Low-threshold spikes - Wikipedia
Shahidul (ed.). Calcium Signaling. Advances in Experimental Medicine and Biology. Vol. 740. pp. 1219-47. doi:10.1007/978-94-007 ... Antiepileptic drugs can control absence seizures by inhibiting the T-type calcium channels which prevents low-voltage calcium ... T-type calcium channels have been known to play a role in the spike-and-wave discharges of absence seizures. ... The T-type calcium channel is found in neurons throughout the brain. These channels produce particularly large currents in ...
Cofactor (biochemistry) - Wikipedia
Calcium is, therefore, a cell signaling molecule, and not usually considered a cofactor of the enzymes it regulates. Other ... Clapham DE (2007). "Calcium signaling". Cell. 131 (6): 1047-58. doi:10.1016/j.cell.2007.11.028. PMID 18083096. S2CID 15087548. ... Calcium is another special case, in that it is required as a component of the human diet, and it is needed for the full ... Niki I, Yokokura H, Sudo T, Kato M, Hidaka H (October 1996). "Ca2+ signaling and intracellular Ca2+ binding proteins". Journal ...
Cyclic ADP-ribose - Wikipedia
cADPR is a cellular messenger for calcium signaling. It stimulates calcium-induced calcium release at lower cytosolic ... Galione A, Chuang K (2020). "Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores". Calcium Signaling ... Lee HC (2011). "Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling". Science China Life Sciences. 54 ... Guse AH (2004). "Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR)". Curr. Mol. ...
Fluo-3 - Wikipedia
Calcium Signaling Protocols. Humana Press, 2006 (Articles without KEGG source, Articles containing unverified chemical ... Fluo-3 is a fluorescence indicator of intracellular calcium (Ca2+), developed by Roger Y. Tsien. It is used to measure Ca2+ ... Once inside the cell, unspecific esterases cleave the ester effectively trapping fluo-3. As calcium is a key second messenger ... Tsien, R.Y. (1980). "New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis ...
Mitoplast - Wikipedia
Garg, Vivek; Kirichok, Yuriy (2019). "Patch-Clamp Analysis of the Mitochondrial Calcium Uniporter". Calcium Signalling. Methods ... Fieni, Francesca; Bae Lee, Sung; Jan, Yuh; Kirichok, Yuriy (2012). "Activity of the mitochondrial calcium uniporter varies ...
Quisqualic acid - Wikipedia
... which triggers downstream signaling cascades. Calcium signaling involves protein effectors such as kinases (CaMK, MAPK/ERKs), ... Marambaud P, Dreses-Werringloer U, Vingtdeux V (May 2009). "Calcium signaling in neurodegeneration". Molecular ... which are calcium channels that eventually increase the Calcium concentration in the cell. The effects of quisqualic acid ... Sodium and calcium ions together generate an excitatory postsynaptic potential (EPSP) that triggers action potentials. Its ...
Tmem110 - Wikipedia
TMEM110 is a positive modulator of calcium flux mediated by the STIM-ORAI signaling in vertebrates. STIMATE can physically ... Oh-hora, Masatsugu; Rao, Anjana (2008-01-01). "Calcium signaling in lymphocytes". Current Opinion in Immunology. 20 (3): 250- ... reduces the puncta formation of STIM1 at ER-PM junctions and remarkably inhibits the calcium/calcineurin/NFAT signaling axis. ... thereby coupling to and gating the ORAI calcium channels on the plasma membrane. Depletion of TMEM110 with RNAi knockdown or ...
Pathophysiology of Parkinson's disease - Wikipedia
Marambaud P, Dreses-Werringloer U, Vingtdeux V (2009). "Calcium signaling in neurodegeneration". Mol Neurodegener. 4 (1): 20. ... The activated motor neurons then transmit their signals, via action potential, to motor neurons in the spinal cord. However, ... During this time, microglia generate reactive oxygen species and release signals to recruit peripheral immune cells for an ... Alpha-synuclein activates ATM (ataxia-telangiectasia mutated), a major DNA damage repair signaling kinase. Alpha-synuclein ...
Mitochondrial membrane transport protein - Wikipedia
Nicholls DG (2005). "Mitochondria and calcium signaling". Cell Calcium. 38 (3-4): 311-7. doi:10.1016/j.ceca.2005.06.011. PMID ... load and oxidative stress The mitochondrial calcium uniporter which transports calcium from the cytosol of the cell into the ... Sam50 and Sam35 are responsible for the binding of precursors of β-barrel proteins, which contain conserved β-signal that is ... Yamano K, Yatsukawa Y, Esaki M, Hobbs AE, Jensen RE, Endo T (February 2008). "Tom20 and Tom22 share the common signal ...
Dale Sanders - Wikipedia
On top of his extensive discoveries, he has also written influential reviews on calcium signalling in plants, which have 3,300 ... Their speculations that the TPC1 channel is involved in Calcium-induced calcium release were proven for the first time in ... "The language of calcium signaling". Annual Review of Plant Biology. 61: 593-620. doi:10.1146/annurev-arplant-070109-104628. ... "The Language of Calcium Signaling". Annual Review of Plant Biology. 61 (1): 593-620. doi:10.1146/annurev-arplant-070109-104628 ...
George J. Augustine - Wikipedia
Finch, Elizabeth A.; Augustine, George J. (1998). "Local Calcium Signalling by Inositol-1,4,5-trisphosphate in Purkinje Cell ... Augustine, George J.; Santamaria, Fidel; Tanaka, Keiko (2003). "Local Calcium Signaling in Neurons". Neuron. 40 (2): 311-346. ... showing that it is triggered by a remarkably local calcium signal. He has been influential in discovering the role of several ... ISBN 978-1-60535-380-7. Augustine, George J.; Charlton, Milton P.; Smith, Stephen J. (1987). "Calcium Action in Synaptic ...
Heterosynaptic plasticity - Wikipedia
2012.) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspectives in Biology. Retrieved from http://cshperspectives ... Therefore, heterosynaptic dopamine signaling in mammals can be best represented by dopamines biological functions of mediating ...
Homosynaptic plasticity - Wikipedia
2012.) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspectives in Biology. Retrieved from http://cshperspectives ... Ca2+ is one signaling ion that causes this AMPA receptor density change by inducing a cascade of biological changes within the ... According to Hebb, these two cells are strengthened because their signaling occurs together in space and/or time, also known as ... In order to create input-specific changes in synaptic strength, the Ca2+ signal must be restricted to specific dendritic spines ...
Jean-Pierre Kinet - Wikipedia
This work eventually led to the identification of key channel proteins involved in calcium signaling in immune and other non- ... While continuing to investigate Fc𝛆RI biology, his lab also began to study calcium signaling in immune cells. ... Vig, Monika; Kinet, Jean-Pierre (January 2009). "Calcium signaling in immune cells". Nature Immunology. 10 (1): 21-27. doi: ... is a French-American immunologist known for his work studying the role of calcium signaling in the immune response. He is a ...
Biological roles of the elements - Wikipedia
Brini, Marisa; Calì, Tito; Ottolini, Denis; Carafoli, Ernesto (2013). "Intracellular Calcium Homeostasis and Signaling". ... Chlorine, potassium, magnesium, calcium and phosphorus have important roles due to their ready ionization and utility in ... "Calcium". Linus Pauling Institute, Oregon State University, Corvallis, Oregon. 1 September 2017. Retrieved 31 August 2019. ... Signals of Distinction". Anti-Cancer Agents in Medicinal Chemistry. 11 (2): 181-190. doi:10.2174/187152011795255920. PMC ...
Spiral wave - Wikipedia
Verkhratsky A, Orkand RK, Kettenmann H (1998). "Glial calcium: homeostasis and signaling function". Physiol. Rev. 78: 99-141. ... Xenopus oocyte calcium waves, and glial calcium waves in cortical tissue culture. Winfree AT. (2001). The Geometry of ... Lechleiter J, Girard S, Peralta E, Clapham D (1991). "Spiral calcium wave propagation and annihilation in Xenopus laevis ...
Regucalcin - Wikipedia
Regucalcin has a suppressive effect on calcium signaling from the cytoplasm to the nucleus in the proliferative cells. Also, ... Yamaguchi M (March 2000). "Role of regucalcin in calcium signaling". Life Sciences. 66 (19): 1769-80. doi:10.1016/S0024-3205(99 ... Yamaguchi M (August 2012). "Role of regucalcin in brain calcium signaling: involvement in aging". Integrative Biology. 4 (8): ... Yamaguchi M (May 2014). "Regulatory role of regucalcin in heart calcium signaling: Insight into cardiac failure (Review)". ...
T-cell receptor - Wikipedia
NFAT activation depends on calcium signaling. IP3 produced by PLC-γ is no longer bound to the membrane and diffuses rapidly in ... Signal 1 is provided by the T-cell receptor when recognising a specific antigen on a MHC molecule. Signal 2 comes from co- ... The signalling motifs involved in TCR signalling are tyrosine residues in the cytoplasmic tail of these adaptor proteins that ... Binding of IP3 to calcium channel receptors on the endoplasmic reticulum (ER) induces the release of calcium (Ca2+) into the ...
Parvalbumin - Wikipedia
Parvalbumin is a small, stable protein containing EF-hand type calcium binding sites. It is involved in calcium signaling. ... Therefore, calcium-binding proteins must distinguish calcium in the presence of high concentrations of other metal ions. The ... Calcium binding proteins like parvalbumin play a role in many physiological processes, namely cell-cycle regulation, second ... Other calcium-binding protein markers are calretinin (most abundant subtype in DLPFC, about 50%) and calbindin. Interneurons ...
Phospholipase - Wikipedia
... an essential step in calcium signaling to regulate intracellular processes. There are four major classes, termed A, B, C, and D ... "Role of protons in calcium signaling". The Biochemical Journal. 478 (4): 895-910. doi:10.1042/BCJ20200971. ISSN 1470-8728. PMID ... Acids trigger the release of bound calcium from cellular stores and the consequent increase in free cytosolic Ca2+, ... PLCs play a central role in signal transduction, releasing the second messenger inositol triphosphate. Phospholipase D - ...
Alexei Verkhratsky - Wikipedia
Verkhratsky, Alexei; Untiet, Verena; Rose, Christine R. (7 February 2019). "Ionic signalling in astroglia beyond calcium". The ... Verkhratsky, Alexej; Orkand, Richard K.; Kettenmann, Helmut (1998). "Glial calcium: homeostasis and signaling function". ... calcium signalling, and brain ageing. He is an elected member and vice-president of Academia Europaea, of the German National ... which create ionic signals coordinated in space and time; these ionic signals control the activity of astroglial homeostatic ...
Soma (biology) - Wikipedia
Bazargani, N; Attwell, D (February 2016). "Astrocyte calcium signaling: the third wave". Nature Neuroscience. 19 (2): 182-9. ... A current theory of how such survival signals are sent from axon endings to the soma includes the idea that NGF receptors are ... 2004). "Trafficking the NGF signal: implications for normal and degenerating neurons". NGF and Related Molecules in Health and ... and this produces a signal that must be transported up the length of the axon to the nucleus. ...
Antony Galione - Wikipedia
Galione established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium signals, and ... Galiones research investigates calcium signalling. HC Lee established the concept of multiple calcium mobilising messengers ... The discovery of lysosomes as calcium stores mobilised by NAADP has identified an entirely new signalling role for these ... in 1985 followed by a PhD in 1989 for research on calcium signalling in the salivary gland of the blowfly, supervised by ...
Inositol-trisphosphate 3-kinase - Wikipedia
In this way, IP4 may actually serve to prolong the calcium signal by activating the influx of calcium stores from the ... Therefore, calcium homeostasis is essential for proper cell function and response to extracellular signals. In order to prepare ... If nature already had an energy-independent mechanism for termination of the calcium signaling pathway, why was the evolution ... ITP3K plays a role in regulating or cooperating with intracellular calcium signals that occur following the liberation of ...
Polycystin 2 - Wikipedia
Cantiello HF (June 2004). "Regulation of calcium signaling by polycystin-2". American Journal of Physiology. Renal Physiology. ... and may modulate intracellular calcium homeostasis and other signal transduction pathways. This protein interacts with ...
Tripartite synapse - Wikipedia
Perea, Gertrudis (September 2005). "Glial calcium signaling and neuron-glia communication". Cell Calcium. 38 (3-4): 375-382. ... Perea, Gertrudis (16 March 2005). "Properties of Synaptically Evoked Astrocyte Calcium Signal Reveal Synaptic Information ... Through changes in their calcium concentration excitability, astrocytes are able to detect neurotransmitters and other signals ... astrocytes are capable of producing transient changes in their intracellular calcium concentrations through release of calcium ...
Glossary of medicine - Wikipedia
"Chapter 5 Intracellular Calcium Homeostasis and Signaling". In Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life ... Contents: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z See also References Calcium - Calcium ions (Ca2+) contribute to ... Eyes signal information which is used by the brain to elicit the perception of color, shape, depth, movement, and other ... Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular ...
Inositol trisphosphate - Wikipedia
Today the IP3 signaling pathway is well mapped out, and is known to be important in regulating a variety of calcium-dependent ... Berridge, M. J. (2016). "The Inositol Trisphosphate/Calcium Signaling Pathway in Health and Disease". Physiological Reviews. 96 ... Bezprozvanny, I.; Hayden, M.R. (2004). "Deranged neuronal calcium signaling and Huntington disease". Biochemical and ... When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular ...
SK channel - Wikipedia
They are also involved in calcium signaling. SK channel activation can mediate neuroprotection in various models of cell death ... Calcium enters the cell via voltage activated calcium channels as well as through NMDA receptors. Calcium does not directly ... In addition to being activated by calcium flow through voltage-gated calcium channels, SK channels can be activated by calcium ... SK channels (small conductance calcium-activated potassium channels) are a subfamily of calcium-activated potassium channels. ...
Hilmar Bading - Wikipedia
Hilmar Badings work is focused on neuronal calcium signaling and gene regulation in the nervous system. He identified calcium ... His work highlighted the spatial aspects of calcium signals and in particular the importance of nuclear calcium in governing ... Hagenston, Anna M.; Bading, Hilmar (2011-11-01). "Calcium signaling in synapse-to-nucleus communication". Cold Spring Harbor ... Bading, Hilmar (2013-09-01). "Nuclear calcium signalling in the regulation of brain function". Nature Reviews. Neuroscience. 14 ...