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*  Bongkrekic acid | CAS 11076-19-0 | SCBT - Santa Cruz Biotechnology
Buy Bongkrekic acid (CAS 11076-19-0), an apoptosis inhibitor through prevention of PARP cleavage, from Santa Cruz. Purity: ≥98 ... Bongkrekic acid (CAS 11076-19-0) Bongkrekic acid , CAS 11076-19-0 is rated 5.0 out of 5 by 1. ... Bongkrekic acid is a mitochondrial permeability transition pore blocker that acts as an inhibitory ligand of the mitochondrial ... PubMed ID 15063741) used bongkrekic acid to inhibit mitochondrial adenine nucleotide translocase 3 (ANT3)-mediated apoptosis in ...
https://www.scbt.com/scbt/product/bongkrekic-acid-11076-19-0/
*  Associated Effluxes of Calcium and Adenine Nucleotides from Mitochondria: Mediation by Thyroxine and other Agents, and...
... and Inhibition by Bongkrekic Acid and Adenosine Diphosphate. MUTHANNA H. AL-SHAIKHALY, HAROLD BAUM ... and Inhibition by Bongkrekic Acid and Adenosine Diphosphate Message Subject (Your Name) has forwarded a page to you from ... and Inhibition by Bongkrekic Acid and Adenosine Diphosphate ... and Inhibition by Bongkrekic Acid and Adenosine Diphosphate ...
http://www.biochemsoctrans.org/content/7/1/215
*  The mitochondrial transporter family (SLC25): physiological and pathological implications | SpringerLink
McGivan (1992) Amino acid transport in mitochondria. In: Kilberg MS, Häussinger D (eds) Mammalian amino acid transport. Plenum ... bongkrekic acid. CAC. carnitine/acylcarnitine carrier. CATR. carboxyatractyloside. CoA. coenzyme A. CIC. citrate carrier ... Aquila H, Misra D, Eulitz M, Klingenberg M (1982) Complete amino acid sequence of the ADP/ATP carrier from beef heart ... since their polypeptide chains consist of three tandemly related sequences of about 100 amino acids, and the repeats of the ...
https://link.springer.com/article/10.1007%2Fs00424-003-1099-7
*  Plus it
... bongkrekic acid; BAPTA/AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; CsA, cyclosporin A; CsH, cyclosporin H; ...
http://cancerres.aacrjournals.org/content/61/10/3894
*  TCDB » SEARCH
Sulfate and phosphate are also transported using an antiport mechanism (Todisco et al. 2014). Inhibited by bongkrekic acid. ... The mitochondrial basic amino acid transporter, in mBAC1 (transports the basic L-amino acids arginine, lysine, ornithine, and ... Basic amino acid carrier2, BAC2 of 296 aas and 6 TMSs. This hyperosmotic stress-inducible porter transports proline in addition ... The main physiological role of SLC25A29 is to import basic amino acids into mitochondria for mitochondrial protein synthesis ...
http://tcdb.org/search/result.php?tc=2.A.29.7
*  KAKEN - Research Projects | Elucidaton of molecular mechanism of remodeling for cardiolipin (KAKENHI-PROJECT-26450139)
Journal Article] Bongkrekic Acid Analogue, Lacking One of the Carboxylic Groups of its Parent Compound, Shows Moderate but pH- ... Journal Article] Efficient Total Synthesis of Bongkrekic Acid and Apoptosis Inhibitory Activity of its Analogues2015. *. Author ...
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26450139/
*  Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide...
Finally, both bongkrekic acid and NAC significantly reduced spontaneous Ca(2+) wave occurrences under PC. Altogether, these ... Inhibition of ANT by bongkrekic acid (20 μM) prevented PC-induced mitochondrial ROS production. In addition, PC increased type ... Long chain fatty acids bind to carnitine and form long chain acyl carnitine (LCAC), to enter into the mitochondria. They are ...
https://www.ncbi.nlm.nih.gov/pubmed/25619687
*  Jasmonates: Novel Anticancer Agents Acting Directly and Selectively on Human Cancer Cell Mitochondria | Cancer Research
... bongkrekic acid + methyl jasmonate (BA + MJ)-treated (•) and bongkrekic acid + cyclosporine A + methyl jasmonate (BA + CSA + MJ ... Cyclosporine A (CSA) at 10 μmol/L and/or bongkrekic acid (BA) at 50 μmol/L were added 15 minutes before the addition of methyl ... Cyclosporine A and bongkrekic acid prevented the effect of methyl jasmonate ( Fig. 3B). In contrast, methyl jasmonate and ... Methyl jasmonate at 1 mmol/L, with or without cyclosporine A (0.25 μmol/L) and/or bongkrekic acid (50 μmol/L) was added for 24 ...
http://cancerres.aacrjournals.org/content/65/5/1984.full
*  Bongkrek acid - Wikipedia
Bongkrek acid (also known as bongkrekic acid) is a respiratory toxin more deadly than other mitochondrial poisons cyanide or 2, ... Garcia, R. A.; Hotchkiss, J. H.; Steinkraus, K. H. (1999). "The Effect of Lipids on Bongkrekic (Bongkrek) Acid Toxin Production ... Henderson, P. J. F.; Lardy, H. A. (1970). "Bongkrekic Acid: An Inhibitor of Adenine Nucleotide Translocase of Mitochondria" ( ... "Structure of Bongkrekic Acid". Tetrahedron. 29 (11): 1541-1547. doi:10.1016/S0040-4020(01)83395-0. Bhavbhuti M. Mehta, Afaf ...
https://en.wikipedia.org/wiki/Bongkrek_acid
*  β-Phenylethyl isothiocyanate mediated apoptosis; Contribution of Bax and the mitochondrial death pathway | ScholarBank@NUS
Bongkrekic acid. CsA. cyclosporine A. glutathione. GSH. mBCl. mitochondrial membrane potential. mitochondrial permeability ... Accordingly, using pharmacological inhibitors of MPT namely cyclosporine A, trifluoperazine and Bongkrekic acid we were unable ...
http://scholarbank.nus.edu.sg/handle/10635/32001
*  GM 6001 - Creative Enzymes
ProductNameBongkrekic Acid, Triammonium Salt. EC No.. CAS No.11076-19-0 ...
https://www.creative-enzymes.com/product/GM-6001_2533.html
*  Mitochondria in energy-limited states: mechanisms that blunt the signaling of cell death | Journal of Experimental Biology
ADP and bongkrekic acid) (Brustovetsky et al., 2002). However, the occurrence of an in vivo MPTP in N. crassa mitochondria was ... Bcl-2 protects against apoptosis induced by antimycin A and bongkrekic acid without restoring cellular ATP levels. Biochim. ...
http://jeb.biologists.org/content/211/12/1829
*  Regulation of mitochondrial permeability transition pore by PINK1 | Molecular Neurodegeneration | Full Text
Indeed CsA treatment fully rescued the reduced TMRM fluorescence in PINK1−/− MEFs (Figure 5). Bongkrekic acid also partially ... Henderson PJ, Lardy HA: Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria. J Biol Chem. 1970 ... or Bongkrekic acid (BkA, 10 μM), or the calcineurin inhibitor FK-506 (5 μM). B. The bar graph shows quantification of calcein ... Bongkrekic acid (BkA, 10 μM, Sigma), FK-506 (5 μM, Sigma), 0.1% vehicle (DMSO), Tocopherol (50 μM, 4 hr, Sigma) or NAC (1 mM, 2 ...
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-7-22
*  Abstract: A fluorescence-based technique for screening compounds that protect against damage to brain mitochondria
These events were blocked by cyclosporin A (CsA) or Bongkrekic acid (BKA), inhibitors of the mitochondrial permeability ... Antioxidants Energy Supplements Essential Fatty Acids Multi Vitamins Probiotics Vitamins See More ». Amino Acids Minerals ...
http://www.prohealth.com/library/showarticle.cfm?libid=10742
*  Stimulation of mitochondrial calcium ion efflux by thiol-specific reagents and by thyroxine. The relationship to adenosine...
Both efflux rates were kept at a low value by bongkrekic acid added before the stimulating agent. It is concluded that Ca2+ ...
http://www.biochemj.org/content/182/2/455
*  Plus it
Inhibition of the mitochondrial ATP/ADP translocase by bongkrekic acid, which prevents ATP export from the mitochondrion, also ... Increases in cytosolic LC-CoA in the β-cell can result from glucose metabolism and from free fatty acids (FFAs) delivered by ... However, truncation of the last 26-36 amino acids from Kir6.2 (Kir6.2ΔC) allows this subunit to reach the surface membrane in ...
http://diabetes.diabetesjournals.org/content/53/suppl_3/S113
*  Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells | Molecular Cancer | Full Text
To test whether the MTP is important for ATO toxicity in T-47D cells, bongkrekic acid (BA) and cyclosporine A (CsA), both ... supporting the glutamine-TCA hub that is essential for anabolism of amino acids and fatty acids needed for cell division [16]. ... HIF-1α can up regulate the enzymes of the glycolytic pathway and lactic acid dehydrogenase, sustaining the Warburg effect in ... Subbarayan PR, Lima M, Ardalan B: Arsenic trioxide/ascorbic acid therapy in patients with refractory metastatic colorectal ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-142
*  Example Natural Products
Bongkrekic acid. adenine nucleotide translocase, mPTP Boromycin. Antiviral, Bacteriocidal. Bryostatin. PKC pathway. Oncology ...
http://isomerase.co.uk/index.php/more-info/examples
*  Acyclic Acids (Ethanoic Acids) < Carboxylic Acids << Organic Compounds (Organic Chemicals) <<< Compounds, Elements & more @...
... a 2 carbon straight-chain saturated carboxylic acid, that has an open-chain molecular structures as opposed to ring-shaped ... dicarboxylic acids *Adipates *2-Aminoadipic Acid *Dimethyl Adipimidate *Bongkrekic Acid *Fumarates *Dimethyl Fumarate * ... Acyclic Acids (Ethanoic Acids). "Acyclic Acids (Ethanoic Acids)" Acyclic Acid. In organic chemistry, Acyclic Acids (Ethanoic ... Uronic Acids *Glucuronates *Glucuronic Acid *Glucuronides *Hexuronic Acids *Iduronic Acid *Tricarboxylic Acids *Aconitic Acid * ...
http://wellnessadvocate.com/?uid=84521
*  Find Research Outputs - NYU Scholars
Bongkrekic Acid Attendance at Well-Child Visits After Reach Out and Read. Needlman, R. D., Dreyer, B. P., Klass, P. & ...
https://nyuscholars.nyu.edu/en/publications/index/
*  Government policy interventions to reduce human antimicrobial use: protocol for a systematic review and meta-analysis |...
... or bongkrekic acid? or brefeldin? or butirosin sulfate? or calcimycin? or candicidin? or capreomycin? or carbenicillin? or ... or penicillanic acid? or penicillic acid? or penicillin?? or piperacillin? or pivampicillin? or polymyxin b? or polymyxin? or ... or clavulanic acid? or clavulanic acid? or clindamycin? or cloxacillin? or colistin? or cyclacillin? or dactinomycin? or ... or fusidic acid? or gentamicin? or gramicidin? or hygromycin? or imipenem? or josamycin? or kanamycin? or kitasamycin? or ...
https://0-systematicreviewsjournal-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s13643-017-0640-2
*  Mitochondrial carrier - Wikipedia
Another inhibitor, bongkrekic acid, is believed to stabilize a second conformation, with the pit facing the matrix. In this ... amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP translocase ... 4P5W​ Mitochondrial carriers transport amino acids, keto acids, nucleotides, inorganic ions and co-factors through the ... "Functional and structural role of amino acid residues in the even-numbered transmembrane alpha-helices of the bovine ...
https://en.wikipedia.org/wiki/Mitochondrial_carrier
*  KAKEN - Researchers | ABE Masato (30543425)
Journal Article] Bongkrekic Acid Analogue, Lacking One of the Carboxylic Groups of its Parent Compound, Shows Moderate but pH- ... Journal Article] Efficient Total Synthesis of Bongkrekic Acid and Apoptosis Inhibitory Activity of its Analogues2015. *. Author ... Journal Article] Molecular design, synthesis, and evaluation of novel potent apoptosis inhibitors inspired from bongkrekic acid ... Journal Article] Molecular design, synthesis, and evaluation of novel potent apoptosis inhibitors inspired from bongkrekic acid ...
https://nrid.nii.ac.jp/nrid/1000030543425/
*  Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine
... both of which are blocked by bongkrekic acid. Virology. 2006;347(2):379-391. [PubMed] ... 1-piperazineethanesulfonic acid (HEPES), 140 mM NaCl and 2.5 mM CaCl2, pH 7.4). Resuspended cells in 100 μL of binding buffer ... Cells were washed with buffer tris/borate/ethylenediaminetetraacetic acid (EDTA) (TBE) buffer and resolved in 1% agarose gel. ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2950399/
*  CARBOXYATRACTYLATE INHIBITS THE UNCOUPLING EFFECT OF FREE FATTY-ACIDS - статья | ИСТИНА - Интеллектуальная Система...
The degree of inhibition decreases in the order: carboxyatractylate , bongkrekic acid, palmitoyl-CoA, ADP , atractylate. GDP is ... The degree of inhibition decreases in the order: carboxyatractylate , bongkrekic acid, palmitoyl-CoA, ADP , atractylate. GDP is ... CARBOXYATRACTYLATE INHIBITS THE UNCOUPLING EFFECT OF FREE FATTY-ACIDSстатья Статья опубликована в высокорейтинговом журнале ... Carboxyatractylate inhibits the uncoupling effect of free fatty-acids / A. ANDREYEV, T. BONDAREVA, V. DEDUKHOVA et al. // FEBS ...
https://istina.msu.ru/publications/article/3506037/