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*  Active Caspases and Cleaved Cytokeratins Are Sequestered into Cytoplasmic Inclusions in Trail-Induced Apoptosis | JCB
Caspases can be divided into two classes: (1) initiator caspases, with long prodomains, such as caspases-8 and -9, which either ... caspase-3-GFP (C and D), caspase-7-GFP (E and F), or caspase-8-GFP (G and H). At 24 h after transfection, cells were incubated ... indirect activation of caspase-9, and downstream effector caspases. Cleavage of Bid, a caspase-8 substrate, only previously has ... 1998). Caspase-7, a major effector caspase, was present in MCF-7 cells primarily as its intact 35-kD proform (Fig. 1 A, lane 1 ...
http://jcb.rupress.org/content/148/6/1239
*  Apoptosis-associated speck-like protein containing a CARD (ASC) | P2X7
It promotes pyropoptosis in macrophages and induces caspase-mediated apoptosis (involving caspase-8 and caspase-9). ... It is a component of several inflammatory complexes, inflammasomes, which are important for caspase-1 activation, processing ...
http://www.p2x7.co.uk/proteins/apoptosis-associated-speck-like-protein-containing-a-card/
*  Role of factors downstream of caspases in nuclear disassembly during apoptotic execution | Philosophical Transactions of the...
Role of factors downstream of caspases in nuclear disassembly during apoptotic execution. K. Samejima, P. Villa, W. C. Earnshaw ... They also suggest that activation of the downstream factors (rather than the caspases) is the critical event that occurs at the ... Biochemical frac-tionation of these extracts reveals that a column fraction enriched in endogenous active caspases is un-able ... These apoptotic changes appear to require the function of multiple caspases (cysteine aspar-tases, a specialized class of ...
http://rstb.royalsocietypublishing.org/content/354/1389/1591
*  Caspase 8 - Wikipedia
Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... Cowling V, Downward J (October 2002). "Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis ... "Entrez Gene: CASP8 caspase 8, apoptosis-related cysteine peptidase".. *^ a b c Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, ... Caspase 3. Pro-apoptotic:. BAX. BAK1/Bcl-2 homologous antagonist killer. Bcl-2-associated death promoter. Anti-apoptotic:. Bcl- ...
https://en.wikipedia.org/wiki/CASP8
*  Caspase 8 - Wikipedia
Caspase-10, Caspase-2, Caspase-3, Caspase-6, Caspase-7, Caspase-9, DEDD, FADD, FasL, FasR, IFT57, NOL3, PEA15, RIPK1, TNFRSF10B ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... Cowling V, Downward J (October 2002). "Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis ... Biochemically, caspase-8 was found to enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 ( ...
https://en.wikipedia.org/wiki/Caspase_8
*  Caspase-8 deficiency - Wikipedia
Caspase-8 deficiency (CEDS) is a very rare genetic disorder of the immune system. It is caused by mutations in the CASP8 gene ... Biochemically, caspase-8 was found to enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 ( ... Caspase-8 is involved in the initiation of the cell death signal cascade. Cell death counters proliferation of lymphocytes, ... CEDS is caused by homozygous mutations in caspase-8. Caspase-8 is a 51 kb gene with 13 exons encoding for a 496 amino acid ...
https://en.wikipedia.org/wiki/Caspase-8_deficiency
*  Caspase 8 siRNA vector (ab12496) | Abcam
Ab12490 Caspase 3 siRNA vector ?ab12496 Caspase 8 siRNA vector ?ab12504 Caspase 9 siRNA vector ... I have now added the western blot image for the caspase 3 knockdown. It can be viewed on www.abcam.com/ab12490. If you do have ... I am interested in the SiRNA for Human Caspase-8. I will really apprciate if you send me the following information: 1) Is it ... I'm interesting in your siRNA vectars against several caspases but there are no datas on your web pages. Could you show me the ...
https://www.abcam.com/caspase-8-sirna-vector-ab12496.html
*  Caspase 8 Substrate 1, chromogenic
... derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA ... pNA has maximum absorption around 408 nm.; Caspase-8 substrate with Km = 66 uM; Substrate for granzyme B; Ac-IETD-pNA; Ac - Ile ... peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. ... pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. ...
https://www.anaspec.com/products/product.asp?id=29428&productid=11923
*  Anti-Caspase-8 antibody [ABM14C1] (ab220171) | Abcam
Mouse monoclonal Caspase-8 antibody [ABM14C1]. Validated in WB, IHC, Flow Cyt and tested in Human. Cited in 1 publication(s). ... All lanes : Anti-Caspase-8 antibody [ABM14C1] (ab220171) at 2 µg/ml. Lane 1 : Molt-4 cell lysate. Lane 2 : Kato III cell lysate ... Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell ... This product Mouse Anti-Caspase-8 antibody [ABM14C1] (ab220171) WB, Flow Cyt, IHC-P ...
https://www.abcam.com/caspase-8-antibody-abm14c1-ab220171.html
*  Caspase-8 Substrates
BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.
https://www.biovision.com/products/apoptosis-related-products/caspases/caspase-8/caspase-8-substrates.html
*  The caspase-8 inhibitor FLIP promotes act... & related info | Mendeley
... rapidly induces cell death through recruitment and activation of caspase-8 via the adaptor protein Fas-associated death domain ... The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways. *Kataoka T ... there was activation of the transcription factors NF-κB and AP-1 and recruitment of the caspase-8 inhibitor and FADD- ... rapidly induces cell death through recruitment and activation of caspase-8 via the adaptor protein Fas-associated death domain ...
https://www.mendeley.com/research-papers/caspase8-inhibitor-flip-promotes-activation-nf%CE%BAb-erk-signaling-pathways/
*  anti-Caspase 8 Primary Antibodies
Ausgesuchte Qualitäts-Hersteller für Caspase 8 Antikörper. Hier bestellen. ... Monoklonale und polyklonale Caspase 8 Antikörper für viele Methoden. ... We observed that NDMP generation was dependent on the extrinsic caspase apoptotic pathway (caspase 3 and caspase 8), cAMP ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ...
https://www.antikoerper-online.de/apoptose-pathway-9/caspase-8-antibody-2847/
*  anti-Caspase 8 antibody | GeneTex
Anti-Caspase 8 pAb (GTX31285) is tested in Human, Mouse samples. 100% Ab-Assurance. ... caspase 8, apoptosis-related cysteine peptidase) for ELISA, WB. ... caspase) family. Sequential activation of caspases plays a ... caspase 8, apoptosis-related cysteine peptidase. Background. This gene encodes a member of the cysteine-aspartic acid protease ... Caspase-8 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus human caspase-8 isoform ...
http://www.genetex.com/Caspase-8-antibody-GTX31285.html
*  anti-Caspase 8 antibody | GeneTex
Anti-Caspase 8 pAb (GTX50675) is tested in Human samples. 100% Ab-Assurance. ... Caspase 8 antibody (caspase 8, apoptosis-related cysteine peptidase) for WB. ... Storage Conditions: Caspase 8 antibody. Storage Buffer. saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ... caspase 8, apoptosis-related cysteine peptidase. Background. Most upstream protease of the activation cascade of caspases ...
http://www.genetex.com/Caspase-8-antibody-GTX50675.html
*  Product Overview anti-Caspase 8 Antibodies
Order monoclonal and polyclonal Caspase 8 antibodies for many applications. Selected quality suppliers for anti-Caspase 8 ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... anti-Caspase Recruitment Domain Family, Member 9 Antibodies * anti-Caspase Recruitment Domain-Containing Protein 18 (ICEBERG) ... anti-Caspase 7, Apoptosis-Related Cysteine Peptidase Antibodies * anti-Caspase 6, Apoptosis-Related Cysteine Peptidase ...
http://www.antibodies-online.com/apoptosis-pathway-9/caspase-8-antibody-2847/
*  Caspase 8 - Caspase-8 Summary Report | CureHunter
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS ... by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death ... A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS ... there were no changes in caspase-3-like activity, which is activated downstream of caspase-8; this may indicate that the ...
http://www.curehunter.com/public/keywordSummaryD053181.do
*  Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. - PubMed - NCBI
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.. Günther C1, Martini E, Wittkopf N, Amann K, ... b) Western blot for RIP3 and cleaved caspase-3 of IEC lysates isolated from TNF-α treated control and Casp8ΔIEC mice. Actin ... e) Representative immunofluorescence staining for TUNEL and active caspase-3 in crypts of the terminal ileum of a CD-patient. ( ... Increased caspase-8 independent cell death within crypts of Casp8ΔIEC mice ...
https://www.ncbi.nlm.nih.gov/pubmed/21921917
*  Caspase-8 Antibody Staining Protocol for Immunohistochemistry
... Description: The caspases represent a family of sulphydryl ... Caspase-8, also called FLICE, has an N-terminal domain with sequence homology to the death effector domain of FADD that allows ... Caspase-8 is activated by association with the Fas/FADD death-inducing signaling complex to release two active subunits, p18 ... This association with the cell surface death receptors has shown caspase-8 to be a proximal regulator of apoptosis. ...
http://www.ihcworld.com/_protocols/antibody_protocols/caspase8_novocastra.htm
*  Vital Nonapoptotic Functions for Caspase-8 in B Cells | Science Signaling
... was due to increased cell death mediated by caspase-3. Coimmunoprecipitation studies revealed that caspase-8 was recruited to ... Caspase-8 is known to be important in regulating T cells. To study B cell-specific roles for caspase-8, Lemmers et al. ... Deletion of caspase-8 inhibited the increase in B cell numbers elicited by agonists for the Toll-like receptors (TLRs), TLR2, - ... Vital Nonapoptotic Functions for Caspase-8 in B Cells Message Subject. (Your Name) has forwarded a page to you from Science ...
https://stke.sciencemag.org/content/2007/378/tw95
*  Caspase-8 Activity & Apoptosis | Nexcelom Bioscience
Caspase-8 Activity & Apoptosis. Caspase-8. Caspase-8 belongs to a family of evolutionally conserved cysteine proteases that ... When detecting caspase-8, we utilize a specific FITC-conjugated caspase-8 inhibitor, IETD-FMK. IETD-FMK is cell-permeable and ... Because Caspase-8 activation is such an early step in the extrinsic apoptosis pathway, measurement of Caspase-8 is an ... Cellometer Caspase-8 Apoptosis Kit. The CaspGLOW™Fluorescein Active Caspase-8 Staining Kit offers a simple, sensitive method ...
https://www.nexcelom.com/caspase-8-activity-apoptosis/
*  Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles | The Journal of Immunology
Caspase expression and processing were analyzed by Western blotting using rat anti-mouse caspase-8 mAb (1G12; kindly donated by ... This difference might be attributable to the ability of caspase-10, a close homologue of caspase-8 that occurs in humans but ... Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles. Tae-Bong Kang, Tehila Ben-Moshe, Eugene E. Varfolomeev, Yael Pewzner- ... Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles. Tae-Bong Kang, Tehila Ben-Moshe, Eugene E. Varfolomeev, Yael Pewzner- ...
http://www.jimmunol.org/content/173/5/2976.long
*  Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer
Caspases were marked with FLICA reagents covalently marked with a fluorescent probe: FAM (6-fluorescein amidite) for caspase 8 ... Once inside the cell, the caspase inhibitors bind specifically through the peptide moiety to caspases that have been activated ... but only caspase 9 in SW620 cells [54]. After 48 hours, the two caspases were fully activated. Our results here emphasize the ... caspase 9) pathways are linked by protein Bid: activated caspase 8 splits Bid, which then later activates caspase 9. Both ...
https://www.hindawi.com/journals/omcl/2015/154164/
*  APOFLUOR™ GREEN CASPASE 8 ACTIVITY KIT (03FAM239) - MP Biomedicals
Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. ...
https://www.mpbio.com/product.php?pid=03FAM239&country=223
*  Caspase 8 ELISA & Assay Kits
Compare and order Caspase 8 ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. Recommended ... Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive ... Search Caspase 8 ELISA Kits for other reactivities: Guinea Pig,. Pig (Porcine),. Cow (Bovine),. Dog (Canine),. Chicken,. Goat, ... Caspase 8 Antigen Profile Antigen Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. ...
https://www.antibodies-online.com/apoptosis-pathway-9/caspase-8-elisa-kit-2848/
*  Casp8ap2 MGI Mouse Gene Detail - MGI:1349399 - caspase 8 associated protein 2
J:55798 Imai Y, et al., The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis ...
http://www.informatics.jax.org/marker/MGI:1349399