Determination of cardiac volumes and mass with FLASH and SSFP cine sequences at 1.5 vs. 3 Tesla: a validation study. - Oxford...
PURPOSE: To compare cardiac cine MR imaging using steady state free precession (SSFP) and fast low angle shot (FLASH) techniques at 1.5 and 3 T, and to establish their variabilities and reproducibilities for cardiac volume and mass determination in volunteers. To assess the feasibility of SSFP imaging in patients at 3 T and to determine comparability to volume data acquired at 1.5 T. MATERIALS AND METHODS: Ten healthy volunteers underwent cardiac magnetic resonance imaging using SSFP and segmented gradient-echo FLASH, using both a 1.5 and a 3 T MR system on the same day. Ten patients with impaired left ventricular (LV) function were also studied at both field strengths with SSFP. RESULTS: For both SSFP and FLASH, field strength had no effect on the quantification of LV and right ventricular (RV) volumes, mass, or function (P | or = 0.05 for field strength for all parameters). At both 1.5 and 3 T, SSFP ...https://www.neuroscience.ox.ac.uk/publications/105339
Glucose Tolerance and Left Ventricular Pressure-Volume Relationships in Frequently Used Mouse Strains
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.https://www.hindawi.com/journals/bmri/2011/281312/ref/
Analysis of left ventricular systolic function during elevated external cardiac pressures : an examination of measured...
BACKGROUND: Variations or disturbances in intrathoracic and extracardiac pressures (ECP) occur in critically ill and anaesthetised patients. There are uncertainties concerning the analysis of left ventricular pressure-volume relationship (LVPVR) and the calculation of systolic function parameters when conducted without reference to transmural left ventricular pressure (LVPtm) in the setting of elevated ECP. METHODS: In 7 anaesthetised adult pigs, we measured LVPVR using conductance volumetry and tip manometry along with measurement of pericardial and other intrathoracic pressures. Experimental pericardial infusion and pleural insufflation were performed. Transient controlled preload reductions were accomplished using balloon occlusion of the inferior vena cava. Preload recruitable stroke work (PRSW) was calculated using both intracavitary left ventricular pressure (LVPic) and LVPtm, and differences were tested for using a paired t-test. RESULTS: The ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:293003
Effect of Chronic Pressure and Volume Overload on Left Heart Volumes in Subjects with Congenital Heart Disease | Circulation
Left heart volumes were determined angiographically in 50 subjects of whom 18 had no abnormality of the left heart, 12 had lesions causing pressure overload of the left ventricle, and 20 had lesions causing volume overload of the left ventricle. The left heart volumes were in the normal range in the presence of pressure overload, but, with volume overload, end-diastolic, end-systolic, and atrial volumes were in excess of normal. A linear relationship was demonstrated between end-diastolic and end-systolic volumes, regardless of the pressure load on the ventricle. Thus, for all but one of the cases studied, total left ventricular ejection volume formed a nearly constant proportion of end-diastolic volume.. ...http://circ.ahajournals.org/content/30/2/205
Evaluation of the Ability of Echocardiography to Measure Acute Alterations in Left Ventricular Volume | Circulation
Measurement of acute serial changes in left ventricular volume is often desirable. Although left ventricular volumes estimated echocardiographically correlate well with results of angiographic methods, the sensitivity with which echocardiography can detect acute alterations in volume is unknown. Accordingly, the effect on transverse left ventricular dimension of interventions known to alter left ventricular volume (tilting and administration of nitroglycerin and phenylephrine) was studied in six normal subjects. Tilting significantly reduced end-diastolic dimension (from 48 ± 1.7 to 41.8 ± 1.5 mm, P , .01) and end-systolic dimension (from 32.2 ± 0.6 to 27.5 ± 0.8 mm, P , .001). Nitroglycerin also reduced end-diastolic dimension (from 44.8 ± 2.3 to 39.8 ± 2.1 mm, P , .02) and end-systolic dimension (from 30.2 ± 1.3 to 26.5 ± 1.2, P , .005). In contrast, phenylephrine increased end-diastolic dimension (from 42.3 ± 2.6 to 45.6 ± 2.6 mm, P , ...http://circ.ahajournals.org/content/50/5/901
Ventricular pressure-volume curve indices change with end-diastolic pressure. | Circulation Research
Many indices have been proposed to describee the diastolic pressure-volume curve mathematically and permit quantification of the elastic properties of the myocardium itself in hopes that changes in the muscle caused by disease would b.e reflected in the diastolic pressure-volume curve. To date, none of the proposed indices has been shown convincingly to discriminate one group of patients from another. While this situation in part arises from the relatively large amount of noise introduced by the technical difficulties of measuring synchronous pressures and volumes during diastole in man, ther is a more fundamental difficulty. In practice, one can measure only a short segment of the entire pressure-volume curve, and the values of all diastolic pressure-volume curve parameters investigated change significantly when one uses different segments of the same pressure-volume curve to compute them. These results ...http://circres.ahajournals.org/content/39/6/772
HD live Silhouette Mode With Spatiotemporal Image Correlation for Assessment of the Fetal Heart
The purpose of this article is to present our experience with normal and abnormal fetal cardiac structures reconstructed in the HDlive silhouette mode (GE Healthcare Japan, Tokyo, Japan) with spatiotemporal image correlation (STIC). Twenty-two fetuses with normal hearts and 1 fetus with a congenita...https://insights.ovid.com/ultrasound-medicine/jultm/2016/07/000/hd-live-silhouette-mode-spatiotemporal-image/15/01219985
Quantification of right ventricular volume in dogs: a comparative study between three-dimensional echocardiography and computed...
In the present study, the right ventricles of 10 Beagle dogs were investigated by means of 3DE and CCT in comparison with the reference method CMRI. The major challenge for determining right ventricular volume is the right ventricle itself. The complex shape with its segmentation in body, inflow and outflow tract, the thin RV wall and the heavy trabeculation make the RV measurement in two-dimensional echocardiography difficult . CMRI is the gold standard for RV volumetric quantification in human medicine  and overcomes the limitation of 2D echocardiography by using a three-dimensional volume set, as well as the 3D modalities 3DE and CCT. Although the assessment of left ventricular function using two- and three-dimensional volume estimation is part of various veterinary publications -, there are to the best knowledge of the author no veterinary studies concerning the evaluation of right ventricular function either by means of ...https://0-bmcvetres-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12917-014-0242-3
Poor Correlation Between Pulmonary Arterial Wedge Pressure and Left Ventricular End-diastolic Volume after Coronary Artery...
Robert M. Hansen, Christian E. Viquerat, Michael A. Matthay, Jeanine P. Wiener-Kronish, Teresa DeMarco, Satinder Bahtia, James D. Marks, Elias H. Botvinick, Kanu Chatterjee; Poor Correlation Between Pulmonary Arterial Wedge Pressure and Left Ventricular End-diastolic Volume after Coronary Artery Bypass Graft Surgery. Anesthesiology 1986;64(6):764-770. Download citation file:. ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1974382
Cardiac magnetic resonance imaging - Wikipedia
Cardiovascular magnetic resonance imaging (CMR), sometimes known as cardiac MRI, is a medical imaging technology for the non-invasive assessment of the function and structure of the cardiovascular system. It is derived from and based on the same basic principles as magnetic resonance imaging (MRI) but with optimization for use in the cardiovascular system. These optimizations are principally in the use of ECG gating and rapid imaging techniques or sequences. By combining a variety of such techniques into protocols, key functional and morphological features of the cardiovascular system can be assessed. In the investigation of cardiovascular disease the physician has a wide variety of tools available. The key disadvantages of CMR are limited availability, expense, and special skills/technical training needed to perform CMR (vs other types of MRI). New volumetric acquisitions can shorten and simplify the scan as they can replace several sequences, acquiring the entire ...https://en.wikipedia.org/wiki/Cardiac_magnetic_resonance_imaging
No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure. - Physiology, Anatomy and Genetics
BACKGROUND: Whether the myocardium in nonischemic heart failure experiences oxygen limitation remains a long-standing controversy. We addressed this question in patients with dilated cardiomyopathy (DCM) using a dual approach. First, we tested the changes in myocardial oxygenation between rest and stress states, using oxygenation-sensitive cardiovascular magnetic resonance. Second, we sought to assess the functional consequences of oxygen limitation at rest by measuring myocardial energetics before and after short-term oxygen supplementation. METHODS AND RESULTS: Twenty-six subjects (14 DCM and 12 normal) underwent cardiac magnetic resonance imaging at 3 Tesla to assess cardiac volumes, function, oxygenation, and first-pass perfusion (0.03 mmol/kg Gd-DTPA bolus) at stress and rest (4-6 minutes IV adenosine, 140 μg/kg per minute). Signal intensity change (SIΔ) and myocardial perfusion reserve index (MPRI) were measured from oxygenation and perfusion images, ...https://www.dpag.ox.ac.uk/publications/577727
Effect of filming projection and interobserver variability on angiographic biplane left ventricular volume determination. |...
Although biplane right anterior oblique-left anterior oblique (RAO/LAO) quantitative left ventricular (LV) angiography is commonly performed, justification of LV volume calculation using the area length method (originally formulated from anteroposterior-lateral (AP/LAT) angiograms) has been limited. To assess whether RAO/LAO and AP/LAT LV volumes are similar when computed by the area length method formula, we performed biplane cine LV angiography in both RAO/LAO and AP/LAT projections in random sequence in 21 patients and four LV models of known volume. LV silhouettes were drawn independently by two trained observers. Calculated angiographic volume of the models correlated almost exactly with their true volume (r = 0.999), establishing the absolute accuracy of this system. Rotation of the LV models through 90 degrees of obliquity at 10 degree increments demonstrated a mean change from true volume of only ...http://circ.ahajournals.org/content/59/1/96
Repaired Tetralogy of Fallot: Ratio of Right Ventricular Volume to Left Ventricular Volume as a Marker of Right Ventricular...
Purpose:To compare indexed right ventricular (RV) end-diastolic volume (RVEDVi) and the ratio of RV volume to left ventricular (LV) volume (RV/LV ratio) in prediction of significant pulmonary regurgitation (PR) after tetralogy of Fallot (TOF) repairhttp://www.biomedsearch.com/nih/Repaired-Tetralogy-Fallot-Ratio-Right/22771877.html
Accuracy of volume determination by two-dimensional echocardiography: defining requirements under controlled conditions in the...
The accuracy of two-dimensional echocardiographic left ventricular volume measurement in an isolated heart preparation was tested using Simpson's reconstruction of progressively fewer short-axis cross sections of known location. Echocardiographic images from five ejecting hearts submerged in a special tank were obtained under conditions designed for maximal accuracy of echocardiographic volume assessment. Echocardiographic determinations of 52 volumes at various times throughout the cardiac cycle were compared, by least-squares linear regression, with simultaneous direct-volume measurements by volumetric chamber (range 9.4-44.8 ml). Echocardiographic and direct measurements correlated well for all numbers of cross sections from 1-19 (r = 0.84-0.97); however, variability of direct volume predicted from a given echocardiographic measurement increased nonlinearly as the number of cross sections ...http://circ.ahajournals.org/content/67/4/889
Heart Failure Therapeutics Market to Grow through 2025, According to New Report by GlobalData Recently Uploaded at...
LONDON - In the past year, total sales of heart failure (HF) therapeutics across the 7 major markets (including Japan, the US and 5EU) were estimated at around USD 3.2 billion. This figure is predicted to increase in the years to come, registering a 13.5% CAGR. By 2025, total heart failure therapeutics sales across 7MM are likely to touch USD 11.5 billion.. Meantime, the chronic heart failure therapeutics market across 7MM is expected to increase from USD 3.1 billion in the previous year up to USD 10.1 billion by 2025, posting a CAGR of 12.7%. In 2015, the US dominated the chronic heart failure therapies market, accounting for a share of over 60% of total sales. The uptake of Novartis' Entresto is anticipated to perform as a strong driver of the chronic heart failure and also total heart failure markets in the 7MM; in 2022 it will likely reach peak sales worth of USD 5.9 billion.. The acute heart failure therapeutics market is expected to grow from USD 188.1 million in the past year to around ...https://marketpublishers.com/lists/20739/news.html
Evaluation of absolute left ventricular volume by gated equilibrium blood pool scintigraphy using count based method clinical...
Anno H.; Takeuchi A.; Ejiri K.; Koga S.; Furuta T.; Shimokata T.; Kurokawa H.; Kaneko K.; Kondo T.; E.A., 1987: Evaluation of absolute left ventricular volume by gated equilibrium blood pool scintigraphy using count based method clinical studyhttps://eurekamag.com/research/005/395/005395869.php
Effect of Plethora and Hemorrhage on Left Ventricular Volume and Pressure | Circulation Research
By combining conventional methods for recording pressures from the left ventricle and pleural cavity with a new procedure for estimating end-diastolic volume (EDV) and end-systolic volume (ESV) of the left ventricle it was found in the closed-chest dog that plethora increased EDV, ESV and stroke volume while hemorrhage had the opposite effect. There were linear relationships between EDV and ESV, and between EDV and stroke volume. There was little change in left ventricular "effective" end-diastolic pressure when the EDV changed over a wide range, beginning with the smallest EDV consistent with life; but after a certain large EDV had been reached, large increases in effective end-diastolic pressure were associated with little or no further increase in EDV.. ...http://circres.ahajournals.org/content/5/3/273
Influence of the Nozzle Geometry of a Diesel Single-Hole Injector on Liquid and Vapor Phase Distributions at Engine-Like...
The paper describes an experimental activity on the spatial and temporal liquid- and vapor-phase distributions of diesel fuel at engine-like conditions. The influence of the k-factor (0 and 1.5) of a single-hole axial-disposed injector (0.100 mm diameter and 10 L/d ratio) has been studied by spraying fuel in an optically-accessible constant-volume combustion vessel.A high-speed imaging system, capable of acquiring Mie-scattering and Schlieren images in a near simultaneous fashion mode along the same line of sight, has been developed at the Michigan Technological University using a high-speed camera and a pulsed-wave LED system. The time resolved pair of schlieren and Mie-scattering images identifies the instantaneous position of both the vapor and liquid phases of the fuel spray, respectively. The studies have been performed at three injection pressures (70, 120 and 180 MPa), 23.9 kg/m3 ambient gas density and 900 K gas temperature in the vessel. A pre-combustion of reactants filling the ...http://papers.sae.org/2013-24-0038/
NIOSHTIC-2 Publications Search - 10001666 - Effects of Explosive Properties on Free-surface Displacement Pulses and Crater...
Constant-volume charges of precipitated petn (pentaeythrite tetranitrate) at three specific gravities (0.50, 1.00, and 1.50) Were used in laboratory tests to examine the effects of changes in explosive properties on free-surface displacement pulses and on crater dimensions. The tests were performed in large blocks of cement-mortar. The values for the detonation, velocity, detonation pressure, sphttps://www.cdc.gov/niosh/nioshtic-2/10001666.html
Performance of 3-Dimensional Echocardiography in Measuring Left Ventricular Volumes and Ejection Fraction | JACC: Journal of...
The assessment of left ventricular (LV) volume and ejection fraction (EF) is vital to the practice of cardiology. These measures are used to inform prognosis in most cardiac patient populations, determine treatment decisions for a variety of therapies, and function as eligibility criteria in many clinical trials (1-5). Despite their importance, there is no consensus on the best method to routinely measure EF and volumes.. Two-dimensional echocardiography (2DE) is the most ubiquitous tool for assessing LV size and systolic function. Measurement of EF is the most common reason for referring a patient for an echocardiogram (6). This test is noninvasive, portable, inexpensive, radiation free, and quick. It does not, however, provide reliable, reproducible, and accurate measures of EF or volumes (7). Traditionally, 2DE has used the method of disks to calculate LV volumes based on areas in only 2 imaging planes (6). This method is ...http://www.onlinejacc.org/content/59/20/1799
Volumes and Compliances Measured Simultaneously in the Right and Left Ventricles of the Dog | Circulation Research
In 10 normal dogs, the right and left ventricular volumes and compliances were determined in the fresh post-mortem heart. With the use of a SigmaMotor pump, Ringer's solution at 23°C was simultaneously infused into both ventricles within an hour after death. When the ventricles were full but open to atmospheric pressure, the mean volumes were 35.8 ml/m2 for the right and 23.1 ml/m2 for the left ventricle; when the transmural pressure was increased by 10 mm Hg, the mean volumes were 56.9 ml/m2 for the right and 41.9 ml/m2 for the left ventricle; at 20 mm Hg, the values were 60.8 and 48.5 ml/m2, respectively. The initial volumes and the increases in volume produced by increase in transmural pressure were affected by the position of the ventricular septum and by the presence of rigor mortis. With infusions into only one ventricle, right and left ventricular volumes were 20 to 74% greater at 10 mm Hg than the ...http://circres.ahajournals.org/content/20/5/565
Right and left ventricular diastolic pressure-volume relations: a comprehensive review.
Ventricular compliance alterations can affect cardiac performance and adaptations. Moreover, diastolic mechanics are important in assessing both diastolic and systolic function, since any filling impairment can compromise systolic function. A sigmoidhttp://www.biomedsearch.com/nih/Right-Left-Ventricular-Diastolic-Pressure/23179133.html
Memorial Cardiac And Vascular Institute Centralizes Cardiac Care Through It's New 'Total Heart Center' At Memorial Regional...
Hollywood, Fl (PRWEB) July 28, 2015 -- The Memorial Cardiac and Vascular Institute (MCVI) has opened its new Total Heart Center at Memorial Regional Hospital,http://www.prweb.com/releases/2015/07/prweb12874973.htm
Volume overload - ONA
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for drug therapy testing results, patient care information and more. Download our FREE app today.https://www.oncologynurseadvisor.com/critical-care-medicine/volume-overload/article/585946/
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