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*  Caspase-3 (P42574) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/protein/P42574
*  Gasdermin (IPR007677) | InterPro | EMBL-EBI
Certain gasdermins are cleaved by inflammatory and apoptotic caspases [PMID: 29990470]. Gasmedin E is cleaved by caspase-3 and ... Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.. Nature 547 99-103 2017 ...
http://www.ebi.ac.uk/interpro/entry/IPR007677
*  SAP domain (IPR003034) | InterPro | EMBL-EBI
Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.. J. Biol. Chem. ... Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.. Nature 401 168-73 1999 ... Mammalian Acinus, a protein which induces apoptotic chromatin condensation after cleavage by caspase-3 [PMID: 10490026]. Acinus ...
http://www.ebi.ac.uk/interpro/entry/IPR003034
*  Microcosm Targets
Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1). [Source:Uniprot/SWISSPROT;Acc: ... 1 2 3 4 5 6 7 8 9 10 11 .. 24 next ,,. Gene Name. Transcript. Description. GO Terms. Score. Energy. P-value. Length. Total ... 3. 27 [+]. ACVR2A. ENSMMUT00000000059. Activin receptor type-2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA ... Doublesex and mab-3-related transcription factor 3. [Source:Uniprot/SWISSPROT;Acc:Q9NQL9]. ...
https://www.ebi.ac.uk/enright-srv/microcosm/cgi-bin/targets/v5/hit_list.pl?genome_id=3512
*  BioModels Database
Caspase 9 Xiap binding. Caspase 9-Apaf-1 Xiap binding. Caspase 9-Xiap Apaf-1 binding. cleaved Caspase 3-Xiap binding. Caspase 9 ... Caspase 9-Xiap degradation. Apaf-1-Caspase 9-Xiap degradation. Apaf-1-Caspase 9 degradation. Caspase 3 turnover. Caspase 3 ... Caspase 9 cleaved. APAF-1-Caspase 9 cleaved complex. Apaf-1-Caspase 9 cleaved -XIAP complex. Apaf-1-Caspase 9 cleaved -XIAP ... Caspase 9 cleaved-Xiap degradation. Caspase 9 cleaved degradation. Apaf-1 Caspase 9 cleaved degradation. Apaf-1 Caspase 9 ...
https://www.ebi.ac.uk/compneur-srv/biomodels-main/publ-model.do?mid=BIOMD0000000103
*  Microcosm Targets
Caspase-activated deoxyribonuclease) (Caspase-activated DNase) (CAD). [Source:Uniprot/SWISSPROT;Acc:Q99N34]. ... 1 2 3 4 5 6 7 8 9 10 11 .. 22 next ,,. Gene Name. Transcript. Description. GO Terms. Score. Energy. P-value. Length. Total ... 3. 44 [+]. Herc2_predicted. ENSRNOT00000019245. Probable E3 ubiquitin-protein ligase HERC2 (EC 6.3.2.-) (HECT domain and RCC1- ... 3. 31 [+]. Phr1_predicted. ENSRNOT00000014583. Probable E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2 ...
https://www.ebi.ac.uk/enright-srv/microcosm/cgi-bin/targets/v5/hit_list.pl?genome_id=5171
*  PDB 3d6h structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI
... structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type ... Caspase-1 subunit p10. '> Caspase-like domain superfamily * Occurring in:. *Caspase-1 subunit p20. *Caspase-1 subunit p10. '> ... Caspase-1 subunit p10. '> Peptidase C14, caspase non-catalytic subunit p10 * Occurring in:. *Caspase-1 subunit p20. '> ... Caspase-1 subunit p10. '> Peptidase C14A, caspase catalytic domain * Occurring in:. *Caspase-1 subunit p20. * ...
http://www.ebi.ac.uk/pdbe/entry/pdb/3D6H
*  BioModels Database
Caspase 9 Xiap binding. Caspase 9-Apaf-1 Xiap binding. Caspase 9-Xiap Apaf-1 binding. cleaved Caspase 3-Xiap binding. Caspase 9 ... Caspase 9-Xiap degradation. Apaf-1-Caspase 9-Xiap degradation. Apaf-1-Caspase 9 degradation. Caspase 3 turnover. Caspase 3 ... Caspase 9 cleaved-Xiap degradation. Caspase 9 cleaved degradation. Apaf-1 Caspase 9 cleaved degradation. Apaf-1 Caspase 9 ... cleaved Caspase 9-Apaf-1 XIAP binding. cleaved Caspase 9-Xiap Apaf-1 binding. Caspase 3 cleavage by cleaved Caspase 9. Caspase ...
https://www.ebi.ac.uk/compneur-srv/biomodels-main/publ-model.do?mid=BIOMD0000000102
*  PDB 3qnw structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI
New peptide binding mode observed for the non-canonical caspase conformation. ... Structure of human caspase-6 in complex with Z-VAD-FMK: ... Caspase-6 subunit p18. *Caspase-6 subunit p11. '> Caspase-like ... Caspase-6 subunit p11. '> Peptidase C14A, caspase catalytic domain * Occurring in:. *Caspase-6 subunit p18. *Caspase-6 subunit ... Caspase-6 subunit p18. *Caspase-6 subunit p11. '> Peptidase C14 family * Occurring in:. *Caspase-6 subunit p18. '> Peptidase ...
http://www.ebi.ac.uk/pdbe/entry/pdb/3QNW
*  Compound Report Card
Caspase-6 Homo sapiens 0.944 CHEMBL6110 Thioredoxin glutathione reductase Schistosoma mansoni 0.940 ...
https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1448
*  Death-like domain superfamily (IPR011029) | InterPro | EMBL-EBI
For example, the DED of FADD recruits two DED-containing caspases, caspase-8 and caspase-10, to form the death-inducing signal ... Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during ... The induction of apoptosis results in the activation of caspases, a family of aspartyl-specific cysteine proteases that are the ...
https://www.ebi.ac.uk/interpro/entry/IPR011029
*  Cathepsin D-like catalytic domain (IPR034129) | InterPro | EMBL-EBI
Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts.. Am. J. Pathol. 161 89-96 2002 ...
http://www.ebi.ac.uk/interpro/entry/IPR034129
*  Microcosm Targets
caspase 2, apoptosis-related cysteine protease [Source:RefSeq_peptide;Acc:NP_001036160]. ... 1 2 3 4 5 6 7 8 9 10 11 .. 16 next ,,. Gene Name. Transcript. Description. GO Terms. Score. Energy. P-value. Length. Total ... 3. 3. 3 [+]. cacna1d. ENSDART00000089956. calcium channel, voltage-dependent, L type, alpha 1D subunit [Source:RefSeq_peptide; ... 3. 8. 8 [+]. LOC795942. ENSDART00000091547. Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium ...
https://www.ebi.ac.uk/enright-srv/microcosm/cgi-bin/targets/v5/hit_list.pl?genome_id=6649
*  Domain architectures: Peptidase C14, p20 domain (IPR001309) | InterPro | EMBL-EBI
Peptidase C14, caspase non-catalytic subunit p10 (IPR002138) Sulfatase-modifying factor enzyme (IPR005532) ...
http://www.ebi.ac.uk/interpro/entry/IPR001309/domain-organisations