TY - JOUR. T1 - Servo controlled versus manual cooling methods in neonates with hypoxic ischemic encephalopathy. AU - Buchiboyina, Ashok. AU - Ma, Eric. AU - Yip, Andrew. AU - Wagh, Deepika. AU - Tan, Jason. AU - McMichael, Judy. AU - Bulsara, Max K.. AU - Rao, Shripada. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Background Therapeutic hypothermia is known to improve outcomes in neonates with hypoxic ischemic encephalopathy (HIE). There are no studies that have compared servo controlled cooling (SCC) versus manually controlled cooling (MCC) methods in HIE. Aim To compare the outcomes of SCC versus MCC in neonates with HIE. Methods and outcome measures Between Jan 2008 and May 2011, MCC with cool-gel packs was used to achieve rectal temperatures of 33.5 to 34.5 °C in our units. Subsequently, we changed to SCC to achieve rectal temperatures of 33 to 34 °C. 105 neonates received SCC whereas 95 received MCC. Retrospective study with multivariate analysis was conducted comparing thermoregulation (primary ...
... and ethical grounds that a person dies when brain death occurs.1Yet, the brain is highly vulnerable to a... ... The singular importance of the brain to life is exemplified by agreement on medical, legal, ... Brain Ischemia Global Ischemia Focal Ischemia Ischemic Brain Injury Global Brain Ischemia These keywords were added by machine ... Nemoto E.M. (1985) Brain Ischemia. In: Lajtha A. (eds) Alterations of Metabolites in the Nervous System. Springer, Boston, MA. ...
It is well-established that ischemia leads to very complex and heterogenous changes in microcirculation and metabolism of the ... Raichle, M. A., 1983, The pathophysiology of brain ischemia, Ann. Neurol., 13: 2.PubMedCrossRefGoogle Scholar ... Middle Cerebral Artery Brain Cortex Sham Control Ischemic Brain Damage Stroke Group These keywords were added by machine and ... Microcirculation and Mitochondrial Function in Focal Brain Ischemia. In: Longmuir I.S. (eds) Oxygen Transport to Tissue VIII. ...
This reduction in blood flow restricts oxygen to the brain and may result in dead brain tissue, cerebral infarction... ... Cerebral or brain ischemia occurs when there is not enough blood flow to the brain. ... Brain ischemia may be categorized as focal ischemia or global ischemia, and the cause for ischemia can range from congenital ... brain ischemia may result in irreversible brain damage, stroke or cardiac arrest. Treatments for brain ischemia include ...
Brain ischemia is an interruption of the supply of blood to the brain, which disrupts the flow of oxygen and nutrients that are ... Brain ischemia is an interruption of the supply of blood to the brain, disrupting the flow of oxygen and nutrients needed to ... Most commonly, brain ischemia involves not the carotid artery, but one of the smaller blood vessels in the brain. Blood vessels ... When brain ischemia involves the areas of the brain responsible for regulating functions such as breathing and heart rate, this ...
Role of oxygen free radicals in carcinogenesis and brain ischemia.. Floyd RA1. ... may be a key event in stroke-induced brain injury. Oxygen free radicals may play a key role in carcinogenesis by mediating ... recent results show that oxidative damage plays a key role in brain injury that occurs in stroke. Subtle changes, such as ...
... Call for Papers. Brain injury of diverse ... Transient global ischemic brain injury may result from cardiac arrest where cerebral perfusion diminishes to the point that ... How different or similar the mechanisms of these two brain injuries and their management are and whether they can be grouped ... We invite our peers to submit original research and review articles that seek to define the mechanisms of brain injury after ...
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Brain Ischemia: Alzheimers Disease Mechanisms. Ryszard Pluta, MD, PhD (Editor). Head of Laboratory of Ischemic and ... Chapter 9. Dual Role of Autophagy in Ischemia-Reperfusion Brain Injury: Linking Ischemic Autophagy to Alzheimers Disease. ( ... Dual Role of Mitophagy Following Ischemia-Reperfusion Brain Injury: Ischemic Mitophagy Link to Alzheimers Disease. (Marzena ... Chapter 4. Alzheimers Disease-Related Proteins Following Ischemia-Reperfusion Brain Injury. (Ryszard Pluta, MD, PhD, Marzena ...
... Ling-Hua Tang, Zhong-Yuan Xia ... It has been confirmed that PCr is effective in preventing and treating cardiac and renal ischemia-reperfusion injury. In this ... indicated that PCr can decrease the morphological damage and the neuron apoptosis of the ischemia-reperfusion injury brain ... Compared with sham-operated group (sham group), TUNEL-positive cells, MDA, and level of CaM activity increased in ischemia- ...
Affiliations: Center of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, University of South ... Rather than the conventional cell replacement mechanism, we advance alternative pathways of graft-mediated brain repair ...
Focal brain ischemia occurs when a blood clot has occluded a cerebral vessel. Focal brain ischemia reduces blood flow to a ... During brain ischemia, the brain cannot perform aerobic metabolism due to the loss of oxygen and substrate. The brain is not ... The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. Symptoms of brain ischemia can include ... Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is insufficient blood flow to ...
... brain disorder) abbreviated? H/I stands for Hypoxia-Ischemia (brain disorder). H/I is defined as Hypoxia-Ischemia (brain ... New trends in brain hypoxia ischemia research. Effects of the 21-amino steroid tirilazad mesylate (U-74006F) on brain damage ... and practitioners contribute nine chapters on recent and significant research on brain hypoxia-ischemia. ... S.v. "H/I." Retrieved March 21 2019 from https://www.acronymfinder.com/Hypoxia_Ischemia-(brain-disorder)-(H%2fI).html ...
Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery ... surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. A single intranasal ... reduced neurologic deficit scores and recovery from cerebral ischemia. Intranasally delivered FBP might be a promising strategy ... that by obstructing Fas signaling in cerebral ischemia inhibits apoptosis. ...
Brain ischemia may be analyzed from two different perspectives: that of oxygen deprivation (hypoxic damage per se) and that of ... systems are needed in order to dissect and clarify which molecular mechanisms have to be promoted and/or blocked.Brain ischemia ... is one of the players deregulated after ischemia and OGD. In addition, neuroprotective intervention either by estradiol or by ... Intense efforts are being undertaken to understand the pathophysiological mechanisms triggered after brain ischemia and to ...
... studies have suggested both exercise and mitochondrial biogenesis contribute to improved post-ischemic recovery of brain ... In the ischemia-exercise group, only peroxisome proliferator activated receptor coactivator-1 (PGC-1) expression was increased ... On the other hand, the benefit of exercise-induced mitochondrial biogenesis in brain has been confirmed. In this study, we ... We subjected adult male rats to ischemia, followed by either treadmill exercise or non-exercise and analyzed the effect of ...
... in brain tissue in simulated ischemia in rats. The study seeks to cast light on NO as a signalling molecule in a modeled ... "The development of brain ischemia is often commonly referred to not only by physicians, but also other "specialists" as James ... In this new study, the team of scientists conducted experimental analysis of NO role in brain tissue in simulated ischemia in ... Nitric oxide: Experimental analysis of its role in brain tissue in simulated ischemia. Pensoft Publishers ...
Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.. ... Docosahexaenoic acid released from membrane phospholipids during brain ischemia is a major source of lipid peroxides. Leukocyte ... The newly discovered brain messenger 10,17S-docosatriene potently inhibited leukocyte infiltration, NFkappaB, and ... These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid ...
What to look for to determine whether you have a childbirth brain injury case and the settlement value of these medical ... Causes of Infant Brain Ischemia Infant brain ischemia can occur when blood and oxygen flood to the baby are cut off or ... Brain ischemia occurs when brain cells are permanently damaged due to a lack of adequate blood flow. The human brain requires a ... Types of Injuries Caused by Infant Brain Ischemia Brain ischemia is not an injury but rather the name of a medical condition ( ...
PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.. [Sofiyan Saleem, Hean Zhuang, Artur J de Brum-Fernandes, ... Development of drugs to stimulate the DP1 receptor in brain could provide a new therapeutic strategy against cerebral ischemia ... Ischemia-reperfusion injury was produced by a 90-min occlusion of the right middle cerebral artery followed by a 4-day ... Therefore, in this study, the effect of the DP1 receptor on the outcome of cerebral ischemia in wildtype (WT) and DP1 knockout ...
... a cerebral ischemia-reperfusion (I/R) group, and (iii) an I/R+bexarotene group. Brain water content was measured by the dry wet ... Results After 24 h, 48 h, and 72 h post-I/R, several effects were observed with bexarotene administration: (i) brain water ... in the ischemic brain. The retinoid X receptor agonist bexarotene suppresses MMP-9 expression in endothelial cells and displays ... over-expression disrupts the blood-brain barrier (BBB) ... Brain damage Is the Subject Area "Brain damage" applicable to ...
A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia. Mei Li, Meiling Sun, Lijuan Cao, Jin-hua Gu, ... We hypothesized that TIGAR plays a neuroprotective role in brain ischemia as neurons do not rely on glycolysis but are ... We found that TIGAR was highly expressed in brain neurons and was rapidly upregulated in response to ischemia/reperfusion ... Supplementation of NADPH also reduced ischemia/reperfusion brain injury and alleviated TIGAR knockdown-induced aggravation of ...
2. Brain Ischemia Overview. 3. Pipeline Therapeutics*An Overview of Pipeline Products for Brain Ischemia ... Pipeline Therapeutics assessment of products for Brain Ischemia. The report assesses the active Brain Ischemia pipeline ... Brain Ischemia - Pipeline Insight, 2018 report offers comprehensive Insight of the pipeline (under development) therapeutics ... Table 1: Total Products for Brain Ischemia. Table 2: Products in Clinical Stage. Table 3: Products in Non-clinical Stage. Table ...
... activity and pathological outcome following transient cerebral ischemia, which was induced in 33 chronically … ... Outcome after ischemia in the developing sheep brain: an electroencephalographic and histological study Ann Neurol. 1992 Jan;31 ... The length of this depression correlated with the duration of ischemia (r = 0.88). After 30 or 40 minutes of ischemia, EEG ... After 10 or 20 minutes of ischemia, EEG activity was depressed and then progressively recovered and mild selective neuronal ...
This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN ... Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. ... Brain Ischemia (Cerebral Ischemia). Subscribe to New Research on Brain Ischemia Localized reduction of blood flow to brain ... Cerebral Ischemia; Encephalopathy, Ischemic; Ischemia, Cerebral; Brain Ischemias; Cerebral Ischemias; Ischemia, Brain; ...