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*  Transgenic RasH2 mouse carcinogenicity studies now available in Lyon | Charles River
Please contact us to discuss how this model can be incorporated into your carcinogenicity testing program.. *RasH2 is a Taconic ... and this alternative approach is proposed to be added in the current ICH S1 carcinogenicity testing guideline revision. ... Transgenic RasH2 Mouse Carcinogenicity Studies Now Available in Lyon. We value the use of alternative models as part of our ... Transgenic RasH2 Mouse Carcinogenicity Studies Now Available in Lyon. Featured Story Oct. 26 2017. ...
https://www.criver.com/insights/transgenic-rash2-mouse-carcinogenicity-studies-now-available-lyon
*  James Huff, Ph.D. - Retired
In: Testing, Predicting, and Interpreting Chemical Carcinogenicity [Kitchen KT, ed], Marcel Dekker. ... Huff JE [1997]. Carcinogenicity of chemicals used for polyethylene terephthalate plastic drink bottles. Eur J Oncol 2:515-520. ... Huff J [2001]. Carcinogenicity of Bisphenol-A in Fischer Rats and B6C3F1 Mice. Odontology Nov;89[1]:12-20. ... Huff J [2002]. Absence of toluene carcinogenicity in rodents following long-term inhalation exposure. Int J Occup Environ ...
https://www.niehs.nih.gov/about/od/deputy/huff/
*  Carcinogenicity Assessment Using Biosensors: Mitomycin-C As A Case Study
Such technologies could transform routine testing and interpretation. ... Carcinogenicity Assessment Using Biosensors: Mitomycin-C As A Case Study. Authors: H.A. Alhadrami ...
http://www.nsti.org/procs/Nanotech2014v2/3/M6.367
*  Genetic Toxicology Association - 2014 GTA Meeting Poster Abstracts
Since no single test is capable of detecting all relevant genotoxic endpoints, a battery of in vitro and in vivo tests for ... The Bhas-42 cell transformation assay (CTA) is a sensitive short term system for predicting chemical carcinogenicity. In recent ... Only one of a total of 22 compounds tested in CAA in HPBL was positive with unknown mechanism. Of 54 candidates tested in rat ... Testing of Flavor and Fragrance Materials in Turkey Egg Genotoxicity Assay (TEGA) and Comparison of the Results In Ovo, In ...
http://www.gta-us.org/scimtgs/2017Meeting/posters2017.html
*  Shield Yourself from Environmental Cancer Risks - page 1
Glucosinolates reduce the carcinogenicity of many environmental toxins by boosting the genetic expression of important ... Blood Tests A to Z * Male Panel * Female Panel * Chemistry Panel & Complete Blood Count ...
http://www.lifeextension.com/magazine/2013/4/Shield-Yourself-from-Environmental-Cancer-Risks/Page-01
*  Rapid and Sensitive RP-HPLC Method for Determination of Potential Genotoxic Impurity in Dasatinib Drug Substance
System suitability test: The USP plate count for carboxamide peak from standard solution should not less than 5000 [19]. The ... Genotoxicity and carcinogenicity study. The carboxamide [2-Amino-N-(2-chloro-6-methyl phenyl) thizaole-5-carboxamide] impurity ... Inject blank into the chromatography by following the test method conditions. Inject six replicates of standard solution into ... Injected standard solution in replicate (six time) and evaluate system suitability test; the system suitability results were ...
http://www.tsijournals.com/articles/rapid-and-sensitive-rphplc-method-for-determination-of-potential-genotoxic-impurity-in-dasatinib-drug-substance-13412.html
*  Toxicological Research
Development of a Test Method for the Evaluation of DNA Damage in Mouse Spermatogonial Stem Cells. ... Prediction of Non-Genotoxic Carcinogenicity Based on Genetic Profiles of Short Term Exposure Assays. ... Alternatives to in vivo Draize rabbit eye and skin irritation tests with a focus on 3D Reconstructed human cornea-like ... Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm. ...
http://www.toxicolres.org/main.html
*  NIOSHTIC-2 Publications Search - 20033962 - Workshop report: chronic inhalation toxicity and carcinogenicity testing of...
... a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was held in Chapel Hill, ... On May 8-10, 1995, a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was ... Workshop report: chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles.. ... available screening tests which can be used to develop a minimum data set for (a) making decisions about the potential health ...
https://www.cdc.gov/niosh/nioshtic-2/20033962.html
*  KAKEN - Research Projects | Study on Rapid Carcinogenicity Test Using Transgenic Mice (KAKENHI-PROJECT-05508005)
Short-term (*6 months) rapid carcinogenicity tests of various genotoxic carcinogens, 4-nitroquinoline-1-oxide, cyclophosphamide ... The present studies were conducted as a model for the rapid carcinogenicity testing system. ... rasH2/CB6F1 mouse seems to be a promising candidate as an animal model for the development of a rapid carcinogenicity testing ... Only a very few lung adenomas but no other tumors were seen as spontaneous tumors during the months of carcnogenicity tests. ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05508005/
*  The International Program for the Evaluation of Short-Term Tests for Carcinogenicity (IPESTTC) | SpringerLink
The major impetus for developing the International Program for the Evaluation of Short-term Tests for Carcinogenicity (IPESTTC ... in press). International Program for the Evaluation of Short-Term Tests for Carcinogenicity. Elsevier/North Holland: Amsterdam. ... de Serres F.J. (1980) The International Program for the Evaluation of Short-Term Tests for Carcinogenicity (IPESTTC). In: ... The major impetus for developing the International Program for the Evaluation of Short-term Tests for Carcinogenicity (IPESTTC ...
https://link.springer.com/chapter/10.1007/978-1-4684-4121-5_36
*  Test for carcinogenicity Test for carcinogenicity - Business
All rights reserved ©Shanghai Biomaterials Research & Testing Center 沪ICP备05015887号 网站建设,,中国企业港 ...
http://sbrtc.com/en/business/?class_id=20
*  Ratio estimates, the delta method, and quantal response tests for increased carcinogenicity | RTI
... is routinely applied to carcinogenicity data as a test for linear trend in lifetime tumor incidence rates. The computing ... The Cochran-Armitage test (Cochran, 1954, Biometrika 10, 417-451; and Armitage, 1955, Biometrics 11, 375-386) ... demonstrates the use of the delta method for estimating the variance of ratio statistics derived from animal carcinogenicity ... Bieler, G., & Williams, R. (1993). Ratio estimates, the delta method, and quantal response tests for increased carcinogenicity ...
https://www.rti.org/publication/ratio-estimates-delta-method-and-quantal-response-tests-increased-carcinogenicity
*  STUDIES TO EVALUATE THE SAFETY OF RESIDUES OF VETERINARY DRUGS IN HUMAN FOOD: CARCINOGENICITY TESTING - PDF
... per sex is appropriate for carcinogenicity testing. The route of administration for carcinogenicity testing of veterinary drug ... 4 compounds do not need to be routinely tested for carcinogenicity. Such tests may however be required if, for example, 1) the ... 3. REFERENCES OECD Test Guideline 451. Carcinogenicity Studies. In: OECD Guideline for the Testing of Chemicals. Organization ... 2. OECD Test Guideline 453. Combined ChronicToxicity/Carcinogenicity Studies. In: OECD Guideline for the Testing of Chemicals. ...
http://docplayer.net/22519151-Studies-to-evaluate-the-safety-of-residues-of-veterinary-drugs-in-human-food-carcinogenicity-testing.html
*  rasH2 Helps Improve Drug Testing | Taconic Biosciences
rasH2 Mice and Short-term Carcinogenicity Testing. It is interesting to note that while a number of different transgenic models ... Thyagarajan helps us understand the nature of proposed changes to carcinogenicity safety testing to significantly reduce the ... is the most widespread transgenic model used today and has been approved by the FDA for short-term carcinogenicity testing to ... rasH2 Helps Improve Drug Testing. Nina Weisbroth, MPA. Wednesday, November 11, 2015. ...
https://www.taconic.com/taconic-insights/quality/rash2-helps-improve-drug-testing.html
*  tADMET™ Portfolio | Taconic Biosciences
"rasH2 is a thoroughly robust model that provides confidence in carcinogenicity testing and dramatically reduces the timeline, ... make rasH2 a dominant and valuable force in carcinogenicity testing." ...
https://www.taconic.com/find-your-model/tadmet-portfolio/
*  Umu Chromotest - Wikipedia
CS1 maint: Multiple names: authors list (link) Mohn (1981). "Bacterial systems for carcinogenicity testing". Mutation Research ... The umu test, using only a single Salmonella strain, could potentially test a greater range of new chemicals with the same ... doi:10.1016/0165-1110(81)90032-4. Purchase (1982). "An appraisal of predictive tests for carcinogenicity". Mutation Research. ... A simple colorimetric test is possible by adding a lactose analog which is degraded by β-galactosidase, producing a colored ...
https://en.wikipedia.org/wiki/Umu_Chromotest
*  SOS chromotest - Wikipedia
doi:10.1016/0165-1110(81)90032-4. Purchase (1982). "An appraisal of predictive tests for carcinogenicity". Mutation Research. ... The test is performed over a few hours in columns of a 96-well microplate with increasing concentrations of test samples. This ... Mohn (1981). "Bacterial systems for carcinogenicity testing". Mutation Research. 87: 191-210. ... The test is a colorimetric assay which measures the expression of genes induced by genotoxic agents in Escherichia coli, by ...
https://en.wikipedia.org/wiki/SOS_chromotest
*  Application of Biological Markers to Carcinogen Testing: Harry A. Milman: Hardcover: 9780306414909: Powell's Books
Application of Biological Markers to Carcinogen Testing by Harry A. Milman available in Hardcover on Powells.com, also read ... Carcinogenicity testing.. Subject:. Tumor markers -- Diagnostic use -- Congresses.. Related Subjects. Health and Self-Help. ...
http://www.powells.com/book/application-of-biological-markers-to-carcinogen-testing-9780306414909
*  Documenten en publicaties - RIVM
Part of the ILSI/HESI Program on Alternative Methods for Carcinogenicity Testing. 26 mei 2012, PDF , 730kB ... 39-week carcinogenicity study with cyclosporin A in XPA-/- mice, wild type mice and XPA-/-.P53+/- double transgenic mice. ...
https://www.rivm.nl/Zoeken/Documenten_en_publicaties?searchbase=0&searchrange=100&sp=H4sIAAAAAAAAAKtWKk5NLErOSEosTlWyUjJQ0lEqzi8qyS9KSS0C8h2DnV39XDz93KHiaZmpOSlAcRA7Pj8pKzW5JC8xN1WpFgAIzCj+SAAAAA==&f=versioncreationdate%253A%255BNOW%252FDAY-6MONTH+TO+NOW%255D
*  Atriance 5 mg/ml solution for infusion - - (eMC)
Carcinogenicity and mutagenicity Carcinogenicity testing of nelarabine has not been performed. Nelarabine however, is known to ...
https://www.medicines.org.uk/emc/medicine/20045
*  KAKEN - Research Projects | THE STUDY OF HOMOLOGOUS RECOMBINATION AND GENE REPAIR IN MOUSE SOMATIC CELLS. (KAKENHI-PROJECT...
Publications] Yoichi Gondo: 'Transgenic mouse for the carcinogenicity test. (in Japanese)' Pharma Sandoz. No.3 (21). 22-23 ( ... Publications] Yoichi Gondo and Motoya Katsuki: 'Transgenic system for the genotoxicity test. (in Japanese)' The Tissue Culture ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07640823/
*  In silico assessment of toxicity of heat-generated food contaminants.
Carcinogenicity Tests. Carcinogens / toxicity. Computer Simulation. Cookery*. Expert Systems. Food Contamination / analysis*. ... A large majority of the compounds has not been tested for potential adverse effects on human health, which makes it difficult ... and identification of potential toxicants for targeted testing by standard laboratory procedures. A comparison between the ...
http://www.biomedsearch.com/nih/In-silico-assessment-toxicity-heat/18334278.html
*  Altweb: Publications: Articles: Reducing Animal Research at the U.S. Army Medical Research Institute of Chemical Defense
Welfare implications of carcinogenicity testing. The use of transgenic rodents for carcinogenicity testing could also lead to ... Carcinogenicity testing. The chronic rodent bioassay uses a large number of animals (400-500 per compound), and is prone to ... The majority of transgenic animal strains in toxicology have been used for genotoxicity and carcinogenicity testing. In the ... Three different types of transgenic strains have been employed in the generation of transgenic mice for carcinogenicity testing ...
http://altweb.jhsph.edu/pubs/ecvam/ecvam28.html
*  Search Results - - 25 Results - Digital Library
... the Federal Government's carcinogenicity testing program; and the results of OTA's analysis of the extent of agency action on ... State educational testing practices This report discusses state educational testing practices. Testing as an indicator of ... While there are many questions surrounding the use of tests for various purposes, when American public policy turns ... tests for human genetic disorders; and the impact of intellectual property law on biotechnology. The assessment was requested ...
https://digital.library.unt.edu/explore/collections/OTA/browse/?sort=date_d&fq=untl_institution%3AUNTGD&fq=str_title_serial%3AOTA+background+papers&display=brief
*  Search Results - - 22 Results - Digital Library
... the Federal Government's carcinogenicity testing program; and the results of OTA's analysis of the extent of agency action on ... State educational testing practices Description: This report discusses state educational testing practices. Testing as an ... While there are many questions surrounding the use of tests for various purposes, when American public policy turns ...
https://digital.library.unt.edu/explore/partners/UNTGD/browse/?fq=str_title_serial%3AOTA+background+papers&fq=untl_collection%3AOTA&display=list