Volume 5, Issue 14 | Oncotarget
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction
Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft
Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent ... can induce growth inhibition and promote caspase-dependent apoptosis in human colon cancer cells. This involves the inhibition ... 14 Nestel P, Fujii A and Zhang L: An isoflavone metabolite reduces arterial stiffness and blood pressure in overweight men and ... 14). Furthermore, its value as a potential antidiabetic agent in regulating lipid metabolism by the activation of PPAR-α and ...
Browsing Clinical Medicine (Scholarly Publications) by Title
Regeneration of the Aging Lung: A Mini-Review | Gerontology | Karger Publishers
... and activated caspase-3), and proliferation (PCNA) compared to tissue from age-matched nonsmokers. These studies indicate that ... 14.. Tsuji T, Aoshiba K, Nagai A: Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med 2006 ... keratin 14 (Krt14), and nerve growth factor receptor (NGFR) [29]. Their stem cell capacity is high, with the potential to self- ... 14,15]. Endothelial and alveolar cells from emphysema patients had shorter telomeres, increased expression of cellular ...
World Journal of Gastrointestinal Oncology - Baishideng Publishing Group
Curcumin induces apoptosis through caspase dependent pathway in human colon carcinoma cells. Molecular Biology Reports 2022; 49 ... 14. Christoffer Briggs Lambring, Sagar Shelake, Faraz Hasan, Riyaz Basha. Phytochemicals Targeting Tumor Microenvironment in ... Colorectal Disease 2012; 14(6) doi: 10.1111/j.1463-1318.2012.02960.x ...
Molecular Vision: Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa
Eguchi R, Tone S, Suzuki A, Fujimori Y, Nakano T, Kaji K, Ohta T. Possible involvement of caspase-6 and −7 but not caspase-3 in ... Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci USA. 2008; 105:12815-9. [PMID: ... Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose ... Caspases can be subdivided into initiator and executioner caspases and are generally activated by specific cell intrinsic or ...
Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway | eLife
2010) The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila Cell Death Differ 17:534-539. ... 3) The TNF staining in the hair follicle shows a surprisingly strong overlap with caspase staining, which does support the ... which recognizes cleaved effector caspases as well as the activity of the initiator caspase Dronc (Figure 1B) (Fan and Bergmann ... as shown by caspase-3 staining (red in E, white in E′). Genotype: hh-Gal4,UAS-myr-mRFP UAS-hid UAS-p35 hep1/Y (mRFP is also ...
Atopic dermatitis: MedlinePlus Genetics
Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family ... 2008 Apr 3;358(14):1483-94. doi: 10.1056/NEJMra074081. No abstract available. Citation on PubMed ... 2011 Oct 6;365(14):1315-27. doi: 10.1056/NEJMra1011040. No abstract available. Citation on PubMed ...
Antiproliferative and Apoptotic Effects of Shemamruthaa, a Herbal
... caspase-3, and caspase-9 mRNA and protein levels compared with mammary carcinoma-induced rats. Proliferating cell nuclear ... Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032), Apoptotic : CK(6986) : AC(5304), Caspase-3 Activation : CK( ... 137) : AC(90), Caspase-9 Activation : CK(70) : AC(46), Tumor Suppressor Protein p53 Upregulation : CK(585) : AC(431) ... After 3 months of induction period, the rats were treated with SM (400 mg/kg body weight) for 14 days. Our study shows that SM- ...
Cetyltrimethylammonium chloride-loaded mesoporous silica nanoparticles as a mitochondrion-targeting agent for tumor therapy -...
Caspase-3 activity was measured by caspase-3 activity assay kit. The MCF-7 cells were seeded into 6-well plates (1 × 105 cells ... 3.5 Visualization of LMP, caspase-3 activity level. The necrosis and apoptosis of cells are possibly related to the lysosomal ... 2.8 Visualization of lysosomal membrane permeabilization (LMP) and assay of caspase-3 activity. The cells were seeded in 15 mm ... Moreover, compared with the control group, CTAC@MSNs induce a slight increase of caspase-3 activity after incubating with MCF-7 ...
European Crohn´s and Colitis Organisation - ECCO - P079 Valproic acid increases MiR449a expression in intestinal mucosa from...
Caspase Inhibitor VI | Atpase Signal
... centrations of compound 35 for 24 h and then the expressions of Caspase Inhibitor VI NTCP, PARP, Bax, Bcl-2 and caspase-3 were ... Caspase Inhibitor VI. Bioorganic & Medicinal Chemistry Letters. Design, synthesis and biological evaluation of benzamide ... The apoptosis induced by 35 was characterized by the regulation of markers, including an increase in Bax, cleaved- caspase 3, ... and increased the cleavage of caspase 3 and PARP (Fig. 6E). These results indicate that compound 35 acts as an NTCP inhibitor ...
October | 2020 | Caspase Pathway
Posted in Caspase Pathway ICP27 contains an RGG box and has been shown to be methylated dur. Posted on October 30, 2020. by ... Posted in Caspase Pathway The transfer rates in the presence of two and three mismatched ba. Posted on October 27, 2020. by ... Posted in Caspase Pathway Methods: Patients. treated with simultaneous TEVAR and end. Posted on October 31, 2020. by casp4137 ... Posted in Caspase Pathway Brains were collected 24 h after MCAO and infarct volumes were an. Posted on October 29, 2020. by ...
The Putative Role of the Non-Gastric H+/K+-ATPase ATP12A (ATP1AL1) as Anti-Apoptotic Ion Transporter: Effect of the H+/K+...
8D) and caspase+ cells (Fig. 8F), respectively, are only evident after 72 h if the cells are stimulated by 1 mM butyrate (Fig. ... Caspase activity was quantified using the CaspACE™ FITC-VAD-FMK in situ marker (Promega), a FITC conjugate of the membrane ... or positive for caspase activation (Casp+ cells; E, F). Measurements were made at time points 0 h, 24 h, 48 h and 72 h after ... or positive for caspase activation (Casp+ cells; E, F). Measurements were made at time points 0 h, 24 h, 48 h and 72 h after ...
Fer, 14 ml, was added, overlaid with a single volume of 0.25 M sorbitol, 0.2 | Caspase1-Inhibitors caspase1inhibitor.com
14 ml, was added, overlaid with a single volume of 0.25 M sorbitol, 0.2 M EDTA, and 10 mM Mes/Tris, pH 6.9, with centrifugation ... By inhibitor caspase November 20, 2023. Fer, 14 ml, was added, overlaid with a single volume of 0.25 M sorbitol, 0.2 M EDTA, ... Fer, 14 ml, was added, overlaid with a single volume of 0.25 M sorbitol, 0.2 ... Fer, 14 ml, was added, overlaid with a single volume of 0.25 M sorbitol, 0.2 ...
NIOSHTIC-2 Search Results - Full View
nanoparticles is characterized by increased oxidative stress and caspase-3 activation at days 1 and 3 post exposure. Whether ... 0.05) at days 1 and 3 before being decreased by 35%, 25%, 20%, and 7% at days 14, 28, 56, and 90 respectively (P. ... 14, 28, 56 and 90 days (n=6/group). Compared to saline-control animals, the concentration of malondialdehyde (MDA) per gram of ...
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The non-apoptotic role of caspase-2 in cell cycle regulation and DNA repair | Cancer Community
These non-apoptotic mechanisms may underlie the role of caspase-2 as a tumor suppressor. ... We propose a model where caspase-2 regulates the cell cycle and protects DNA replication forks to prevent DNA damage accrual in ... The non-apoptotic role of caspase-2 in cell cycle regulation and DNA repair. We propose a model where caspase-2 regulates the ... How exactly caspase-2 contributes to DNA repair is unclear. Caspase-2-deficient cells show a significantly higher percentage of ...
Publications | Institute for Structural and Chemical Biology | University of Leicester
Caspase-8 complexes defines the catalytic dimer architecture for coordinated control of cell fate. Nature Communications 12(1): ... Sci., 14, 2826-2838. DOI: 10.1039/D2SC06098A.. Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K. The Bulk ... Mater. Interfaces 14, 49604−49616. DOI:10.1021/acsami.2c16647. Cross JM, Coulson ME, Smalley JP, Pytel WA, Ismail O, Trory JS, ... Sci., 14, 3682-3692. DOI: 10.1039/d2sc06432d.. Cowan R, Trokter M,Oleksy A, Fedorova M, SawmynadenK, Worzfeld T, Offermanns S, ...
C1QBP regulates apoptosis of renal cell carcinoma via modulating xanthine dehydrogenase (XDH) mediated ROS generation
... followed by triggering caspase promoter caspase-8 activation and downstream bax expression, mitochondrial cytochrome c release ... F) The expression of C1QBP, XDH, cleaved-caspase-3, bcl2, and bax was examined by western blot in ACHN and 786-O cells with ... C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/ ... The results demonstrated that C1QBP enhanced the expression of apoptotic protein bax and cleaved-caspase-3 and diminished anti- ...
Mitochondrial Proteins | Harvard Catalyst Profiles | Harvard Catalyst
Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice. Virol J. ...
Jon Morrow, PhD, MD | Directory of Faculty Research Interests
Caspase Remodeling of the Spectrin Membrane Skeleton during Lens Development and Aging*Lee A, Morrow J, Fowler V. Caspase ... Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells*Wang K, Posmantur R, Nath R, McGinnis ... Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosisWilliams S, Smith A, Cianci C, ... Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*Brown ...
Caspase-1 initiates apoptosis in the absence of gasdermin D ⋆ MedBiz Pro
A 438079 hydrochloride Supplier | CAS 899431-18-6 | A438079 HCl | Tocris Bioscience
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis | Journal of Cell Science | The Company of Biologists
... caspase-3, caspase-6 and caspase-7. Activated caspases rapidly cleave multiple substrates (Dix et al., 2008; Luthi and Martin, ... which activate a group of aspartate-specific proteases known as caspases (Youle and Strasser, 2008). Caspases, in turn, cleave ... Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J. Cell Biol ... Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. ...
Derek Abbott | Pathology | School of Medicine | Case Western Reserve University
Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate ... 2016). Active caspase-1 induces gasdermin D-dependent plasma membrane pores that are blocked by lanthanides. Journal of ... 2018) Mechanism of gasdermin D recognition by inflammatory caspases and their 2 inhibition by a gasdermin D-derived peptide ... 2020 Jul 14;53(1):106-114.e5. doi: 10.1016/j.immuni.2020.06.007. Epub 2020 Jun 17. PMID: 32553275 ...
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Caspase Cascade (7) CD28 Signaling in T-Helper Cell (43) CD4 and CD8 T-Cell Lineage (32) CD40 Signaling (1) Cellular Apoptosis ... EGF Pathway (14) Embryonic Stem Cell Pluripotency in Mouse (6) ErbB Family Pathway (9) ERK Signaling (19) FAK1 Pathway (4) Fas ... Soluble Receptors (14) Steroid Receptors/Nuclear Receptors (2) Synaptic Vesicle Trafficking/Endocytosis (2) Tau (2) TCRs (14) ... Apoptosis Through Death Receptors (14) Autophagy (6) B cell Development and Activation (86) BAFF in B-Cell Signaling (2) B-Cell ...