Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative ... Ensemble dynamics of hippocampal regions CA3 and CA1 Neuron. 2004 Nov 18;44(4):581-4. doi: 10.1016/j.neuron.2004.11.003. ... Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative ... The results provide converging evidence that CA3 is capable of performing nonlinear transformations of sensory input patterns, ...

Title: Spike-based computational models of bio-inspired memories in the hippocampal CA3 region on SpiNNaker. Authors: Daniel ... This is possible thanks to the recurrent collateral network architecture that constitutes CA3, the main sub-region of the ... This region of the brain acts as a short-term memory with the ability to store associations of information from different ... In this work, we developed two spike-based computational models of fully functional hippocampal bio-inspired memories for the ...

Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in ... Hippocampal pathology is central to Alzheimers disease (AD) and other forms of dementia such as frontotemporal lobar ... CA1 Region, Hippocampal / pathology * CA2 Region, Hippocampal / pathology * CA3 Region, Hippocampal / pathology ... Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. Consistent with ...

In male rats, TRAP significantly increased hippocampal neurogenesis, while in females, TRAP increased granule cell layer width ... 2). Sex did not significantly affect the outcome in any hippocampal region (CA1: F (1,19) = 1.717, p = 0.514; DG: F (1,19) = ... 2e, Students t test, p = 0.058). Within the CA1 and CA3, TRAP had no significant effect on GFAP (Fig. 2d, CA1 p = 0.690; CA3 p ... Overlapping tiles were stitched together to create final images for each hippocampal subregion (dentate gyrus, CA1, CA3). ...

CA3 also sends a small set of output fibers to the lateral septum. The region is conventionally divided into three divisions. ... Diagram of hippocampal regions in a rat brain. Jerome Engel TAP, ed. Epilepsy: A Comprehensive Textbook in Three Volumes. ... The pyramidal cells in CA3 send some axons back to the dentate gyrus hilus, but they mostly project to regions CA2 and CA1 via ... CA3 has been implicated in a number of working theories on memory and hippocampal learning processes. Slow oscillatory rhythms ...

1993b) Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region. Eur J ... e, EGFP-expressing cells in the hilus of the dentate gyrus near the hilar-CA3 border. f, g, EGFP expression in area CA3 of the ... 1994) Inhibitory CA1-CA3-hilar region feedback in the hippocampus. Science 265:1722-1724. ... Cell counting was performed to determine the colocalization of EGFP with GABAergic cell markers in various hippocampal regions ...

1a-c). The highest presence at this age was in the dentate gyrus (DG) and hippocampal CA3 layer (CA3). Strong epichaperome ... Regions of study were designated by using Panoramic Viewer Software (3DHistech Ltd, Budapest, Hungary). Regions were exported ... 1: The epichaperome is expressed in the PS19 mouse brain in a region- and age-dependent manner.. ... Regions of interest were digitally drawn around respective brain regions and background corrected values were converted into ...

The temporal lobe is the most epileptogenic region of the brain. In fact, 90% of patients with temporal interictal epileptiform ... Hippocampal sclerosis involves hippocampal cell loss in the CA1 and CA3 regions and the dentate hilus. The CA2 region is ... Hippocampal sclerosis. Approximately two thirds of patients with temporal lobe epilepsy treated surgically have hippocampal ... The temporal lobe is the most epileptogenic region of the brain. In fact, 90% of patients with temporal interictal epileptiform ...

Hippocampal cytoarchitecture was visualized with Nissl staining. The secretion of inflammatory factors as well as the marker ... Down-regulating MAPK phosphorylation level protected epilepsy by inhibiting hippocampal neuron apoptosis and enhancing ... hippocampal neuron cell viability. Losmapimod effectively improved the memory ability, reduced the frequency of the seizures, ... Hippocampal cytoarchitecture was visualized with Nissl staining. The secretion of inflammatory factors were detected by western ...

1990) Interleukin-1β inhibits long-term potentiation in the CA3 region of mouse hippocampal slices. Eur J Pharmacol 181:323-326 ... CA3), stratum oriens and radiatum (sr) of CA1 and CA3 areas, and stratum lucidum CA3 (C, D, G, H, arrowheads).f, Fissura ... 1997) Interleukin-1β does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the ... and CA3 (Fig.3E) areas. Scattered, faintly stained neurons were observed in control sections of CA3 area (Fig. 3E) and in the ...

... heterozygote double-knockout mice exhibit stronger ERK activation in the hippocampal CA3 pyramidal cell layer and hilar region ... All Spry proteins exhibit a highly conserved C-terminal cysteine-rich region and a variable N-terminal region, both containing ... Apart from cell death in the core region, ischemia induces a series of morphological and biochemical alterations in the ... Activation of Spry2 (conserved cysteine-rich region in green) in response to receptor tyrosine kinase (RTK) stimulation is ...

Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of ... Surgical Menopause Enhances Hippocampal Amyloidogenesis Following Global Cerebral Ischemia. Scott, E.L.; Zhang, Q.G.; Dong, Y ... Long-term estrogen deprivation leads to elevation of Dickkopf-1 and dysregulation of Wnt/?-Catenin signaling in hippocampal CA1 ...

... cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via ... into the spatially more specific place cell activity characteristic of the CA3 region. Furthermore, the dentate gyrus is ... The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes. Several lines of evidence ... Furthermore, several types of GABAergic interneurons are present in this region, providing inhibitory control over granule cell ...

... neuronal injury and apoptosis in rat hippocampal tissues. The effects caused by propofol were attenuated by esketamine. ... The morphological changes of neurons in the hippocampal CA1, CA3 and dentate gyrus (DG) regions were observed under a ... HE staining was used for histopathological observation of the rat hippocampi in CA1, CA3 and DG regions. Results show that ... a) Representative images of HE staining for detecting the morphological changes of neurons in rat hippocampal CA1 region. The ...

CA3 and dentate gyrus regions. The results show a significant increase of CO activity in all of the regions studied in the ... The animal group maintained in the control environment showed decreased CO activity in the hippocampal areas studied (CAl, CA3 ... A total of 4 sections per animal and hippocampal region studied were used. ... this is the first time this technique has been used to determine oxidative metabolism of these hippocampal areas (CA1, CA3 and ...

The brain was cut into three coronal sections to observe the structure of hippocampal CA1, CA3 and DG regions. After dewaxing, ... NMN treatment alleviated microglial and astrocyte activation and inhibited inflammatory response in hippocampal CA1 at 8 days ... Scale bar: 40 nm (n =3 per group). B) Quantitative analysis of NEUN fluorescence intensity in CA1 region (n =3 per group). C) ... Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal ...

WSEs attenuated damage to hippocampal neurons in the CA2 and CA3 region by 80%.24 In stress models, rodents pretreated with WSE ... Neuroprotective effects of Withania somnifera Dunn in hippocampal sub-regions of female albino rat. Phytother Res. 2001;15(6): ... Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of- ...

B) Confocal micrographs of immunostaining for FXGs, indicated by FXR2P, in mossy fibers in the CA3 and CA4 regions, ... Hippocampal FXGs are lost in adulthood in the Mus genus. Our findings that adult hippocampal FXGs are rare in two different M. ... Because guinea pig hippocampus is more elaborated than that in other rodents with defined CA4 and CA3 regions, we quantified ... We observed FXGs in P2 animals in axons of all examined brain regions including mossy fibers, CA3 associational fibers, ...

Cholinergic suppression of glutamatergic synaptic transmission in hippocampal region CA3 exhibits laminar selectivity: ... Activation of intrinsic hippocampal theta oscillations by acetylcholine in rat septo-hippocampal cocultures. J Physiol 1999, ... Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo. J Neurosci 2010, 30: 13431- ... Primary rat hippocampal cultures were prepared according to a previously described protocol [31] with modification. Hippocampi ...

The loss of functional integration in MTL subsystem regions was predictive of autobiographical episodic retrieval performance. ... CA3) hippocampal subfield supports recent, but not remote, episodic retrieval. In this study, we demonstrated that recent and ... We conclude that human CA3 is necessary for the retrieval of episodic memories long after their initial acquisition and ... Graph theoretic analyses of 7.0-Tesla resting-state fMRI data revealed that CA3 damage disrupted functional integration across ...

... round granules surrounded by fine target-like punctate staining within the CA3 region of the hippocampus and hippocampal ... Minimal PrP Deposition in Restricted Brain Regions. Figure 3. Figure 3. Neuropathology in transgenic mice following inoculation ... the presence and severity of disease-specific vacuolation in 9 standard gray matter regions and 3 white matter regions, a ... hippocampal formation, basal ganglia, and thalamus in humans with VPSPr (5). The PrP-positive granules within the hippocampus ...

... current generator underlying cholinergically induced gamma frequency field potential oscillations in the hippocampal CA3 region ... N. Hájos and O. Paulsen, "Network mechanisms of gamma oscillations in the CA3 region of the hippocampus," Neural Networks, vol ... I. Oren, E. O. Mann, O. Paulsen, and N. Hájos, "Synaptic currents in anatomically identified CA3 neurons during hippocampal ... and hippocampal [77] pyramidal cells. The discrepancies between findings for hippocampal versus neocortical PVChCs highlight ...

Hippocampal sections of 3- and 12-month-old WT and KO mice were stained for NeuN and neurons counted in the CA1, CA2, and CA3 ... The spectra were acquired in m/z 300-2000 region in the positive ion mode [M+Na]+. For every spectrum acquisition, 10,000 shots ... D and E) Hippocampal neuron loss (D) and Purkinje cell loss (E) was attenuated by mannose restriction (n = 6 per group; 2-way ... The progressive loss of hippocampal neurons (Figure 8D and Supplemental Figure 6B) and Purkinje cells (Figure 8E and ...

Mouse hippocampal neurons, isolated from the CA1-CA3 region, were cultured on micro-islands (Bekkers and Stevens, 1991; ... Hippocampal culture preparation: All procedures in this study were approved by the Animal Care Committee of Indiana University ... We tested myrcenes impact on CB1 signaling in autaptic hippocampal neurons using whole-cell, patch-clamp recording. At 1μM, ... Straiker A and Mackie K (2007) Metabotropic suppression of excitation in murine autaptic hippocampal neurons. J Physiol 578(Pt ...

Dentate Gyrus and CA3 Region of the Hippocampus. In this drawing, Cajal details the finer structure of hippocampal dentate ... which make mossy fiber synapses onto pyramidal cells in the CA3 region. The relatively narrow focus of this piece allowed Cajal ... The interstitial nuclei of Cajal are a group of neurons in the diencephalon region of the brain that are involved in the ... Signals from the retina (A) enter the brain by the optic nerve (B) and terminate in two different brain regions - the lateral ...

Montgomery SM, Buzsáki G (2007) Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task ... Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013) [Model]. ... Magee JC (1999) Dendritic lh normalizes temporal summation in hippocampal CA1 neurons. Nat Neurosci 2:508-14 [Journal] [PubMed] ... Fisahn A, Yamada M, Duttaroy A, Gan JW, Deng CX, McBain CJ, Wess J (2002) Muscarinic induction of hippocampal gamma ...

... and dorsal hippocampal area CA3 (dCA3) in rats at different time-points after a single 2-hour exposure to immobilization stress ... We observed enhancements in neuronal translation in both brain regions 1 hour after stress. This initial increase persisted in ... Hippocampal and amygdalar cell-specific translation is similar soon after stress but diverge over time.. Title. Hippocampal and ... Hippocampal and amygdalar cell-specific translation is similar soon after stress but diverge over time.. ...

Lead levels were detected in blood (41.1μg/dl) and brain (16.7-29.4μg/g). Concentrations of lead in various brain regions did ... The hippocampal formation is a critical neural structure for learning and memory processes, whereas cortical and subcortical ... CA3 stratum radiatum and presubiculum, and in the agranular insular, cingulate, entorhinal, orbital, parietal and perihinal ... A similar strategy but using probes which correspond to the unique regions of human UDPGT-Br1 and human UDPGT-Br2 showed that ...

... unusually in the hilar ambit of the dentate gyrus and the CA1 and CA3 regions (Thom et al. In one happened, a threefold ... Equal of the most frequent histologic abnormalities observed in roughly 66% of patients with TLE is hippocampal sclerosis or ... terminal region. Youve seen the headlines speech that many than one-half of English adults are corpulent treatment zinc ...

Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo. J Neurophysiol 87:669-78 [ ... Heterogeneity of synaptic plasticity at unitary CA3-CA1 and CA3-CA3 connections in rat hippocampal slice cultures. J Neurosci ... McMahon DB, Barrionuevo G (2002) Short- and long-term plasticity of the perforant path synapse in hippocampal area CA3. J ... Jonas P, Sakmann B (1992) Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal ...