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*  CLIC4 (chloride intracellular channel 4)
... chloride intracellular channel 4), Authors: Velayuthan C Padmakumar, Stuart H Yuspa. Published in: Atlas Genet Cytogenet Oncol ... organization retina vasculature morphogenesis in camera-type eye extracellular exosome cellular response to calcium ion ... angiogenesis endothelial cell morphogenesis voltage-gated ion channel activity chloride channel activity protein binding ... angiogenesis endothelial cell morphogenesis voltage-gated ion channel activity chloride channel activity protein binding ...
http://atlasgeneticsoncology.org/Genes/CLIC4ID40102ch1p36.html
*  Chloride channel - Wikipedia
In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three CLC ... GABAA Glycine Receptor Calcium-activated chloride channel Jentsch, Thomas J.; Stein, Valentin; Weinreich, Frank; Zdebik, Anselm ... Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many ... The structure of these channels are not like other known channels. The chloride channel subunits contain between 1 and 12 ...
https://en.wikipedia.org/wiki/Chloride_channel
*  Action Potential Gating of Calcium Channels and Transmitter Release - OpenThesis
To test the hypothesis that individual N-type calcium channels open with a low probability, single channel recordings of N-type ... and L-type current activation. Using this approach I determined that N-type channels activate more slowly than L-type. ... I conclude from these studies that N-type voltage-gated calcium channels have a very low probability of opening (< 5%) during ... To understand how calcium current is activated physiologically, the activation and resulting current from N-type calcium ...
http://www.openthesis.org/documents/Action-Potential-Gating-Calcium-Channels-225784.html
*  Permeant Anions Control Gating of Calcium-dependent Chloride Channels, The Journal of Membrane Biology | 10.1007/s00232-004...
"Permeant Anions Control Gating of Calcium-dependent Chloride Channels, The Journal of Membrane Biology" on DeepDyve, the ... Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels ... Permeant Anions Control Gating of Calcium-dependent Chloride Channels. Permeant Anions Control Gating of Calcium-dependent ... Permeant Anions Control Gating of Calcium-dependent Chloride Channels. Perez-Cornejo, P.; Santiago, J.; Arreola, J. ...
https://www.deepdyve.com/lp/springer_journal/permeant-anions-control-gating-of-calcium-dependent-chloride-channels-MOJZwK0270
*  T-TYPE CALCIUM CHANNEL BLOCKER - Patent application - There is provided a T-type calcium channel blocker that is a compound of...
Therefore, it is considered very useful to find T-type calcium channel blockers having a weak or little L-type calcium channel ... 0004]Recently, compounds having T-type calcium channel blocking action in addition to L-type calcium channel blocking action ... The T-type calcium channel blocker as set forth in 2., wherein Rb is C1-6alkyl group, CN or NH2;4. The T-type calcium channel ... calcium channel blockers, or therapeutic agents or preventive agents against diseases for which T-type calcium channel blocking ...
http://www.patentsencyclopedia.com/app/20100105636
*  Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons | Biochemical Journal
The T-type Ca2+ channel Cav3.2 is expressed in nociceptive and mechanosensitive sensory neurons. The mechanosensitive D-hair ( ... Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons. Cécile Hilaire, Olivier ... Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons ... Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons ...
http://www.biochemj.org/content/441/1/463
*  The Year in Valvular Heart Disease | JACC: Journal of the American College of Cardiology
VHD produces important changes in cardiac ion-channel gene expression, discrete ion-channel subunit changes differentiate ... Calcification score from EBCT for AV calcium content in 61 patients with AS and AVA of 0.7 to 2.0 cm2 (13) showed AV Agatston ... After TVR comparison of outcomes between the 2 types of valves showed the incidence of thrombosis of mechanical valves is ... Human atrial ion channel and transporter subunit gene expression. Messenger ribonucleic acid expression was quantified in ...
http://www.onlinejacc.org/content/49/3/361
*  Abstract 10762: Inositol Triphosphate Receptor Activation Provides Inotropic Support to Human Ventricular Myocytes | Circulation
Core 4. Heart Rhythm Disorders and Resuscitation ScienceSession Title: Ion Channels and Cellular Function ... Article Types. *→ General Preparation Instructions. *→ Research Guidelines. *→ How to Submit a Manuscript ...
http://circ.ahajournals.org/content/126/Suppl_21/A10762
*  Epilepsy drugs could treat Alzheimer's and Parkinson's
BioMed »Epilepsy »L-type »Molecular Target »STM »T-type »calcium channel »neurodegenerative disorder »signaling pathway ... Further reports about: , BioMed , Epilepsy , L-type , Molecular Target , STM , T-type , calcium channel , neurodegenerative ... by L-type and T-type calcium channel blockers, suggesting that more than one calcium-signaling mechanism exists to regulate ... They found that neurons showed an increase in viability after treatment with either L-type or T-type calcium channel inhibitors ...
http://www.innovations-report.com/hrml/reports/studies/epilepsy-drugs-treat-alzheimer-039-s-parkinson-039-s-142477.html
*  James C. Barrow, Harleysville US - Patent applications
Pyridyl Amide T-Type Calcium Channel Antagonists - The present invention is directed to pyridyl amide compounds which are ... PYRAZINYL AMIDE-T TYPE CALCIUM CHANNEL ANTAGONISTS - The present invention is directed to pyrazinyl amide compounds which are ... HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS - The present invention is directed to heterocycle amide compounds which ... Quinazolinone T-Type Calcium Channel Antagonists - The present invention is directed to quinazolinone compounds which are ...
http://www.patentsencyclopedia.com/inventor/james-c-barrow-harleysville-us-1/
*  R-type calcium channel - Wikipedia
The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms ... "Entrez Gene: CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit". Soong TW, Stea A, Hodson CD, Dubel SJ, ... This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in ... They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have ...
https://en.wikipedia.org/wiki/R-type_calcium_channel
*  N-type calcium channel - Wikipedia
... which is also similar to another type of calcium channels, known as P-type calcium channels. N-type calcium channels are ... N-type calcium channels are voltage gated calcium channels that are distributed throughout the entire body. These channels are ... The inhibition of this channel by calcium channel blockers can lead to renal microcirculation. N-type calcium channels have ... N-type calcium channels have known functions in the kidney, and heart. There are many known N-type calcium channel blockers, ...
https://en.wikipedia.org/wiki/N-type_calcium_channel
*  Benidipine - Wikipedia
... and N-type calcium channel blocker. It is reno- and cardioprotective. Benidipine is dosed as 2-8 mg once daily. Benidipine is ... Benidipine is a calcium channel blocker. Benidipine has additionally been found to act as an antagonist of the ... Benidipine (INN), also known as Benidipinum or benidipine hydrochloride, is a dihydropyridine calcium channel blocker for the ...
https://en.wikipedia.org/wiki/Benidipine
*  Calcium channel - Wikipedia
the receptor-operated calcium channels (in vasoconstriction) P2X receptors L-type calcium channel blockers are used to treat ... T-type calcium channel blockers are used to treat epilepsy. Increased calcium conductance in the neurons leads to increased ... A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous as voltage- ... "calcium channel" at Dorland's Medical Dictionary Striggow F, Ehrlich BE (August 1996). "Ligand-gated calcium channels inside ...
https://en.wikipedia.org/wiki/Calcium_channel
*  Targetable T-type Calcium Channels Drive Glioblastoma | Cancer Research
... which inhibits the T-type calcium channel Cav3.2. This calcium channel was highly expressed in human GBM specimens and enriched ... Targetable T-type Calcium Channels Drive Glioblastoma. Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, ... Targetable T-type Calcium Channels Drive Glioblastoma. Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, ... Targetable T-type Calcium Channels Drive Glioblastoma. Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, ...
http://cancerres.aacrjournals.org/content/77/13/3479
*  Voltage-dependent L-type calcium channel - DrugBank
Voltage-dependent L-type calcium channel subunit alpha-1C. Q13936. Details. Voltage-dependent L-type calcium channel subunit ... Voltage-dependent L-type calcium channel subunit alpha-1F. O60840. Details. Voltage-dependent L-type calcium channel subunit ... Voltage-dependent L-type calcium channel subunit beta-1. Q02641. Details. Voltage-dependent L-type calcium channel subunit beta ... Voltage-dependent L-type calcium channel subunit beta-3. P54284. Details. Voltage-dependent L-type calcium channel subunit beta ...
https://www.drugbank.ca/bio_entities/BE0008715
*  Mus musculus calcium channel, voltage-dependent, T type, alpha 1G subu - Nucleotide - NCBI
Mus musculus calcium channel, voltage-dependent, T type, alpha 1G subunit (Cacna... Mus musculus calcium channel, voltage- ... Mus musculus calcium channel, voltage-dependent, T type, alpha 1G subunit (Cacna1g), transcript variant 3, mRNA. NCBI Reference ... See the reference protein sequence for voltage-dependent T-type calcium channel subunit alpha-1G isoform c (NP_001171359.1). ... Calcium Regulation in the Cardiac Cell Calcium Regulation in the Cardiac CellCalcium is a common signaling mechanism, as once ...
https://www.ncbi.nlm.nih.gov/nuccore/NM_001177888
*  Marine Drugs | Free Full-Text | Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives
... were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel ... Keywords: N-type calcium channel; Cav2.2; channel blocker; pain; FLIPR N-type calcium channel; Cav2.2; channel blocker; pain; ... were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel ... Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives. Ellen C. Gleeson 1,2. ...
http://www.mdpi.com/1660-3397/13/4/2030
*  Lateral Mobility of Presynaptic L-Type Calcium Channels at Photoreceptor Ribbon Synapses | Journal of Neuroscience
2011) Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ... Lateral Mobility of Presynaptic L-Type Calcium Channels at Photoreceptor Ribbon Synapses. Aaron J. Mercer, Minghui Chen and ... 2004) Role of lipid microdomains in P/Q-type calcium channel (Cav2.1) clustering and function in presynaptic membranes. J Biol ... 2004) The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. J Neurosci ...
http://www.jneurosci.org/content/31/12/4397
*  Voltage-dependent L-type calcium channel subunit alpha-1D - DrugBank
Voltage-dependent L-type calcium channel subunit alpha-1D. Details. Name. Voltage-dependent L-type calcium channel subunit ... Voltage-dependent L-type calcium channel subunit alpha-1D. Q01668. Details. Drug Relations. Drug Relations. DrugBank ID. Name. ...
https://www.drugbank.ca/biodb/bio_entities/BE0002359
*  Voltage-dependent L-type calcium channel subunit alpha-1S - DrugBank
Voltage-dependent L-type calcium channel subunit alpha-1S. Details. Name. Voltage-dependent L-type calcium channel subunit ... The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage ... voltage-gated calcium channel activity / high voltage-gated calcium channel activity / metal ion binding ... Voltage-gated calcium channel activity. Specific Function. Voltage-sensitive calcium channels (VSCC) mediate the entry of ...
https://www.drugbank.ca/biodb/polypeptides/Q13698
*  Voltage-dependent L-type calcium channel subunit beta-2 - DrugBank
Voltage-dependent L-type calcium channel subunit beta-2. Details. Name. Voltage-dependent L-type calcium channel subunit beta-2 ... Voltage-dependent L-type calcium channel subunit beta-2. Q08289. Details. Drug Relations. Drug Relations. DrugBank ID. Name. ...
https://www.drugbank.ca/biodb/bio_entities/BE0002354
*  Voltage-dependent L-type calcium channel subunit beta-4 - DrugBank
Voltage-dependent L-type calcium channel subunit beta-4. Details. Name. Voltage-dependent L-type calcium channel subunit beta-4 ... Voltage-dependent L-type calcium channel subunit beta-4. O00305. Details. Drug Relations. Drug Relations. DrugBank ID. Name. ...
https://www.drugbank.ca/biodb/bio_entities/BE0002356
*  Selective T-Type Calcium Channel Blockade Alleviates Hyperalgesia in ob/ob Mice | Diabetes
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels J Neurosci ... New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects ... Recent studies have highlighted the importance of T-type calcium channels (T-channels) in peripheral nociception; therefore, ... Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception EMBO J 2005; ...
http://diabetes.diabetesjournals.org/content/58/11/2656.full
*  N-Type Calcium Channels - N-Type Calcium Channel Summary Report | CureHunter
CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their ... Channels, N-Type Calcium; Channels, Neural-Type Calcium; N Type Calcium Channel; N Type Calcium Channels; N Type VDCC; N Type ... N-Type Calcium Channel; Calcium Channels, N-Type; N-Type VDCC; N-Type Voltage-Dependent Calcium Channels; Calcium Channel, N- ... Type; Calcium Channels, N Type; Calcium Channels, Neural-Type; Channel, N-Type Calcium; ...
http://www.curehunter.com/public/keywordSummaryD020864-N-Type-Calcium-Channels-N-Type-Calcium-Channel.do