Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in ... Hippocampal pathology is central to Alzheimers disease (AD) and other forms of dementia such as frontotemporal lobar ... CA1 Region, Hippocampal / pathology * CA2 Region, Hippocampal / pathology * CA3 Region, Hippocampal / pathology ... Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. Consistent with ...

The temporal lobe is the most epileptogenic region of the brain. In fact, 90% of patients with temporal interictal epileptiform ... Hippocampal sclerosis involves hippocampal cell loss in the CA1 and CA3 regions and the dentate hilus. The CA2 region is ... Hippocampal sclerosis. Approximately two thirds of patients with temporal lobe epilepsy treated surgically have hippocampal ... The temporal lobe is the most epileptogenic region of the brain. In fact, 90% of patients with temporal interictal epileptiform ...

The Avpr1b is prominent in hippocampal CA2 pyramidal cells and in the anterior pituitary corticotrophs. Decades of research on ... The Avpr1b is prominent in hippocampal CA2 pyramidal cells and in the anterior pituitary corticotrophs. Decades of research on ... Hitti, F. L., and Siegelbaum, S. A. (2014). The hippocampal CA2 region is essential for social memory. Nature 508, 88-92. doi: ... Possible points of intersection between hippocampal (HIPP) Avpr1b, which are localized to pyramidal cells in the CA2 region, ...

It is now well-established that the hippocampal CA2 region plays an important role in social recognition memory in adult mice. ... Development of the hippocampal CA2 region and the emergence of social recognition ... Postnatal development of hippocampal CA2 structure and function during the emergence of social recognition of peers ... Adult-born granule cells (abGCs) project to the CA2 region of the hippocampus, but no previous studies have assigned a ...

They pass through hippocampal commissures to reach contralateral regions of hippocampus. Hippocampal commissures have dorsal ... Commissural fibers that originate from CA3 Pyramidal cells go to CA3, CA2 and CA1 regions. Like mossy cells, a single CA3 ... Hippocampal sulcus (sulc.) or fissure is a cell-free region that separates the CA1 field from the dentate gyrus. Because the ... Fimbria-fornix fibers are the hippocampal and subicular gateway to and from subcortical brain regions. Different parts of this ...

1992) Nuclear and cytoplasmic localization of basic fibroblast growth factor in astrocytes and CA2 hippocampal neurons. J ... A, Immunoreactivity is observed within hippocampal parenchyma, demonstrating successful antibody penetration into this region ... A, Colocalization of FGF-2-IR (brown) and GFAP-IR (pink) within area CA2 demonstrates that both the pyramidal cells in CA2 (P, ... within hippocampal area CA2 (A) and dentate gyrus (B) and immunofluorescence confocal images localizing FGF receptor-1 (FGFR1) ...

WSEs attenuated damage to hippocampal neurons in the CA2 and CA3 region by 80%.24 In stress models, rodents pretreated with WSE ... Neuroprotective effects of Withania somnifera Dunn in hippocampal sub-regions of female albino rat. Phytother Res. 2001;15(6): ... Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of- ...

2021) Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social ... 2022) A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. ...

... researchers have determined that a small region of the hippocampus known as CA2 is essential for social memory, the ability of ... The hippocampal CA2 region is essential for social memory. Nature, Published Online February 23 2014. doi: 10.1038/nature13028 ... A few studies have suggested that CA2 might be involved in social memory, as this region has a high level of expression of a ... "However, the role of CA2, a relatively small region of the hippocampus sandwiched between CA3 and CA1, has remained largely ...

D,β1(-/-) mice stained with anti-Nav1.1 illustrating lack of staining of many neurons in the CA2/CA3 region and in the outer ... Voltage-clamp analysis of hippocampal neurons. Hippocampal neurons from young littermate mice (16-18 d postnatal) were acutely ... CA2, and CA3 (Kearney et al., 2001). Ectopic expression of Nav1.3 in this region would be predicted to result in ... but Nav1.1 expression is reduced and Nav1.3 expression is increased in a subset of pyramidal neurons in the CA2/CA3 region, ...

Hippocampal sections of 3- and 12-month-old WT and KO mice were stained for NeuN and neurons counted in the CA1, CA2, and CA3 ... The spectra were acquired in m/z 300-2000 region in the positive ion mode [M+Na]+. For every spectrum acquisition, 10,000 shots ... D and E) Hippocampal neuron loss (D) and Purkinje cell loss (E) was attenuated by mannose restriction (n = 6 per group; 2-way ... The progressive loss of hippocampal neurons (Figure 8D and Supplemental Figure 6B) and Purkinje cells (Figure 8E and ...

We recorded spontaneous synchronized epileptiform bursts from hippocampal slices from guinea pig using an array of 16 ... extracellular electrodes placed over the stratum pyramidale of CA2 and CA3. The slices were made epileptogenic with the GABA ... These results indicate that CA2 is a unique region which must possess unusual cellular and/or synaptic connectivity properties ... The initiation and spread of epileptiform bursts in the in vitro hippocampal slice Neuroscience. 1987 May;21(2):441-55. doi: ...

Lead exposure caused a decrease in [3H] MK-801 binding to NMDA receptors in the hippocampal formation including CA2 stratum ... Lead levels were detected in blood (41.1μg/dl) and brain (16.7-29.4μg/g). Concentrations of lead in various brain regions did ... A similar strategy but using probes which correspond to the unique regions of human UDPGT-Br1 and human UDPGT-Br2 showed that ... The hippocampal formation is a critical neural structure for learning and memory processes, whereas cortical and subcortical ...

2014). The hippocampal CA2 region is essential for social memory. Nature. 508:88-92. ... We are now examining the CA2 neural circuitry in more detail to determine how this region participates in memory encoding. As ... 2010). Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop. Neuron 66:560-572. ... 2014). Dendritic Na(+) spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons. ...

Field, Hippocampus CA2 Hippocampal CA2 Region Hippocampal Sector CA2 Hippocampus CA2 Field Region, Hippocampal CA2 Sector CA2, ... Hippocampal CA2 Region. Hippocampal Sector CA2. Hippocampus CA2 Field. Radiatum, CA2 Stratum. Radiatums, CA2 Stratum. Region, ... Hippocampal CA2. Sector CA2, Hippocampal. Stratum Pyramidale, CA2. Stratum Radiatum, CA2. Stratum Radiatums, CA2. ... CA2 Field, Hippocampus. CA2 Pyramidal Cell Area. CA2 Pyramidal Cell Layer. CA2 Stratum Pyramidale. CA2 Stratum Radiatum. CA2 ...

5. High-power micrographs of CA2 hippocampal region of two typical treatment and glutamate treatment groups. Nearly normal ... 5. High-power micrographs of CA2 hippocampal region of two typical treatment and glutamate treatment groups. Nearly normal ... A consistent pattern was recognized in all regions examined. The results are summarized according to hippocampal region in ... Greater loss of cellularity in all regions aside from DG (D ). Magnified CA2 region shows greater loss of cellularity in ...

... severely targets the hippocampal formation in humans and mouse models of this condition. The adult hippocampus hosts the ... DGC axons (named Mossy fibers) contact the CA3 and CA2 hippocampal regions [3,4,5]. The third synapse of the circuit is ... The hippocampus is one of the brain areas most affected in patients with AD [1]. This region is divided into the CA1, CA2, CA3/ ... As a result of adult hippocampal neurogenesis (AHN), new DGCs are incorporated into the hippocampal circuit throughout life. ...

Abbreviations: anterior commissure, Aca; hippocampal subfields, CA1, CA2, CA3; corpus callosum, cc; dentate gyrus, DG; dorsal ... The µ-opioid receptor (MOR), also known as OPRM1, is highly expressed in several brain regions and the most targeted opioid ... Additional phenotypic characterization is recommended for brain region and experimental paradigm of interest. ...

Social memory and the role of the hippocampal CA2 region. Front Behav Neurosci. 2019;13:233. ... Young WS, Li J, Wersinger SR, Palkovits M. The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is ... influences hippocampal neurophysiological activity [38], raising the temperature of hippocampal slices increases excitatory ... Similar results were found in brain homogenates in three different regions in which Il1b, Il6, Cox2 and Rankl mRNA levels were ...

The Dendrites of CA2 and CA1 Pyramidal Neurons Differentially Regulate Information Flow in the Cortico-Hippocampal Circuit. J ... Hippocampal" by people in this website by year, and whether "CA1 Region, Hippocampal" was a major or minor topic of these ... "CA1 Region, Hippocampal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "CA1 Region, Hippocampal" by people in Profiles. ...

Role of Hippocampal CA2 how can i get lioresal Region in Triggering Sharp-Wave Ripples. Individual Differences in Motor ...

Brain-State- and Cell-Type-Specific Firing of Hippocampal CA2 Region in Triggering Sharp-Wave Ripples. For this analysis, CA1 ... hypothesized causal link between neural activity during the cheap generic trazodone intense visual stimuli used in this region ...

Transmission Electron Microscopy (TEM) was performed to observe the ultrastructure of hippocampal cornu ammonis (CA)1 (CA1) ... "Identifying core regions for path integration on medial entorhinal cortex of hippocampal formation," Brain Sciences, vol. 10, ... CA2, CA3, and dentate gyrus (DG). The CA1 has been reported to be linked with depression [23]. Accordingly, we chose to focus ... Y. Li, Y. Luo, J. Tang et al., "The positive effects of running exercise on hippocampal astrocytes in a rat model of depression ...

In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and ... Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region ... Isolation of region-specific astrocytes and RNA-Seq were performed to determine differential gene expression in animals that ... By using the amygdala (AMY) and white matter (WM) as reference regions, MBH:AMY and MBH:WM T2 signal ratios were calculated as ...

Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model. ... Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding. Neuron. 2018;100(4):926- ... Reset of hippocampal-prefrontal circuitry facilitates learning. Nature. 2021;591(7851):615-619. ... Differential Synaptic Dynamics and Circuit Connectivity of Hippocampal and Thalamic Inputs to the Prefrontal Cortex. Cereb ...

Quantitatively, granule cells of the dentate gyrus were most numerous, followed by CA1, subiculum, CA4, and CA2-3. In the ... keywords = "Abeta, Alzheimer{\textquoteright}s disease, CA1 region, Dentate gyrus, Stereology, Tauopathy", ... The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, ... N2 - The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of ...

Distinct labels for CA1 and CA2 Immunolabeling (purple, CA2); transgenic EGFP (green, proximal CA1); transgenic tdTomato (red, ... Graves AR, Moore SJ, Bloss EB, Mensh BD, Kath WL, Spruston N. Hippocampal pyramidal neurons comprise two distinct cell types ... Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1. Proc Natl Acad Sci U.S.A. 106:11794-99, ... Mizuseki K, Diba K, Pastalkova E, Buzsaki G. Hippocampal CA1 pyramidal cells form functionally distinct sublayers. Nature ...

... γ3 and γ4 stargazin-like proteins are detected only in the CNS and display differential distributions among brain regions and ... The hippocampus stains for γ2 and γ4 throughout the layers of the every CA region and the dentate gyrus, whilst γ3 appears to ... In the CA2, staining of neuropil and cell bodies is more intense than in CA1. G. Staining of the soma of the CA3 hippocampal ... CA2 and CA3 regions of Ammons horn strained strongly, with lesser immunostaining in the subiculum and CA4 regions (Figure 5A ...

Interestingly, we also observed neuronal degeneration in CA2, CA3 and dentate gyrus regions of the hippocampus, with injury ... Amnesia with hippocampal lesions after cardiopulmonary arrest. Neurology. 1984. 34. 679. 681. 6538660. DeOlmos. JS. Ingram. WR ... but survivors often show evidence of injury in selectively vulnerable regions of the brain. In humans, vulnerable regions ... and CA1 hippocampal neurons after cardiac arrest (. Fig. 5F. ) but demonstrated only faint staining of neurites in VPm (. Fig. ...