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*  CLIC4 (chloride intracellular channel 4)
... chloride intracellular channel 4), Authors: Velayuthan C Padmakumar, Stuart H Yuspa. Published in: Atlas Genet Cytogenet Oncol ... organization retina vasculature morphogenesis in camera-type eye extracellular exosome cellular response to calcium ion ... angiogenesis endothelial cell morphogenesis voltage-gated ion channel activity chloride channel activity protein binding ... angiogenesis endothelial cell morphogenesis voltage-gated ion channel activity chloride channel activity protein binding ...
http://atlasgeneticsoncology.org/Genes/CLIC4ID40102ch1p36.html
*  Health outcomes associated with beta-blocker and diltiazem treatment of unstable angina | JACC: Journal of the American College...
We did not collect data on veterans who were discharged on more than one type of calcium channel blocker. We have no ... 1990) Pharmacologic management of ischemic heart disease with β-blockers and calcium channel blockers. Am Heart J 120:739-742. ... Diltiazem, a benzothiazepine calcium channel blocking agent, is frequently used in clinical practice to treat acute ischemic ... Two-thirds of the veterans were being treated with either beta-blockers or calcium channel blockers at admission, and, as ...
http://www.onlinejacc.org/content/32/5/1305
*  Chloride channel - Wikipedia
In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three CLC ... GABAA Glycine Receptor Calcium-activated chloride channel Jentsch, Thomas J.; Stein, Valentin; Weinreich, Frank; Zdebik, Anselm ... Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many ... The structure of these channels are not like other known channels. The chloride channel subunits contain between 1 and 12 ...
https://en.wikipedia.org/wiki/Chloride_channel
*  Action Potential Gating of Calcium Channels and Transmitter Release - OpenThesis
To test the hypothesis that individual N-type calcium channels open with a low probability, single channel recordings of N-type ... and L-type current activation. Using this approach I determined that N-type channels activate more slowly than L-type. ... I conclude from these studies that N-type voltage-gated calcium channels have a very low probability of opening (< 5%) during ... To understand how calcium current is activated physiologically, the activation and resulting current from N-type calcium ...
http://www.openthesis.org/documents/Action-Potential-Gating-Calcium-Channels-225784.html
*  Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects...
In our first series of experiments we studied the pharmacodynamic and pharmacokinetic effects of the calcium channel blocker ... Source Type:Master's Thesis. Keywords:horse equine cardiology atrial physiology electrophysiology echocardiography mechanical ...
http://www.openthesis.org/documents/Atrial-AV-nodal-physiology-in-542823.html
*  DailyMed - DILTIAZEM HYDROCHLORIDE- diltiazem hydrochloride capsule, extended release
Diltiazem hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium antagonist). Chemically, diltiazem ... 180 mg - ammonio methacrylate copolymer NF, type A, ammonio methacrylate copolymer NF, type B, ammonium hydroxide, D&C yellow # ... Hemodynamic And Electrophysiologic Effects: Like other calcium channel antagonists, diltiazem decreases sinoatrial and ... 240 mg - ammonio methacrylate copolymer NF, type A, ammonio methacrylate copolymer NF, type B, ammonium hydroxide, D&C yellow # ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0636b402-6b94-472d-807f-4824272614f7
*  Permeant Anions Control Gating of Calcium-dependent Chloride Channels, The Journal of Membrane Biology | 10.1007/s00232-004...
"Permeant Anions Control Gating of Calcium-dependent Chloride Channels, The Journal of Membrane Biology" on DeepDyve, the ... Halide permeation in wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels ... Permeant Anions Control Gating of Calcium-dependent Chloride Channels. Permeant Anions Control Gating of Calcium-dependent ... Permeant Anions Control Gating of Calcium-dependent Chloride Channels. Perez-Cornejo, P.; Santiago, J.; Arreola, J. ...
https://www.deepdyve.com/lp/springer_journal/permeant-anions-control-gating-of-calcium-dependent-chloride-channels-MOJZwK0270
*  BestBets: Intravenous diltiazem for the control of ventricular rate in patients with recent onset atrial fibrillation and left...
Exp atrial fibrillation or atrial fibrillation.mp or AF.mp] AND [exp calcium channel blockers or calcium channel blocker.mp or ... Study type (level of evidence). Outcomes. Key results. Study Weaknesses. Goldenberg et al,. 1994,. USA. 37 Patients with atrial ... You wonder therefore whether diltiazem, a calcium antagonist, may be of use. Search Strategy. Medline 1966 to week 4 April 2009 ...
http://bestbets.org/bets/bet.php?id=420
*  T-TYPE CALCIUM CHANNEL BLOCKER - Patent application - There is provided a T-type calcium channel blocker that is a compound of...
Therefore, it is considered very useful to find T-type calcium channel blockers having a weak or little L-type calcium channel ... 0004]Recently, compounds having T-type calcium channel blocking action in addition to L-type calcium channel blocking action ... The T-type calcium channel blocker as set forth in 2., wherein Rb is C1-6alkyl group, CN or NH2;4. The T-type calcium channel ... calcium channel blockers, or therapeutic agents or preventive agents against diseases for which T-type calcium channel blocking ...
http://www.patentsencyclopedia.com/app/20100105636
*  Selective N-Type Calcium Channel Antagonist Omega Conotoxin MVIIA Is Neuroprotective Against Hypoxic Neurodegeneration in...
Second, if calcium entry through N-type calcium channels is prevented, the delayed generation of damage is prevented. ... Background and Purpose Neuroprotection by antagonists of both L-type and N-type calcium channels occurs in in vivo models of ... that neuroprotection by selective N-type calcium channel antagonists is mediated directly through neuronal calcium channels. In ... and Q-type channels in addition to blocking N-type channels. Valentino et al11 confirmed in vivo that CTX MVIIC was a much more ...
http://stroke.ahajournals.org/content/27/11/2124
*  Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons | Biochemical Journal
The T-type Ca2+ channel Cav3.2 is expressed in nociceptive and mechanosensitive sensory neurons. The mechanosensitive D-hair ( ... Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons. Cécile Hilaire, Olivier ... Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons ... Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons ...
http://www.biochemj.org/content/441/1/463
*  Buy Online Diltiazem - Diltiazem Pharmacy Paris
In cardiac nodal tissue, L-type calcium channels play an important role in and in of the action potentials. Ranitidine produced ... Currently approved CCBs bind to L-type calcium channels located on the vascular smooth muscle, cardiac myocytes, and cardiac ... In some cases intravenous calcium has been administered 1 g calcium chloride or 3 g calcium gluconate over 5 minutes and ... may be potentiated by calcium channel blockers. When used concomitantly, anesthetics and calcium blockers should be titrated ...
http://diltiazem.kvir.info
*  Epilepsy drugs could treat Alzheimer's and Parkinson's
BioMed »Epilepsy »L-type »Molecular Target »STM »T-type »calcium channel »neurodegenerative disorder »signaling pathway ... Further reports about: , BioMed , Epilepsy , L-type , Molecular Target , STM , T-type , calcium channel , neurodegenerative ... by L-type and T-type calcium channel blockers, suggesting that more than one calcium-signaling mechanism exists to regulate ... They found that neurons showed an increase in viability after treatment with either L-type or T-type calcium channel inhibitors ...
http://www.innovations-report.com/hrml/reports/studies/epilepsy-drugs-treat-alzheimer-039-s-parkinson-039-s-142477.html
*  James C. Barrow, Harleysville US - Patent applications
Pyridyl Amide T-Type Calcium Channel Antagonists - The present invention is directed to pyridyl amide compounds which are ... PYRAZINYL AMIDE-T TYPE CALCIUM CHANNEL ANTAGONISTS - The present invention is directed to pyrazinyl amide compounds which are ... HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS - The present invention is directed to heterocycle amide compounds which ... Quinazolinone T-Type Calcium Channel Antagonists - The present invention is directed to quinazolinone compounds which are ...
http://www.patentsencyclopedia.com/inventor/james-c-barrow-harleysville-us-1/
*  R-type calcium channel - Wikipedia
The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms ... "Entrez Gene: CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit". Soong TW, Stea A, Hodson CD, Dubel SJ, ... This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in ... They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have ...
https://en.wikipedia.org/wiki/R-type_calcium_channel
*  Q-type calcium channel - Wikipedia
The Q-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the ... They are poorly understood, but like R-type calcium channels, they appear to be present in cerebellar granule cells. They have ... Q-Type Calcium Channel at the US National Library of Medicine Medical Subject Headings (MeSH). ... one that determines most of the channel's properties. ...
https://en.wikipedia.org/wiki/Q-type_calcium_channel
*  P-type calcium channel - Wikipedia
The P-type calcium channel is a type of voltage-dependent calcium channel. Similar to many other high-voltage-gated calcium ... P-type calcium channels play a similar role to the N-type calcium channel in neurotransmitter release at the presynaptic ... There are many different types of calcium channels, so to prove that the P/Q type calcium channels are directly involved, a P/Q ... corresponds to what is functionally defined as the P-type and Q-type isoforms. P-type and Q-type calcium channels are closely ...
https://en.wikipedia.org/wiki/P-type_calcium_channel
*  T-type calcium channel - Wikipedia
Long-Lasting calcium channels). The new T-type channels were much different from the L-type calcium channels due to their ... T-type calcium channels are low-voltage activated calcium channels that open during membrane depolarization. These channels aid ... Calcium channel blockers (CCB) such as mibefradil can also block L-type calcium channels, other enzymes, as well as other ... Novel T-type calcium channel inhibitors have recently been discovered which more selectively target the CaV3.3 channel sub-type ...
https://en.wikipedia.org/wiki/T-type_calcium_channel
*  N-type calcium channel - Wikipedia
... which is also similar to another type of calcium channels, known as P-type calcium channels. N-type calcium channels are ... N-type calcium channels are voltage gated calcium channels that are distributed throughout the entire body. These channels are ... The inhibition of this channel by calcium channel blockers can lead to renal microcirculation. N-type calcium channels have ... N-type calcium channels have known functions in the kidney, and heart. There are many known N-type calcium channel blockers, ...
https://en.wikipedia.org/wiki/N-type_calcium_channel
*  L-type calcium channel - Wikipedia
The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated ... This channel has four subunits (Cav1.1, Cav1.2, Cav1.3, Cav1.4). L-type calcium channels are responsible for the excitation- ... In cardiac myocytes, the L-type calcium channel passes inward Ca2+ current and triggers calcium release from the sarcoplasmic ... Rossier, Michel F. (2016). "T-Type Calcium Channel: A Privileged Gate for Calcium Entry and Control of Adrenal Steroidogenesis ...
https://en.wikipedia.org/wiki/L-type_calcium_channel
*  Targetable T-type Calcium Channels Drive Glioblastoma | Cancer Research
... which inhibits the T-type calcium channel Cav3.2. This calcium channel was highly expressed in human GBM specimens and enriched ... Targetable T-type Calcium Channels Drive Glioblastoma. Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, ... Targetable T-type Calcium Channels Drive Glioblastoma. Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, ... Targetable T-type Calcium Channels Drive Glioblastoma. Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, ...
http://cancerres.aacrjournals.org/content/77/13/3479
*  Voltage-dependent L-type calcium channel - DrugBank
Voltage-dependent L-type calcium channel subunit alpha-1C. Q13936. Details. Voltage-dependent L-type calcium channel subunit ... Voltage-dependent L-type calcium channel subunit alpha-1F. O60840. Details. Voltage-dependent L-type calcium channel subunit ... Voltage-dependent L-type calcium channel subunit beta-1. Q02641. Details. Voltage-dependent L-type calcium channel subunit beta ... Voltage-dependent L-type calcium channel subunit beta-3. P54284. Details. Voltage-dependent L-type calcium channel subunit beta ...
https://www.drugbank.ca/bio_entities/BE0008715
*  Mus musculus calcium channel, voltage-dependent, T type, alpha 1G subu - Nucleotide - NCBI
Mus musculus calcium channel, voltage-dependent, T type, alpha 1G subunit (Cacna... Mus musculus calcium channel, voltage- ... Mus musculus calcium channel, voltage-dependent, T type, alpha 1G subunit (Cacna1g), transcript variant 3, mRNA. NCBI Reference ... See the reference protein sequence for voltage-dependent T-type calcium channel subunit alpha-1G isoform c (NP_001171359.1). ... Calcium Regulation in the Cardiac Cell Calcium Regulation in the Cardiac CellCalcium is a common signaling mechanism, as once ...
https://www.ncbi.nlm.nih.gov/nuccore/NM_001177888
*  Marine Drugs | Free Full-Text | Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives
... were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel ... Keywords: N-type calcium channel; Cav2.2; channel blocker; pain; FLIPR N-type calcium channel; Cav2.2; channel blocker; pain; ... were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Cav2.2 channel ... Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives. Ellen C. Gleeson 1,2. ...
http://www.mdpi.com/1660-3397/13/4/2030