Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different ... Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 2007;317:239-42. ... A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A ... Class I PI3Ks form heterodimers consisting of regulatory and p110 catalytic subunits; they are activated by signals from growth ...