... a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was held in Chapel Hill, ... On May 8-10, 1995, a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was ... Workshop report: chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles.. ... available screening tests which can be used to develop a minimum data set for (a) making decisions about the potential health ...
The major impetus for developing the International Program for the Evaluation of Short-term Tests for Carcinogenicity (IPESTTC ... in press). International Program for the Evaluation of Short-Term Tests for Carcinogenicity. Elsevier/North Holland: Amsterdam. ... de Serres F.J. (1980) The International Program for the Evaluation of Short-Term Tests for Carcinogenicity (IPESTTC). In: ... The major impetus for developing the International Program for the Evaluation of Short-term Tests for Carcinogenicity (IPESTTC ...
... is routinely applied to carcinogenicity data as a test for linear trend in lifetime tumor incidence rates. The computing ... The Cochran-Armitage test (Cochran, 1954, Biometrika 10, 417-451; and Armitage, 1955, Biometrics 11, 375-386) ... demonstrates the use of the delta method for estimating the variance of ratio statistics derived from animal carcinogenicity ... Bieler, G., & Williams, R. (1993). Ratio estimates, the delta method, and quantal response tests for increased carcinogenicity ...
Short-term (*6 months) rapid carcinogenicity tests of various genotoxic carcinogens, 4-nitroquinoline-1-oxide, cyclophosphamide ... The present studies were conducted as a model for the rapid carcinogenicity testing system. ... rasH2/CB6F1 mouse seems to be a promising candidate as an animal model for the development of a rapid carcinogenicity testing ... Only a very few lung adenomas but no other tumors were seen as spontaneous tumors during the months of carcnogenicity tests. ...
Carcinogenicity Testing. The Department of Health and Human Services National Toxicology Program is currently testing 2EE for ... Mutagenicity Testing. The mutagenicity of 2ME was tested in Salmonella typhimurium strains TA 1535, TA 1537, TA 98, and TA 100 ... Mutagenicity Testing. The mutagenicity of 2EE was tested in Salmonella typhimurium strains TA 1535, TA 1537, TA 98, and TA 100 ... Altered behavioral test results; altered brain neurochemical concentrations. 28. F, pregnant. Rat. Dermal, 1.0 or 2.0 ml/day, ...
Carcinogenicity in Animals. Metronidazole has been shown to be carcinogenic in mice and rats [see Carcinogenesis, Mutagenesis, ... Culture and sensitivity testing of bacteria are not routinely performed to establish the diagnosis of bacterial vaginosis [see ... Interference with Laboratory Tests. Metronidazole may interfere with certain types of determinations of serum chemistry values ... Standard methodology for the susceptibility testing of the potential bacterial vaginosis pathogens, Gardnerella vaginalis and ...
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Carcinogenicity testing ; Carcinogenicity Tests--Congresses ; Data Collection--Congresses ; Mutagenicity Tests--Congresses ; ... Toxicity testing. ; Toxicity testing--United States. ; Toxicology--methods. Additional Subjects. Carcinogenicity testing ; ... Carcinogenicity testing ; Chemicals--Testing ; Chemical mutagenesis ; Teratogenic agents Holdings. Library. Call Number. ... Chronic toxicity testing. ; Toxicology--Dose-response relationship. ; Carcinogenicity testing. ; Carcinogens--Dose-response ...
Carcinogenicity, Mutagenicity, And Impairment Of Fertility. The carcinogenic and mutagenic potential of REPREXAIN™ has not been ... Laboratory Tests. Because serious GI tract ulcerations and bleeding can occur without warning symptoms, physicians should ... A patient with symptoms and/or signs suggesting liver dysfunction, or in whom an abnormal liver test has occurred, should be ... testing or referral, repeated "loss" of prescriptions, tampering with prescriptions and reluctance to provide prior medical ...
Factors affecting possible carcinogenicity of inhaled nitropyrene aerosols / Ronald K. Wolff ... [et al.]. by Wolff, Ronald K ... The Use of short- and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation by ... BHA and cancer risk : the role of prostaglandin H synthase in the carcinogenicity of butylated hydroxyanisole / door Pauline ... Molecular and cellular aspects of carcinogen screening tests : proceedings of a meeting held in Hanover, Federal Republic of ...
Pentosan polysulfate sodium was not clastogenic or mutagenic when tested in the mouse micronucleus test or the Ames test (S. ... Carcinogenicity, Mutagenesis, Impairment of Fertility. Long-term carcinogenicity studies of ELMIRON® in F344/N rats and B6C3F1 ... The dosages tested were up to 60 times the maximum recommended human dose (MRHD) in rats, and up to 117 times the MRHD in mice ... Laboratory Test Findings. Pentosan polysulfate sodium did not affect prothrombin time (PT) or partial thromboplastin time (PTT ...
Provides FDAs thinking on non-clinical engineering tests that are submitted in IDEs and PMAs to support safety/effectiveness ... carcinogenicity.. Delivery Systems. Because delivery catheters are externally communicating products in contact with ... Appendix A: Test Summary Checklist. Test. Sizes Tested and Sample Sizes. Test Method or Standard Reference. Accept/Reject ... Test Summaries. You should briefly describe all tests performed.. Test Data Summaries. You should include test data summaries ...
National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.; Litton-Bionetics, inc.; Carcinogenesis Testing ... Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity. Author:. National Cancer Institute (U.S.). Division of Cancer ... schema:name "Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity"@en ;. schema:productID "4251262" ;. schema: ... rdfs:label "Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity" ;. schema:description "Online version:" ;. schema: ...
... per sex is appropriate for carcinogenicity testing. The route of administration for carcinogenicity testing of veterinary drug ... 4 compounds do not need to be routinely tested for carcinogenicity. Such tests may however be required if, for example, 1) the ... 3. REFERENCES OECD Test Guideline 451. Carcinogenicity Studies. In: OECD Guideline for the Testing of Chemicals. Organization ... 2. OECD Test Guideline 453. Combined ChronicToxicity/Carcinogenicity Studies. In: OECD Guideline for the Testing of Chemicals. ...
SCARLET Workshop on in silico methods for carcinogenicity and mutagenicity. 2-4 April, Milan, Italy SCARLET: Structure-Activity ... In Vitro Testing Industrial Platform "Integrated In Vitro Testing Strategies - implementation challenges" ... European Partnership for Alternative Approaches to Animal Testing Annual conference 2011: « Integrated Testing Strategies (ITS ... 16th Congress on Alternatives to Animal Testing - Linz 2010 16th International Congress on In Vitro Toxicology - ESTIV 2010. 2 ...
... the Global In Vitro Toxicology Testing Market is accounted for $12.30 billion in 2015 and is expected to reach $32.45 billion ... Carcinogenicity. • Neurotoxicity. • Dermal Toxicity. • Genotoxicity. • Other Toxicity Endpoints & Tests. Regions Covered:. • ... However, strict regulations and predictive ability of in vitro testing over in vivo testing are hampering the market. Growing ... In Vitro Toxicology Testing Market Size, Share, Analysis, Report and Forecast to 2022. Press Release • Jan 20, 2017 00:37 EST ...
... have been utilized in modeling of carcinogenicity as continuous values (logTD50). These descriptors can be calculated using ... rtest2=0.7514, stest=0.684; split 2: rtest2=0.7998, stest=0.600; split 3: rtest2=0.7192, stest=0.728). View Full-Text ... Additive SMILES-Based Carcinogenicity Models: Probabilistic Principles in the Search for Robust Predictions. Andrey A. Toropov ... "Additive SMILES-Based Carcinogenicity Models: Probabilistic Principles in the Search for Robust Predictions." Int. J. Mol. Sci. ...
Application of Biological Markers to Carcinogen Testing by Harry A. Milman available in Hardcover on Powells.com, also read ... Carcinogenicity testing.. Subject:. Tumor markers -- Diagnostic use -- Congresses.. Related Subjects. Health and Self-Help. ...
Carcinogenicity testing. Additional Subjects. Carcinogencity testing Holdings. Library. Call Number. Additional Info. Location ...
Testing carcinogenicity of contaminants in edible oils. II. Argemone oil in mustard oil. ... Testing carcinogenicity of contaminants in edible oils. II. Argemone oil in mustard oil. ...
Testing carcinogenicity of contaminants in edible oils. I. Indigenous solvent extracted peanut oils. ... Testing carcinogenicity of contaminants in edible oils. I. Indigenous solvent extracted pe ...
rasH2 Mice and Short-term Carcinogenicity Testing. It is interesting to note that while a number of different transgenic models ... Thyagarajan helps us understand the nature of proposed changes to carcinogenicity safety testing to significantly reduce the ... is the most widespread transgenic model used today and has been approved by the FDA for short-term carcinogenicity testing to ... rasH2 Helps Improve Drug Testing. Nina Weisbroth, MPA. Wednesday, November 11, 2015. ...
How good is the evidence of carcinogenicity? How large are test samples? Are test animals predisposed to tumors of certain ... We should accept a situation in which a small part of the time the tests proving carcinogenicity are wrong . . . to eliminate ... including the relatively heavy importance given test results that show carcinogenicity in animals and what the council called " ... the situations in which people are not protected because a test showing no hazard was wrong." ...
Chronic Toxicity and Carcinogenicity Studies Ongoing During FY 2016. Test Article. CASRN*. Species. Length. Routes. Status. ... Test Article. CASRN*. Species. Length. Route. Status. Study Scientist. 1020 Long multiwalled carbon nanotube. N/A. Mice, rats. ... Toxicology and Carcinogenicity Studies. NTP performs toxicity studies to provide dose-setting information for chronic studies ... Toxicology and carcinogenicity studies fall into two categories: prechronic toxicity studies and chronic two-year toxicology ...