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*  Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations. -...
Eukaryotic Top1s are the cellular target of the plant-derived anticancer indole alkaloid camptothecin (CPT), which reversibly ... identifies genes associated with biosynthesis of camptothecin, an anti-carcinogenic molecule. *B L Manjunatha. , H R Singh. , + ... Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations.. *. ... Eukaryotic Top1s are the cellular target of the plant-derived anticancer indole alkaloid camptothecin (CPT), which reversibly ...
https://www.semanticscholar.org/paper/Structural-insight-of-DNA-topoisomerases-I-from-ca-Sirikantaramas-Meeprasert/6ff3c048374326c109ef18376c47afa5e9df4f9b
*  Support Protocols | BD Biosciences-US
Protocol for Camptothecin-induced Apoptosis:. *Prepare a 1 mM stock solution of Camptothecin (Sigma Cat. No. C-9911) in DMSO. ... Camptothecin has been shown to induce apoptosis in a dose-dependent manner in vitro. Camptothecin is routinely used as a ... Induction of Apoptosis by Treatment with Camptothecin. Camptothecin, an extract of the Chinese tree Camptotheca acuminata, is a ... Add 4-6 µM (final concentration) Camptothecin to cell suspension (eg, 5 x 105 cells/ml in tissue culture medium). ...
http://www.bdbiosciences.com/us/resources/protocols/s/celldeath
*  Synthesis, a UC Davis Cancer Center Publication - Featured clinical trial
Topotecan is a synthetic camptothecin, a compound derived from the bark of the Chinese camptotheca tree. The drug is a ... Previous research has shown that bortezomib can enhance the sensitivity of camptothecins. This Phase I study is designed to ...
http://www.ucdmc.ucdavis.edu/synthesis/issues/fall_winter_06/featured_trial/featured_trial.html
*  camptotheca | MTPR
In the 1950s, National Cancer Institute researchers in the U.S. isolated the alkaloid camptothecin from the leaves, and today, ...
http://mtpr.org/term/camptotheca
*  VackvSuG: Camptotheca checkpoint mechanism Baicalin wild type enzyme RPA-4 subunits, of RFC effects in vivo.
... but not in response to camptothecin. Increased chemosensitivity to this drug may sensitize cancer cells to camptothecin. ... DNA damage which results in apoptosis camptothecin cytotoxicity may signal the Ku autoantigen RCD-8 which may signal the ... treatment involved in DNA damage-induced RPA2 induced apoptosis was augmented camptothecin-induced RPA2 phosphorylation. RPA ... activation undergoes hyperphosphorylation in response to cellular genotoxic insults predominantly mediated by camptothecin ...
http://lnwme.blogspot.com/2009/09/camptotheca-checkpoint-mechanism.html
*  Patent US4031098 - Camptothecin analogues - Google Patents
... in which the 1-ethyl of camptothecin is replaced by various members of substitutents such as alkyls (except ethyl), alkenyls, ... Camptothecin analogues showing more potent anti-tumor activity than a naturally occurring alkaloid camptothecin, which also ... Camptothecin derivatives. US4604463 *. Jul 5, 1984. Aug 5, 1986. Kabushiki Kaisha Yakult Honsha. Camptothecin derivatives and ... Camptothecin analogues showing more potent anti-tumor activity than a naturally occurring alkaloid camptothecin, which also ...
http://www.google.com/patents/US4031098?dq=artistshare
*  Camptothecin: A promising antiretroviral drug | SpringerLink
The plant alkaloid camptothecin (CPT) has demonstrated the ability to inhibit replication of the equine anemia virus (E1AV) and ... X. Isolation of camptothecin and 9-methoxy-camptothecin fromErvatamia heyneana. J Nat Prod 42:275-277;1977.Google Scholar ... Biochemistry of camptothecin. In Potmesil M, Pinedo H, eds. Camptothecins: New Anticancer Agents. Boca Raton, CRC Press, 9-19; ... camptothecin. In: Potmesil M, Pinedo H, eds. Camptothecins: New Anticancer Agents. Boca Raton, CRC Press; 59-65;1995.Google ...
https://link.springer.com/article/10.1007/BF02253574
*  Camptothecin Resistance | Cancer Research
MXR confers cross-resistance to a variety of camptothecins. A, cross-resistance profiles for the camptothecins tested; relative ... To further characterize the resistance to the camptothecins, cytotoxicity assays were performed using a series of camptothecins ... The cell lines demonstrated much less resistance to camptothecin and to several camptothecin analogues. Reduced accumulation ... Camptothecin Resistance. Mariafiorella Brangi, Thomas Litman, Marco Ciotti, Kenryu Nishiyama, Glenda Kohlhagen, Chris Takimoto ...
http://cancerres.aacrjournals.org/content/59/23/5938
*  Camptothecin Radiation Sensitization | SpringerLink
The camptothecin analog CPT-11 has recently been approved for the treatment of 5-fluorouracil (5-FU)-resistant colorectal ... The current status of camptothecin analogues as antitumor agents. J Natl Cancer Inst 1993; 85 (4): 271-291.PubMedCrossRefGoogle ... Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985; 260 (27): 14873-14878. ... The camptothecins (CPT) are potent radiation sensitizers and are in their infancy in clinical studies. The combination of CPT ...
https://link.springer.com/chapter/10.1007/978-1-59259-325-5_5
*  Patent US6455699 - Camptothecin analogs and methods of preparation thereof - Google Patents
The T/C camptothecin is designated with "+++." An increment or decrement of 10% as compared to the camptothecin T/C on day 14 ... Highly lipophilic Camptothecin derivatives. US6150343 *. Aug 29, 1997. Nov 21, 2000. University Of Pittsburgh. Camptothecin ... Thus, 7-trimethylsilyl-11-flouro camptothecin is more efficacious than camptothecin in its antitumor effects in vivo. ... 7-trimethylsilyl camptothecin showed better activity than camptothecin against sarcoma 180 in B6D2F1 mice at several equivalent ...
http://www.google.com/patents/US6455699?dq=U.S.+Patent+No.+4,528,643
*  Camptothecin (CPT) The report: post #1
IC50 Value: 50 nM(in MDA-MB-231 cell line) Target: topoisomerase Camptothecin (CPT) has recently been undergoing phase I ... In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks wi... ... Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for ... Camptothecin (CPT) The report - posted in Immunology Products: Biological Activity of Campathecin ...
http://www.protocol-online.org/forums/topic/33290-camptothecin-cpt-the-report/
*  US5559235A - Water soluble camptothecin derivatives - Google Patents
The present invention relates to water soluble, camptothecin derivatives of formula (I), ##STR1## wherein: 1) R 1 and R 2 ... 7-Substituted camptothecin derivatives US4473692A (en) * 1981-09-04. 1984-09-25. Kabushiki Kaisha Yakult Honsha. Camptothecin ... 7-Substituted camptothecin derivatives US4473692A (en) * 1981-09-04. 1984-09-25. Kabushiki Kaisha Yakult Honsha. Camptothecin ... Synthesis of camptothecin and analogs thereof US5122526A (en) 1992-06-16. Camptothecin and analogs thereof and pharmaceutical ...
https://patents.google.com/patent/US5559235A/en
*  US4943579A - Water soluble prodrugs of camptothecin - Google Patents
Water-soluble derivatives of camptothecin have the formulae: ##STR1## wherein R' is selected from the group consisting of R=CO ... Production of camptothecin and camptothecin-like compounds US3903276A (en) * 1972-03-20. 1975-09-02. American Home Prod. N- ... Production of camptothecin and camptothecin-like compounds US3903276A (en) * 1972-03-20. 1975-09-02. American Home Prod. N- ... Nitrogen-based homo-camptothecin derivatives US20040034050A1 (en) * 2002-06-03. 2004-02-19. Yang Li-Xi. Homo-camptothecin ...
https://patents.google.com/patent/US4943579?oq=7%2C190%2C101
*  Camptothecin-Based Regimens for Treatment of Ewing Sarcoma: sPast Studies and Future Directions
... Lars Wagner ... Over the past decade, camptothecin agents such as topotecan and irinotecan have demonstrated activity against Ewing sarcoma, ... Previous studies have shown camptothecin-based combinations to be tolerable outpatient strategies that are attractive for ... and activity of commonly used camptothecin-based regimens. Also discussed are strategies for incorporating these regimens into ...
https://www.hindawi.com/journals/sarcoma/2011/957957/abs/
*  Camptothecin-Based Regimens for Treatment of Ewing Sarcoma: sPast Studies and Future Directions
Lars Wagner, "Camptothecin-Based Regimens for Treatment of Ewing Sarcoma: sPast Studies and Future Directions," Sarcoma, vol. ... Camptothecin-Based Regimens for Treatment of Ewing Sarcoma: sPast Studies and Future Directions. Lars Wagner ...
https://www.hindawi.com/journals/sarcoma/2011/957957/cta/
*  Camptothecin - Wikipedia
"Curran Synthesis of Camptothecin". "Comins Synthesis of Camptothecin". "Rapaport Synthesis of Camptothecin". Takimoto CH, Calvo ... Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening ... A. J. Lu; Z. S. Zhang; M. Y. Zheng; H. J. Zou; X. M. Luo; H. L. Jiang (2007). "3D-QSAR study of 20 (S)-camptothecin analogs". ... D. J. Adams; M. L. Wahl; J. L. Flowers; B. Sen; M. Colvin; M. W. Dewhirst; G. Manikumar; M. C. Wani (2005). "Camptothecin ...
https://en.wikipedia.org/wiki/Camptothecin
*  Metabolism and Pharmacokinetics of the Camptothecin Analogue CPT-11 in the Mouse | Cancer Research
Metabolism and Pharmacokinetics of the Camptothecin Analogue CPT-11 in the Mouse. Norimasa Kaneda, Hiroshi Nagata, Tomio Furuta ... These values were markedly higher than those of camptothecin (CPT, 0.98 and 3.7 ng/ml) or 7-ethyl-10-hydroxycamptothecin (SN-38 ... A new water-soluble derivative of camptothecin, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), did ... Metabolism and Pharmacokinetics of the Camptothecin Analogue CPT-11 in the Mouse ...
http://cancerres.aacrjournals.org/content/50/6/1715
*  Crystalline form of 5(S)-(2-hydroxyethoxy)-20(S)-camptothecin - Patent # 7601732 - PatentGenius
... camptothecin diastereoisomer of 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin is described that is characterized by having an X- ... camptothecin.. 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin is a 5-alkoxy substituted 20(S)-camptothecin analog having a penta ... camptothecin is described chemically as 5(R)-(2'-hydroxyethoxy)-20(S)-camptothecin. 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin ... No.5,734,056 describes camptothecin analogues. Topotecan, an analogue of camptothecin, is discussed in U.S. Pat. No. 5,004,758 ...
http://www.patentgenius.com/patent/7601732.html
*  CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines
CKD-602 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, belotecan) is a synthetic water-soluble camptothecin derivative and ... CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. *Authors: *Young-Yim Kim ... Kim, Y., Park, C., Kim, S., Phi, J., Kim, J., Kim, C., Wang, K., Cho, B.'CKD-602, a camptothecin derivative, inhibits ... Kim, Y., Park, C., Kim, S., Phi, J., Kim, J., Kim, C., Wang, K., Cho, B.'CKD-602, a camptothecin derivative, inhibits ...
https://www.spandidos-publications.com/or/21/6/1413
*  Pharmaceuticals | Free Full-Text | Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of...
We nasally administered the anti-tumor drug camptothecin (CPT) in solution and in methoxy poly(ethylene glycol) (MPEG)/poly(e- ... Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors. Hiroyuki Taki † ... We nasally administered the anti-tumor drug camptothecin (CPT) in solution and in methoxy poly(ethylene glycol) (MPEG)/poly(e- ... "Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors." ...
http://www.mdpi.com/1424-8247/5/10/1092
*  Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA...
Right-hand panels: upon release from the thymdine block into Camptothecin containing medium (CPT; 10 µm), again Cdt1 is ... Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA ... We show that these patient-derived cells exhibit sensitivity to camptothecin (CPT), impaired CPT-induced topoisomerase I (Topo ... Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA ...
https://www.ncbi.nlm.nih.gov/pubmed/20064923
*  Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU...
20(S)-Camptothecin (CAM), topotecan (TPT, active ingredient in Hycamtin) and 9-amino-20(S)-camptothecin (9AC) are topoisomerase ... Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU- ... The greater susceptibility of humans and dogs to the myelotoxicity of camptothecins, compared to mice, was evident in vitro at ...
https://www.ncbi.nlm.nih.gov/pubmed/9054963?dopt=Abstract
*  9781157367390: Chemotherapeutic agents: Chemotherapy, Pawpaw, Biosynthesis of doxorubicin, Camptothecin, Epothilone,...
Camptothecin, Epothilone, Aminopterin, ABVD, Cyclophosphamide von Source: Wikipedia bei AbeBooks.de - ISBN 10: 1157367399 - ... Chemotherapeutic agents: Chemotherapy, Pawpaw, Biosynthesis of doxorubicin, Camptothecin, Epothilone, Aminopterin, ABVD, ... Chemotherapeutic agents: Chemotherapy, Pawpaw, Biosynthesis of doxorubicin, Camptothecin, Epothilone, Aminopterin, ABVD, ... Chapters: Chemotherapy, Pawpaw, Biosynthesis of doxorubicin, Camptothecin, Epothilone, Aminopterin, ABVD, Cyclophosphamide, ...
https://www.abebooks.de/9781157367390/Chemotherapeutic-Agents-Chemotherapy-Pawpaw-Biosynthesis-1157367399/plp
*  CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I-DNA Binding, and Increases...
... camptothecin-induced cellular DNA damage, and cellular camptothecin sensitivity. Our results show that the PS506 epitope is an ... and increased sensitivity to camptothecin. In contrast, PS506 was not detected in normal cells or cancer cell lines with lower ... Topoisomerase I is the target for a potent class of chemotherapeutic drugs derived from the plant alkaloid camptothecin that ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050427