Modernizing the NTPs Carcinogenicity Testing ProgramSpeaker: W Casey (ICCVAM member, NIEHS) ... Abstract Number 11: Modernizing the NTPs Carcinogenicity Testing Program. Speaker: W Casey (ICCVAM member, NIEHS) ... Abstract P268: Retrospective Evaluation of the Acute Fish Toxicity Test for Pesticide Registration. Presenter: P Ceger (ILS, ... Abstract P505: Developing a Defined Approach for Eye Irritation Testing. Presenter: N Choksi (ILS, contractor supporting ...
Laboratory Tests. There are no specific laboratory tests recommended.. Carcinogenesis, Mutagenesis, And Impairment Of Fertility ... Lifetime carcinogenicity studies of zaleplon were conducted in mice and rats. Mice received doses of 25 mg/kg/day, 50 mg/kg/day ... symbol copying test, and the variability component of the divided attention test for 2.5 hours after ethanol administration. ... Sonata 10 mg potentiated the CNS-impairing effects of ethanol 0.75 g/kg on balance testing and reaction time for 1 hour after ...
Details on test animals or test system and environmental conditions:. TEST ANIMALS. - Source: Harlan Sprague-Dawley ( ... Carcinogenicity: via dermal route. Link to relevant study records. Reference. Endpoint:. carcinogenicity: dermal. Type of ... Specific details on test material used for the study:. - Name of test material (as cited in study report): triethylene glycol ... REMOVAL OF TEST SUBSTANCE. - Washing (if done): no. TEST MATERIAL. - Amount(s) applied (volume or weight with unit): 50 µL. - ...
Studies have not been performed to determine potential for carcinogenicity. The Ames test and unscheduled DNA repair test were ... Laboratory Tests. Blood levels should be determined at least weekly for patients with reduced renal function, for individuals ... Susceptibility Tests. Cycloserine clinical laboratory standard powder is available for both direct and indirect methods1 of ...
... of carcinogenicity in male rats and "clear evidence" of carcinogenicity in female mice. Concentrations tested were 0, 200, 600 ... Two-year carcinogenicity bioassay of furan in F344 Rats. Technical Report for NCTR Experiment No. E2168.08 (Test No. E2168.02). ... Responses of transgenic mouse lines p531/2 and TgzAC to agents tested in conventional carcinogenicity bioassays. Toxicol Sci. ... 7.3.2.1 Carcinogenicity and genotoxicity. Carcinogenicity is a critical endpoint for furfuryl alcohol. A 2-year inhalation ...
... we take into account the dose for animal testing for reproductive and developmental toxicity and carcinogenicity testing. If ... For genotoxicity effects, we look at in vivo testing over in vitro testing. However, adverse outcomes in several in vitro tests ... In addition to dose, for carcinogenicity testing we look for tumors in more than one species and sex. We look for tumors in ... The EPA evaluations include the type of cells affected and in vitro versus in vivo testing [51 Fed. Reg. 34006- 34012 (1986)]. ...
... the Draize eye test, the Lethal Dose 50% test and carcinogenicity). ... Draize eye irritancy test. The traditional method for testing irritation and damage to the eye is the Draize test. The test ... LD test. LD stands for Lethal Dose - the dose of a substance that will kill a percentage of the test animals. A single dose of ... Problems with irritancy tests. The first problem with these tests is that they are very, very cruel. Irritation to the skin and ...
Filters: Keyword is Carcinogenicity Tests [Clear All Filters]. Journal Article. Chen Y-S, Wang R, Dashwood W-M, Löhr CV, ... A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.. Arch ... Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an A-to-Z guide to chemopreventive agents, ...
GARDASIL HAS NOT BEEN TESTED FOR CARCINOGENICITY. Information in the package insert states that the vaccine has not been tested ... Lack of carcinogenicity testing of the vaccine. - Replacement It may be most inappropriate and have deeply tragic consequences ... There is no incentive for vaccine promoters to test for carcinogenicity. Absence of evidence is not evidence of absence. ... Could it be that since the FDA failed to require the manufacturer to test for, evaluate and quantify the risks of residual ...
Most of the available information is the result of animal testing. Although animal testing is a useful way for scientists to ... IARC and DHHS have not classified mercury as to its human carcinogenicity. EPA has determined that mercury chloride (an ... Still, some animal testing has shown kidney tumors to develop if the animals are given large doses of lead (27-371 mg/kg/day). ... Despite the fact that the carcinogenicity of mercury is still uncertain, ATSDR compared the lifetime exposure dose for adults ...
... carcinogenicity and reproductive testing and metabolic fate) shall be used to assess systemic toxicity. ... Additional tests may be needed depending on the outcome of the above mentioned tests and taking into consideration the whole ... If appropriate the tests shall be performed without and with mammalian metabolic activation and the compatibility of the test ... If corrosive properties are known, either from published data or specific in vitro tests, then further in vivo tests shall not ...
Carcinogenicity studies, however, were negative.. Clinical data indicated that in a few individuals these ingredients produced ... Although, genotoxicity tests for these ingredients were mostly negative, there were some assays that were positive. ...
Tests are available to measure levels of chlorobenzene in breath, urine, and body tissues. These tests are not usually ... The U.S. Environmental Protection Agency (EPA) considered chlorobenzene to be not classifiable as to human carcinogenicity. ... Because chlorobenzene leaves the body quickly, these tests have to be taken within a few days after exposure. These tests ... Can I get a medical test to check for chlorobenzene?. ... Can I get a medical test to check for chlorobenzene?. *How can ...
She managed expert committees examining alternatives to carcinogenicity testing, immunotoxicology, the evaluation of ... Developmental immunotoxicology testing (DIT): Development of a testing framework. Presented at the 2003 Annual Eurotox Meeting ... Absence of potential carcinogenicity associated with hydrogen peroxide exposures. Presented at the 2000 Annual Meeting of the ... Assessment of the carcinogenicity associated with oral exposures to hydrogen peroxide. Food and Chemical Toxicology 2000; 38(11 ...
The highest dose tested in mice for 2 years (3000 mg/kg/day) is approximately 5 times the MRHD on a body surface area (mg/m2) ... There was no evidence of carcinogenicity. In mice, oral administration of levetiracetam for 80 weeks (doses up to 960 mg/kg/day ... The listing is alphabetized: abnormal liver function test, acute kidney injury, anaphylaxis, angioedema, agranulocytosis, ... reduced fetal weights and increased incidence of fetal skeletal variations were observed at the highest dose tested. There was ...
Ophthalmologic testing (including visual acuity testing, formal visual field testing and dilated funduscopic examination) was ... Two-year carcinogenicity studies with pregabalin were conducted in rats and mice. No tumours were observed in rats at exposures ... Pregabalin is not genotoxic based on results of a battery of in vitro and in vivo tests. ... In the clinical studies where ophthalmologic testing was conducted, the incidence of visual acuity reduction and visual field ...
... p53 Induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Environ. Health ... low toxicity in several in vitro assays, Ames test negative [61], co-occurrence with DON [62] swine: some minor non-significant ... Enniatins (ENN) were second most common, with 96% of the samples testing positive followed by DON and emodin with 89% positives ... Masked mycotoxins are mycotoxin conjugates that typically remain undetected when testing for the parent toxin. They may be ...
OECD Test Guideline 429). Germ cell mutagenicity Mouse lymphocyte Result: negative. Carcinogenicity IARC: No component of this ... Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M). data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 ... Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). ... Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such ...
In vivo tests showed mutagenic effects. Carcinogenicity No data available. Reproductive toxicity No data available ... Material tested:KCL 741 Dermatril? L. This recommendation applies only to the product stated in the safety data sheet, supplied ... Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). ... static test LC50 - Daphnia magna (Water flea) - 0,038 mg/l - 48 h (US-EPA) ...
... as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. ... The OECD has published the Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine ... Disruption originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, ... Data and research on test guidelines including chemical testing and assessment, chemical safety, animal welfare, endocrine ...
Carcinogenicity Tests 80 * Hazardous Substances 70 * Reference Books 65 * Pesticides 64 * Toxic Substances 41 ...
The dermal carcinogenicity of catalytic cracked clarified oil (0.1%, 1% or 10% in toluene; CAS# 64741 -62 -4) was tested in a ... Carcinogenicity: via oral route. Endpoint conclusion. Endpoint conclusion:. no study available. Carcinogenicity: via inhalation ... Results of mouse skin painting tests and initiation/promotion assays, together with modified Ames tests, and chemical (PAH) ... The test substance elicited skin irritation that was similar in extent and incidence to that seen in the vehicle controls, with ...
Further, isofetamid was tested for genotoxicity in an adequate range of in vitro and in vivo assays and based on these studies ... Genotoxicity and carcinogenicity. There was no evidence that isofetamid was carcinogenic in mice and rats. ... On test day 6 of the assay, mice received ³H‑methyl thymidine by tail vein injection and were sacrificed 5 h later. Cell ... There was no evidence that isofetamid was carcinogenic in mice and rats, and isofetamid was tested for genotoxicity in an ...
Carcinogenicity Data: No adverse reproductive effects are anticipated. Reproductive Data: No adverse mutagenic effects are ... TOXICOLOGICAL INFORMATION Meaningful toxicological test data could not be found for this product. TOXICOLOGICAL DATA: SUBSTANCE ...
No health risks, including no carcinogenicity, were found for the GM maize tested, reaffirming the conclusions of previous risk ... This research tested GM maize MON 810, resistant to European corn borer and grown in Spain, and NK 603 with tolerance to the ... 4. Streamlining future testing regimes according to the established evidence base brings important advantages for the EU in ... In aggregate, this provides a significant contribution to clarifying and augmenting the evidence base on testing procedures. ...
Repair Assay Micronucleus Test (Mice) Dominant Lethal Test (Mice) Long-term carcinogenicity studies in mice and rats have been ... Thus, 2 of the 8 tests were positive, but results of the following 3 in vivo test systems gave negative results:. Rat ... Eight in vitro mutagenicity tests have been conducted with ciprofloxacin, and the test results are listed below:. Salmonella/ ... Chinese Hamster V79 Cell HGPRT Test (Negative) Syrian Hamster Embryo Cell Transformation Assay (Negative) Saccharomyces ...
There was no evidence of carcinogenicity of MCA in mice or rats in a lifetime study (NTP, 1992). Tests for mutagenicity and ... In a review of the carcinogenicity of TCA in rodents by the U.S. EPA (1991), the results from a carcinogenicity study of TCA ( ... A chi-square lack of fit test was performed for the model fits. The degrees of freedom for this test are equal to k minus the ... No adequate long-term/carcinogenicity studies on MBA were identified. The results of these carcinogenicity studies relating to ...
Alpha-methylstyrene was tested in a guideline study for carcinogenicity in rats and mice (NTP, 2007).. ... NTP stated that alpha-methylstyrene showed some evidence of carcinogenicity based on the increased incidences of renal tubule ... Based on the available data classification for carcinogenicity is not warranted according to EC regulation 1272/2008. ... NTP stated that alpha-methylstyrene showed equivocal evidence of carcinogenicity based on marginally increased incidences of ...
Update on results from recent carcinogenicity study Results from a recent study (Tg RasH2) evaluating carcinogenicity in ... The U.S. Department of Health and Human Services (HHS) has created a Test-to-Treat locator to help identify pharmacies and ... Results from a separate, non-clinical 6-month carcinogenicity study in mice demonstrated that LAGEVRIO was not carcinogenic. ... Patients residing in long-term care facilities, patients hospitalized before or on the same day of a positive SARS-CoV-2 test, ...