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*  Inhibition of osteoclast differentiation and bone resorption by N-methylpyrrolidone - Zurich Open Repository and Archive
NMP could prove useful for the treatment of osteoporosis or other bone diseases associated with excessive bone resorption. ... NMP could prove useful for the treatment of osteoporosis or other bone diseases associated with excessive bone resorption. ... Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of ... Osteoclasts are multinucleated cells that play a crucial role in bone resorption. In this study, we investigated the effects of ...
http://www.zora.uzh.ch/id/eprint/52664/
*  Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone...
Acid Phosphatase; Adult; Animals; Bone Density; Bone Resorption; Bone and Bones; Cathepsin K; Cathepsins; Cells, Cultured; ... Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone ... normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone ... and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We ...
http://www.forskningsdatabasen.dk/en/catalog/2190605663
*  Cathepsin K Expression and Activity in Canine Osteosarcoma - Schmit - 2011 - Journal of Veterinary Internal Medicine - Wiley...
... and its secretion by osteoclasts is responsible for degrading organic bone matrix. People with pathologic bone resorption have ... Serum CatK concentrations were quantified in normal dogs and dogs with OS and its utility as a bone resorption marker was ... Canine OS is associated with pathologic bone resorption, and CatK inhibitors might aid in the management of canine OS-related ... Circulating CatK concentrations will be increased in dogs with OS, and will be a surrogate marker of bone resorption. ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2011.00834.x/abstract?globalMessage=0
*  Tartrate-Resistant Acid Phosphatase (TRACP) and Alkaline Phosphatase (ALP) Detection: ELISAs and Antibodies
Bone metabolism is mutually balanced between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Two ... Either bone metabolism kit may be selected depending on user interest.. The TRACP and ALP Assay Kit allows for the simultaneous ... The Bone Specific Alkaline Phosphatase (Rat), Polyclonal antibody (Cat. # M190) was raised against a conjugate of the KLH ... An alternative option for the study of bone metabolism is the TRACP and ALP Assay Kit (Cat. # MK301), which contains a soluble ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Bone_Research/Tartrate-Resistant_Acid_Phosphatase?sitex=10020:22372:US&PEBCL1=ponLxm0pDXCL239zqObwDwBIf8&PEBCL1_pses=ZG0BE04C4D8D678C370EBE4D66FE367E7CA57CDF9DDA80E0357F04DBE8454CDB0A1A4A5805C7ACB11B839B4F83EBF4AA17F1B201758CB11EAD
*  MCP-1 Is Induced by Receptor Activator of Nuclear Factor-B Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte...
However, these cells were negative for bone resorption. In the presence of RANKL, MCP-1 significantly increased the number of ... Addition of MCP-1 reversed GM-CSF suppression of osteoclast formation, recovering the bone resorption phenotype. MCP-1 and ... and negative for bone resorption. CD1a, a dendritic cell marker, was expressed in GM-CSF, RANKL, and macrophage colony- ... TRAP-positive multinuclear bone-resorbing osteoclasts (p = 0.008). When RANKL signaling through NFATc1 was blocked with ...
https://research-repository.griffith.edu.au/handle/10072/4810
*  "Osteopetrorickets due to Snx10 deficiency in mice results from both fa" by Liang Ye, Leslie R. Morse et al.
These studies established an essential role for Snx10 in bone homeostasis and underscore the importance of gastric ... resulting in impaired bone mineralization). Osteopetrorickets, the paradoxical association of insufficient mineralization in ... and bone resorption. We also discovered that Snx10 is highly expressed in stomach epithelium, with mutations leading to high ... and bone resorption. We also discovered that Snx10 is highly expressed in stomach epithelium, with mutations leading to high ...
https://escholarship.umassmed.edu/oapubs/2487/
*  Osteopetrosis core NGS panel | Connective Tissue Gene Tests
Osteopetrosis is a disorder of increased bone density due to defects in bone resorption. Several different forms are recognized ... Osteopetrosis is a disorder of increased bone density due to defects in bone resorption. Several different forms are recognized ... OPTA1 is characterized by diffuse osteosclerosis with pronounced involvement of cranial bones. The cranial vault may be ... Malignant osteopetrosis patients have restricted cranial foramina, reduced bone marrow volume, fractures, deafness, ...
http://ctgt.net/panel/osteopetrosis-core-ngs-panel
*  "Adalimumab Therapy Has a Beneficial Effect on Bone Metabolism in Patie" by Sundaram G. Veerappan, Martin Healy et al.
METHODS: Parathyroid hormone, vitamin D, bone formation markers, bone resorption marker, pro-inflammatory cytokines, anti- ... Moreover, there was a sustained but not significant fall in serum CTx, a bone resorption marker. No significant change was seen ... AIM: To evaluate the impact of adalimumab therapy on bone metabolism using a combined in vivo and in vitro model. ... CONCLUSIONS: This first study evaluating the role of adalimumab as a possible bone protector in Crohn's disease patients has ...
https://epubs.rcsi.ie/anatart/68/
*  Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during
Changes in markers of bone formation and resorption The changes in the levels of the markers of bone formation and resorption ... 1998), and it also prevents bone loss and restores bone strength in ovariectomized rats by reducing bone resorption (Simonet et ... bone formation and resorption were accelerated during pregnancy, especially in the late stages. After delivery, bone resorption ... 1996). These conditions must be the cause of the loss of bone density during lactation. Other triggers by which bone resorption ...
http://spotidoc.com/doc/11213/serum-osteoprotegerin-osteoclastogenesis-inhibitory-facto..
*  Osteoporosis Treatment - INDIEBOUND
Osteoporosis occurs when the rate of resorption in the bones overtakes the rate of bone formation. The anti-resorptive agents ... Osteoporosis is a disease that affects the bones. As the bones start loosing their usual density they become weaker & are more ... Exercising not only helps in lessening the rate of bone loss & increase bone density, it improves physical posture, body ... One way to slow down the rate of bone loss is to add ample amounts of calcium and vitamin D in the diet. Calcium-rich foods ...
http://indiebound.org.au/osteoporosis-treatment/
*  Bone resorption - Wikipedia
During childhood, bone formation exceeds resorption. As the aging process occurs, resorption exceeds formation. Bone resorption ... Bone reabsorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and ... In some cases where bone resorption outpaces ossification, the bone is broken down much faster than it can be renewed. The bone ... Light weight bearing exercise tends to eliminate the negative effects of bone resorption. Bone resorption is highly stimulated ...
https://en.wikipedia.org/wiki/Bone_resorption
*  Bone Resorption | SpringerLink
... the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, its origins, its ... Bone Resorption, the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, ... Bone resorption Cytokines Internist Osteoclasts bone complication nutrition pathophysiology physiology Editors and affiliations ... Because osteoporosis may be considered a disease in which the bone resorption rate exceeds formation, a separate chapter deals ...
https://link.springer.com/book/10.1007%2Fb136184
*  Monocytes mediate osteoclastic bone resorption by prostaglandin production | SpringerLink
... to active bone resorption surfaces in both physiological and pathological situations and may play a key role in bone resorption ... Monocyte-induced osteoclastic bone resorption may play an important role in physiologic bone remodeling and in bone destruction ... Bone matrix sustained comparable resorption as demonstrated by a 2-fold decrement in the extracted dry weights of the bones ... to active bone resorption surfaces in both physiological and pathological situations and may play a key role in bone resorption ...
https://link.springer.com/article/10.1007/BF02407164
*  JCI - The mechanisms of estrogen regulation of bone resorption
7) report that increased production of TNF-α by T cells in bone marrow mediates the increased bone resorption and bone loss in ... The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000. ... These factors increase bone resorption, mainly by increasing the pool size of pre-OCs in bone marrow (2, 3), and are ... The mechanisms of estrogen regulation of bone resorption. B. Lawrence Riggs Endocrine Research Unit, Mayo Clinic and Foundation ...
https://www.jci.org/articles/view/11468
*  Bone resorption test for osteoporosis - Journal Advocate
Did you realize that bone loss actually begins around the age of thirty-five? The first obvious clue is when we begin to lose ... In addition to this, I would recommend a Bone Resorption Test. This is a must test. The bone resorption test can be done ... Unfortunately by the time a bone density change is noted it may already be too late. The bone resorption test is a urine test ... Bone resorption test for osteoporosis. By Dr. Teresa C. Hill. For the Journal-Advocate ...
http://www.journal-advocate.com/columnist_teresahill/ci_32126554/bone-resorption-test-osteoporosis
*  Bone Resorption - Orthopaedic Web Links
Orthopedics , OCOSH Classification , Bone Diseases , Bone Resorption. Bone Resorption (Subscribe) Bone loss due to normal or ... OCOSH Classification: Bone Diseases: Bone Resorption - OCOSH Classification: Bone Diseases: Metabolic Bone Diseases ... OCOSH Classification: Bone Diseases: Bone Resorption - OCOSH Classification: Investigations: Radiology - General: Radiology - ... SNOMED-CT Bone resorption disorder (finding) Concept ID: 68921007. OCOSH Code: D000387 68921007 M89.5 BD_BR_ANH. Osteolysis (28 ...
https://www.orthopaedicweblinks.com/OCOSH_Classification/Bone_Diseases/Bone_Resorption/index.html
*  Bone Resorption Summary | CureHunter Mobile
Bone Resorption Summary Description: Bone loss due to osteoclastic activity.. Also Known As: Bone Losses, Osteoclastic; Bone ... Resorptions; Loss, Osteoclastic Bone; Losses, Osteoclastic Bone; Osteoclastic Bone Losses Show All ,, Networked: 12154 relevant ... Key Therapies for Bone Resorption. Efficacy Chart ,, * Ovariectomy (Oophorectomy) : 6 outcomes 21 studies in 146 results ... Key Drugs and Agents for Bone Resorption. Efficacy Chart ,, Drugs and Important Biological Agents (IBA) related to treatments: ...
http://www.curehunter.com/m/keywordSummaryD001862.do
*  Dissociation between bone resorption and bone formation in osteopenic transgenic mice | PNAS
This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo. ... Generally, it has been assumed that bone formation and bone resorption functions are linked mechanistically during bone ... Dissociation between bone resorption and bone formation in osteopenic transgenic mice. David A. Corral, Michael Amling, ... Dissociation between bone resorption and bone formation in osteopenic transgenic mice. David A. Corral, Michael Amling, ...
https://www.pnas.org/content/95/23/13835?ijkey=549e25d6f95830fa926de9d3a475b3e57e1bd410&keytype2=tf_ipsecsha
*  Bone Resorption - Stock Image C024/9603 - Science Photo Library
... osteoclasts are breaking down bone and releasing minerals, to transfer calcium from the bone fluid into the blood. - Stock ... Keywords: anatomical, anatomy, artwork, bone, bone minerals, decalcified, drawing, human bone, illustration, medical, medical ... Caption: Illustration showing bone resorption; osteoclasts are breaking down bone and releasing minerals, to transfer calcium ... illustration, musculoskeletal, musculoskeletal system, osteoclast, osteoclasts, remodeling, resorb, resorption, skeletal, ...
http://www.sciencephoto.com/media/663420/view
*  Patent US8153588 - Methods useful in the treatment of bone resorption diseases - Google Patents
... the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months. ... The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, ... This is a process where bone resorption is closely linked to bone formation, through the concerted action of the bone active ... Bone growth factors and inhibitors of bone resorption for promoting bone formation. ...
http://www.google.com/patents/US8153588?dq=6,606,102
*  Pediatric Osteoporosis Medication: Bisphosphonate bone-resorption inhibitors, Vitamin Supplementation, Calcium, Vitamin D
... or bone mass) at least 2.5 standard deviations below peak bone mass (defined as the bone mass achieved by healthy adults aged ... Bisphosphonate bone-resorption inhibitors. Class Summary. These agents decrease bone resorption and prevent bone loss from ... Pamidronate inhibits both normal and abnormal bone resorption. It appears to inhibit bone resorption without as much impact on ... Prediction of bone loss with biochemical bone markers. Adapted from Ross PD, Knowlton W. Rapid bone loss is associated with ...
https://emedicine.medscape.com/article/985221-medication
*  High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. - PubMed - NCBI
High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses.. Frings-Meuthen P1, ... exacerbates disuse-induced bone and muscle loss by causing further protein wasting and an increase in bone resorption. Changes ... greater excretion of the bone resorption markers COOH- (CTX) and NH(2)- (NTX) terminal telopeptide of type I collagen in HDBR ... Serum concentrations of the bone formation markers bone-specific alkaline phosphatase (bAP) and NH(2)-terminal propeptide of ...
https://www.ncbi.nlm.nih.gov/pubmed/21596917
*  Thyrocalcitonin Inhibition of Bone Resorption Induced by Parathyroid Hormone in Tissue Culture | Science
Thyrocalcitonin Inhibition of Bone Resorption Induced by Parathyroid Hormone in Tissue Culture ... Thyrocalcitonin Inhibition of Bone Resorption Induced by Parathyroid Hormone in Tissue Culture ... Thyrocalcitonin Inhibition of Bone Resorption Induced by Parathyroid Hormone in Tissue Culture ... Thyrocalcitonin Inhibition of Bone Resorption Induced by Parathyroid Hormone in Tissue Culture ...
http://science.sciencemag.org/content/151/3708/330
*  Bone Markers in Osteoporosis: Bone Turnover Markers, Bone Formation Markers, Bone Resorption Markers
Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and ... The field of bone turnover markers has developed considerably in the past decade. ... Bone Resorption Markers. The most useful markers of bone resorption are degradation products derived from the enzymatic ... Markers of bone resorption predict hip fracture in elderly women, the EPIDOS Prospective Study. J Bone Miner Res 1996 Oct; 11( ...
https://emedicine.medscape.com/article/128567-overview
*  Subperiosteal bone resorption | Radiology Reference Article | Radiopaedia.org
Subperiosteal bone resorption is the most consistent and specific finding of hyperparathyroidism and is virtually pathognomonic ... Subperiosteal bone resorption. Dr Daniel J Bell ◉ and Dr Jeremy Jones ◉ et al. ... Subperiosteal bone resorption is the most consistent and specific finding of hyperparathyroidism and is virtually pathognomonic ... While the terminal tufts of the phalanges are the most commonly involved bones, many others are involved:. *tufts of the distal ...
https://radiopaedia.org/articles/subperiosteal-bone-resorption?lang=us