The carrier frequency for a disease-causing variant in ABCA4 may be as high as 1:20; although the true prevalence of ... The economic burden of vision loss and eye disorders among the United States population younger than 40 years. Ophthalmology ... Worldwide carrier frequency and genetic prevalence of Autosomal Recessive inherited retinal diseases. Proc Natl Acad Sci U S A ... wherein the transgene remains in an episomal state. Gene editing therapies cut or alter single nucleotide(s) within the ABCA4 ...

1998) High risk of cerebral vein thrombosis in carriers of a prothrombin gene mutation and in users of oral contraceptives. N ... as well as other prothrombotic states (for example, hypofibrinolysis, increased levels of tissue factor), induced by increased ... In a series of 277 patients with deep vein thrombosis, the risk of thrombosis among carriers of the 677C-T genotype was ... 1999) The risk of recurrent deep vein thrombosis among heterozygous carriers of both factor V leiden and the G20210A ...