Loading...
Dextranase from Penicillium minioluteum: Reaction Course, Crystal Structure, and Product Complex  Dextranase from Penicillium minioluteum: Reaction Course, Crystal Structure, and Product Complex
The structure of the catalytic domain of Cel6A from T. fusca in complex with a non-hydrolysable substrate analogue has been ... The main domain of the enzyme is a right-handed β-helix, which is connected to a β-sandwich domain at the N-terminus. Using NMR ... Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. ... The architecture of the catalytic cleft differs significantly from other GH 5 enzyme structures. We therefore suggest that ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:167694
Structures of 'hot' cancer target solved | August 1, 2016 Issue - Vol. 94 Issue 31 | Chemical & Engineering News  Structures of 'hot' cancer target solved | August 1, 2016 Issue - Vol. 94 Issue 31 | Chemical & Engineering News
Catalytic domain 2 (CD2) is the main site for deacetylation. Catalytic domain 1 (CD1), in contrast, is often called the "low ... Both groups solved structures of the isolated catalytic domains. In addition, Matthias's group solved a structure of CD1 and ... Domain CD1 (blue) and CD2 (dark red) form an ellipsoid complex with pseudo-twofold symmetry. The linker (green) connecting the ... Domain. CD1 (blue) and CD2 (dark red) form an ellipsoid complex with pseudo-twofold symmetry. The linker (green) connecting the ...
more infohttps://cen.acs.org/articles/94/i31/Structures-hotcancer-target-solved.html?utm_source=InLine&utm_medium=InLine&utm_campaign=YIR16
MMP3 - Wikipedia  MMP3 - Wikipedia
... and the calcium ion are present in the catalytic domain approximately 12 Å away from the catalytic zinc. The catalytic zinc ion ... a catalytic domain; and a hemopexin-like domain at the carboxy-terminal. The propeptide consists of approximately 80-90 amino ... The catalytic domain contains two zinc ions and at least one calcium ion coordinated to various residues. One of the two zinc ... The catalytic domain of MMP-3 can be inhibited by tissue inhibitors of metalloproteinases (TIMPs). The n-terminal fragment of ...
more infohttps://en.wikipedia.org/wiki/MMP3
PDB-5wte: Cryo-EM structure for Hepatitis A virus full particle - Yorodumi  PDB-5wte: Cryo-EM structure for Hepatitis A virus full particle - Yorodumi
RNA dependent RNA polymerase / Peptidase S1, PA clan / RdRp of positive ssRNA viruses catalytic domain profile. / Hepatitis A ... RNA-directed RNA polymerase, catalytic domain / Viral coat protein subunit / Peptidase C3A/C3B, picornaviral / Picornavirus/ ... RNA-directed RNA polymerase, catalytic domain / Viral coat protein subunit / Peptidase C3A/C3B, picornaviral / Picornavirus/ ... RNA-directed RNA polymerase, C-terminal domain / Picornavirus capsid / Superfamily 3 helicase of positive ssRNA viruses domain ...
more infohttps://pdbj.org/emnavi/quick.php?id=pdb-5wte
Changes in Lolium perenne transcriptome during cold acclimation in two genotypes adapted to different climatic conditions | BMC...  Changes in Lolium perenne transcriptome during cold acclimation in two genotypes adapted to different climatic conditions | BMC...
Enriched SMART domains revealed the presence of functional domains such as serine-threonine protein kinase catalytic (S_TKc), ... serine-threonine phosphatases, family 2C, catalytic (PP2Cc), heat shock factor (HSF), cyclin, and formin homology (FH) domains ... Enrichment of functional domains such as S_TKc, PP2Cc, HSF, cyclin, and FH during cold acclimation indicates the activation of ... Additional file 13: Major functional domains of differentially expressed proteins in 'Veyo' genotype of perennial ryegrass ( ...
more infohttps://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-015-0643-x
den Hertog group  den Hertog group
Comparative kinetic analysis and substrate specificity of the tandem catalytic domains of the receptor-like protein-tyrosine ... Involvement of the membrane distal catalytic domain in pervanadate-induced tyrosine phosphorylation of receptor protein- ... Catalytically active membrane-distal phosphatase domain of RPTPα is required for Src activation. Vacaru, A.M. and den Hertog, J ... Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains. ...
more infohttps://www.hubrecht.eu/research-groups/den-hertog-group/
Complement Component C1r Antibody [Unconjugated] (AF1807): Novus Biologicals  Complement Component C1r Antibody [Unconjugated] (AF1807): Novus Biologicals
The B chains contain the serine protease catalytic domain. The full-length (amino acid residues 1‑705) of human C1r was ... The A chains contain multiple domains in the order of CUB1-EGF-CUB2-CCP1-CCP2-Activation Peptide. ...
more infohttps://www.novusbio.com/products/complement-component-c1r-antibody_af1807
Gene Info  Gene Info
CC] proton-transporting two-sector ATPase complex, catalytic domain *[MF] hydrogen-exporting ATPase activity, phosphorylative ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=659656&LLNO=90423
Gene Info  Gene Info
CC] proton-transporting V-type ATPase, V1 domain *[CC] proton-transporting two-sector ATPase complex, catalytic domain *[CC] ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=371614&LLNO=66144
Biology | Free Full-Text | A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G  Biology | Free Full-Text | A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G
Several high-resolution structures of the APOBEC3G catalytic domain have been generated, but none reveal how this enzyme binds ... Several high-resolution structures of the APOBEC3G catalytic domain have been generated, but none reveal how this enzyme binds ... These observations were supported by A3G catalytic domain-ssDNA chemical shift perturbation experiments. The overall data set ... Concordant with both models, changing the conserved arginine at position 313 to glutamate abolished both catalytic and ...
more infohttp://mdpi.com/2079-7737/1/2/260/xml
Protein alignment agains all known databases - Biology-Online  Protein alignment agains all known databases - Biology-Online
E.g. catalytic domain, localization domain, dimerization domain... In my case, the catalytic domain is known, and I want to ... What I need is actually to look for other domains. Is there a tool somewhere that can look for all known domains within a given ... So, the your identified domain is spanning whole sequence or not?. no. say, a protein is ~300 residues; one domain is known - ... if you have detected some domains, you can't have other domains in the same sequence! ...
more infohttps://www.biology-online.org/biology-forum/viewtopic.php?t=18762&hilit=Blast
SDAP : Structural Database of Allergenic Proteins  SDAP : Structural Database of Allergenic Proteins
PF00217: ATP:guanido phosphotransferase, C-terminal catalytic domain Pfam is a database of multiple sequence alignments and ... Plo i 1.0101 - Pfam domains. Sequence. Pfam sequence. Pfam family. Allergens from. this Pfam family. Pfam database. Pfam region ... hidden Markov models covering protein domains and families. Inspect MotifMate results for Plo i 1.0101. AutoMotif contains a ...
more infohttp://fermi.utmb.edu/cgi-bin/SDAP/sdap_02?dB_Type=0&allid=655
WikiGenes - CPD-9675 - 2,2,2-trichloroethanoate  WikiGenes - CPD-9675 - 2,2,2-trichloroethanoate
Extracellular domain deletion and catalytic domain point mutations. Thompson, D.K., Garbers, D.L. J. Biol. Chem. (1995) [Pubmed ... Expression of the putative cyclase catalytic region (HCAT) resulted in the formation of an active enzyme that migrated as a ...
more infohttps://www.wikigenes.org/e/chem/e/119236.html
Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans  Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans
The amino-acid sequence of the GTF-SI catalytic domain had 58% and 90% identity to the corresponding domains from GTF-S and GTF ... Here, we subcloned the catalytic domain of GTF-SI from S. mutans strain MT8148. The GTF-SI catalytic region contained 844 amino ... a conserved catalytic domain of approximately 900 amino acids and a C-terminal domain of approximately 500 amino acids composed ... Genomic DNA was extracted and purified using a DNeasy kit (Qiagen). The gene sequence corresponding to the catalytic domain of ...
more infohttp://pubmedcentralcanada.ca/pmcc/articles/PMC2935234/
Single-molecule imaging analysis of Ras activation in living cells | PNAS  Single-molecule imaging analysis of Ras activation in living cells | PNAS
Recruitment of GAP334, the Ras-Binding, Catalytic Domain of p120RasGAP, on the Cell Membrane. To test the model for the ... the catalytic domain of p120RasGAP that binds to activated Ras (see Supporting Text)] on the plasma membrane was examined. ... This finding was further confirmed by a pull-down assay, with use of the Ras-binding domain of Raf-1 kinase. The YFP-H-Ras ... 5, third boxes), suggesting that the cholesterol-enriched raft domains (30) may not be involved in slowing the diffusion of ...
more infohttp://www.pnas.org/content/101/19/7317
The Arabidopsis thaliana proteome harbors undiscovered multi-domain molecules with functional guanylyl cyclase catalytic...  The Arabidopsis thaliana proteome harbors undiscovered multi-domain molecules with functional guanylyl cyclase catalytic...
... of multi-domain molecules with potentially functional GC catalytic centers in plants that remain to be discovered and ... Implications of the hypothesis If it turns out that plants do harbor a large number of functional GC domains as part of multi- ... Secondly, recombinant peptides containing the GC domain need to be tested in in vitro GC assays such as the enzyme-linked ... GC search motifs constructed from the alignment of known GCs catalytic centers form vertebrates and lower eukaryotes have led ...
more infohttps://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-11-48
Kinase Protein  Kinase Protein
... by catalytic domains. AGC Protein Kinase STE Protein Kinases CAM Protein Kinase Casein Protein Kinase CMGC ...
more infohttp://www.sinobiological.com/kinase-protein.html
Nitric Oxide  Nitric Oxide
Structure/function of the soluble guanylyl cyclase catalytic domain Kenneth C. Childers , Elsa D. Garcin ... Structure/function of the soluble guanylyl cyclase catalytic domain Kenneth C. Childers , Elsa D. Garcin ... Structure/function of the soluble guanylyl cyclase catalytic domain Kenneth C. Childers , Elsa D. Garcin ... Structure/function of the soluble guanylyl cyclase catalytic domain Kenneth C. Childers , Elsa D. Garcin ...
more infohttps://www.journals.elsevier.com/nitric-oxide
Modulation of the Chromatin Phosphoproteome by the Haspin Protein Kinase | Molecular & Cellular Proteomics  Modulation of the Chromatin Phosphoproteome by the Haspin Protein Kinase | Molecular & Cellular Proteomics
2009) Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc. Natl ... Haspin452-798 catalytic domain fragment was purified as previously reported (5). ... we cocrystallized the kinase catalytic domain with the H3 tail substrate sequence. The structure was refined to 1.9 Å ... a highly positively charged flexible loop linking the histone fold to the macro domain; and (3) a macro domain that is exposed ...
more infohttps://www.mcponline.org/content/13/7/1724?ijkey=dd93a38224c687b036e8b3bbdcebcc5ad2b55d0c&keytype2=tf_ipsecsha
Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus. ...  Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus. ...
The strategy selected for identifying the relevant catalytic domains of the molecule relies upon the production in COS-7 cells ... Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus. ... The strategy selected for identifying the relevant catalytic domains of the molecule relies upon the production in COS-7 cells ... Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus ...
more infohttps://www.semanticscholar.org/paper/Mapping-of-the-catalytic-and-epitopic-sites-of-to-a-Hoshino-Kukimoto/b6e55748c7b1f568e03fccfccf3d1978258bdf46
Co-occurrence Search  Co-occurrence Search
Catalytic Domain (3018) catalytic domain * Genes, rRNA (3010) genes, rrna * BRCA1 gene (2927) brca1 gene ...
more infohttp://linkedlifedata.com/cooccurrence
Co-occurrence Search  Co-occurrence Search
Catalytic Domain (3018) catalytic domain * Genes, rRNA (3010) genes, rrna * BRCA1 gene (2927) brca1 gene ...
more infohttp://linkedlifedata.com/cooccurrence?resultType=Pubmed
Plus it  Plus it
RAS is composed of the core G-domain containing the catalytic machinery and a lipidated C-terminal hypervariable region with ... The Ras-membrane interface: isoform-specific differences in the catalytic domain. Mol Cancer Res 2015 Jan 7. [Epub ahead of ... cystein-rich domain), the second RAS-binding domain found in RAF (site 4; Fig. 5B; ref. 66). Binding at this site can ... The Ras G-domain is subdivided in two lobes (57). The first (residues 1-86), identical in sequence between the Ras isoforms, ...
more infohttp://clincancerres.aacrjournals.org/content/21/8/1810
Ruth Nussinov, Ph.D. | Center for Cancer Research - National Cancer Institute  Ruth Nussinov, Ph.D. | Center for Cancer Research - National Cancer Institute
We performed comprehensive molecular dynamics simulations on the wild-type K-Ras4B (K-Ras4B(WT)-GTP/GDP) catalytic domain, the ... We explained that Raf's activation requires dimerization of the catalytic domain. Thus, Raf's activation requires Ras spatial ... Catalytic Domain Interactions in Small GTPase KRAS4B, Exposing the Effector Binding Site (Lu S, Banerjee A, Jang H, Zhang J, ... The source of the catalytic power is the modulation of the transition state. However, our definition of the transition state is ...
more infohttps://ccr.cancer.gov/Cancer-and-Inflammation-Program/ruth-nussinov?qt-staff_profile_tabs=5
Plus it  Plus it
... mTOR kinase resistant clones harbored mutations in the mTOR catalytic domain. These mutations were not observed in the parental ... Drug-bound FKBP12 complex binds to mTOR FRB domain and selectively inhibits the activity of mTORC1. However, rapalogs ... Deep sequencing results explained these findings: rapamycin resistant clones harbored mutations in the FRB domain of mTOR, in ... It is likely that the mutations identified in each domain prevent binding of the drug. ...
more infohttp://cancerres.aacrjournals.org/content/73/24_Supplement/PD1-8