Role of Heparan Sulfates and Glycosphingolipids in the Pore Formation of Basic Polypeptides of Cobra Cardiotoxin | SpringerLink
Cobra venom contains cardiotoxins (CTXs) that induce tissue necrosis and systolic heart arrest in bitten victims. CTX-induced ... Non-cytotoxic cobra cardiotoxin A5 binds to avß3 integrin and inhibit bone resorption. Identification of cardiotoxins as nonRGD ... Interaction of cardiotoxins with membranes: a molecular modeling study. Biophys J 2002; 83:144-53.CrossRefPubMedGoogle Scholar ... Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin. Toxicon 1993; 31:669-695.CrossRefPubMed ...https://link.springer.com/chapter/10.1007/978-1-4419-6327-7_12
Cardiotoxins | CTD
Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.. ...http://ctdbase.org/detail.go?type=chem&acc=D054715
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : The multiplicity of cardiotoxins from Naja naja atra (Taiwan...
The multiplicity of cardiotoxins from Naja naja atra (Taiwan cobra) venom. ... The multiplicity of cardiotoxins from Naja naja atra (Taiwan cobra) venom. Four novel cardiotoxins were isolated from Naja naja ... Analysis on the secondary structure of pre-mRNAs of N. naja atra cardiotoxin 4 gene and N. naja sputatrix cardiotoxin 3 gene ... The hypervariable segments encoded by the second and third exon of cardiotoxin genes are located at or near the tips of loop ...http://www.antibody-antibodies.com/pubmed-PubMed:10708798-PubMedArticl.html
5, A and B, a-c). We then stained cardiotoxin-damaged TA muscle sections from day 3, 7, and 14 postinjection (Fig. 5, B, d-l, ... B: uninjured TA muscle (a-c, ×10 fields) and cardiotoxin-damaged TA muscle (d-l, ×20 fields = 0.12 mm2) at D3 (d-f), D7 (g-i), ... Cardiotoxin was injected into the left hindlimb TA muscles of WT, Id3-null, and Id-mutant mice. Groups of mice were killed at 3 ... Cardiotoxin-damaged TA muscle sections at D3 postinjury were costained with antibodies to Pax7 (left) and either p-S1/5/8 (top ...http://ajpcell.physiology.org/content/298/5/C1087
Biology-Online • View topic - What is the most poisonous snake in da world?
And also their venom contains neurotoxins and cardiotoxins. Neurotoxins cause damage to the nervous system, such as parts of ... the brain controlling motor functions, while cardiotoxins attack the heart. 'The roots of education is bitter, but the fruit is ...http://www.biology-online.org/biology-forum/about1419.html?hilit=Pungent
couuntries without snakes | Python Jungle
Its venom mainly consists of neuro and cardiotoxins. This means a bite can lead to paralysis of the muscles or even cardiac ... Its venom contains postsynaptic neurotoxins, cardiotoxins, and cytotoxic activity. The Mali cobra is responsible for the most ...http://pythonjungle.com/tag/couuntries-without-snakes/
Elapidae - Wikipedia
Their venom is mainly neurotoxic, although many of them also possess several other types of toxins, including cardiotoxins and ...https://en.m.wikipedia.org/wiki/Elapid
Cardiotoxin III - Wikipedia
Cardiotoxin III (CTX III, also known as cytotoxin 3) is a sixty amino-acid polypeptide toxin from the Taiwan Cobra Naja atra. ... "Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway". Clin. Exp. Pharmacol. Physiol. 32 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Cardiotoxin_III&oldid=899751861" ...https://en.wikipedia.org/wiki/Cardiotoxin_III
Cardiotoxin on myoblasts: post #1
I've only been able to find one paper so far using cardiotoxin to injure myoblasts in culture (they used it on C2C12 myotubes ... Cardiotoxin on myoblasts - posted in Tissue and Cell Culture: ... I've only been able to find one paper so far using cardiotoxin ... Also tagged with one or more of these keywords: cardiotoxin, myoblast, C2C12, primary. Protocols and Techniques Forums → ... Cardiotoxin on myoblasts. Started by assembler01, Oct 05 2012 01:00 PM ...http://www.protocol-online.org/forums/topic/27199-cardiotoxin-on-myoblasts/
Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom
C.-M. Chien, S.-Y. Chang, K.-L. Lin, C.-C. Chiu, L.-S. Chang, and S.-R. Lin, "Taiwan cobra cardiotoxin III inhibits Src kinase ... L.-W. Chen, P.-H. Kao, Y.-S. Fu, S.-R. Lin, and L.-S. Chang, "Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is ... Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom. ... C.-C. Hung, S.-H. Wu, and S.-H. Chiou, "Sequence characterization of cardiotoxins from Taiwan cobra: isolation of a new isoform ...https://www.hindawi.com/journals/ecam/2014/621756/ref/
Time-Dependent Block of Ultrarapid-Delayed Rectifier K+ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2...
Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na+ channels. However, it remains unknown whether it has any effects on K+ currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were investigated in this study. In H9c2 cells, ACO suppressed ultrarapid-delayed rectifier K+ current (IKur) in a time- and concentration-dependent fashion. The IC50 value for ACO-induced inhibition of IKur was 1.4μM. ACO could accelerate the inactivation of IKur with no change in the activation time constant of this current. Steady-state inactivation curve of IKur during exposure to ACO could be demonstrated. Recovery from block by ACO was fitted by a single-exponential function. The inhibition of IKur by ACO could still be observed in H9c2 cells preincubated with ruthenium red (30μM). Intracellular dialysis with ACO (30μM) had no effects on IKur. IKur elicited by ...http://oxfordindex.oup.com/view/10.1093/toxsci/kfn189
Quarterly Equine Disease Author Bio | The Horse | TheHorse.com
Cardiotoxins in Horses May 28, 2017. Learn about several substances that can cause heart muscle damage and death in horses. ...http://www.thehorse.com/authors/221/equine-disease-quarterly
Follistatin: A Novel Therapeutic for the Improvement of Muscle Regeneration | Journal of Pharmacology and Experimental...
Muscle injury was induced by a 100-µl injection of a 10 µM cardiotoxin (CTX) solution (cardiotoxin 1 from Naja naja atra, part ... Cardiotoxin Injury.. Cardiotoxin injury was induced similar to what was described by Garry et al. (2000), with slight ... cardiotoxin. ELISA. enzyme-linked immunosorbent assay. FSD. follistatin domain. FSH. follicle-stimulating hormone. FST288. ... Cardiotoxin Injury/Hind Limb Immobilization.. Lower limb muscles were injured using the aforementioned protocol. Following the ...http://jpet.aspetjournals.org/content/349/2/355.full
Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle |...
Cardiotoxin experiments. 50 μl of 10 μM cardiotoxin (Sigma-Aldrich) were injected into the calf muscles of 8- to 12-week-old ... we injected gastrocnemius muscles of 2-month-old mice with cardiotoxin and analyzed muscle fiber morphology 5, 10 and 21 days ...http://dev.biologists.org/content/135/11/2043
An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration | Development
Muscle injury with cardiotoxin. Cardiotoxin (CTX; Sigma) was prepared in PBS (10 μM) and 50 μl was injected percutaneously into ... Therefore, we induced injury by injection of cardiotoxin (CTX) into Pax7+/CE;R26ReGFP-DTA/lacZ EDL muscle grafts that had ... B-E) Fluorescent microscopy on cross-sections of established Pax7+/CE;R26ReGFP-DTA/lacz EDL grafts four weeks post-cardiotoxin ... Absence of the myogenic response to acute injury in satellite cell-ablated mice. (A) Tamoxifen (tmx) and cardiotoxin (CTX) ...http://dev.biologists.org/content/138/17/3639?ijkey=4345ab60aea7ea2f2cb1c8a9ca732a2c780c67dd&keytype2=tf_ipsecsha
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts | JCB
JAK1/STAT1/STAT3 were activated during cardiotoxin-induced muscle regeneration. (A) After the injection of cardiotoxin (CTX), ... Cardiotoxin-induced muscle injury and regeneration. TA muscles of 6-8-wk-old C57BL/6 mice were injected with 25 μl of 10 μM ... JAK1/STAT1/STAT3 are up-regulated and activated in cardiotoxin-induced regenerating muscles. Because MSC-derived primary ... muscles in response to cardiotoxin-induced muscle injury (Charge and Rudnicki, 2004). In this injury-induced muscle ...http://jcb.rupress.org/content/179/1/129.long
This page includes the following topics and synonyms: Systolic Dysfunction, Left Ventricular Dysfunction, Left Ventricular Failure, Systolic Heart Failure, Left Ventricular Systolic Dysfunction, Heart Failure with Reduced Ejection Fraction.http://www.fpnotebook.com/CV/CHF/SystlcDysfnctn.htm
Protocols and Video Articles Authored by Silvia Brunelli
Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection' ... Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection. Ombretta Guardiola1, Gennaro Andolfi1, Mario Tirone2, ...https://www.jove.com/author/Silvia_Brunelli
'food safety' Protocols and Video...
Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection', 'Improved Polymerase Chain Reaction-restriction ... Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection. Ombretta Guardiola1, Gennaro Andolfi1, Mario Tirone2, ...https://www.jove.com/keyword/food+safety
Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1 | PNAS
After 15 days of irradiation, the tibialis anterior (TA) muscle was injected with cardiotoxin (CTX), and muscles were harvested ...http://www.pnas.org/content/101/5/1206
Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the...
Cardiotoxins / adverse effects, pharmacology, therapeutic use. Controlled Clinical Trials as Topic. Databases, Factual. Female ...http://www.biomedsearch.com/nih/Evidence-Report-efficacy-safety-mitoxantrone/20439849.html
Print - Biology-Online
Cardiotoxin. As shown in Table 1, the cardiotoxins are the most abundant components of Naja venom, with MMs ranging from 6.7 to ... Six cardiotoxins were verified in Agki venom, in which two cardiotoxins (GI numbers 1054811 and 3342766) are the same as Naja ... GF-LC-MS/MS played well in the detection of cardiotoxins, but missed the signals of phospholipase A2, and shotgun-LC-MS/MS and ... In Naja venom, 74% of the identified proteins and peptides are cardiotoxins and neurotoxins, but only one haemotoxin was found ...https://www.biology-online.org/kb/print.php?aid=3407
PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle | Skeletal Muscle |...
Using muscle-specific gain- and loss-of-function models for PGC-1α in combination with the myotoxic agent cardiotoxin (CTX), we ... Cardiotoxin injury. In anesthetized mice (O2/sevoflurane, 3 % sevoflurane) kept on a warm plate, the lower limbs were shaved ... Fibrosis after multiple cardiotoxin injections in mTG mice. a Hydroxyproline measurement in mTG mice 3 weeks after the third ... Additional file 4: M1 and M2 marker expression in mKO mice before and in early days after cardiotoxin injury. Relative gene ...https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-016-0110-x
Patent US6153421 - Cloned genomes of infectious hepatitis C viruses and uses thereof - Google Patents
Cardiotoxin molecular toxicology modeling. US20070082332 *. Jan 8, 2003. Apr 12, 2007. Gene Logic, Inc.. Molecular ...http://www.google.com/patents/US6153421?dq=5179747
Cytotoxin 3b precursor - Naja atra (Chinese cobra)
Cardiotoxin, Toxin. Biological process. Cytolysis. ,p>This section provides information about the protein and gene name(s) and ...https://www.uniprot.org/uniprot/Q98960