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*  Effect of bis (tributyl tin) oxide on permeability of the blood-brain barrier: a transient increase. | Occupational &...
RESULTS--A transient increase in paracellular permeability at the blood-brain barrier was found 2 h after the dose of TBTO. ... OBJECTIVES--To study the effect of bis (tributyl tin) oxide (TBTO) on permeability of the blood-brain barrier. METHODS-- ... Effect of bis (tributyl tin) oxide on permeability of the blood-brain barrier: a transient increase. ... Effect of bis (tributyl tin) oxide on permeability of the blood-brain barrier: a transient increase. ...
http://oem.bmj.com/content/51/11/735
*  Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI | Protocol
A technique is described for broadly opening the blood-brain barrier in the mouse using microbubbles and ultrasound. Using this ... Disruption of the blood-brain barrier after administration of a T1-shortening contrast agent (such as manganese or a gadolinium ... However, because Mn2+ does not readily cross the blood-brain barrier (BBB), the need to open the BBB has limited the use of AIM ... 4. Blood-brain Barrier Opening with Microbubbles and Ultra Sound (BOMUS). *Give an intraperitoneal injection of the manganese ...
https://www.jove.com/video/4055/functional-neuroimaging-using-ultrasonic-blood-brain-barrier
*  Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates | Science Translational Medicine
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. By Y. Joy Yu, Jasvinder K. Atwal, Yin ... Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. By Y. Joy Yu, Jasvinder K. Atwal, Yin ... Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates Message Subject. (Your Name) has forwarded ... bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β- ...
http://stm.sciencemag.org/content/6/261/261ra154/tab-e-letters
*  Molecules | Free Full-Text | Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction
... as a molecule cannot exhibit pharmacological activity within the brain parenchyma without first transiting this barrier. ... Predicting blood-brain barrier (BBB) permeability is essential to drug development, ... Keywords: blood brain barrier; drug transport; decision tree induction; QSAR modeling blood brain barrier; drug transport; ... Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction. Claudia Suenderhauf 1, Felix ...
http://www.mdpi.com/1420-3049/17/9/10429
*  Leaky blood-brain barriers and memory loss | Science Translational Medicine
The blood-brain barrier (BBB) protects neurons from harmful proteins produced by blood. Breakdown of the BBB has been thought ... Leaky blood-brain barriers and memory loss Message Subject. (Your Name) has forwarded a page to you from Science Translational ... A. Montagne et al., Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302 (2015). [Abstract] ... Age-dependent blood-brain barrier permeability demonstrated an association with cognitive impairment. ...
https://stm.sciencemag.org/content/7/273/273ec22
*  Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier. | Sigma-Aldrich
Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.. [Nanhong Lou, Takahiro Takano, ... We show here that following blood-brain barrier (BBB) breakdown, P2RY12 (purinergic receptor P2Y, G-protein coupled, 12)- ...
https://www.sigmaaldrich.com/catalog/papers/26755608
*  Blood-brain barrier carriers (L-11085, 11750, 12133, 12596, 12599, 12600) - National Research Council Canada
... the receptors exploited by NRC-HHT are enriched in the blood-brain barrier and up-regulated in specific brain diseases. This ... The blood brain barrier (BBB) is the principal hurdle in developing drugs for central nervous system (CNS) diseases such as ... Blood-brain barrier carriers (L-11085, 11750, 12133, 12596, 12599, 12600) factsheet (PDF, 148 KB) ... Therapeutics Beyond Brain Barriers, presenting carrier molecules that can deliver biologics to the brain at Biotransfer 2014 in ...
https://www.nrc-cnrc.gc.ca/eng/solutions/licensing/blood_brain_l11085.html
*  Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion Injury | Stroke
Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke. ... Kuroiwa T, Shibutani M, Okeda R. Blood-brain barrier disruption and exacerbation of ischemia brain edema after restoration of ... In this study we compared blood flow recovery, blood-brain barrier (BBB) permeability, and matrix metalloproteinase-9 (MMP-9) ... Kuroiwa T, Ting P, Martinez H, Klatzo I. The biphasic opening of the blood-brain barrier to proteins following temporary middle ...
http://stroke.ahajournals.org/content/33/11/2711
*  Unraveling the Mysteries of the Blood-Brain Barrier - Research@URMC - University of Rochester Medical Center
Unraveling the Mysteries of the Blood-Brain Barrier The biological phenomenon known as the blood-brain barrier was first ... told biologists very little about how the blood-brain barrier actually operates. That is because blood flow is essential to the ... URMC / Research / Research@URMC / June 2013 / Unraveling the Mysteries of the Blood-Brain Barrier ... and now she is watching the blood-brain barrier in real-time: individual cells are crossing out of the bloodstream across ...
https://www.urmc.rochester.edu/research/blog/june-2013/unraveling-the-mysteries-of-the-blood-brain-barrie.aspx?feed=blogs
*  What's Up Doc: What is blood brain barrier? - News - MetroWest Daily News, Framingham, MA - Framingham, MA
Q: My husband's cancer spread to his brain and the doctor said one of the problems with treatment of brain cancer is that the ... brain has a barrier that makes it hard for the medicines to get in. Can you explain this? ... This is termed the blood brain barrier (BBB).. The endothelial cells that line the walls of the small blood vessels ( ... It turns out that there is a barrier which limits what can get into the brain from the blood that flows through it. ...
http://www.metrowestdailynews.com/x521644901/Whats-Up-Doc-What-is-blood-brain-barrier
*  Nanotechnology Now - Press Release: Nanoparticles cross blood-brain barrier to enable 'brain tumor painting'
Nanoparticles cross blood-brain barrier to enable 'brain tumor painting' Seattle, WA , Posted on August 4th, 2009. Researchers ... Until now, no nanoparticle used for imaging has been able to cross the blood-brain barrier and specifically bind to brain-tumor ... Home , Press , Nanoparticles cross blood-brain barrier to enable 'brain tumor painting' ... Crossing the blood-brain barrier depends on the size of the particle, its lipid, or fat, content, and the electric charge on ...
http://www.nanotech-now.com/news.cgi?story_id=34128
*  4 Parts of the Brain Not Protected by the Blood Brain Barrier | LIVESTRONG.COM
... and neurotransmitters released in the blood from entering the brain. Four areas of the... ... The blood-brain barrier prevents toxic substances, large molecules, ... The area postrema is not covered by the blood brain-barrier because it senses toxins in the blood that the other parts of the ... 4 Parts of the Brain Not Protected by the Blood Brain Barrier by MICHELE NOONAN Aug. 14, 2017. ...
https://www.livestrong.com/article/162348-4-parts-of-the-brain-not-protected-by-the-blood-brain-barrier/
*  The Relationship of Blood-Brain Barrier Damage to Survival Time after Acute Radiation Injury.
The purpose of this study was to investigate whether a relationship exists between alterations of the blood-brain barrier (BBB ... Title : The Relationship of Blood-Brain Barrier Damage to Survival Time after Acute Radiation Injury. ... The purpose of this study was to investigate whether a relationship exists between alterations of the blood-brain barrier (BBB ... Descriptors : *CEREBROVASCULAR SYSTEM , *RADIATION INJURIES , BLOOD CIRCULATION , RADIATION DOSAGE , CAPILLARIES(ANATOMY) , ...
http://www.dtic.mil/docs/citations/AD0757661
*  Revision 22 for 'Blood brain barrier' | Article | Radiopaedia.org
Revision 22 for 'Blood brain barrier'. All Revisions. Blood brain barrier. The blood brain barrier (BBB) forms a physical ... Areas which have fenestrated capillaries and thus lack the blood brain barrier are:. * circumventricular organs (CVO): *area ... sinusoidal: not found in the brain. In the brain, the majority of capillary walls are of the continuous type with tight ... resistance to the passage of lipophobic substances from cerebral capillaries into the brain and is a key reason why there is no ...
https://radiopaedia.org/revisions/592539
*  The Blood-Brain Barrier/Neurovascular Unit in Health and Disease | Pharmacological Reviews
The Blood-Brain Barrier/Neurovascular Unit in Health and Disease Message Subject (Your Name) has forwarded a page to you from ... The Blood-Brain Barrier/Neurovascular Unit in Health and Disease. Brian T. Hawkins and Thomas P. Davis ... The Blood-Brain Barrier/Neurovascular Unit in Health and Disease. Brian T. Hawkins and Thomas P. Davis ... The Blood-Brain Barrier/Neurovascular Unit in Health and Disease. Brian T. Hawkins and Thomas P. Davis ...
http://pharmrev.aspetjournals.org/content/57/2/173
*  Quorum sensing peptides selectively penetrate the blood-brain barrier
... blood-brain barrier, microbiome, Permeability, neurological diseases, STREPTOCOCCUS-PNEUMONIAE, GUT-BRAIN, MICROBIOME, ... Quorum sensing peptides selectively penetrate the blood-brain barrier. Evelien Wynendaele (UGent) , Frederick Verbeke (UGent) ... "Quorum Sensing Peptides Selectively Penetrate the Blood-brain Barrier." PLOS ONE 10.11 (2015): n. pag. Print. ... 2015). Quorum sensing peptides selectively penetrate the blood-brain barrier. PLOS ONE, 10(11). ...
https://biblio.ugent.be/publication/6983661
*  Immune System Cells Key to Maintaining Blood-Brain Barrier - Healthcanal.com : Healthcanal.com
Home Immune System Immune System Cells Key to Maintaining Blood-Brain Barrier ... "When this barrier is breached it must be rapidly repaired in order to maintain the health of the brain and aid in recovery ... controlled through a complex system of gateways and controls that are collectively referred to as the blood-brain barrier (BBB ... nervous system play a critical and previously unappreciated role in maintaining the integrity of the blood-brain barrier," said ...
https://www.healthcanal.com/immune-system/69880-immune-system-cells-key-to-maintaining-blood-brain-barrier.html
*  Raptor Pharmaceutical Inc. to Collaborate with Roche (JOBS) on Therapeutic Delivery Across Blood-Brain Barrier | BioSpace
to Collaborate with Roche (JOBS) on Therapeutic Delivery Across Blood-Brain Barrier - read this article along with other ... to Collaborate with Roche (JOBS) on Therapeutic Delivery Across Blood-Brain Barrier. Published: Jun 09, 2009 ... will be able to deliver therapeutic and diagnostic molecules across the blood-brain barrier; that the Company will ever earn or ... based technology program designed to deliver therapeutics across the blood-brain barrier ("BBB"), with the potential to provide ...
https://www.biospace.com/article/releases/raptor-pharmaceutical-inc-to-collaborate-with-roche-a-href-http-www-biospace-com-joblistingcompany-aspx-job_customer_entity_id-44679-and-source-news/
*  Gut Microbes Shore Up Blood-Brain Barrier - International Probiotics Association
Researchers are also linking blood-brain barrier integrity to dementia in an article titled Blood-brain barrier breakdown in ... "The brain is wider than the sky."-Emily Dickinson. Protecting such a wonder is no easy task but the blood-brain barrier (BBB) ... A high-functioning blood brain barrier is obviously crucial to a high-functioning mind. Yet defense of the brain from ... Yet domestic disturbances can also impact blood brain barrier function and thus brain function. For instance metabolic ...
http://internationalprobiotics.org/gut-microbes-shore-blood-brain-barrier/
*  Microemboli Composed of Cholesterol Crystals Disrupt the Blood-Brain Barrier and Reduce Cognition | Stroke
Microemboli Composed of Cholesterol Crystals Disrupt the Blood-Brain Barrier and Reduce Cognition. Joseph H. Rapp, Xian Mang ... Microemboli Composed of Cholesterol Crystals Disrupt the Blood-Brain Barrier and Reduce Cognition ... Microemboli Composed of Cholesterol Crystals Disrupt the Blood-Brain Barrier and Reduce Cognition ... Microemboli Composed of Cholesterol Crystals Disrupt the Blood-Brain Barrier and Reduce Cognition ...
http://stroke.ahajournals.org/content/early/2008/06/19/STROKEAHA.107.496737
*  Visualizing a Parasite Crossing the Blood Brain Barrier
"Crossing the blood-brain barrier is a rare event in part because this structure is designed to protect the brain from pathogens ... But they only saw infected cells within blood vessels, and these cells were not able to cross the blood brain barrier. ... Visualizing a Parasite Crossing the Blood Brain Barrier News Feb 17, 2016 ... The team's findings suggest that the current theories about how Toxoplasma crosses the blood-brain barrier are probably not the ...
https://www.technologynetworks.com/diagnostics/news/visualizing-a-parasite-crossing-the-blood-brain-barrier-213717
*  Blood-brain barrier in stress: a gateway to various brain diseases.
... Sharma, H S Uppsala University, Medicinska ... 1998 (English)In: New Frontiers of Stress Research: Modulation of Brain Function., Academic Publishers Inc. , 1998, 259- p. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:89195
*  Blood brain barrier in Radiology - Sumer's Radiology Blog
Why do brain pathologies enhance on Gd MRI: Contrast will not leak into the brain until the Blood brain barrier is damaged. ... Extra-axial tumors such as meningiomas and schwannomas are not derived from brain cells and do not have a blood-brain barrier. ... Blood brain barrier in Radiology Reviewed by Sumer Sethi on Monday, May 12, 2014 Rating: 5 ... 2016 WHO Classification Brain Tumours. WHO brain tumour classification has been updated in 2016. The 2016 World Health ...
http://sumerdoc.blogspot.com/2014/05/blood-brain-barrier-in-radiology.html
*  IJMS | Free Full-Text | CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier
... which form the morphological basis of the blood-brain barrier (BBB). The mechanisms of extravasation of tumor cells are highly ... We observed that activation of CB2 receptors with JWH-133 reduced the adhesion of melanoma cells to the layer of brain ... First, we identified the presence of CB1, CB2(A), GPR18 (transcriptional variant 1) and GPR55 receptors in brain endothelial ... Our data identify CB2 as a potential target in reducing the number of brain metastastes originating from melanoma. ...
https://www.mdpi.com/1422-0067/15/5/8063
*  Guidelines for the Design of Magnetic Nanorobots to Cross the Blood-Brain Barrier - IEEE Journals & Magazine
This study proposes molecular dynamics simulations used to derive guidelines for the design of the superparamagnetic nanocapsules (spherical-like or rod-li
http://ieeexplore.ieee.org/document/6678802/?reload=true