calcium/calmodulin dependent protein kinase II inhibitor 1. Intracellular. 9.5. 1.37e-7. ... transmembrane p24 trafficking protein 2. Membrane, Intracellular. 69.3. 3.36e-6. HK1. hexokinase 1. Intracellular. 41.4. 3.39e- ... The Human Protein Atlas project is funded. by the Knut & Alice Wallenberg Foundation. ... phosphatidylcholine transfer protein. Intracellular. 2.3. 3.43e-6. ZDHHC4. zinc finger DHHC-type palmitoyltransferase 4. ...

Calcium supplementation during sepsis exacerbates organ failure and mortality via calcium/calmodulin-dependent protein kinase ... Parenteral calcium for intensive care unit patients. Cochrane Database Syst Rev. 2008;4:CD006163.DOIPubMedGoogle Scholar ... Besides age and diagnostic PCR Ct value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently ... Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently ...

ADAMTS9: ADAM metallopeptidase with thrombospondin type 1 motif 9; CAMK1D: Calcium/calmodulin-dependent protein kinase 1D; ... Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J. Biol. Chem., 281: 28858- ... This gene product is an integral membrane protein that is a G-protein coupled 7-transmembrane receptor, its predominant ... Cyclin-dependent kinase inhibitor 2A/2B; FTO: Fat mass and obesity associated; HHEX: Haematopoietically expressed homeobox; ...

Stratton studies Ca2+/calmodulin dependent protein kinase II (CaMKII), a calcium-sensitive protein encoded by four genes in ... MOLECULAR UNDERSTANDING OF CALCIUM-SENSITIVE PROTEIN COULD EXPLAIN THE MYSTERIES OF LONG-TERM MEMORY - AND MORE ... Investigating Long-Term Memory at the Molecular Level Through a Calcium-Sensitive Protein ... either because of a mutation in this specific protein or because of mutations in other proteins that impact long-term memory," ...

calcium/calmodulin-dependent protein kinase kinase 1 Synonyms:. CaM-KK , cam-kk alpha , cam-kk1 , camkk 1 , camkka [-] ( ...

Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation ... Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation ... Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation ... Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation ...

Here the authors show that protein kinase D1 is inactivated by excitotoxicity in a model of stroke and that its activation can ... that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-dependent mechanism mediated by protein ... Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on ... Protein kinase D1 (PKD1), together with PKD2 and PKD3, constitute a family classified within the calcium/calmodulin-dependent ...

... protein kinase A; and CaMKII alpha: calcium/calmodulin-dependent protein kinase II alpha) [101, 102, 103, 104]. These kinases ... Ocular dominance plasticity is stably maintained in the absence of alpha calcium calmodulin kinase II (alphaCaMKII) ... As a second messenger, calcium activates many intracellular signaling cascades mainly including three critical kinases (ERK: ... Calcium: a second messenger. Glutamate-gated AMPA and NMDA receptors regulate intracellular calcium level. ...

... studies have indicated that β-carotene intake alleviates brain fog through the calcium/calmodulin-dependent protein kinase IV ( ... Kinase, Language, Mental Health, Molecule, Nutrients, Pandemic, Protein, Vegetables, Vitamin A, Vitamin C, Vitamin E, Vitamins ... and protein-protein interaction networks lead to cognitive dysfunction.. Importantly, cognitive function is not stable, as it ... Tags: Aging, Alzheimers Disease, Anti-Inflammatory, Antioxidant, Beta-Carotene, Blood, Brain, Brain Fog, Calcium, Cancer, ...

Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 ... CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. ... CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. ...

Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase DMI-3 OS=Medicago trun…. ... Protein kinase-like. 1515. 2. 118606. Recoverin. - Molecular Function: calcium ion binding (GO:0005509). Calcium-binding EF- ... Symbols: ATCPK2, CPK2 , CPK2 (CALMODULIN-DOMAIN PROTEIN KINASE CDPK ISOFORM 2); calcium- and c…. ... Protein kinase. - Molecular Function: protein kinase activity (GO:0004672). - Molecular Function: ATP binding (GO:0005524). - ...

enables calcium-dependent protein serine/threonine kinase activity IBA Inferred from Biological aspect of Ancestor. more info ... enables calmodulin-dependent protein kinase activity IBA Inferred from Biological aspect of Ancestor. more info ... MAP kinase-activated protein kinase 2. Names. MAPK-activated protein kinase 2. MAPKAP kinase 2. NP_032577.1. *EC 2.7.11.1 ... Mapkapk2 MAP kinase-activated protein kinase 2 [Mus musculus] Mapkapk2 MAP kinase-activated protein kinase 2 [Mus musculus]. ...

20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin -dependent protein kinase II-induced mitogen-activated protein ... protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). ... Rozengurt, E. (2011). Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda), ... Fields, A. P., & Murray, N. R. (2008). Protein kinase C isozymes as therapeuthic targets for treatment of human cancers. ...

Source Reference: Ozcan L, et al "Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression ... The improvements also occurred when they knocked out downstream processes, including p38 and MAPK-activating protein kinase 2 ( ... Mouse Studies Point to Kinase as Diabetes Treatment Target. by Kristina Fiore, Staff Writer, MedPage Today November 24, 2013 ... Although kinases can act very generally, Tabas said he and colleagues are working on an allosteric version that will more ...

Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II. ... The Differential Regulation of p38a by the Neuronal Kinase Interaction Motif Protein Tyrosine Phosphatases, a Detailed ... Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46 ... Oligonucleotides , Peptides , Bioconjugation , Organic Synthesis , Molecular Biology , Protein Services , Bioanalytical , ...

The granule cell enriched Ca(2+)/calmodulin dependent protein kinase (Cam kinase-Gr) may serve as a calcium activated switch ... Axons ; Calcium ; Calmodulin ; Protein kinases ; Cerebral cortex ; Immunohistochemistry ; Chromatin ; Rats ; Electron ... Nuclear and Axonal Localization of Ca(2+)/Calmodulin-Dependent Protein Kinase Type Gr in Rat Cerebellar Cortex.. ... Cam kinase-Gr is also evident in the axons of granule cells and present to a lesser extent in the cytoplasm and dendrites of ...

Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase ... Parsons RG, Davis M . A metaplasticity-like mechanism supports the selection of fear memories: role of protein kinase a in the ... Alkon DL . Calcium-mediated reduction of ionic currents: a biophysical memory trace. Science 1984; 226: 1037-1045. ... Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods 2013; ...

Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. J Immunol ... It is one member of a large family of genes comprised of cAMP-dependent anion transporter cell membrane proteins. These imp... ... It belongs to a larger related multifamily of cAMP-dependent anion transporter cell membrane molecules. These key proteins are ... Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. J Nutr;138(10):1859-65. 2008 ...

Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin ... Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proceedings of the ... Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. The Journal of ...

The CaMKII (calcium/calmodulin-dependent protein kinase II) pathway regulates key cellular processes and functions throughout ... An NIH-funded research project found that calcium modulator CaMKII protects the optic nerve in mice, opening the door to new ...

1996) Localization of alpha type II calcium calmodulin-dependent protein kinase at glutamatergic but not gamma-aminobutyric ... ChR2 activation of IL neurons reduces freezing in a frequency- and time-dependent manner. A, Top left, Green areas represent ... 2007) Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron ... 2013) Inhibition of the PI3 kinase cascade in corticolimbic circuit: temporal and differential effects on contextual fear and ...

calcium/calmodulin dependent protein kinase IV , CaMK IV , CaMK-GR , CaMKIV , caMK ... calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited ... The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/ ...

60 different kinases, including well-established targets and novel targets. ... Tocriscreen Kinase Inhibitor 3.0 is a bioactive compound library of 210 kinase inhibitors supplied pre-dissolved in DMSO, ... calcium/calmodulin-dependent protein kinases, 4%) and Other Kinases (includes CAMKK, CK1 and STE, 14%). ... Major IUPHAR kinase subfamilies covered by Tocriscreen Kinase Inhibitor 3.0 Library. TK (tyrosine kinase, 29%); CMGC (includes ...

Calcium/calmodulin-dependent protein kinase II mediates Group I metabotropic glutamate receptor-dependent protein synthesis and ... Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. ... protein isolation, protein synthesis assays, Western blotting, genotyping, RNA isolation and qPCR miRNA/mRNA arrays, ... Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein- ...

pThr286]Ca2+/calmodulin-dependent protein kinase II (rat) (α subunit) monoclonal antibody (22B1) - ALX-802-009 ... polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase ... pThr286]Ca2+/calmodulin-dependent protein kinase II (rat) (α subunit) monoclonal antibody (22B1). ... Ca2+/Calmodulin-dependent Protein Kinase II) thiophosphorylated at (Thr286).. ...

Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone. J ...

CAMK2B encodes calcium/calmodulin-dependent protein kinase type II subunit β, a kinase expressed in the brain that has an ... Abbvie reports preclinical profile of kinase inhibitor ABBV-712. * Aurinia Therapeutics AUR-300 proven useful in systemic ... Current antiviral agents for COVID-19 treatment target viral proteins, which are susceptible to mutation during SARS-CoV-2 ... A potential strategy to fight emerging drug resistances is the development of compounds targeting host proteins that are ...

"Identification of Small Molecule Inhibitors and Heterobifunctional Degraders of Calcium/calmodulin Dependent Protein Kinase ... "The development of selective kinase inhibitors to treat autoimmune disease finding a cure for Dr. Jekyll and Mr. Hyde" ... "High-throughput chemistry accelerates the optimization of small molecule therapeutics, chemical biology probes, and protein ...

During breeding season, CALM and calcium/calmodulin-dependant protein kinase 2 (CaMK2) levels are highest in the hypothalamus ... mammalian ependymin-related protein (MERP) and the iroquois-class homeodomain protein 2 (IRX2). The TATA box binding protein ( ... mammalian ependymin-related protein (MERP) and the iroquois-class homeodomain protein 2 (IRX2). The TATA box binding protein ( ... It also includes the calcium binding protein 4, which has an important role in synaptic function in photoreceptor cells [54] ...