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*  Abstract 5053: Deficiency of ASC (Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain) in Bone...
Further, improved myocardial I/R injury was also observed in the caspase-1−/− mice, compared with WT mice (IA/AAR: 20.2% vs. ... ASC is an adaptor protein that forms inflammasome whose activation leads to caspase-1-dependent interleukin (IL)-1β generation ... Abstract 5053: Deficiency of ASC (Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain) in Bone ... Abstract 5053: Deficiency of ASC (Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain) in Bone ...
http://circ.ahajournals.org/content/120/Suppl_18/S1041.1
*  Apoptosis-associated speck-like protein containing a CARD (ASC) | P2X7
It promotes pyropoptosis in macrophages and induces caspase-mediated apoptosis (involving caspase-8 and caspase-9). ... It is a component of several inflammatory complexes, inflammasomes, which are important for caspase-1 activation, processing ... and secretion of pro-inflammatory cytokines (IL-1β, IL-18). ...
http://www.p2x7.co.uk/proteins/apoptosis-associated-speck-like-protein-containing-a-card/
*  caspase-1 [Mus musculus] - Protein - NCBI
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs.. Niu Z, Shi Q, Zhang W, Shu Y, Yang N, Chen B, Wang Q, ... Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles. [J Leukoc Biol. 2016] Caspase-1 as a ... LSBio CASP1 / Caspase 1 Elisa Kits [LifeSpan BioSciences, Inc.] LSBio CASP1 / Caspase 1 Elisa Kits. LifeSpan BioSciences, Inc. ... Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. [Nat Commun. 2017] ...
https://www.ncbi.nlm.nih.gov/protein/86198305
*  Caspase-1: the inflammasome and beyond. - PubMed - NCBI
Caspase-1: the inflammasome and beyond.. Sollberger G1, Strittmatter GE, Garstkiewicz M, Sand J, Beer HD. ... Caspase-1 plays a fundamental role in innate immunity and in several important inflammatory diseases as the protease activates ... Caspase-1 itself is activated in different inflammasome complexes, which assemble in response to a variety of exogenous and ... More recently, pyroptosis, a caspase-1-dependent type of programmed cell death, has been identified that is able to support ...
https://www.ncbi.nlm.nih.gov/pubmed/23676582?dopt=Abstract
*  Anti-Caspase-1 antibody (ab1872) | Abcam
Rabbit polyclonal Caspase-1 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 29 publication(s ... Infection induces apoptosis and increases caspase 3 for sure. We are unsure whether infection would induce caspase 1. However, ... You are offering a lot of antibodies for caspase-1, but which one is the most reliable?. Thank you very much for your support. ... We are currently trying to set up a IHC protocol for the detection of caspase-1 in human tissue (FFPE).. Two antibodies have ...
https://www.abcam.com/caspase-1-antibody-ab1872.html
*  Anti-Caspase-1 antibody (ab1872) | Abcam
Rabbit polyclonal Caspase-1 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 32 publication(s ... Anti-Caspase-1 antibody (ab1872). Rabbit polyclonal Caspase-1 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, ... Immunofluorescence analysis of caspase-1 in H9c2 cardiomyocytes treated with control, medium and high glucose using ab1872 (1: ... Immunocytochemistry/ Immunofluorescence - Anti-Caspase-1 antibody (ab1872)This image is courtesy of an Abreview submitted by ...
https://www.abcam.com/caspase-1-antibody-ab1872.html?productwalltab=abreviews
*  'caspase 1' Protocols and Video...
Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction', 'A Simple Fluorescence ... caspase 1' include 'Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization ... Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation', 'The Ex Vivo Colon Organ ... Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay', 'Visualization ...
https://www.jove.com/keyword/caspase+1
*  Caspase 1 - Wikipedia
... and a caspase, in this case Caspase-1. In some cases, where the signaling proteins contain their own CARDs, like in NLRP1 and ... Caspase-1 is produced as a zymogen that can then be cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the ... Active Caspase 1 contains two heterodimers of p20 and p10. It contains a catalytic domain with an active site that spans both ... Activated Caspase 1 proteolytically cleaves pro IL-1β and pro IL-18 into their active forms, IL-1β and IL-18. The active ...
https://en.wikipedia.org/wiki/Caspase_1
*  Caspase 1 Primary Antibodies
28 Caspase 1 Primary Antibodies: Thermo Fisher antibodies are validated for applications including western blotting, ... Host server : magellan-srch-1-prod-blue:8080/127.0.1.1:8080. git-commit: 251f14a7b7a26678539ac2ce55da85eace2393ce git-url: http ...
https://www.thermofisher.com/antibody/primary/query/Caspase+1
*  Sf caspase-1 - Wikipedia
Like other caspases, Sf caspase-1 is an aspartate-specific cysteine protease that is produced as an inactive proenzyme and ... The Sf caspase-1 proenzyme is cleaved after the amino acid residues Asp-28 and Asp-195, resulting in a smaller 12 kDa fragment ... The protein Sf caspase-1 is the insect ortholog of the human effector caspases CASP3 (CPP32) and CASP7 (MCH3) in the species ... Some experiments also showed cleavage of Sf caspase-1 at the residue Asp-184, resulting in a 18 kDa instead of 19 kDa fragment ...
https://en.wikipedia.org/wiki/Sf_caspase-1
*  Protocol to activate caspase-1 - Please help! - Immunology
Caspase-3 should NOT be activated, which is the issue. Caspase-1 is the only think I'm looking to be activated and that doesn't ... Caspase-3 activation is almost the last step of cell death. All different pathways end up with activation of caspase-3. So I'm ... is a unique form of cell death that does not depend on the activation of caspase-3. There is detectable activation of caspase-7 ... Protocol to activate caspase-1 - Please help! - (Jul/02/2013 ). I've followed a LOT of protocols from the literature and ...
http://www.protocol-online.org/biology-forums-2/posts/29729.html
*  Caspase-1 | definition of Caspase-1 by Medical dictionary
What is Caspase-1? Meaning of Caspase-1 medical term. What does Caspase-1 mean? ... Looking for online definition of Caspase-1 in the Medical Dictionary? Caspase-1 explanation free. ... Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis.. Is suppression of ... The initiator caspases including caspase-1, -8, -9, typically caspase-8 and caspase-9, are activated by two alternative ...
http://medical-dictionary.thefreedictionary.com/Caspase-1
*  Caspase 1 with inhibitor - Stock Image C025/1626 - Science Photo Library
Caspase-1 is a protease, an enzyme that cleaves proteins. It is found predominantly in the cell cytoplasm, where it activates ... Due to this activity caspase-1 is also known as ICE (interleukin-1-beta converting enzyme). Like other caspases it also plays a ... Molecular model of caspase-1 complexed with an inhibitor. ... interleukin-1-beta, a molecule that mediates immune and ... Caspase-1 is a protease, an enzyme that cleaves proteins. It is found predominantly in the cell cytoplasm, where it activates ...
http://www.sciencephoto.com/media/665865/view/caspase-1-with-inhibitor
*  Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response | PNAS
Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response. Mary K. Stewart ... Salmonella mutants lacking YdiV are unable to fully repress flagellin at systemic sites, rendering them vulnerable to caspase-1 ... Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response ... Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response ...
http://www.pnas.org/content/108/51/20742.short
*  Nigericin for generating a caspase-1 activation response.
... nigericin can be used as a positive control to generate a robust caspase-1 activation response in a variety of cell lines. ... Inflammatory caspases, such as caspase-1, play a critical role in the mechanism to trigger the lytic programmed cell death ... The amount of caspase-1 activity detected directly correlated to the duration of the exposure period; the longer the cells were ... ICT's caspase-1 inhibitor reagent, FAM-YVAD-FMK (kit catalog #9146) was used to monitor the caspase-1 induction response in ...
https://immunochemistry.com/product/nigericin/
*  Caspase 1, MBL International | VWR
Learn more about Caspase 1, MBL International. We enable science by offering product choice, services, process excellence and ...
https://us.vwr.com/store/product/24905980/caspase-1-mbl-international
*  caspase-1 substrate | CAS 143305-11-7 | SCBT - Santa Cruz Biotechnology
Buy caspase-1 substrate (CAS 143305-11-7), to inhibit the cleavage of the IL-1β precursor by ICE, from Santa Cruz. Purity: ≥93 ... caspase-1 substrate Inhibits the cleavage of the IL-1β precursor by ICE *Home. ... The Caspase-1 substrate sequence (NEAYVHDAPVRSLN) corresponds to the native cleavage site C-terminal to Asp-116 of the ... caspase-1 substrate (CAS 143305-11-7) *bvseo_sdk, java_sdk, bvseo-3.2.0 ...
https://www.scbt.com/scbt/product/caspase-1-substrate-143305-11-7/
*  Frontiers | A New Twist in the Regulation of Legionella Replication through ASC and Caspase-1 | Microbiology
... to link NLRs to pro-caspase-1, a critical step in the activation of caspase-1. Legionella pneumophila (Legionella) is a Gram- ... a molecular platform that drives the activation of caspase-1, a protease responsible for the maturation and secretion of IL-1b ... A New Twist in the Regulation of Legionella Replication through ASC and Caspase-1 ... but relies on caspase-7, another protein substrate of caspase-1 (Akhter et al., 2009). In addition, Naip5 contributes to the ...
https://www.frontiersin.org/articles/10.3389/fmicb.2011.00057/full
*  Caspase-1 inhibitor I | CAS 143313-51-3 | SCBT - Santa Cruz Biotechnology
... caspase-4, and caspase-5, from Santa Cruz. Purity: ≥95%, MF: C23H32N4O8 ... Buy Caspase-1 inhibitor I (CAS 143313-51-3), an inhibitor of caspase-1, ... caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family ... Caspase-1 inhibitor I (CAS 143313-51-3) Caspase-1 inhibitor I , CAS 143313-51-3 is rated 5.0 out of 5 by 2. ...
https://www.scbt.com/scbt/product/caspase-1-inhibitor-i-143313-51-3/
*  Delta9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: involvement of Bcl-2 and caspase-1.
... cell death characterized by certain cellular changes and regulated by various gene products including Bcl-2 and caspase-1. The ... Caspase 1. Cysteine Endopeptidases / physiology*. DNA / biosynthesis, isolation & purification. DNA Fragmentation. ... These data suggest that THC treatment of cultured immune cells induces apoptosis through the regulation of Bcl-2 and caspase ... and the drug induced apoptosis was blocked by the caspase inhibitor, Ac-Tyr-Val-Ala-L-aspartic acid aldehyde. ...
http://www.biomedsearch.com/nih/Delta9-tetrahydrocannabinol-induces-apoptosis-in/9694974.html
*  Detect Caspase 1 Activation with FAM FLICA Caspase 1 Assay Kit
Detect caspase 1 activation in vitro with the FAM FLICA Caspase 1 Assay Kit to investigate apoptosis and pyroptosis. The FAM ... Home / Cell Viability Assays / Caspases / Caspase-1 / FAM-FLICA® Caspase-1 Assay Kit. ... for Poly caspases (91), caspase-1 (97), caspases-3, 7 (93), and caspase-9 (912) according to the manufacturer's instructions ( ... FAM-FLICA® Caspase-1 Assay Kit. $211.00 - $592.00. Detect caspase-1 activity with the FAM FLICA Caspase-1 Assay Kit. This in ...
https://immunochemistry.com/product/fam-flica-caspase-1-assay-kit/
*  Expression of Interleukin-18 and Caspase-1 in Cutaneous T-Cell Lymphoma | Clinical Cancer Research
Expression of Interleukin-18 and Caspase-1 in Cutaneous T-Cell Lymphoma. Kei-ichi Yamanaka, Rachael Clark, Rebecca Dowgiert, ... IL-18, caspase-1, IL-1β, IL-12, IL-23 p19, and IFN-γ mRNA levels from skin biopsy. Skin biopsy samples were taken from the ... Levels of plasma caspase-1 were also measured in the same patient populations, and data were analyzed in a fashion similar to ... The primer pairs specific for IL-18, caspase-1, IL-1β p35 and p40 subunits of IL-12, p19 subunit of IL-23, IFN-γ, and β-actin ...
http://clincancerres.aacrjournals.org/content/12/2/376
*  Caspase-1 Inhibitor Z-YVAD-FMK - Creative Enzymes
YVAD is the specific recognition sequence for ICE/caspase-1 ... interleukin-1β converting enzyme, Ki = 0.76 nM) activity. ... YVAD is the specific recognition sequence for ICE/caspase-1. The inhibitor is designed as a methyl ester to facilitate cell ... Contact Us  45-1 Ramsey Road, Shirley, NY 11967, USA.  Email: info@creative-enzymes.com.  Tel: 1-631-562-8517 1-516-512-3133 ... Fax: 1-631-938-8127. Distributors To view the contact information for a specific location, select the desired country: Country ...
https://www.creative-enzymes.com/product/Caspase1-Inhibitor-ZYVADFMK_2381.html
*  DIGITAL.CSIC: Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo
Caspase-1 expression mediated by an adenoviral vector was able to kill directly cells and to sensitise the remaining cells to ... Ectopic expression of caspase-1 has been shown to trigger apoptosis. However, the role of caspase-1 in apoptosis is now ... Caspase-1 mediated sensitisation to cisplatin and γ-radiation was also observed in vivo. Altogether, we conclude that caspase-1 ... In patients, high levels of caspase-1 expression may be associated with spontaneous regression in neuroblastomas and with a ...
https://digital.csic.es/handle/10261/24781