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*  CA 074|Cathepsin B inhibitor|CAS# 134448-10-5
Co-treatment of cultures with the cathepsin B inhibitors CA-074 or Z-FA-FMK suppressed the cytostatic effects of ... p,,strong,CA-074,/strong,, a specific cathepsin B inhibitor, also abolished the neurotoxic effects caused by Abeta42-activated ... Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone ... Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone ...
http://www.apexbt.com/ca-074.html
*  CTSZ rabbit monoclonal antibody - (H00001522-K) - Products - Abnova
The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell ...
http://www.abnova.com/products/products_detail.asp?catalog_id=H00001522-K
*  Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits - BIOQUANT OSTEO
Two cathepsin K inhibitors (CatKIs) were compared with alendronate (ALN) for their effects on bone resorption and formation in ... Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits Jon Hasfjord ...
https://osteo.bioquant.com/bibliography-entries/2016/4/5/cathepsin-k-inhibitors-prevent-bone-loss-in-estrogen-deficient-rabbits
*  British Library EThOS: Involvement of cathepsin B-like genes in disease resistance in Arabidopsis thaliana
The focus of this current research is to examine the roles of Cathepsin B genes in the model plant Arabidopsis. There are three ... Partially purified Cathepsin B protein was inhibited by a variety of peptide inhibitors but evidence of inhibition by several ... a cysteine protease, with homology to mammalian Cathepsin B proteases, was isolated in a screen for genes up-regulated in the ... Involvement of cathepsin B-like genes in disease resistance in Arabidopsis thaliana ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.657047
*  N-substituted peptidyl nitriles as cysteine cathepsin inhibitors - Patent # 6812237 - PatentGenius
... which are useful as cysteine cathepsin inhibitors ##STR1## ... The cysteine cathepsins, e.g. cathepsins B, L and S, are a ... such as cathepsin B, L and/or S, and forthe treatment of cathepsin dependent conditions, such as cathepsin B, L and/or S ... b) For Cathepsin L: Recombinant human cathepsin L is activated prior to use in this assay: To 500 uL of a 510 nM solution of ... The compounds of the invention are particularly useful as cathepsin inhibitors, primarily as cathepsin B inhibitors, and can be ...
http://www.patentgenius.com/patent/6812237.html
*  ScholarWorks: Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells
Caspase inhibitors did not affect cathepsin B release into the cytosol by hypertonicity. In addition, cathepsin B inhibitors ... Caspase; Cathepsin B; Cytochrome c. Issue Date. 201311. Publisher. AMER PHYSIOLOGICAL SOC. Citation. AMERICAN JOURNAL OF ... Combined inhibition of caspases and cathepsin B conferred significantly more protection from hypertonicity-induced cell death ... a lysosomal pathway of cell death characterized by partial lysosomal rupture and release of cathepsin B from lysosomes to the ...
http://scholarworks.unist.ac.kr/handle/201301/4120
*  Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor
Targeting Cathepsin B for Cancer Therapies.. Ruan H, Hao S, Young P, Zhang H., Horiz Cancer Res 56(), 2015 PMID: 26623174 ... Cathepsin S: therapeutic, diagnostic, and prognostic potential.. Wilkinson RD, Williams R, Scott CJ, Burden RE., Biol. Chem. ... Lysosomal cathepsin B: correlation with metastatic potential.. Sloane BF, Dunn JR, Honn KV., Science 212(4499), 1981 PMID: ... Cysteine cathepsins: multifunctional enzymes in cancer.. Mohamed MM, Sloane BF., Nat. Rev. Cancer 6(10), 2006 PMID: 16990854 ...
https://pub.uni-bielefeld.de/publication/2703442
*  anti-Cathepsin L antibody [2H7] | GeneTex
... cathepsin L1) for ELISA, WB. Anti-Cathepsin L mAb (GTX50040) is tested in Human samples. 100% Ab-Assurance. ... Major excreted protein, cathepsin L, CATL, FLJ31037, cathepsin L1, CTSL, cathepsin L1 preproprotein. ... cathepsin L1. Background. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain- ... Storage Conditions: Cathepsin L antibody [2H7]. Storage Buffer. Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium ...
http://www.genetex.com/Cathepsin-L-antibody-2H7-GTX50040.html
*  Cathepsin K Human, Mouse Monoclonal Antibody, Clone: 3F9 | BioVendor.com - BioVendor
... specific for Human Cathepsin K, produced in vitro, azide-free. ... Mouse monoclonal Cathepsin K antibody (Clone 3F9) validated for ... The Human Cathepsin K is the part of the Human Procathepsin K. The Human Cathepsin K containing 224 amino acid residues ( ... In the cartilage, cathepsin K has a potent aggrecan-degrading aktivity and cathepsin K-generated aggrecan cleavage products ... Humans lacking cathepsin K exhibit pycnodysostosis, which is characterized by short stature and osteosclerosis. Cathepsin K ...
https://www.biovendor.com/cathepsin-k-human-mouse-monoclonal-antibody-clone-3f9-1
*  Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase |...
Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase. J M Delaissé, P Ledent, G Vaes ... The first two are typical cathepsins B and L with respect to (1) their reactivity with anti-(cathepsin B) and anti-(cathepsin L ... Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase ... Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase ...
http://www.biochemj.org/content/279/1/167
*  "Inhibition of cathepsin B activity attenuates extracellular matrix deg" by Bernadette C. Victor, Arulselvi Anbalagan et al.
A functional role for cathepsin B was confirmed by the ability of CA074, a cell impermeable and highly selective cathepsin B ... Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC. We examined expression of the ... Our study is the first to show that the proteolytic activity of cathepsin B and its co-expression with caveolin-1 contributes ... A statistically significant co-expression of cathepsin B and caveolin-1 was found in IBC patient biopsies, thus validating our ...
https://scholar.uwindsor.ca/biologypub/18/
*  中国科学院水生生物研究所机构知识库(IHB OpenIR): Identification and characterization of a cathepsin L-like cysteine protease from Taenia
Identification and characterization of a cathepsin L-like cysteine protease from Taenia solium metacestode.pdf(1186KB). --. -- ... In this study, we identified a cDNA encoding for a cathepsin L-like cysteine protease from the T solium metacestode (TsCL-1) ... In this study, we identified a cDNA encoding for a cathepsin L-like cysteine protease from the T solium metacestode (TsCL-1) ... Identification and characterization of a cathepsin L-like cysteine protease from Taenia solium metacestode.pdf ...
http://ir.ihb.ac.cn/handle/152342/8802
*  DIGITAL.CSIC: Phylogenetic relationships and gene expression pattern of hree different cathepsin L (Ctsl) isoforms in zebrafish...
Certain cysteine proteases, such as cathepsin L (Ctsl), have been involved in yolk processing mechanisms in oocytes and embryos ... Phylogenetic relationships and gene expression pattern of hree different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the ...
https://digital.csic.es/handle/10261/20964
*  Cathepsin L2 ELISA & Assay Kits
Compare and order Cathepsin L2 ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. Recommended ... Bezeichner auf Proteinebene für Cathepsin L2 cathepsin L2 , cathepsin L , cathepsin L1 , cathepsin L2 preproprotein , cathepsin ... Cathepsin L2 Antigen Profile Beschreibung des Gens The protein encoded by this gene, a member of the peptidase C1 family, is a ... Images for product: Cathepsin L2 (CTSL2) ELISA Kit Diagramm of the ELISA kit to detect Human CTS5with the optical density on ...
https://www.antikoerper-online.de/toll-like-receptors-cascades-pathway-90/cathepsin-l2-elisa-kit-2865/
*  MDL 28170|Calpain and cathepsin B inhibitor, selective|CAS# 88191-84-8
p, MDL 28170 is a selective inhibitor, which inhibites calpain with Ki values of 10nM and cathepsin B with Ki values of 25 nM ... MDL 28170 is a selective inhibitor, which inhibites calpain with Ki values of 10nM and cathepsin B with Ki values of 25 nM ... Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin- ...
http://www.apexbt.com/mdl-28170.html
*  Positive cells in gastric mucosa of ctsz2/2 (p = 0.009) and wt mice | GlyT1 inhibitor glyt1inhibitor.com
... ctsz2/Cathepsin X and Premalignant Host ResponseFigure 1. Colonization efficiency of H. pylori in the corpus mucosa and the ... ctsz2/Cathepsin X and Premalignant Host ResponseFigure 1. Colonization efficiency of H. pylori in the corpus mucosa and the ...
http://glyt1inhibitor.com/index.php/2017/08/07/positive-cells-in-gastric-mucosa-of-ctsz22-p-0-009-and-wt-mice/
*  "Lysosomal cathepsin B participates in the podosome-mediated extracellu" by Chun Tu, Ceasar F. Ortega-Cava et al.
The lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue ... Overall, our results suggest that cathepsin B, delivered by lysosomal vesicles, is involved in the matrix degradtion of ... Using inhibitors and shRNA-mediated depletion, we show that cathepsin B participates in podosomes-mediated focal matrix ... remodeling, have yet to be linked to podosomes with the exception of cathepsin K in osteoclasts. ...
https://scholar.uwindsor.ca/biologypub/23/
*  Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure | Hypertension
Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure. Xian Wu Cheng, Guangxian Zhao, Xoingyi ... Background: Cysteinyl cathepsin K (CatK) is one of the most potent mammalian collagenases involved in cardiovascular disease. ... Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure ... Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure ...
http://hyper.ahajournals.org/content/66/Suppl_1/AP158
*  Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin
DARPin: designed ankyrin repeat protein; CatB: cathepsin B; scCatB: single chain cathepsin B; hcCatB: heavy chain cathepsin B; ... Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer. Clinical cancer research. 1995; ... Inhibition of cathepsin activity. Recombinant cathepsins (human CatB 1 nM, mouse CatB 1 nM, human CatL 1 nM, human CatK 1 nM, ... Non-Invasive Imaging of Cysteine Cathepsin Activity in Solid Tumors Using a 64Cu-Labeled Activity-Based Probe. PloS one. 2011;6 ...
http://thno.org/v07p2806.htm
*  Tear-Derived Cathepsin S Activity as a Novel Diagnostic Marker for Sjögren's Syndrome | IOVS | ARVO Journals
Purpose: : To evaluate the utility of Cathepsin S (CATS) as a biomarker for diagnosing Sjögren's Syndrome (SjS), CATS levels in ... Tear proteins were subsequently eluted and analyzed within 4 hours for CATS activity using the BioVision Cathepsin S Activity ... Tear-Derived Cathepsin S Activity as a Novel Diagnostic Marker for Sjögren's Syndrome ... Tear-Derived Cathepsin S Activity as a Novel Diagnostic Marker for Sjögren's Syndrome ...
http://iovs.arvojournals.org/article.aspx?articleid=2356868
*  Demonstration by electrospray mass spectrometry that the peptidyldipeptidase activity of cathepsin B is capable of rat...
These cleavages were pronounced at pH 5.0 compared with pH 6.0, in agreement with the lower pH optimum for cathepsin B ... From this example of the peptidyldipeptidase activity of cathepsin B we conclude that removal of the C-terminal extension may ... Electrospray mass spectrometric techniques were used to demonstrate that mature (single-chain) recombinant rat cathepsin B is ... Demonstration by electrospray mass spectrometry that the peptidyldipeptidase activity of cathepsin B is capable of rat ...
http://www.biochemj.org/content/294/3/923
*  Structure Cluster - 1CPJ: CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX:...
Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based ... CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED ... Description: CATHEPSIN B protein , Length: 260 No structure alignment results are available for 1CPJ.A, 1CPJ.B explicitly.. ...
http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1CPJ
*  Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans. | Genetics
Cathepsin D purified from a mutant strain has a lower activity per unit mass of pure enzyme. These data suggest that cad-1 is a ... Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.. L A Jacobson, L Jen-Jacobson, J M ... Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.. L A Jacobson, L Jen-Jacobson, J M ... Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.. L A Jacobson, L Jen-Jacobson, J M ...
http://www.genetics.org/content/119/2/355
*  Recombinant human Cathepsin L protein (ab81780) Protocols
There are no specific protocols for Recombinant human Cathepsin L protein (ab81780). Please download our general protocols ...
http://www.abcam.com/recombinant-human-cathepsin-l-protein-ab81780-protocols.html
*  Cathepsin K Expression and Activity in Canine Osteosarcoma - Schmit - 2011 - Journal of Veterinary Internal Medicine - Wiley...
Cathepsin K Expression and Activity in Canine Osteosarcoma. Authors. *. J.M. Schmit,. *From the Department of Veterinary ... Cathepsin K (CatK) is a lysosomal protease with collagenolytic activity, and its secretion by osteoclasts is responsible for ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.00834.x/abstract?globalMessage=0