Receptor, Endothelin ACardiovascular DiseasesReceptors, EndothelinReceptor, Endothelin BEndothelinsEndothelin-1Risk FactorsEndothelin-3Endothelin-2Peptides, CyclicHypertensionViper VenomsBlood PressurePhenylpropionatesAtherosclerosisBiological MarkersCohort StudiesSulfonamidesEndothelium, VascularProspective StudiesRisk AssessmentAntihypertensive AgentsMetabolic Syndrome XVasoconstrictionObesityFollow-Up StudiesDiabetes Mellitus, Type 2Cross-Sectional StudiesPyrrolidinesPrevalenceDiabetes MellitusDyslipidemiasC-Reactive ProteinBody Mass IndexAspartic Acid EndopeptidasesProportional Hazards ModelsTime FactorsIncidenceCholesterolCoronary DiseaseLipidsSmokingVasoconstrictor AgentsCause of DeathSex FactorsLife StyleUnited StatesHomocysteineDiabetic AngiopathiesAge FactorsCholesterol, HDLCholesterol, LDLAzepinesCardiovascular SystemInflammationOligopeptidesPrimary PreventionDietStrokeRiskRats, Sprague-DawleyDiabetes ComplicationsMuscle, Smooth, VascularNitric OxideKidney Failure, ChronicIndansMyocardial InfarctionPiperidinesHypercholesterolemiaTriglyceridesAortaBlood GlucoseMetalloendopeptidasesVasodilationHyperlipidemiasDose-Response Relationship, DrugVascular DiseasesCoronary Artery DiseaseCardiovascular AgentsJapanCarotid ArteriesHypolipidemic AgentsArteriesMyocardiumArteriosclerosisCells, CulturedHydroxymethylglutaryl-CoA Reductase InhibitorsCase-Control StudiesOxidative StressHemodynamicsKidneyPredictive Value of TestsInsulin ResistanceChronic DiseaseKidney DiseasesCarotid Intima-Media ThicknessDisease Models, AnimalMortalityVascular ResistanceComorbidity