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*  Abstract 1480: A Cullin 4a E3 Ligase Complex Mediates Rapid Degradation of the Calcineurin Regulatory Protein MCIP1.4 In...
The modulatory calcineurin-interacting protein 1 (MCIP1) is an endogenous feedback inhibitor of calcineurin. We have previously ... These findings identify a new pathway through which it may be possible to regulate calcineurin activity in the heart. ... Abstract 1480: A Cullin 4a E3 Ligase Complex Mediates Rapid Degradation of the Calcineurin Regulatory Protein MCIP1.4 In ... Abstract 1480: A Cullin 4a E3 Ligase Complex Mediates Rapid Degradation of the Calcineurin Regulatory Protein MCIP1.4 In ...
http://circ.ahajournals.org/content/116/Suppl_16/II_305.2
*  Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction...
Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation. 2001;104:97 ...
http://hyper.ahajournals.org/content/70/1/137
*  The role of modulatory calcineurin-interacting proteins in calcineurin signaling. - Semantic Scholar
MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is ... Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback ... regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice ... Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like ...
https://www.semanticscholar.org/paper/The-role-of-modulatory-calcineurin-interacting-pro-Rothermel-Vega/d221e26404a31e613efb8603a1c32365b5faa3f9
*  Pharmacokinetics of Sublingual Versus Oral Tacrolimus in Patients Awaiting Kidney Transplantation - Tabular View -...
Calcineurin inhibitors display high pharmacokinetic (the body's effects on a drug) variability and necessitate use of blood ... Calcineurin inhibitors display high pharmacokinetic (the body's effects on a drug) variability and necessitate use of blood ... Tacrolimus (Prograf) belongs to a class of medications known as the calcineurin inhibitors. It is a maintenance drug that is ... Tacrolimus (Prograf) belongs to a class of medications known as the calcineurin inhibitors. It is a maintenance drug that is ...
https://clinicaltrials.gov/ct2/show/record/NCT00629122
*  Calcineurin - Wikipedia
Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory ... Calcineurin/NFAT signaling is required for perinatal lung maturation and function. Calcineurin has been shown to interact with ... Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporin, voclosporin, ... Wang MG, Yi H, Guerini D, Klee CB, McBride OW (1996). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and ...
https://en.wikipedia.org/wiki/Calcineurin
*  Calcineurin-like phosphoesterase - Wikipedia
The calcineurin-like phosphoesterases are a family of enzymes related to calcineurin. It includes a diverse range of ...
https://en.wikipedia.org/wiki/Calcineurin-like_phosphoesterase
*  Calcineurin B homologous protein 1 - Wikipedia
It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity ... Lin X, Sikkink RA, Rusnak F, Barber DL (Dec 1999). "Inhibition of calcineurin phosphatase activity by a calcineurin B ... Calcineurin B homologous protein 1 is protein encoded in humans by the CHP1 gene (formerly CHP). The protein encoded by this ... Calcineurin B homologous protein 1 has been shown to interact with sodium-hydrogen antiporter 1, sodium-hydrogen antiporter 3, ...
https://en.wikipedia.org/wiki/Calcineurin_B_homologous_protein_1
*  Regulator of Calcineurin 1 (RCAN1) | SpringerLink
Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived ... Calcineurin signaling and muscle remodeling. Cell. 2000;101:689-92.PubMedPubMedCentralCrossRefGoogle Scholar ... Future studies showed that the DSCR1 gene product is a calcineurin regulator, and the new name "regulator of calcineurin (RCAN ... Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007;21:3023-8.PubMedPubMedCentralCrossRef ...
https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_389
*  Calcineurin inhibitors/everolimus/methylprednisolone | SpringerLink
Calcineurin inhibitors/everolimus/methylprednisolone. Post-transplant diabetes mellitus and diabetic nephropathy: case report ...
https://link.springer.com/article/10.1007%2Fs40278-019-56682-8
*  DailyMed - Search Results for Calcineurin Inhibitors
SEARCH RESULTS for: Calcineurin Inhibitors [Drug Class] (69 results) * Share : JavaScript needed for Sharing tools. Bookmark & ...
https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Calcineurin%20Inhibitors&searchdb=class
*  Produktübersicht anti-Calcineurin A Antikörper
Ausgesuchte Qualitäts-Hersteller für Calcineurin A Antikörper. Hier bestellen. ... Monoklonale und polyklonale Calcineurin A Antikörper für viele Methoden. ... Bezeichner auf Proteinebene für anti-Calcineurin A (CAN) Antikörper calcineurin A , Calcineurin A , protein phosphatase-2B , ... Fruit Fly (Drosophila melanogaster) Calcineurin A (CAN) Interaktionspartner * results suggest a key role for calcineurin in ...
https://www.antikoerper-online.de/abstract/Calcineurin+A+
*  A Role for Calcineurin Dysfunction in Schizophrenia? | Science Signaling
A Role for Calcineurin Dysfunction in Schizophrenia? Message Subject. (Your Name) has forwarded a page to you from Science ... Miyakawa et al. subjected a strain of mutant mice that lacked forebrain calcineurin to a battery of tests and observed a ... In an accompanying article, Gerber et al. demonstrated that the PPP3CC gene, which encodes the calcineurin γ catalytic subunit ... The authors discuss possible mechanisms whereby abnormalities in calcineurin signaling could predispose to the pathogenesis of ...
http://stke.sciencemag.org/content/2003/193/TW291
*  calcineurin binding protein 1 ELISA Kits | Biocompare.com
Compare calcineurin binding protein 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, ... calcineurin binding protein 1 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based ... Your search returned 101 calcineurin binding protein 1 ELISA ELISA Kit across 8 suppliers. ...
https://www.biocompare.com/pfu/110627/soids/2-320310/ELISA_Kit/ELISA_calcineurin_binding_protein_1
*  Lirias: Calcineurin inhibitor nephrotoxicity
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with ... In this review, the authors summarize the clinical features and histologic appearance of both acute and chronic calcineurin ... The main question--whether nephrotoxicity is secondary to the actions of cyclosporine and tacrolimus on the calcineurin-NFAT ... The authors critically review the current evidence relating systemic blood levels of cyclosporine and tacrolimus to calcineurin ...
https://lirias.kuleuven.be/handle/123456789/238282
*  Redox response of the endogenous calcineurin inhibitor Adapt 78. - PubMed - NCBI
Redox response of the endogenous calcineurin inhibitor Adapt 78.. Narayan AV1, Stadel R, Hahn AB, Bhoiwala DL, Cornielle G, ... Adapt 78 (DSCR 1/calcipressin/MCIP 1) is a potent natural inhibitor of calcineurin, an important intracellular phosphatase that ... which may contribute to its known calcineurin-regulating and cytoprotective activities, and further suggest that Adapt 78 plays ... and accompanied by induction of the classic immune response mediator and calcineurin-pathway-stimulated interleukin-2. These ...
https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_reviews&from_uid=16109302
*  Do topical calcineurin inhibitors have side effects? | Dermatological Agent - Sharecare
Topical calcineurin inhibitors increase the risk of viral, bacterial, fungal, and protozoal infections, including opportunistic ...
https://www.sharecare.com/health/dermatology-drugs/do-topical-calcineurin-inhibitors-effects
*  Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila | Genetics
Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila. Teresa E. Lee, Lin Yu, Matthew J. Wolf ... Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila. Teresa E. Lee, Lin Yu, Matthew J. Wolf ... Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila. Teresa E. Lee, Lin Yu, Matthew J. Wolf ... Galactokinase Is a Novel Modifier of Calcineurin-Induced Cardiomyopathy in Drosophila Message Subject (Your Name) has forwarded ...
http://www.genetics.org/content/early/2014/07/24/genetics.114.166777.supplemental
*  Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients | Cochrane
Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients. What is the issue? ... Calcineurin inhibitors (CNI) can reduce acute transplant rejection and immediate graft loss but are associated with significant ... Calcineurin inhibitors (CNI, cyclosporin and tacrolimus) are an important part of treatment to suppress the immune system to ... Calcineurin inhibitor withdrawal or tapering for kidney transplant recipients. Cochrane Database of Systematic Reviews 2017, ...
https://www.cochrane.org/CD006750/RENAL_calcineurin-inhibitor-withdrawal-or-tapering-kidney-transplant-recipients
*  Interaction between Calcineurin and Ca2+/Calmodulin Kinase-II in Modulating Cellular Functions
... Manabu Kubokawa, Kazuyoshi ... Roles of calcineurin (CaN), a Ca2+/calmodulin- (CaM-) dependent protein phosphatase, and Ca2+/CaM-dependent protein kinase-II ( ...
https://www.hindawi.com/journals/er/2011/587359/abs/
*  Reduced exposure to calcineurin inhibitors in renal transplantation.
... Ekberg, Henrik LU ; Tedesco-Silva, Helio; Demirbas, Alper ... Calcineurin: antagonists & inhibitors, Cyclosporine: administration & dosage, Diabetes Mellitus: etiology, Graft Rejection: ... Calcineurin: antagonists & inhibitors,Cyclosporine: administration & dosage,Diabetes Mellitus: etiology,Graft Rejection: ... Reduced exposure to calcineurin inhibitors in renal transplantation.}, url = {http://dx.doi.org/10.1056/NEJMoa067411}, volume ...
https://lup.lub.lu.se/search/publication/aa04283e-d7c9-4510-af77-c47a4bcc577b
*  Spironolactone and Prevention of Calcineurin Inhibitor Toxicity in Kidney Transplant Recipients
Home » Topics » Kidney Transplantation » Research » Spironolactone and Prevention of Calcineurin Inhibitor Toxicity in Kidney ... More From BioPortfolio on "Spironolactone and Prevention of Calcineurin Inhibitor Toxicity in Kidney Transplant Recipients". * ... Spironolactone and Prevention of Calcineurin Inhibitor Toxicity in Kidney Transplant Recipients. 2014-08-27 03:17:39 , ... kidney transplant recipients receiving calcineurin inhibitors. Study Design. Allocation: Randomized, Control: Placebo Control, ...
https://www.bioportfolio.com/resources/trial/70382/Spironolactone-and-Prevention-of-Calcineurin-Inhibitor-Toxicity-in-Kidney-Transplant-Recipients.html
*  Synthesis of new calcineurin inhibitors via Pd-catalyzed cross-coupling reactions
In the present thesis, I tried to vary the central nitrogen-heterocyclic cores, the functionalised side chains and its position of attachment. As a synthetic strategy, palladium-catalyzed coupling reactions were used to introduce side chains and aryl substituents into the central heterocycle. In this way the utility of such reactions to heterocyclic systems, which were neglected so far, could be figured out. Halogen substituted diaryl heterocycles are important intermediates in the synthesis of general structures. The introduction of the desired side chains by Carbon-Carbon bond formation reactions was achieved by Sonogashira coupling and Heck coupling. Buchwald-Hartwig amination and nucleophilic substitution were used to establish side chains which are connected to the core heterocycle by heteroatom-Carbon bonds. Sonogashira reaction turned out to be the most effective and convenient method to introduce functionalized alkynyl group into the heterocyclic cores. In the present work, more than 180 ...
https://edoc.hu-berlin.de/handle/18452/15929
*  Calcineurin and Its Regulator Sra/DSCR1 Are Essential for Sleep in Drosophila | Journal of Neuroscience
2010) Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Dev Biol 344:957-967. ... Calcineurin and Its Regulator Sra/DSCR1 Are Essential for Sleep in Drosophila. Yasuhiro Nakai, Junjiro Horiuchi, Manabu Tsuda, ... 2006) The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Curr Biol 16:1435-1440. ... Calcineurin regulates sleep and locomotor activity. Why do sra mutants sleep less than wild-type flies? Sra's role as a CN ...
http://www.jneurosci.org/content/31/36/12759.full
*  Transcriptomic Analysis Reveals Genes Mediating Salt Tolerance through Calcineurin/CchA-Independent Signaling in Aspergillus...
Transcriptomic Analysis Reveals Genes Mediating Salt Tolerance through Calcineurin/CchA-Independent Signaling in Aspergillus ...
https://www.hindawi.com/journals/bmri/2017/4378627/sup/