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E-cadherin evades endocytosis | JCB  E-cadherin evades endocytosis | JCB
E-cadherin interacts with other E-cadherin molecules on neighboring cells to form cell-cell adhesions. E-cadherin that is not ... the group shows that clathrin-dependent endocytosis removes E-cadherin that is not interacting in trans with other E-cadherins ... E-cadherins engaged in trans interactions, however, activated Rac and Cdc42, which blocked their internalization. So far it is ... E-cadherin endocytosis is blocked by IQGAP1 unless actin filaments are disrupted by Lat-A. ...
more infohttp://jcb.rupress.org/content/166/2/153.3
British Library EThOS: The molecular mechanism of cadherin-mediated adhesion  British Library EThOS: The molecular mechanism of cadherin-mediated adhesion
My work examines the role of a conserved tryptophan residue, Trp2, in the adhesive domain of cadherins that has been shown to ... Our results thus define the mechanism of cadherin adhesion as a dynamic balance between the conflicting tendencies of Trp2 to ... Structural studies have shown Trp2 to be integrated into its own cadherin domain, integrated into the domain an opposing ... Using conformation specific antibodies I show that Trp2 integrates into the domain fold of its own cadherin molecule in ...
more infohttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603783
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. | Broad Institute  Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. | Broad Institute
... we use two methods to inhibit E-cadherin function that distinguish between E-cadherin's cell-cell adhesion and intracellular ... is necessary for E-cadherin loss-induced metastasis. These findings indicate that E-cadherin loss in tumors contributes to ... Animals, Cadherins, Cell Communication, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, ... We find the E-cadherin binding partner beta-catenin to be necessary, but not sufficient, for induction of these phenotypes. In ...
more infohttps://www.broadinstitute.org/publications/broad3481
Role of classical cadherins in epidermal junction and barrier formation - Kölner UniversitätsPublikationsServer  Role of classical cadherins in epidermal junction and barrier formation - Kölner UniversitätsPublikationsServer
Loss of E-cadherin in combination with knock down of the only other epidermal classical cadherin, P-cadherin, resulted in an ... Therefore, the aim of this thesis was to ask how E-cadherin regulates tight junctions and if E-cadherin has a specific function ... Daher erscheint es wahrscheinlich, dass E-cadherin diese zellulären Prozesse im Zusammenspiel mit anderen, E-cadherin ... the question if classical cadherins are necessary or if other classical cadherins can compensate for the loss of E-cadherin. ...
more infohttp://kups.ub.uni-koeln.de/3325/
Synaptic Anchorage of AMPA Receptors by Cadherins through Neural Plakophilin-Related Arm Protein-AMPA Receptor-Binding Protein...  Synaptic Anchorage of AMPA Receptors by Cadherins through Neural Plakophilin-Related Arm Protein-AMPA Receptor-Binding Protein...
E-cadherin was stained with the same anti-E-cadherin antibody (5 μg/ml) as above. Secondary antibodies were used at a 1:300 ... The resulting cadherin-NPRAP-ABP/GRIP complexes serve as anchorages for AMPARs. Exogenous NPRAP that was bound to cadherins at ... Cadherin function at synaptic junctions. The present work suggests that cadherin intracellular domains bind NPRAP, which in ... The NPRAP-ABP complex binds cadherin and GluR2. NPRAP binds the cytoplasmic tails of E- and N-cadherin, suggesting that NPRAP- ...
more infohttp://www.jneurosci.org/content/27/32/8505
E-cadherin Immunohistochemistry Stain and Acute Erythroid Leukemia, the
Emerging Story | OMICS International  E-cadherin Immunohistochemistry Stain and Acute Erythroid Leukemia, the Emerging Story | OMICS International
E-Cadherin is calcium-dependent cell adhesion molecule encoded by CDH1 gene at chromosome 16q22.1. Ecadherin regulates cell- ... E-cadherin. E-cadherin (epithelial cadherin) is a polypeptide protein belongs to cadherins family whose primary function is to ... E-cadherin was moderately positive (≈ 40%) in immature erythroid precursors. E-cadherin stain is a useful marker that more ... E-cadherin is encoded by CDH1 gene which is located on the long (q) arm of chromosome 16 at position 22.1. [3] It is mainly ...
more infohttps://www.omicsonline.org/open-access/ecadherin-immunohistochemistry-stain-and-acute-erythroid-leukemia-theemerging-story-2157-7099-1000352.php?aid=59564
Cadherin-20  Cadherin-20
This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a ... cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since ... Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in ... Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high ...
more infohttps://pharos.nih.gov/idg/targets/Q9HBT6
CTNNB1 catenin (cadherin-associated protein), beta 1 and formation of branching point structures beta-catenin / LEF...  CTNNB1 catenin (cadherin-associated protein), beta 1 and formation of branching point structures beta-catenin / LEF...
... with cadherins; CAS-chromosome segregation 1-like (yeast) binds with E-cadherin but not with beta-catenin. Which interacts with ... cadherins (the (CDH1) E-cadherin/catenin complex) include the beta-catenins a multifunctional molecule Locus: 3p22.1 [§§; ^]. ... Catenin Beta 1, CTNNB are cell adhesion molecules called (p120*␠-catenin) cadherins (the (CDH1) E-cadherin/catenin complex) ... with cadherins; CAS-chromosome segregation 1-like (yeast) binds with E-cadherin but not with beta-catenin. Which interacts with ...
more infohttps://faroucheombre.wordpress.com/2012/03/25/ctnnb1-catenin-cadherin-associated-protein-beta-1-and-formation-of-branching-point-structures-beta-catenin-lef-demonstrating-nucleation-at-tbe1-site-tcf7l2/
2012 Group 8 Project - CellBiology  2012 Group 8 Project - CellBiology
The main difference between the two groups of cadherins is the classical cadherins contain five cadherin repeats with the third ... Cadherins are a family of transmembrane proteins formed from multiple repeats of cadherin-specific motif (a recurrent molecular ... β-Catenin binds directly to the cadherin cytoplasmic domain, with the α-catenin binding to it, connecting the cadherin protein ... Cadherins are classified into two groups: Classical Cadherins and Protocadherins. ...
more infohttps://cellbiology.med.unsw.edu.au/cellbiology/index.php/2012_Group_8_Project
Pathway Central: Remodeling of Adherens Junctions  Pathway Central: Remodeling of Adherens Junctions
... is the best-characterized Cadherin and represents the prototype of classical Cadherins. The extracellular domain of E-Cadherin ... E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin ... Ubiquitinated Ctnn-Beta and E-Cadherin is degraded in the 26S Proteasome complex. The ubiquitinated E-Cadherin may get degraded ... binds to the juxtamembrane region of E-Cadherin and stabilizes Cadherin molecules at the cell surface. Additional proteins and ...
more infohttp://www.sabiosciences.com/pathway.php?sn=Remodeling_of_Adherens_Junctions
What are Cadherins?  What are Cadherins?
Cadherins are a group of proteins that help cells stick together. They are the main components of certain types of junctions ... Classical cadherins include E-cadherin, N-cadherin, P-cadherin and N-cadherin 2. They all have a similar structure, with five ... Cadherin structure. Cadherins are named for calcium dependent adhesion. The external domain of a cadherin molecule - the part ... Cadherins' role in cancer. E-cadherin, a member of the cadherin family, has a very important role in organizing the epithelium ...
more infohttps://www.news-medical.net/health/What-are-Cadherins.aspx
E-Cadherin | SpringerLink  E-Cadherin | SpringerLink
Epithelial cadherin; Uvomorulin E-cadherin, a 120 kDa molecule, is a prototypical member of the classical cadherin family of ... Thus, E-cadherin and other members of the cadherin family play a crucial role in establishing and maintaining the integrity of ... E-cadherin, a 120 kDa molecule, is a prototypical member of the classical cadherin family of single-pass transmembrane proteins ... E-cadherin is the main adhesion molecule of the adherens junctions of epithelial cells, and via catenins it is linked to the ...
more infohttps://link.springer.com/referenceworkentry/10.1007/978-3-642-27841-9_1777-2
Cadherin-16 (IPR030721) | InterPro | EMBL-EBI  Cadherin-16 (IPR030721) | InterPro | EMBL-EBI
Cadherins are transmembrane proteins that mediate cell-cell adhesion in animals [PMID: 22833291]. Cadherin-16 (CDH16) or kidney ... CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas.. ... Expression of Ksp-cadherin during kidney development and in renal cell carcinoma.. Br. J. Cancer 92 2010-7 2005 ... CDH16 colocalises with CDH1/E-cadherin on the basolateral plasma membrane of thyrocytes, and might play a role during thyroid ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR030721
Re: cadherins  Re: cadherins
... From:. [email protected] --part1_c5.f6ea0ca.27fcf0de_boundary Content-Type: text/plain; charset='US-ASCII' ... We use Zymeds cadherins, fresh slides (a must) protease 1 4-8 min, 32 min ,BR,incubation, Hope this helps. Dana,/FONT,,/HTML ... Content-Transfer-Encoding: 7bit We use Zymeds cadherins, fresh slides (a must) protease 1 4-8 min, 32 min incubation, Hope this ...
more infohttp://www.histosearch.com/histonet/Apr01/Re.cadherins.html
Dystroglycan-type cadherin-like (IPR006644) | InterPro | EMBL-EBI  Dystroglycan-type cadherin-like (IPR006644) | InterPro | EMBL-EBI
Dystroglycan-type cadherin-like (IPR006644). Short name: Cadg Overlapping homologous superfamilies *Cadherin-like superfamily ( ... Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins.. Curr. Biol. 12 R197-9 ... In animals, cadherin domain-containing proteins are adhesion molecules that modulate a wide variety of processes including cell ... Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+- ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR006644
CDH13 cadherin 13 [Homo sapiens (human)] - Gene - NCBI  CDH13 cadherin 13 [Homo sapiens (human)] - Gene - NCBI
cadherin-13. Names. H-cadherin (heart). T-cad. T-cadherin. cadherin 13, H-cadherin (heart). heart cadherin. NP_001207417.1. *EC ... Cadherin; Cadherin domain. pfam08758. Location:74 → 159. Cadherin_pro; Cadherin prodomain like. cl09101. Location:636 → 727. E_ ... Cadherin; Cadherin domain. pfam08758. Location:27 → 112. Cadherin_pro; Cadherin prodomain like. cl09101. Location:550 → 641. E_ ... Cadherin; Cadherin domain. pfam08758. Location:27 → 112. Cadherin_pro; Cadherin prodomain like. cl09101. Location:589 → 680. E_ ...
more infohttps://www.ncbi.nlm.nih.gov/gene?term=%28human%5BOrganism%5D%29%20AND%20CDH13%5BGene%20Name%5D
CDH5 cadherin 5 [Homo sapiens (human)] - Gene - NCBI  CDH5 cadherin 5 [Homo sapiens (human)] - Gene - NCBI
cadherin-5. Names. 7B4 antigen. VE-cadherin. cadherin 5, type 2 (vascular endothelium). cadherin 5, type 2, VE-cadherin ( ... CA; Cadherin repeats. pfam00028. Location:263 → 364. Cadherin; Cadherin domain. pfam01049. Location:633 → 775. Cadherin_C; ... CA; Cadherin repeats. pfam00028. Location:272 → 373. Cadherin; Cadherin domain. pfam01049. Location:635 → 786. Cadherin_C; ... CA; Cadherin repeats. pfam00028. Location:272 → 373. Cadherin; Cadherin domain. pfam01049. Location:635 → 786. Cadherin_C; ...
more infohttps://www.ncbi.nlm.nih.gov/gene/1003
E-Cadherin: Novus Biologicals  E-Cadherin: Novus Biologicals
E-Cadherin in Cell-Cell Adhesion and Cancer Diagnostics. E-Cadherin is a member of the cadherin superfamily and is fundamental ... E-Cadherin as a Cancer Biomarker. E-cadherin is a calcium-regulated adhesion molecule expressed in most normal epithelial ... E-cadherin is also associated with gland formation, stratification, and epithelial polarization, while loss of E-cadherin can ... Specifically, E-cadherin is an approximately 100 kDa epithelial cell glycoprotein whose extracellular domain interacts with ...
more infohttps://www.novusbio.com/antibody-news/tag/e-cadherin
Cadherin Types and Role in Cell-Cell Adhesion  Cadherin Types and Role in Cell-Cell Adhesion
Cadherins are Ca2+ dependent cell-cell adhesion molecules that mediate adhesion between cells and tissues in organisms. They ... E-Cadherin. This cadherin is present in epithelial cells, hence the name 'E-Cadherin'. Defects in E-Cadherin adhesion have been ... N-Cadherin. This cadherin is present in neurons, fibroblasts, and muscle cells, hence the name 'N-Cadherin'. Defects in N- ... P-Cadherin P-Cadherins are found in placenta and mutations in this cadherin have been associated with hypotrichosis with ...
more infohttps://www.news-medical.net/life-sciences/Cadherin-Types-and-Role-in-Cell-Cell-Adhesion.aspx
VE-cadherin - wikidoc  VE-cadherin - wikidoc
VE-cadherin is a classical cadherin from the cadherin superfamily and the gene is located in a six-cadherin cluster in a region ... Cadherin 5, type 2 or VE-cadherin (vascular endothelial cadherin) also known as CD144 (Cluster of Differentiation 144), is a ... "Entrez Gene: CDH5 cadherin 5, type 2, VE-cadherin (vascular epithelium)".. *↑ Corada M, Liao F, Lindgren M, Lampugnani MG, ... "Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin". Arterioscler ...
more infohttps://www.wikidoc.org/index.php/VE-cadherin
Anti-pan Cadherin antibody (ab74635) | Abcam  Anti-pan Cadherin antibody (ab74635) | Abcam
Rabbit polyclonal pan Cadherin antibody validated for IHC and tested in Human, Mouse, Rat, Chk, Cow, Dog, Xl and Mk. Immunogen ... This antibody recognizes members of the Cadherin family of proteins including E-cadherin, N-cadherin, P-cadherin and R-cadherin ... In adhesion junctions cadherins are bound to beta and gamma catenins which in turn bind to alpha catenin, an actin binding ... Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. Individual ...
more infohttp://www.abcam.com/pan-cadherin-antibody-ab74635.html
Human pan Cadherin peptide (ab17098) | Abcam  Human pan Cadherin peptide (ab17098) | Abcam
Buy our Human pan Cadherin peptide. Ab17098 is a blocking peptide for ab16505 and has been validated in BL. Abcam provides free ... In adhesion junctions cadherins are bound to beta and gamma catenins which in turn bind to alpha catenin, an actin binding ... Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. Individual ... Cadherins are members of a multigene family of single chain glycoprotein receptors mediating calcium dependent cell-cell ...
more infohttps://www.abcam.com/human-pan-cadherin-peptide-ab17098.html
E-Cadherin Antibody (Dako Omnis) | Agilent  E-Cadherin Antibody (Dako Omnis) | Agilent
Down-regulation of E-cadherin expression has been observed in a number of carcinomas and is usually associated with advanced ... cadherin is a 120 kDa transmembrane cell adhesion molecule. It has a significant function in intercellular adhesion of ... Anti-E-cadherin, NCH-38 recognizes the 120 kDa mature form and 82 kDa fragment of E-cadherin in Western blots of A431 cells ... FLEX Monoclonal Mouse Anti-Human E-Cadherin Clone NCH-38 Ready-to-Use (Dako Omnis) - EN / FR / DE Instructions for Use, Code ...
more infohttps://www.agilent.com/en/product/immunohistochemistry/antibodies-controls/primary-antibodies/e-cadherin-
N-cadherin: stabilizing synapses | JCB  N-cadherin: stabilizing synapses | JCB
2010) show that overexpression of N-cadherin augments spine stability. Furthermore, knockdown of N-cadherin or expression of a ... How does synaptic activity regulate the expression and localization of N-cadherin? Can N-cadherin function as a tag for ... N-cadherin mediates plasticity-induced long-term spine stabilization. J. Cell Biol. 189:589-600. doi:10.1083/jcb.201003007. ... Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. Trends Neurosci. 31:487-494. doi:10.1016/j ...
more infohttp://jcb.rupress.org/content/189/3/397.full
Evolution and diversity of cadherins and catenins  Evolution and diversity of cadherins and catenins
Epithelial cadherin (E-cadherin) is the founding cadherin family member. Its cytoplasmic tail interacts with the armadillo ... major cadherins, protocadherins and cadherin-related proteins. These superfamily members are involved in diverse fundamental ... Cadherin genes encode a superfamily of conserved transmembrane proteins that share an adhesive ectodomain composed of tandem ... Even genomes of ancestral metazoan species such as cnidarians and placozoans encode a limited number of distinct cadherins and ...
more infohttps://insights.ovid.com/pubmed?PMID=28268172