The Pathology of T Cells in Systemic Lupus Erythematosus
Calcineurin Inhibitors. The most commonly used calcineurin inhibitors including cyclosporin and tacrolimus have been proven in ... through the dephosphorylating action of calcineurin [22]. (See Figure 1). Activated NF-ATc2 alters the expression of certain ... Increase in intracellular calcium activates calcineurin in the cytoplasm which enhances the action of the nuclear factor of ... currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin ...
Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis...
M. Sieber and R. Baumgrass, "Novel inhibitors of the calcineurin/NFATc hub - Alternatives to CsA and FK506?" Cell Communication ... Subsequently, Ca2+ dependent functional responses such as the activation of calcineurin and cytokine production are suppressed ...
A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid...
i,Background/Aims,/i,. Antitumor necrosis factor antibodies and calcineurin inhibitors have shown good therapeutic efficacy for ... However, calcineurin inhibitors are used mainly for inducing remission. Other drugs such as thiopurines are used for ... N. Issa, A. Kukla, and H. N. Ibrahim, "Calcineurin inhibitor nephrotoxicity: a review and perspective of the evidence," ... On the other hand, anti-TNF antibodies, such as infliximab (IFX) or adalimumab, and calcineurin inhibitors, such as cyclosporin ...
Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced...
C. Takasu, N. D. Vaziri, S. Li et al., "Treatment with dimethyl fumarate attenuates calcineurin inhibitor-induced ...
A Case Series of Gastrointestinal Tuberculosis in Renal Transplant Patients
A careful monitoring and adjustment of calcineurin inhibitors trough concentrations is warranted to avoid rejection and ... enzyme and increases calcineurin-inhibitor metabolism [32]. Rifampicin association may decrease by 2-5-fold cyclosporine [33] ... immunosuppressive regimen that included calcineurin inhibitors in both patients, and infectious complications (CMV infection in ...
GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
M. V. Jones and G. L. Westbrook, "Shaping of IPSCs by endogenous calcineurin activity," The Journal of Neuroscience, vol. 17, ...
Anti-SARS-CoV-2 Antibody Level among Renal Transplant Recipients: A Case Report from Nepal
... calcineurin inhibitors, antiproliferative agents, rapamycin inhibitors, and corticosteroids) in order to prevent rejection by ...
Combating Kidney Fibrosis
... focusing in minimization protocols and their impact in kidney transplant fibrosis emphasizing the benefit to use calcineurin ...