Apoptosis Regulating ProteinApoptosis Inducing FactorTumor Suppressor Protein p53bcl-X ProteinFlow CytometryAnnexin A5TransfectionRNA, Small InterferingAmino Acid Chloromethyl KetonesRNA, MessengerProto-Oncogene ProteinsDose-Response Relationship, DrugGlucoseEnzyme InhibitorsReactive Oxygen SpeciesAntineoplastic AgentsCysteine Proteinase InhibitorsMice, Inbred C57BLMembrane Potential, MitochondrialCell CycleReverse Transcriptase Polymerase Chain ReactionPhosphorylationPoly(ADP-ribose) PolymerasesImmunohistochemistryProinsulinDown-RegulationCell DeathTime FactorsCaspase 7TNF-Related Apoptosis-Inducing LigandCell DivisionMembrane GlycoproteinsTumor Necrosis Factor-alphaJurkat CellsUp-RegulationGene Expression Regulation, NeoplasticGene Expression RegulationMice, KnockoutGene ExpressionProto-Oncogene Proteins c-aktGenes, bcl-2Rats, Sprague-DawleyNF-kappa BHL-60 CellsAntigens, CD95Epithelial CellsOxidative StressPancreatectomyNeoplasm ProteinsMolecular Sequence DataGroup VI Phospholipases A2bcl-2 Homologous Antagonist-Killer ProteinNecrosisMice, TransgenicMembrane ProteinsMice, Nudebcl-Associated Death ProteinGlucose Transporter Type 2Antineoplastic Agents, PhytogenicDNA DamageMyeloid Cell Leukemia Sequence 1 ProteinReceptors, GlucagonCytochrome c GroupCarrier ProteinsCalciumRNA InterferenceCeramides