Cartilage development requires the function of Estrogen-related receptor alpha that directly regulates sox9 expression in...
ESRRa regulates survival but not proliferation of cartilaginous cells.. (A-F) 1-cell stage of embryos were injected with either ... Esrra regulates survival of cartilaginous cells. Defective formation of pharyngeal cartilage upon knockdown of esrra suggests ... These results suggest that Esrra may play a minor role in proliferation but is necessary for survival of cartilaginous cells in ... ESRRa regulates development of neural crest cells for cartilage development.. (A-J) Embryos at 1-cell stage were injected with ...
Precision therapeutic targeting of human cancer cell motility | Nature Communications
... and prolongs survival at nanomolar blood concentrations after oral administration. Comprehensive molecular, cellular and ... we identify that KBU2046 inhibits cell motility and cell invasion in vitro. Across three different murine models of human ... We use the unique characteristics of small molecules to probe and selectively modulate cell motility. By coupling efficient ... We identify a unique cell motility regulatory mechanism and synthesize a targeted therapeutic, providing a platform to pursue ...
Dietary fructose improves intestinal cell survival and nutrient absorption | Nature
A high-fructose diet in mice improves the survival of intestinal epithelial cells, which leads to an increase in gut surface ... Here we show that dietary fructose improves the survival of intestinal cells and increases intestinal villus length in several ... The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the ... In hypoxic intestinal cells, fructose 1-phosphate inhibits the M2 isoform of pyruvate kinase to promote cell survival5-7. ...
Epidemiology | British Journal of Cancer
Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer * ... Leukocyte telomere length and renal cell carcinoma survival in two studies *Catherine L Callahan ... Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study *Ronan T Gray ... Vitamin D receptor and calcium-sensing receptor polymorphisms and colorectal cancer survival in the Newfoundland population * ...
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria | Nature
Yano, S., Tokumitsu, H. & Soderling, T. R. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase ... Endoplasmic reticulum PI3P lipid binding targets malaria proteins to the host cell. Cell 148, 201-212 (2012) ... Extended Data Figure 5 An in vitro ring-stage survival assay (RSA) level is associated with PI3P elevation in the presence and ... Cytoprotective autophagy as a pro-survival strategy in ART-resistant malaria parasites *Deepika Kannan ...
Original Paper | Oncogene
IGF-II induces CREB phosphorylation and cell survival in human lung cancer cells *Nicolle M Linnerth ... Disruption of B-myb in DT40 cells reveals novel function for B-Myb in the response to DNA-damage *Dörthe Ahlbory ... Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis *Mamta Gupta ... Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway *Kenneth Rogulski ...
News & Comment | Cellular & Molecular Immunology
4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8+ T cell *Eunjung Cho ... The role of TIA1 and TIAL1 in germinal center B cell function and survival *Yongqiang Wang ... Revealing the identity of regulatory T-cell-suppressed self-reactive CD4+ T cells *Judith N. Mandl ... Cellular & Molecular Immunology (Cell Mol Immunol) ISSN 2042-0226 (online) ISSN 1672-7681 (print) ...
Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial | Nature Medicine
Neoantigen-reactive T cell clonotypes increased and persisted in peripheral blood after treatment. Cell therapy with autologous ... Adoptive cell therapy with tumor-infiltrating lymphocytes in metastatic lung cancer patients is safe and elicits antitumor ... The primary end point was safety and secondary end points included objective response rate, duration of response and T cell ... In exploratory analyses, we found T cells recognizing multiple types of cancer mutations were detected after TIL treatment and ...
Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation | Nature
... macrophage-like cells and myeloblasts, respectively. These sequences, termed erb, mac and myb, have their counterparts in the ... MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis *Julian ... Roussel, M., Saule, S., Lagrou, C. et al. Three new types of viral oncogene of cellular origin specific for haematopoietic cell ... Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation. *M. Roussel1, ...
Nature Chemical Biology
Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique ... Survival of the sweetest tooth *Gene Chong. Research Highlight. 22 Nov 2023. ... Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique ... Polarized focal adhesion kinase activity within a focal adhesion during cell migration *Xiaoquan Li ...
The Evidence of Glioblastoma Heterogeneity | Scientific Reports
Fluorescence-activated cell sorting and cDNA-microarray analyses revealed that each subclone was composed of distinct ... In a mouse model featuring xenografts of the subclones, the progression and invasion of tumors and animal survival were also ... Because most cancers have a clonal origin, cancer stem cells (CSCs) must generate phenotypically diverse progenies including ... Our results suggest that single cell-derived subclones from a patient can produce phenotypically heterogeneous self-renewing ...
Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model | Scientific...
Human GB (NG97, the most responsive line in the previous study) cells were inoculated (s.c.) on the back of RAG−/− mice. PnV ( ... Macrophages were activated in vitro by the venom, becoming more phagocytic; these results confirm that this cell is a target of ... The venom increased monocytes, neutrophils and NK cells, and this effect was the opposite of that observed in the animals ... neutrophils and NK cells isolated from the spleen (by flow cytometry) and the presence of macrophages (Iba-1 positive) within/ ...
Browse Articles | Leukemia
Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States *Ludovic Saba ... Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution *Sakurako Suma ... Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients *Julius C ... Development of osteonecrosis and improved survival in B-ALL: results of Childrens Oncology Group Trial AALL0232 *Leonard A. ...
Varicella zoster virus reactivation after autologous SCT is a frequent event and associated with favorable outcome in myeloma...
... reactivation after ASCT is a frequent event carrying a significant disease burden and it is associated with improved survival. ... Immortal person-time bias in the association between herpes zoster and survival following autologous stem cell transplantation ... Safety and efficacy of chimeric antigen receptor (CAR)-T-cell therapy in persons with advanced B-cell cancers and hepatitis B ... Use of inactivated varicella vaccine in recipients of hematopoietic-cell transplants. N Engl J Med 2002; 47: 26-34. ...
Unspliced XBP1 controls autophagy through FoxO1 | Cell Research
In a paper recently published in Cell Research, Zhu and co-workers uncover a novel biological function of the unspliced form of ... The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK cells *Yufeng Wang ... Cell Research (Cell Res) ISSN 1748-7838 (online) ISSN 1001-0602 (print) ... In a paper recently published in Cell Research, Zhu and co-workers uncover a novel biological function of the unspliced form of ...
Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis | Scientific Reports
After plating cells as described above, non-adherent cells were removed, and adherent cells were stimulated with either LPS ( ... and survival was followed up to 15 days. Following CLP, the AVR-25 + imipenem group demonstrated better survival (,80%) than ... Cell lines. Human peripheral blood mononuclear cells (HPBMCs) were purchased from LeukoPaK (AllCells); 0.5 × 106 cells/well ... cells were treated only with AVR-25. After 48 h of incubation, cells were lysed and assayed for TLR4 and TLR2 while the ...
Machine learning - Latest research and news | Nature
Identification of CT-based non-invasive radiomic biomarkers for overall survival prediction in oral cavity squamous cell ... Comprehensive modeling of cell culture profile using Raman spectroscopy and machine learning *Hiroki Tanemura ...
Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination...
... arguing against a curtailed B cell or T cell response or a failure of B cells or T cells to migrate to the nasal mucosa. On the ... 3 Univariate and multivariate Kaplan-Meier survival curves.. Kaplan-Meier survival curves comparing (a) SARS-CoV-2 variants ... B cell and T cell) vaccine response. Likewise, a large subset of B cell genes (CD19, CR2, CD79A, CD79B, PAX5 and CD70), ... cells (THY1, CDH5, KIR3DL3, CD160, B3GAT1, NCAM1 and CCL3) and conventional dendritic cells (XCR1). Thus, the predominant ...
Liquid Biopsy
Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and ... Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma ... tumour cells and tumour-educated immune cells. This Collection on Liquid biopsy features Special Issue content guest edited by ... Utility of cell-free DNA from bronchial washing fluid in diagnosis and genomic determination for radiology-suspected pulmonary ...
Graft-versus-host disease - Latest research and news | Nature
Graft-versus-host disease-free, relapse-free, second transplant-free survival in allogeneic hematopoietic cell transplantation ... Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration * ... The macrophage activation marker sCD163 in acute and chronic graft-versus-host disease after pediatric hematopoietic stem cell ... usually a haematopoietic stem cell transplant) that arises from the attack of recipient tissues (such as the skin, liver or gut ...
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling | Nature Cell Biology
Genetic ablation of TMEM9 inhibits colorectal cancer cell proliferation in vitro, ex vivo and in vivo mouse models. Moreover, ... IHC analysis of Lysozyme, a marker of Paneth cells, was performed in TMEM9 KO mouse. (i), Median survival of APCMIN, APCMIN: ... TMEM9 is required for CRC cell proliferation (b). Each CRC cell line (shCtrl versus shTMEM9) was analyzed for cell ... a-c), Screening of cell signallings affected by TMEM9. qRT-PCR of CRC cells (MSI [a] versus MSS [b]) and IECs (c). d, ...
The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves | Nature Microbiology
Microbial interkingdom interactions in roots promote Arabidopsis survival. Cell 175, 973-983 (2018). ... Cell wall damage-induced lignin biosynthesis is regulated by a reactive oxygen species- and jasmonic acid-dependent process in ... Fryda, S. J. & Otta, J. D. Epiphytic movement and survival of Pseudomonas syringae on spring wheat. Phytopathology 68, 1064- ... Ngou, B. P. M., Ahn, H.-K., Ding, P. & Jones, J. D. G. Mutual potentiation of plant immunity by cell-surface and intracellular ...
Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson's...
Glycolytically active glial cells have been shown to produce alanine and lactate to maintain neuronal survival19. Our data ... The cells were suspended in 100 mm NaCl at 12 OD600. Under dark conditions, 10 ml of the cell suspension was illuminated at 50 ... Cell culture and mitochondrial fractionation. S2R+ cells, which were a kind gift from Dr. N. Yanagawa at Kyoto University, were ... Glial glycolysis is essential for neuronal survival in drosophila. Cell Metab. 22, 437-447 (2015). ...
Mechanisms of mitochondrial respiratory adaptation | Nature Reviews Molecular Cell Biology
Failure to execute these regulatory responses causes cell damage and inflammation or senescence, compromising cell survival and ... These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and ... Mitochondrial respiratory function needs to adapt to the energetic demands of the cell. These adaptive responses encompass ... Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and ...
EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor |...
... our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and ... Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. Taken together, ... in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. The SS18-SSX oncoprotein, characteristic ... Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. J Cell Mol ...
Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis | Nature Communications
These Fgfr3-creER-marked endosteal stromal cells contribute to a stem cell fraction in young stages, which is later replaced by ... This study identified a new class of skeletal stem cells in the endosteal space of bone marrow, which are abundant in young ... It is well-described that leptin receptor (LepR)+ perivascular stromal cells provide a major source of bone-forming osteoblasts ... Further, Fgfr3+ endosteal stromal cells give rise to aggressive osteosarcoma-like lesions upon loss of p53 tumor suppressor ...
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor | Nature...
... and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. Depletion of recipient T cells before 7 × 19 CAR-T cell ... Following treatment of mice with 7 × 19 CAR-T cells, both recipient conventional T cells and administered CAR-T cells generated ... Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor ... In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with ...
Brief Communications | Cancer Gene Therapy
HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation ... CTGF expression is indicative of better survival rates in patients with medulloblastoma *Gustavo Alencastro Veiga Cruzeiro ... Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma *Yan Zeng ... Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression * ...
An immunity and pyroptosis gene-pair signature predicts overall survival in acute myeloid leukemia | Leukemia
... we demonstrate that the IPRP score leads to more consistent and accurate survival prediction performance, compared with 10 ... activated CD4 T cells, activated CD8 T cells, natural killer T cells and type 2 T helper cells in the high risk group were ... resulting in cell perforation, which in turn leads to cell death [1]. Compared with apoptosis, cell pyroptosis occurs faster ... D Survival curves of patients in the immune-related clusters. Survival differences were assessed with Log Rank test (cluster B ...
Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted...
The supernatant, containing the RL34 cell-secreted growth factors, was used as the conditioned medium (CM). This CM, with CVE ... This serum-free and grain-derived-nutrient-free medium promoted the proliferation of bovine myoblasts, the main cell source for ... Here, we developed a novel medium containing nutrients extracted from microalga and cell-secreted growth factors. First, rat ... Cultured meat is produced by culturing/proliferating animal muscle cells in vitro. This process requires significant amounts of ...