Here we show that the tumor-associated carbonic anhydrases (CAs) are tightly regulated by this system. Both CA9 and CA12 were ... Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Wykoff CC., Beasley NJ., Watson PH., Turner KJ., Pastorek ... Here we show that the tumor-associated carbonic anhydrases (CAs) are tightly regulated by this system. Both CA9 and CA12 were ... Blotting, Western, Carbonic Anhydrases, Carcinoma, Carcinoma, Renal Cell, DNA-Binding Proteins, Endothelial Growth Factors, ...
4.2 Carbonic anhydrase. Miscellaneous. *Steroidogenesis inhibitor. This article incorporates text from the public domain Pfam ...
Human carbonic anhydrases (CAs) play essential roles in many pathological processes and several CA isoenzymes thus represent ... All currently used inhibitors anhydrase inhibitors contain a sulfonamide or a sulfamate moiety connected to so-called ring ... design of novel and original inhibitors targeting therapeutically relevant isoenzymes of human carbonic anhydrase. ...
Identification and Measurement of Carbonic Anhydrase-II Molecule Numbers in the Rat Carotid Body ... Identification and Measurement of Carbonic Anhydrase-II Molecule Numbers in the Rat Carotid Body Guglielmo Di Tano1, Claudia ... Carbonic anhydrase (CA) in the carotid body (CB) plays an important role in the maintenance of blood PO2 and PCO2/pH ...
Primary Duodenal Adenocarcinoma Expressing Carbonic Anhydrase IX. Primary Duodenal Adenocarcinoma Expressing Carbonic Anhydrase ... Primary duodenal adenocarcinoma is a rare malignancy whose carbonic anhydrase IX (CA9) expression remains poorly understood. A ...
... we discuss the role of the tumour-associated carbonic anhydrase isoform IX (CAIX) in the context of pH regulation. We summarise ... In this review, we discuss the role of the tumour-associated carbonic anhydrase isoform IX (CAIX) in the context of pH ... New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation ... New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation ...
Translation in vitro of rabbit reticulocyte carbonic anhydrase. / Shiels, A.; Carter, N.; Clemens, M. et al. In: Biochemical ... Shiels A, Carter N, Clemens M, Jeffery S. Translation in vitro of rabbit reticulocyte carbonic anhydrase. Biochemical Society ... Shiels, A., Carter, N., Clemens, M., & Jeffery, S. (1980). Translation in vitro of rabbit reticulocyte carbonic anhydrase. ... Shiels, A, Carter, N, Clemens, M & Jeffery, S 1980, Translation in vitro of rabbit reticulocyte carbonic anhydrase., ...
CA12: carbonic anhydrase 12. *CACNA1A: calcium voltage-gated channel subunit alpha1 A ...
Beta carbonic anhydrases (β-CAs) are considered promising targets of novel anthelminthics because these enzymes are present in ... Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and ... Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2 ... The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases. ...
Carbonic anhydrase did not affect the calcium-leaching rate, however, it did catalyze calcium carbonate formation to achieve a ... Additionally, carbonic anhydrase modified the precipitate morphology due to accelerated particle nucleation. Time controlled ... a further increase in the amount of carbonation may be realized by using carbonic anhydrase however pH must be ,10.3. ... and this effect was exaggerated by carbonic anhydrase, while pH controlled tests (,8.5) exhibited the highest rate of ...
... and carbonic anhydrase-9 (CA-9) expression and to correlate the results with recurrence and cancer-specific survival. MATERIALS ... Adenocarcinoma, Aged, Antigens, Neoplasm, Biomarkers, Tumor, Carbonic Anhydrase IX, Carbonic Anhydrases, Disease-Free Survival ... Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. ... Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. ...
Each subunit contains a zinc atom in the active site and displays features characteristic of type I β-carbonic anhydrases. Zinc ... Its structure closely resembles those of other β-type carbonic anhydrases, in particular CAS1 from Sordaria macrospora. The ... CaNce103p falls into the β-carbonic anhydrase class, along with its ortholog ScNce103p from Saccharomyces cerevisiae. The ... which are slightly longer and narrower than those observed in other fungal carbonic anhydrases. CaNce103p is a β-class ...
Carbonic anhydrases (CAs) are zinc-metalloenzymes that interconvert two inorganic carbon (Ci) species, CO2 and HCO3-. In ... Carbonic anhydrases (CAs) are zinc-metalloenzymes that interconvert two inorganic carbon (Ci) species, CO2 and HCO3-. In ... DiMario, Robert John, "The Characterization of Alpha- and Beta-Carbonic Anhydrases of Arabidopsis thaliana" (2016). LSU ...
Interests: FAAH; COX; Pain Therapy; CADD; Machine Learning; Carbonic Anhydrase; Ligand- and Structure-Based Virtual Screening; ...
Influence of pesticides on the pH regulatory enzyme, carbonic anhydrase, from European Seabass liver and bovine erythrocytes ... on the pH regulatory enzyme carbonic anhydrase (CA) of Dicentrarchus labrax (European Seabass) liver (dCA) and bovine ...
... nipponense and provided new Carbonic Anhydrase Inhibitor Gene ID insights forThe reproduction period of M. nipponense and ... The reproduction period of M. nipponense and provided new Carbonic Anhydrase Inhibitor Gene ID insights for. The reproduction ... Uncategorized , The reproduction period of M. nipponense and provided new Carbonic Anhydrase Inhibitor Gene ID insights ... The reproduction period of M. nipponense and provided new Carbonic Anhydrase Inhibitor Gene ID insights. ...
Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells Carbonic anhydrase IX (CA IX) is ... Targeting Carbonic Anhydrase IX Activity and Expression by: Brian P. Mahon, et al. Published: (2015-01-01) ... Carbonic anhydrase IX in oligodendroglial brain tumors by: Pastorekova Silvia, et al. Published: (2008-01-01) ... Carbonic Anhydrase IX-Mouse versus Human by: Martina Takacova, et al. Published: (2019-12-01) ...
The carbonic anhydrase I (CA I) inhibition of copper(II) complexes which goes on competitively was determined by using UV-Vis ... In general, sulfonamides and their derivatives are researched for their inhibitory effects on carbonic anhydrase isoenzymes ( ... Copper(II) sulfonamide complexes having enzyme inhibition activities on carbonic anhydrase I: synthesis, characterization and ... Keywords: Sulfonamide, Carbonic anhydrase I, Enzyme inhibition, Voltammetry, ELECTROCHEMICAL INVESTIGATIONS, AMPEROMETRIC ...
... carbonic anhydrase IX (CA IX), in a cohort of patients with invasive breast cancer. PATIENTS AND METHODS: CA IX expression was ... Carbonic Anhydrase IX, Carbonic Anhydrases, Carcinoma, Ductal, Breast, Cell Hypoxia, Cohort Studies, Disease-Free Survival, ... Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. ... Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. ...
Carbonic Anhydrase I, Human. 2,197. 284. 79. 75. CAH2_HUMAN. P00918. CHEMBL205. Carbonic Anhydrase II, Human. 2,967. 379. 112. ... Carbonic Anhydrase VII, Human. 272. 116. 52. 56. CAH9_HUMAN. Q16790. CHEMBL3594. Carbonic Anhydrase IX, Human. 1,000. 180. 68. ... Carbonic Anhydrase XII, Human. 544. 146. 66. 65. CAH13_HUMAN. Q8N1Q1. CHEMBL3912. Carbonic Anhydrase XIII, Human. 85. 27. 16. ... Carbonic Anhydrase IV, Human. 223. 84. 54. 59. CAH5A_HUMAN. P35218. CHEMBL4789. Carbonic Anhydrase VA, Human. 192. 101. 50. 53 ...
Carbonic Anhydrase Inhibitors for Glaucoma. Your ophthalmologist may have you take this medicine as an eye drop or by mouth as ...
Effects of inhibitors of carbonic anhydrase on the GDPSP/C. A, Bath application of the impermeant carbonic anhydrase inhibitor ... carbonic anhydrase. There are functionally distinct kinds of carbonic anhydrases that play a crucial role in activity-induced ... Role of HCO3− and carbonic anhydrase in the generation of the [K+]o transients. Further evidence pointing to the involvement of ... A withdrawal of CO2/HCO3− as well as the application of a membrane-permeant carbonic anhydrase inhibitor (EZA) led to an ...
Introduction to the carbonic anhydrases. In The Carbonic Anhydrases- New Horizons. (ed. W. R. Chegwidden, N. D. Carter and Y. H ... Carbonic anhydrases in striated muscles. In The Carbonic Anhydrases, New Horizons. (ed. W. R. Chegwidden, N. D. Carter and Y. H ... The membrane carbonic anhydrases: from CO2 transport to tumor markers. In The Carbonic Anhydrases - New Horizons ... Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from ...
CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4- PROPYLTHIOBENZENESULFONAMIDE - 5LLG , canSARS ...
Carbonic anhydrase inhibitor anticonvulsants Pregnancy Category. D - Positive evidence of risk CSA Schedule. Not a controlled ... carbonic anhydrase inhibitor anticonvulsants. There is positive evidence of human fetal risk during pregnancy. Topamax 50 mg is ...
Carbonic anhydrase IX: regulation and role in cancer. Subcell. Biochem. 75, 199-219 (2014). ...