Human Metabolome Database: Showing metabocard for Glycocholic acid (HMDB0000138)
... is a crystalline bile acid involved in the emulsification of fats. It occurs as a sodium salt in the bile of mammals. Its anion ... Bile acids are steroid acids found predominantly in bile of mammals. The distinction between different bile acids is minute, ... Glycocholic acid is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of ... The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl ...http://www.hmdb.ca/metabolites/HMDB0000138
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation | Pharmacological Reviews
... bile salt export pump, multidrug resistance-associated proteins (MRP) 1 to 9, breast cancer resistance protein, and ATP-binding ... Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation. Curtis D. Klaassen and Lauren M. Aleksunes ... Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation. Curtis D. Klaassen and Lauren M. Aleksunes ... Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation. Curtis D. Klaassen and Lauren M. Aleksunes ...http://pharmrev.aspetjournals.org/content/early/2010/01/25/pr.109.002014
"Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Aci" by Jiang Qian
Bile acid 7α-dehydroxylating bacteria often contain bile salt hydrolase, which hydrolyzes the peptide bond in taurine- ... The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The 7α-dehydroxylation ... conjugated bile acids to yield a free bile acid and taurine. Taurine is an organosulfonate containing a sulfite moiety. There ... of the bile acids is the most physiologically important bile acid biotransformation. All known intestinal bacteria capable of ...https://digitalcommons.wku.edu/theses/694/
Ursodeoxycholic acid and cholesterol induce enterohepatic cycling of " by Sanchez N. Mendez, M A. Brink et al.
Dietary cholesterol and bile acids, particularly UDCA, increased cecal bile salt levels, unconjugated bilirubin and ... and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile ... rates into bile, serum and intestinal bilirubin and bile salt levels, and urobilinogen levels in cecum, large intestine, and ... CONCLUSIONS: By causing bile salt malabsorption, dietary UDCA and cholesterol induce enterohepatic cycling of bilirubin. ...https://mouseion.jax.org/stfb1990_1999/1114/
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 276: 28857- ... bile acids suppress the expression of the major bile acid uptake system in conditions of elevated hepatocellular bile acid ... exerted by bile acid-activated FXR lead to increased cellular bile acid efflux and detoxification and decreased bile acid ... FXR induces bile acid efflux and detoxification machinery. The ABCB11 gene encoding BSEP, the chief liver canalicular bile salt ...http://physiologyonline.physiology.org/content/23/5/286
Genetic Defects in Synthesis and Transport of Bile Acids | Pediatric Endocrinology and Inborn Errors of Metabolism, 2e |...
Bile salts represent approximately 50% of the organic constituents of the bile dry weight, while 25% is made up by ... This loss of bile acids is compensated for by de novo synthesis of bile acids in the liver. Bile acids synthesized in the liver ... Deficient bile acid synthesis results in reduced production of the primary bile acids, with consequences for the bile flow and ... Synthesis of Bile Acids. ++. Conversion of cholesterol into bile acids illustrates the high capacity of the liver to convert ...http://accesspediatrics.mhmedical.com/content.aspx?bookid=2042§ionid=154112839
Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro. | Scholars@Duke
Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro.'s profile, publications, research topics, and co- ... Bile salts also caused increased release of glycoproteins from explants of guinea pig gastric antrum and colon. The bile salts ... Bile salts, in concentrations of 1 to 5 mmol/L, caused a dose-dependent release of [3H]-glycoproteins with a range of potencies ... Bile salts stimulate glycoprotein release by guinea pig gallbladder in vitro. Journal Article ...https://scholars.duke.edu/display/pub748370
Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile...
Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes. Exp Toxicol Pathol. 2001; 53: 227-33.. * ... Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile ... Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile ... Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry. 2005; 44: 12598-605.. *CrossRef, ...http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01586.x/references?globalMessage=0
A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts*† | Annals of Internal Medicine |...
A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts(A Comparative Study of the Choleretic ... Effect of Bile Salts and Oleic Acid and Bile Salts*†)(A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid ... A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid and Bile Salts(A Comparative Study of the Choleretic ... Effect of Bile Salts and Oleic Acid and Bile Salts*†)(A Comparative Study of the Choleretic Effect of Bile Salts and Oleic Acid ...http://annals.org/aim/article-abstract/670366/comparative-study-choleretic-effect-bile-salts-oleic-acid-bile-salts
Bile Salt-Fatty Acid Mixed Micelles as Nasal Absorption Promoters. III. Effects on Nasal Transport and Enzymatic Degradation of...
Bile Salt-Fatty Acid Mixed Micelles as Nasal Absorption Promoters. III. Effects on Nasal Transport and Enzymatic Degradation of ... ester prodrugs were investigated in rats using the in situ nasal perfusion technique in the presence of bile salt-fatty acid ... Mixed micelles composed of 15 m M NaGC and 5 m M linoleic acid are incapable of incorporating these esters into the micellar ... To estimate the nasal epithelial membrane and cytoplasmic damaging effect caused by sodium glycocholate (NaGC)-linoleic acid ( ...https://insights.ovid.com/pres/199411020/00006623-199411020-00010
Unit 6 - Cholesterol Metabolism I; Synthesis of Cholesterol, Bile Salts, and Acids Flashcards by Annette Liem | Brainscape
Bile Salts, and Acids flashcards from Annette Liem ... bile acids) and 50% unprotonated (bile salts). -OH groups are ... albumin binds and transports bile salts in blood. -hepatocytes take bile salts from blood with an isoform of Na+-bile ... but sterol nucleus is eliminated by conversion to bile acids and bile salts. -small percentage of cholesterol in feces or bile ... before bile acids leave the liver. -amide bond forms between carboxyl group of bile acid and amino group of glycine (carboxyl) ...https://www.brainscape.com/flashcards/unit-6-cholesterol-metabolism-i-synthesis-2038707/packs/2719068
Bile | Encyclopedia.com
bile* is a greenish-yellow fluid produced by the liver , and passing from there into the duodenum ; it has a number of ... Bile, or gall, is composed of water, bile acids and their salts, bile pigments, cholesterol, fatty acids, and inorganic salts. ... bile pigments, and electrolytes (minerals).. Bile acids and bile salts. The function of these remarkable molecules is ... by increasing the bile acid/cholesterol ratio of bile. This is achieved simply by taking synthetic bile acids by mouth. ...https://www.encyclopedia.com/science-and-technology/biochemistry/biochemistry/bile
The Effect of VSL#3 Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease - Full Text...
The Effect of VSL#3 Probiotic Preparation on the Bile Acid Metabolism in Patients With Inflammatory Bowel Disease. This study ... Change of the spectrum of bile acids in stools and plasma [ Time Frame: Baseline and 6 weeks (plus or minus 5 days). ]. *Change ... Bile acids (BA) play an important role in the gastrointestinal tract - besides facilitating fat (and protein) digestion and ... Alteration in the rate of bile acid synthesis [ Time Frame: Baseline and 6 weeks (plus or minus 5 days) ]. Will be assessed as ...https://clinicaltrials.gov/ct2/show/NCT01765439
Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption - Full Text View ...
Bile Acids and Salts. Anticholesteremic Agents. Hypolipidemic Agents. Antimetabolites. Molecular Mechanisms of Pharmacological ... bowel bile acid will be treated with colesevelam to determine if stool frequency and consistency improves via fecal bile acids ... Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption. The safety and ... Chronic Diarrhea Irritable Bowel Syndrome With Diarrhea Bile Acid Malabsorption Drug: Colesevelam Other: Placebo Phase 2 ...https://clinicaltrials.gov/ct2/show/NCT03270085?recrs=abc&cond=%22Colonic+Diseases%2C+Functional%22&rank=35
Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and...
... function of xenoperfused livers and compatibility with human bile salts and porcine livers. ... Bile acids in xenogeneic ex-vivo liver perfusion: ... bile acid from serum is similar to bile acid excretion in bile ... human bile acids made up 85% of total biliary bile acids. Pig bile acids appeared in patients' sera after 1 hr of perfusion, ... and glyco-3alpha-hydroxy-6-oxo-5beta-cholanoic acid) for markers of pig bile. Bile acids from both serum and bile were ...https://scholars.duke.edu/display/pub765942
Molecules | Free Full-Text | Exploitation of Bile Acid Transport Systems in Prodrug Design
... and reviews the use of bile acids and their derivatives in designing prodrugs capable of exploiting the bile acid transport ... It is a complex process involving numerous transport proteins, which serve to transport bile acids from the small intestine ... This article briefly describes bile acid transport proteins involved in enterohepatic circulation, summarizes the key factors ... and low cost have made bile acids attractive tools in designing pharmacological hybrid molecules and prodrugs with the view of ...http://www.mdpi.com/1420-3049/12/8/1859
Hypocholesterolemic Effect of Indigenous Dadih Lactic Acid Bacteria by Deconjugation of Bile Salts -아세아태평양축산학회지 ...
... to suppress the reabsorption of bile acids into the enterohepatic circulation and to enhance the excretion of bile acids in ... fecal bile acids and microflora was estimated in hypercholesterolemic rats. Anaerobic lactic acid bacteria decreased and ... Administration of milk and fermented milks produced from indigenous dadih lactic acid bacteria on serum lipids and bile acids, ... lactis IS-10285 significantly reduced serum total cholesterol, LDL cholesterol and total bile acids. Milk and fermented milks ...http://www.koreascience.or.kr/article/JAKO200410103437104.page
Age and diet effects on fecal bile acids in infants.
Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 ... Bile Acids and Salts / analysis*. Breast Feeding. Feces / analysis*. Female. Humans. Infant. Infant Food. Infant Nutritional ... At the end of the study, breast-fed infants were excreting 17% of their total bile acids in the form of secondary acids, ... Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 ...http://www.biomedsearch.com/nih/Age-diet-effects-fecal-bile/3335983.html
Mixed oxo-hydroxy bile acids as actual or potential impurities in ursodeoxycholic acid preparation: a 1H and 13C NMR study.
... unprecedented 1H NMR signals and the complete 13C NMR resonances are assigned for the entire set of mixed oxo-hydroxy bile acid ... 0/Bile Acids and Salts; 0/Carbon Isotopes; 0/Protons; 128-13-2/Ursodeoxycholic Acid ... Bile Acids and Salts / isolation & purification*. Carbon Isotopes. Magnetic Resonance Spectroscopy. Protons. Ursodeoxycholic ... of chenodesoxycholic acid, desoxycholic acid and cholic acid, respectively. Partially or totally oxidized products are the ...http://www.biomedsearch.com/nih/Mixed-oxo-hydroxy-bile-acids/10755232.html
RecName: Full=Bile acid receptor; AltName: Full=Farnesoid X-activated - Protein - NCBI
Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 27- ... Recycling of bile acids and salts Recycling of bile acids and saltscomputationally inferred pathway (not manually curated) ... ... RecName: Full=Bile acid receptor; AltName: Full=Farnesoid X-activated receptor; ... RecName: Full=Bile acid receptor; AltName: ... Bile secretion Bile secretionBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins ...https://www.ncbi.nlm.nih.gov/protein/Q62735
Pathways: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsfrom GENTAUR...
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds ... WP1788: Bile acid and bile salt metabolism. WP1828: Hexose transport. WP1847: Metabolism of amino acids and derivatives. WP1877 ... BILE SALTS MIXTURE (Equivalent to Bile Salt No. 3). 100 gm. 28-048. M96 may be involved in the activation of MT ( ... bile salts and organic acids, metal ions and amine compounds. pathways : Transport of glucose and other sugars, bile salts and ...http://www.antibody-antibodies.com/pthw.php?pwid=WP1935
Path Gallstones and Biliary diseases - mechanical cholestasis Flashcards by Charlie Duke | Brainscape
GI absorption of bile acids/salts low absorption in jejunum - active and passive absorption in ileum ... Defective acidification of gallbladder bile. > pH higher precipitation of calcium salts Gallbladder stasis can produce increase ... infectious - Calcium salts and deconjugated bilirubin , cytoeskeleton of bacteria, previous surgery, duodenal diverticula. Pure ...https://www.brainscape.com/flashcards/path-gallstones-and-biliary-diseases-mech-1581835/packs/2931378
Role of bile acid reflux in acute hemorrhagic gastritis | SpringerLink
A model was developed to assess the influence of bile acids on the ability of proximal canine gastric mucosa to maintain an ... Ritchie, W.P., Jr.: Acute gastric mucosal damage induced by bile salts, acid, and ischemia. Gastroenterology68:699, 1975Google ... Bile acid species differ in their capacity to induce lesions. Topical application of bile acids to nonischemic mucosa is not ... Bile Acid Gastritis Acid Reflux Mucosal Blood Flow Mucosal Ischemia These keywords were added by machine and not by the authors ...https://link.springer.com/article/10.1007%2FBF01658286
Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or...
... thymidine uptake after exposure to either conjugated bile acids or an cocktail of conjugated bile salts (see Methods) for 1 hr ... 0.15 mM sodium glycodeoxycholic acid, and 0.05 mM sodium taurodeoxycholic acid. After exposure to bile salts for 1 hour, the ... Acid and bile salt exposure. Cell lines were first cultured in serum-free media for 48 hours before exposure for various times ... Thus other model systems are needed that may reflect the impact of acid and bile salt exposure on the esophagus in vivo. ...https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-7-24
CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 [Homo sapiens (human)] - Gene - NCBI
bile acid and bile salt transport ISS Inferred from Sequence or Structural Similarity. more info ... bile acid transmembrane transporter activity ISS Inferred from Sequence or Structural Similarity. more info ... negative regulation of fatty acid biosynthetic process ISS Inferred from Sequence or Structural Similarity. more info ... The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a ...https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=634&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum