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*  Abstract 2050: Porcine drug metabolism and toxicity in vitro model utilizing transformed hepatocyte cell lines (HepCre) |...
Abstract 2050: Porcine drug metabolism and toxicity in vitro model utilizing transformed hepatocyte cell lines (HepCre). Arun K ... Abstract 2050: Porcine drug metabolism and toxicity in vitro model utilizing transformed hepatocyte cell lines (HepCre) ... Abstract 2050: Porcine drug metabolism and toxicity in vitro model utilizing transformed hepatocyte cell lines (HepCre) ... Abstract 2050: Porcine drug metabolism and toxicity in vitro model utilizing transformed hepatocyte cell lines (HepCre) ...
http://cancerres.aacrjournals.org/content/76/14_Supplement/2050.article-info
*  Inhibition of transforming growth factor beta1 (TGFβ1) signaling increases radiosensitivity in breast cancer cell lines |...
We first established the relative TGFβ1 sensitivity in 6 epithelial cell lines. Non-malignant MCF10A, breast cancer cell line ... Inhibition of transforming growth factor beta1 (TGFβ1) signaling increases radiosensitivity in breast cancer cell lines. ... Inhibition of transforming growth factor beta1 (TGFβ1) signaling increases radiosensitivity in breast cancer cell lines ... Inhibition of transforming growth factor beta1 (TGFβ1) signaling increases radiosensitivity in breast cancer cell lines ...
http://cancerres.aacrjournals.org/content/68/9_Supplement/423
*  Transforming Growth Factor β1 Stimulates Contrasting Responses in Metastatic versus Primary Mouse Prostate Cancer-derived Cell...
Growth Factor β1 Stimulates Contrasting Responses in Metastatic versus Primary Mouse Prostate Cancer-derived Cell Lines in ... Transforming Growth Factor β1 Stimulates Contrasting Responses in Metastatic versus Primary Mouse Prostate Cancer-derived Cell ... Transforming Growth Factor β1 Stimulates Contrasting Responses in Metastatic versus Primary Mouse Prostate Cancer-derived Cell ... Transforming Growth Factor β1 Stimulates Contrasting Responses in Metastatic versus Primary Mouse Prostate Cancer-derived Cell ...
http://cancerres.aacrjournals.org/content/56/14/3359.article-info
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... or with cell lines that express p14ARF (H1299, 911). Unlike transformed cells, HUVECs were not selected for alterations in ... p53 levels and activity upon infection of E1-transformed cells with adenovirus vectors. 911 cells (human cells that express the ... p53 and p53mt24-28 Do Not Impair the Replication and Release of Recombinant Adenovirus in an E1-transformed Cell Line.. In the ... Upon infection of H1299 cells (a p53 −/− cell line derived from a human adenocarcinoma of the lung) and HUVECs, the viruses ...
http://cancerres.aacrjournals.org/content/61/15/5941
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Cell Lines and Reagents. Transformed wild-type (WT), CAD−, and CAD+ mouse embryonic fibroblasts (MEFs; ref. 5) were kindly ... The cell line HT29.C1.16E, a clonal derivative of the colorectal cancer cell line HT29, does not express ICAD during ... Cells were trypsinized and processed as described above.. HT29 cells. HT29 or HT29.C1.16E cells (5 × 106) were seeded. The next ... Both cell lines were sensitive to etoposide, although the CAD− to a lesser extent ( Fig. 1C). The difference in integration ...
http://cancerres.aacrjournals.org/content/66/18/8975
*  Immunoglobulin Heavy Chain Locus Events and Expression of Activation-Induced Cytidine Deaminase in Epithelial Breast Cancer...
... to what extent transformed B cells require these signals, as in established lymphoma cell lines, mutational activity can be ... In three selected cell lines (MDA-MB-231, T47D, and ZR75-1), single tumor cells were obtained by EpCAM+ cell sorting. Firstly, ... Cell lines. A previously described ( 3) panel of six well-characterized breast cancer cell lines (BT474, MDA-MB-231, MCF-7, ... dual VH rearrangements were apparent in each line with differing donor germ-line VH genes. In the other two cell lines, MDA-MB- ...
http://cancerres.aacrjournals.org/content/66/8/3996
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Increased colony formation is suggestive of a more transformed, more metastatic cell line. ... Cells surviving 10 μg/ml FUdR became the MCF-7F cell line, and cells surviving 25 ng/ml Adriamycin became the MCF-7A cell line ... IL-8 release by chemotherapeutic selected MCF-7 breast carcinoma cell lines. Cells from each of the cell lines were seeded in ... To produce the doubly selected cell line, MCF-7A cells were plated at a density of 105 cells per well in six-well tissue ...
http://cancerres.aacrjournals.org/content/61/7/2857
*  Silencing of Prion Protein Sensitizes Breast Adriamycin-Resistant Carcinoma Cells to TRAIL-Mediated Cell Death | Cancer Research
It rapidly induces apoptosis in a variety of transformed cell lines. TRAIL interacts with five receptors, i.e., TRAIL-R1, TRAIL ... Cell lines. TNF-resistant 2101 cells were established from TNF-resistant RA-1 cells transfected by p55 TNF receptor cDNA. ... 3C) indicated that both of the cell lines contained more PrPc than the parental MCF-7 cell line, and that the protein was ... PrPc expression in MCF-7 cells and its derivative cells (2101 and MCF-7/ADR cells). A, the expression of the PRNP gene in cell ...
http://cancerres.aacrjournals.org/content/67/22/10910
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Human AML cell line and siRNA transfection. MonoMac-6 AML cell line, carrying t(9;11)/MLL-AF9, was maintained in the Chen ... Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. Embo J 1998;17:3714-25. ... a myeloid lineage cell marker) and/or c-Kit+ (a stem/progenitor cell marker) cells compared with those of the other AML groups ... bone marrow cells (i.e., transplanted donor cells) were sorted with flow cytometry from whole bone marrow cells collected from ...
http://cancerres.aacrjournals.org/content/76/3/619
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... in vitro reactivation of CTLs by stimulation with the autologous EBV-transformed lymphoblastoid cell line; and (b) an enzyme- ... Cell Lines.. LCLs were generated in vitro by transformation of B cells using the EBV isolate B95.8 (37) and cultured in RPMI ... Immunohistochemical studies on HD biopsies and in vitro analysis of H-RS cell lines suggest that H-RS cells are capable of ... On day 14, cells were cloned by limiting dilution to 0.3 and 3 cells/well (five 96-well plates for each cell dilution) and ...
http://cancerres.aacrjournals.org/content/61/16/6219
*  Differentially Expressed Genes Regulating the Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer | Cancer...
Cell lines. This study used 3 DCIS-like human breast epithelial cell lines. First, referred to as DCIS.COM, is widely available ... The cells spontaneously transformed in culture and later passages (,30) developed into DCIS in MIND xenografts, similar to DCIS ... Interestingly, all 3 cell human DCIS cell lines used in this study somehow displaced the mouse myoepithelial cells, and made ... DCIS cell lines (±shRNAi) cells were seeded into 96-well plates in culture media. At 24, 48, 72, and 96 hours, the cells were ...
http://cancerres.aacrjournals.org/content/72/17/4574.long
*  p16/pRb Pathway Alterations Are Required for Bypassing Senescence in Human Prostate Epithelial Cells | Cancer Research
... and E7-transformed prostate epithelial cell lines. E6 HPEC and E6/E7 HPEC lines are characterized by a pleomorphic cell size, ... E6/E7 cell lines have a similar morphology (data not shown) to E6 lines. B, in contrast, E7 lines show flat, adherent cells ... Two cell lines, Du145 and LnCaP, showed no pRb expression. The Du145 prostate cancer cell line contains a known RB mutation (49 ... p16 expression is uniformly lost in HPV16 E6 cell lines in contrast to E7 cell lines. p16 is not detectable by increasing the ...
http://cancerres.aacrjournals.org/content/59/12/2957.full
*  Gemcitabine and Cytosine Arabinoside Cytotoxicity: Association with Lymphoblastoid Cell Expression | Cancer Research
The lymphoblastoid cell lines used in our study are EBV transformed, so they are neither tumor cell lines nor tumor tissue. ... Two human cancer cell lines, the MDA-MB-231 breast cancer cell line and the pancreatic cancer SU86 cell line, were used to ... Sensitive and resistant cell lines were defined as cell lines with IC50 values of ,0.85 SD from the mean of the IC50 ... Cell lines. Lymphoblastoid cell lines from 60 Caucasian-American, 54 African-American, 60 Han Chinese-American, and 23 Centre d ...
http://cancerres.aacrjournals.org/content/68/17/7050?ijkey=5c7392bc362adbbc4d7f856b9d37be1964c5d483&keytype2=tf_ipsecsha
*  Malignant Transformation in a Nontumorigenic Human Prostatic Epithelial Cell Line | Cancer Research
Can cancer cells transform normal host cells into malignant cells?. Br. J. Cancer., 76: 1134-1138, 1997. ... receptors by the parental BPH-1 cell line or by any of the tumor-derived cell strains. The cells uniformly coexpressed both ... cells with 250,000 rUGM cells or CAFs in suspension. For control grafts, 350,000 cells of each cell type (BPH-1, rUGM, or CAF) ... The present report demonstrates that this cell line can be permanently transformed by its microenvironment to become ...
http://cancerres.aacrjournals.org/content/61/22/8135?ijkey=4967b1fce71d8d0c5f573741152da10359cdb5ad&keytype2=tf_ipsecsha
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486/STOP could reverse transformed phenotype of the CaOV-3 human ovarian cancer cell line in vitro; (b) it was able to inhibit ... Cell Line and Transfection.. CaOV-3 is a cell line derived from human epithelial ovarian carcinoma. CaOV-3 cells were ... 21 cells; (▪), empty vector no. 22 cells; (▵), 486/STOP no. 48 cells; (▴), 486/STOP no. 49 cells. ... Cell Growth in Monolayer.. Cells were plated at 5 × 104 cells/well in 6-well plates in DMEM with 10% FBS and incubated for 24 h ...
http://cancerres.aacrjournals.org/content/63/22/7834
*  Expression of Catalytically Active Telomerase Does Not Prevent Premature Senescence Caused by Overexpression of Oncogenic Ha...
Oncogenic Ras can transform established rodent cell lines but fails to transform primary cells (20) . Transformation of primary ... Cell Lines and Cell Culture.. The human embryo lung fibroblast cell strain LF1 was established and cultured as described ... Cells were washed twice with PBS and harvested by rapid lysis in Laemmli sample buffer (26) . Aliquots (50 μg) of total cell ... The amphotrophic retrovirus packaging cell line PA317 was obtained from the American Type Culture Collection and maintained in ...
http://cancerres.aacrjournals.org/content/59/7/1539?ijkey=b2326807dbca1f3d8b5ffe74e53181abaf7c7741&keytype2=tf_ipsecsha
*  Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance | Cancer Research
These results were confirmed in Ba/F3 cell lines transformed to IL-3 independence with kinase domain mutant EGFR with or ... Cell lines and drug treatments. NCI-H1975 and NCI-H820 NSCLC cell lines were obtained from the American Type Culture Collection ... and S6 signaling equally well in both cell lines. D, left, NCI-H1975 and NCI-H1975CLR cell lines were treated with AG1024 at ... In both NSCLC cell lines and in Ba/F3 cells, 17-DMAG was able to inhibit both upstream (EGFR-PI3K-Akt) and downstream (mTOR- ...
http://cancerres.aacrjournals.org/content/68/14/5827.full
*  Expression of the Epstein Barr Virus Transforming Protein LMP1 Causes a Rapid and Transient Stimulation of the Bcl-2 Homologue...
This effect of LMP1 was associated with a delayed cell death in the EBV-negative Burkitt lymphoma cell line BL41. The ... Virus Transforming Protein LMP1 Causes a Rapid and Transient Stimulation of the Bcl-2 Homologue Mcl-1 Levels in B-Cell Lines. ... Virus Transforming Protein LMP1 Causes a Rapid and Transient Stimulation of the Bcl-2 Homologue Mcl-1 Levels in B-Cell Lines ... Virus Transforming Protein LMP1 Causes a Rapid and Transient Stimulation of the Bcl-2 Homologue Mcl-1 Levels in B-Cell Lines ...
http://cancerres.aacrjournals.org/content/56/20/4610
*  PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression...
... this pattern of ectopic PLAC8 expression in transformed cells was faithfully mirrored in cultured cell lines. While ... siRNA transfection of cell lines. Pancreatic cancer cell lines were transfected with siRNAs using siLentFect Lipid Reagent (Bio ... Cell lines, patient samples, and tissue microarrays. Panc-1 (14) and HEK-293 (15) cells were obtained from the American Type ... 2947; anti-PARP: Cell Signaling, cat. # 9532; anti-caspase-3: Cell Signaling, cat. # 9664 and 9665; anti-LC3A/B: Cell Signaling ...
http://cancerres.aacrjournals.org/content/76/1/96
*  Regan Type of Alkaline Phosphatase in a Human Heteroploid Cell Line | Cancer Research
The C-SPT cells appeared to be the progeny of an unidentified source contaminant rather than of transformed WI-38 cells. ... However, the specific activity of Regan isozyme in WISH cells was only 3 to 6% of that in C-SPT cells. The HeLa cells exhibited ... Regan Type of Alkaline Phosphatase in a Human Heteroploid Cell Line. Robert Rustigian, John P. W. Kelly, David A. Ellis, Leon A ... Regan Type of Alkaline Phosphatase in a Human Heteroploid Cell Line. Robert Rustigian, John P. W. Kelly, David A. Ellis, Leon A ...
http://cancerres.aacrjournals.org/content/34/8/1908
*  Tumor Cell Dependence on Ran-GTP-Directed Mitosis | Cancer Research
We began this study by analyzing the expression of Ran in normal or transformed human cultured cell lines. Ran was abundantly ... Cell, Tumor, and Stem Cell Biology Tumor Cell Dependence on Ran-GTP-Directed Mitosis. Fang Xia, Connie W. Lee and Dario C. ... Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol 2006; 26: 2093-108. ... Deregulated cell division is a pivotal cancer pathway, which results in aberrant cell proliferation, obliteration of cell cycle ...
http://cancerres.aacrjournals.org/content/68/6/1826
*  Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity | Cancer Research
... one SV40-transformed human urothelial cell line (SV-HUC-1), one human lung epidermoid carcinoma cell line (H1355), and one ... H460, H1299, and H1355 are lung cancer cell lines; SC-M1 and HR are gastric cancer cell lines. The 293 cell line is derived ... Results indicate that in MCF-7 (the most sensitive cell line) and NTUB1/T cells (the most resistant cell line), PD98059 [a ... and NTUB1 are human bladder urothelial carcinoma cell lines; SV-HUC-1 is an SV40 large T-transformed human urothelial cell line ...
http://cancerres.aacrjournals.org/content/65/18/8455?ijkey=7846fdcef81302dfadeb2b51f1be84207bab1fed&keytype2=tf_ipsecsha
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The ectopic expression of Rac1 has been shown to inhibit apoptosis of tumor cell lines and transformed fibroblasts ( 20). This ... in control cells) and an increase in the percentage of cells in G2-M (56.4% compared with 50.4% in control cells), indicating a ... for cell cycle analysis) or at 2 × 104 cells per well in 24-well dishes (for cell counting experiments). BMKs were treated with ... A, proliferation of BMK cells from the LSL-K-rasG12D, Rac1flox/flox, and LSL-K-rasG12D;Rac1flox/flox mice. BMK cells were ...
http://cancerres.aacrjournals.org/content/67/17/8089
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Mesenchymal cell lines were therefore experimentally transformed with kinase-inactive ILK (KI-ILK) with a resulting decrease in ... 2A). Compared with the expression in the five epithelial cell lines, ILK protein level in the seven mesenchymal cell lines was ... Compared with the result from all seven mesenchymal hepatoma cell lines, the IC50 values of the five epithelial cell lines were ... It should be noted, however, that one mesenchymal cell line, SNU-182, was slightly sensitive whereas the epithelial cell line ...
http://cancerres.aacrjournals.org/content/68/7/2391
*  Epithelial-to-Mesenchymal Transition and Integrin-Linked Kinase Mediate Sensitivity to Epidermal Growth Factor Receptor...
Mesenchymal cell lines were therefore experimentally transformed with kinase-inactive ILK (KI-ILK) with a resulting decrease in ... 2A). Compared with the expression in the five epithelial cell lines, ILK protein level in the seven mesenchymal cell lines was ... Compared with the result from all seven mesenchymal hepatoma cell lines, the IC50 values of the five epithelial cell lines were ... It should be noted, however, that one mesenchymal cell line, SNU-182, was slightly sensitive whereas the epithelial cell line ...
http://cancerres.aacrjournals.org/content/68/7/2391.long