Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-cell acute lymphoblastic leukemia. Blood, ...

To establish a more direct link of δ-catenin to Alzheimers disease, the researchers transfected into neuronal cells δ-catenin ... Previously, δ-catenin was also implicated in brain and eye development, but not directly in either cataracts or Alzheimers ... Three intronic (non-coding) SNPs in the gene encoding δ-catenin came to the fore. This protein is a key component in cell ... δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and ...

Beta-Catenin shows only cytoplasmic immunoreactivity. Vimentin is, in contrast, strongly positive. Ki-67 marks very rare cells ...

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.  Huang, De; Wang, Yan; Thompson, J ...

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A (2009) 106(2):641-6. ... Endothelial Wnt/beta-catenin signaling reduces immune cell infiltration in multiple sclerosis. Proc Natl Acad Sci U S A (2017) ... Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 183(3):409-17. doi:10.1083/jcb. ... Wnt/β-catenin signaling promotes both CNS angiogenesis and BBB formation by production of Wnts from neural progenitors (138-142 ...

Cbfβ inhibits fat cell formation through an important cell signaling pathway called Wnt/β-catenin. It also inhibits expression ... References: Cbfβ governs osteoblast-adipocyte lineage commitment through enhancing β-catenin signaling and suppressing ...

Wnt/β-Catenin Signaling Determines the Vasculogenic Fate of Postnatal Mesenchymal Stem Cells. Stem Cells. 2016 Jun;34(6):1576- ...

B) The majority of genes in the early β-catenin signature were unaffected by β-CatMO at stage 9; the effect of β-catenin MO ... Interestingly, only 123 β-catenin targets were enriched on the dorsal side and defined an early dorsal β-catenin gene signature ... A) Heat map showing the fold change of early β-catenin signature genes in three β-catenin MO and five dorsal halves with ... In conclusion, most genes in the early β-catenin signature become sensitive to β-catenin depletion only at gastrula stage, ...

2012) TREM2 and beta-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. J Immunol 188:2612-2621, ...

Antibodies for proteins involved in glial cell fate determination pathways, according to their Panther/Gene Ontology Classification

Rapamycin-induced autophagy in osteosarcoma cells is mediated via the biglycan/Wnt/β-catenin signaling axis ...

β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus ...

Regulation of Osteoarthritis Development by Wnt-beta-catenin Signaling through the Endochondral Ossification Process. ...

CRISPR/Cas9-Induced Fam83h knock-out Leads to Impaired Wnt/β-Catenin. Pathway and Altered Expression of Tooth Mineralization ... also the expression level of Fgf10 and mediators of the Wnt/β-catenin pathway was measured in the skin of both Knockout ... Significant down-regulation of CK1a, CK1e, and β-catenin in the dental root of Fam83h-Knockout mice was associated with a ... Additionally, Fam83h has been found to be potentially linked to the Wnt/β-catenin pathway.Objectives: This study aimed to ...

wnt/beta-catenin pathway, gastrointestinal tumors, CRC. Subjects:. 500 Natural sciences and mathematics. 500 Natural sciences ... As proof of principle the siRNA-mediated knock down of β-catenin was verified on mRNA and protein level in LS174T cells. After ... As proof of principle the siRNA-mediated knock down of β-catenin was verified on mRNA and protein level in LS174T cells. After ... Specific knock-downs of β-catenin and PAR-1 were achieved which was confirmed via mRNA analysis. As for CTP4-DTA pDNA delivery ...

Beta-catenin Controls Metastasis in Braf-activated Pten-inactivated Melanomas. GSE32994. Oct4 and jhdm1b infected MEF with or ... Expression data from Thymocytes of WT, TCF-1-deficient and β-catenin transgenic mice. ...

Immunohistochemical (IHC) staining showed CK (-), vimentin (+), CD68 (+), β-catenin (+), p53 (+), S-100 (-), CD34 (-), SMA ... β-catenin staining of the BSC component (positive, × 100); E: P53 staining of the BSC component (positive, × 100); F: Ki-67 ... Immunopositive carcinomatous cells for β-catenin are closely adjacent to the invasion depth (yellow circle, × 20, × 100); K: Ki ...

E-cadherin interacts with the F-actin cytoskeleton via theβ-catenin/α-catenin complex(Rimm et al., 1995), and may also regulate ... We propose that the β-catenin-binding site and β-catenin are required for track assembly, and that the juxtamembrane site ... β-Catenin, but not p120, is required for track formation. As E-cadherin is required for fusion(Uemura et al., 1996), it is ... 4G-I) andβ-catenin (armadillo) mutant embryos(Fig. 4K-L). In wild-type stage 13 embryos, E-cadherin (Fig. 4G) and Shot (Fig. 4H ...

2017) Evolution and diversity of cadherins and catenins Experimental Cell Research 358:3-9. ...

The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancer PARISA SHIRI AGHBASH1,2,4, NIMA HEMMAT1 ... Here, we found that AZD2858 promotes the accumulation of β-catenin in the nuclei of stem cells from the apical papilla (SCAPs) ... Treatment of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway, yet the function of this pathway in tooth ... MicroRNA-188-5p targeting Forkhead Box L1 promotes colorectal cancer progression via activating Wnt/β-catenin signaling JIALIN ...

Beta-catenin activation that is independent of the Wnt signaling pathway have been observed in many types of cancer. This study ... In response to epidermal growth factor (EGF), the team found, PKM2 moves into the cell nucleus and binds to beta-catenin that ... PKM2-dependent beta-catenin activation is instrumental in EGFR-promoted tumor cell proliferation and brain tumor development. ... Levels of beta-catenin phosphorylation and nuclear PKM2 are correlated with grades of glioma malignancy and prognosis. ...

Conditional deletion of ?-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary ... HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling. ... β-Catenin is required for Ron receptor-induced mammary tumorigenesis. Oncogene, 30 34, 3694-704 ... HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical ?-catenin signaling. ...

... catenin pathway to promote bone formation rather than inhibiting bone decomposition, and therefore may be effective in treating ...

Mefloquine targets β-catenin pathway and thus can play a role in the treatment of liver cancer. ... Corrigendum to "Mefloquine targets β-catenin pathway and thus can play a role in the treatment of liver cancer" [Microb. ... Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma. ...

Protein Kinase A-Dependent pSer(675)-?-catenin, a Novel Signaling Defect in a Mouse Model of Congenital Hepatic Fibrosis. ... Cyclic-AMP-Dependent, Rac1-Mediated Nuclear Translocation Of P-Ser-675?-Catenin, A Novel Signaling Defect in Congenital Hepatic ... PKA-Dependent p-SER675-b-Catenin Phosphorylation Increases Cholangiocyte Motility in Pkhd1del4/del4 Mouse, a Model of ...

Canonical Wnt/?-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance. Cancer ...

The emergence of pattern in embryogenesis: Regulation of beta-catenin localization during early sea urchin development. STKE ...

... thereby regulating VHL-mediated β-catenin degradation as well as EGFR/AKT signaling through VHL/β-catenin and the PPARα/AP-1 ... inhibition of miR-23b reduces tumor malignancy by downregulating HIF-1α, β-catenin, MMP2, MMP9, VEGF and ZEB1 and increasing ... δ-catenin palmitoylation mediates activity-induced synapse plasticity. Synaptic plasticity is known to underlie learning and ... A New Candidate Drug Fights Glioblastoma by Targeting a Suite of miRNAs that Regulate Wnt/β-catenin Signaling The small ...

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. Journal of Pathology 243(4), ... PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. Journal of Pathology 243(4), ...

Recent molecular studies have shown that the adamantinomatous type is driven by β-catenin (CTNNB1) mutations, while the ... The former is driven by β-catenin (CTNNB1) mutations and the latter by BRAF V600E mutations. ...