Here we describe and characterize a new germ-granule protein in C. elegans that weve named LOTR-1, after its LOTUS and Tudor ... During C. elegans embryogenesis, germ granules demix or partition into subgranules with refined functions. We show that LOTR-1 ... This combination of LOTUS and Tudor domains can be found in the mammalian proteins TDRD5 and TDRD7, which are required during ... Author summary Germ granules are protein and RNA complexes that are critical for maintaining an animals fertility. Central to ...

... each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health ... homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, ... Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and ... Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and ...

... elegans, we conditioned the nematodes to form an association between the odorant benzaldehyde and starvation. ... Function of Protein Kinase C-1 in memory in Caenorhabditis elegans. Poster Published: June 12, 2013 ... We found that wild-type C. elegans form food-odor associations and retain them for at least 12 hours. Results show that nj1 ... Assays that utilized their naïve attractive response were performed on N2 wild-type C. elegans and the pkc-1 mutant nj1, to ...

... biology approach for glycoprotein discovery in Caenorhabditis elegans reveals glycosylated isoforms of multiple proteins with ... elegans genetic analysis.The second method that I developed is an experimental strategy for identifying proteins that contain ... elegans). Despite the classic strengths of C. elegans for cell biology and genetics, very few chemical biology approaches are ... proteins in different samples are metabolically labeled with azido-substrate analogs, the azido-labeled proteins are marked ...

Caffeine Induces the Stress Response and Up-Regulates Heat Shock Proteins in Caenorhabditis elegans. Mohammad Al-Amin, Ichiro ... Cholesterol-Responsive Metabolic Proteins Are Required for Larval Development in Caenorhabditis elegans. Ichiro Kawasaki, Myung ... Cholesterol-Responsive Metabolic Proteins Are Required for Larval Development in Caenorhabditis elegans. Ichiro Kawasaki, Myung ... Caenorhabditis elegans, a cholesterol auxotroph, showed defects in larval development upon cholesterol starvation (CS) in a ...

How glutamate transporter deletion influences behavior, longevity, and protein expression in Caenorhabditis elegans Meeting ...

Wnt signaling has been demonstrated to regulate diverse cell processes throughout the development of the Caenorhabditis elegans ... Caenorhabditis elegans / physiology* * Caenorhabditis elegans Proteins / genetics * Caenorhabditis elegans Proteins / ... Wnt signaling during Caenorhabditis elegans embryonic development Methods Mol Biol. 2008:469:103-11. doi: 10.1007/978-1-60327- ... Wnt signaling has been demonstrated to regulate diverse cell processes throughout the development of the Caenorhabditis elegans ...

The Caenorhabditis elegans sel-12 gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin. ... a Caenorhabditis elegans S182 Alzheimers disease gene". Nature. 377 (6547): 351-354. Bibcode:1995Natur.377..351L. doi:10.1038/ ... sel-12 also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly). C. elegans ... Stefan Eimer (2003). "Analysis and suppression of mutant sel-12 in C. elegans". Ph.D. Thesis, Ludwig-Maximilians Universität, ...

2008) Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans. Aging Cell, Vol ... Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans ... Over-expression of the C. elegans glyoxalase-1 orthologue CeGly decreases MG modifications of mitochondrial proteins and ... Studies of mutations affecting lifespan in Caenorhabditis elegans show that mitochondrial generation of reactive oxygen species ...

The initial 5 end of most protein-coding transcripts is removed by trans-splicing, and noncoding initiation sites have not ... RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis elegans. ... RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis elegans. The initial 5 end of most protein ... The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures Genome ...

Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a ... Sec1p/Munc18 (SM) proteine und deren Rolle in der Sekretionsregulierung in Saccharomyces cerevisiae und Caenorhabditis elegans ... Keywords: ITC; Syntaxin; SNAREs; Membrane Fusion; Neuronal Secretion; Sec1/Munc18; Biochemitry; Protein-Protein Interactions ... Schlagwörter: ITC; Syntaxin; SNAREs; Membrane Fusion; Neuronal Secretion; Sec1/Munc18; Biochemitry; Protein-Protein ...

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated ... Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated ... Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated ... Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated ...

... of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans. ...

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 2000. 97:5750 ... Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc. Natl. Acad. Sci. USA. ... In HD, the protein with the expanded polyQ may not function as effectively as the wild-type protein, and this may put neurons ( ... In contrast, in control brains there was full-length protein in the total homogenate but no nuclear protein and few huntingtin ...

gi,7505775,pir,,T23603 hypothetical protein K11D2.3 - Caenorhabditis elegans. Match: gi,46229467,gb,EAK90285.1,. score: 406.8. ... gi,7506755,pir,,T33569 hypothetical protein R160.1 - Caenorhabditis elegans. Match: gi,48097876,ref,XP_391965.1,. score: 273.9 ... gi,7448830,pir,,T15189 hypothetical protein F55A12.7 - Caenorhabditis elegans. Match: gi,19112573,ref,NP_595781.1,. score: ... gi,1078839,pir,,B49837 clathrin-associated protein AP50 homolog CEAP - Caenorhabditis elegans gi,451886,gb,AAA27981.1.... ...

PICK1 is a peripheral membrane protein conserved from Caenorhabditis elegans to the human. It is expressed in many tissues with ... The PDZ domain of PICK1 binds to a large number of membrane proteins, especially proteins with C-terminal type II PDZ-binding ... PICK1, PDZ domain, BAR domain, Protein trafficking, AMPA receptor, Long-term potentiation, Long-term depression, Synaptic ... the unique structure of PICK1 enables it to couple membrane proteins to protein-trafficking machinery. ...

... nematode egl-15 protein (Caenorhabditis elegans), g3877838; yeast Cdc 15p (Saccharomyces cerevisiae), g349757; human FGFR1 (flg ... B, in 386C (CRC), substitution of a highly conserved Glu (from C. elegans to man) by a Lys as a result of a missense mutation. ... B, in 386C (CRC), substitution of a highly conserved Glu (from C. elegans to man) by a Lys as a result of a missense mutation. ... For tumor suppressor proteins, highly conserved residues in human and mice have been instrumental in highlighting domains of ...

Several Caenorhabditis elegans hypothetical proteins.. This is a PFAM domain. For full annotation and more information, please ... Acid phosphatases are a heterogeneous group of proteins that hydrolyse phosphate esters, optimally at low pH. The catalytic ... functions of these proteins include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. Fungal ...

Caenorhabditis elegans hypothetical protein W06E11.4.. *Methanocaldococcus jannaschii (Methanococcus jannaschii) hypothetical ... This entry represents the C-terminal domain of proteins that are highly conserved in species ranging from archaea to ... A number of uncharacterised hydrophilic proteins of about 30kDa share regions of similarity. These include, ... proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that ...

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.. Nat Methods (2009 Jan) ... Backbone 1H, 15N and 13C assignments for the 21 kDa Caenorhabditis elegans homologue of brain-specific protein.. J Biomol NMR ... A Caenorhabditis elegans genetic-interaction map wiggles into view.. J Biol (2008) PMC2323036 free full-text archive. Gunsalus ... A protein domain-based interactome network for C. elegans early embryogenesis.. Cell (2008 Aug 8) PMC2596478 free full-text ...

Adachi H, Ishii N. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol ... Kamat JP, Sarma HD, Devasagayam TP, Nesaretnam K, Basiron Y. Tocotrienols from palm oil as effective inhibitors of protein ... Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) ... Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochim Biophys ...

Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans *Shu G ... Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans *Shu G ...

Protein Extract Preparation and Co-immunoprecipitation from Caenorhabditis elegans The JoVE video player is compatible with ...

Uncharacterized protein K02A2.6 OS=Caenorhabditis elegans GN=K02A2.6 PE=2 SV=1. ... Protein prediction analysis (2) Protein prediction analysis (2) Prediction based on longest six frame method >SGN-P226718 (171 ...

Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans. NJ Szewczyk, BK Peterson, SJ ... of Ras and the Mitogen-Activated Protein Kinase Pathway Promotes Protein Degradation in Muscle Cells of Caenorhabditis elegans ...

... the Caenorhabditis elegans homolog of the French Canadian Leigh Syndrome protein LRPPRC (leucine-rich pentatricopeptide repeat ... and Cardiolipin-Induced Changes of Two Caenorhabditis elegans Cytochrome c Proteins. ... Recombinant expression of Caenorhabditis elegans CYC-2.1 and CYC-2.2 allowed for detailed characterization of their structural ... We present evidence that the Snail-related transcription factor CES-1 of Caenorhabditis elegans coordinates these processes in ...

Kindlin-1 is a human homolog of the Caenorhabditis elegans protein UNC-112, a membrane-associated structural/signaling protein ... Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes ... This gene encodes a 677-amino acid protein, kindlin-1, which is thought to play a regulatory role in inhibiting oversecretion ... Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and ...

Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science ... are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo. Development ... Orthologous genes have been isolated in many different species, including Drosophila (Weigel et al.,1989), C. elegans(Mango et ... Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus. Dev. Biol. ...

... biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans ... Divide, conquer and reconstruct: How to solve the 3D structure of recalcitrant Micro-Exon Gene (MEG) protein from Schistosoma ...

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Patterson, ... The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.. Signals ... In Caenorhabditis elegans, defects in a TGF-beta-related pathway cause a reversible developmental arrest and metabolic shift at ... and associated Smad signal transduction proteins. daf-3 encodes a Smad protein that is most closely related to mammalian DPC4, ...