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*  Bcl-2 Protein Targeting by the p53/p21 Complex-Response | Cancer Research
Bcl-2 Protein Targeting by the p53/p21 Complex-Response. Eun Mi Kim, Jongdoo Kim and Hong-Duck Um ... Bcl-2 Protein Targeting by the p53/p21 Complex-Response Message Subject (Your Name) has forwarded a page to you from Cancer ... Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax. Cell Signal 2012;24:1163-72. ... Interactions of endogenous proteins p53 and p21 in IMR-32 neuroblastoma and H460 lung cancer cells. A, IMR-32 cell lysates were ...
http://cancerres.aacrjournals.org/content/78/10/2772
*  Assessment of Dynamic BCL-2 Protein Shuttling Between Outer Mitochondrial Membrane and Cytosol | SpringerLink
In nonapoptotic cells the proapoptotic BCL-2 proteins BAX and BAK but also prosurvival family members, like... ... BCL-2 proteins control stress-dependent commitment to the programmed cell death apoptosis. ... BCL-2 proteins Mitochondria Apoptosis Retrotranslocation BH3-only proteins This is a preview of subscription content, log in to ... The retrotranslocation of BCL-2 proteins from the OMM can be measured using fluorescence-labeled protein in intact cells or ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-8861-7_10
*  The Bcl-2 Protein Family: Arbiters of Cell Survival | Science
Bok, for example, interacts with Mcl-1 and the Epstein-Barr viral protein BHRF1 but not with Bcl-2, Bcl-xL, or Bcl-w (24). ... The pro-survival proteins also seem to maintain organelle integrity. Bcl-2 directly or indirectly prevents the release from ... 4). CED-9 and Bcl-xL can bind to CED-4, which also binds CED-3 and stimulates its activation (28, 29). The BH4 region of Bcl-xL ... These "BH3 domain" proteins (19) may well represent the physiological antagonists of the pro-survival proteins, because ...
https://science.sciencemag.org/content/281/5381/1322?ijkey=ea8a22bcd0c68bdc498b9887f0db8f1a9def4d97&keytype2=tf_ipsecsha
*  BCL-2 | protein | Britannica.com
This protein family, which provides the framework for controlling apoptosis, takes its name from a type of cancer called B-cell ... BCL-2, the first family member, forms the molecular basis for sustaining the lymphoma cancer cells. The BCL-2 family of ... in mammals known as the BCL-2 protein family. ... BCL-2. protein. THIS IS A DIRECTORY PAGE. Britannica does not ... BCL-2, the first family member, forms the molecular basis for sustaining the lymphoma cancer cells. The BCL-2 family of ...
https://www.britannica.com/topic/BCL-2-protein
*  The Bcl-2 Protein Family: Arbiters of Cell Survival | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://science.sciencemag.org/content/281/5381/1322.full
*  Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression.
0/BAX protein, human; 0/HGF protein, human; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 67256-21-7/ ... Proto-Oncogene Proteins c-bcl-2 / metabolism*. Time Factors. Up-Regulation. Young Adult. bcl-2-Associated X Protein / ... Expression of HGF, Bcl-2 and Bax in tumor tissues was investigated by immunohistochemical staining, and the apoptotic index was ... HGF is a potent inhibitor of cell apoptosis in NPC by upregulating Bcl-2 through both autocrine and paracrine EBV-independent ...
http://www.biomedsearch.com/nih/Hepatocyte-growth-factor-suppresses-tumor/19625133.html
*  Antibodies to bcl-2 Protein Family - Product Review 04 | acris-antibodies.com
IntroductionBcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for ... These "BH3 domain" proteins may well represent the physiological antagonists of the pro-survival proteins. ... bcl-x, Bcl-xL , Mcl-1, Bag-1, bax, bak, Blk, Bim, Bad, Bmf, NOXA, PUMA-alpha, PUMA beta* ... Home » Reviews » Antibodies to bcl-2 Protein Family - Product Review 04 Antibodies to bcl-2 Protein Family - Product Review 04 ...
https://www.acris-antibodies.com/reviews/antibodies-bcl-2-protein-family.htm?ab_ag_presentation=Aff+-+Purified&product_property=pSer70
*  The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive...
... for women positive for the E6 protein and 17 times higher (95% CI, 5.5-58.3) for women positive for the bcl-2 protein compared ... including stimulation of apoptosis and inhibition of the expression of the antiapoptotic protein bcl-2. Recently, we found ... The E6 oncoprotein forms a complex with the cellular tumor suppressor protein p53, leading to degradation of p53 via ubiquitin- ... and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer.. M R Pillai, S Halabi, A McKalip, P G ...
http://cebp.aacrjournals.org/content/5/5/329
*  The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized....
Wild-type MEFs, or MEFs overexpressing FLAG-tagged Bcl-xL or Bcl-2, were tested for their sensitivity to ABT-737 (1μM) in the ... Bcl-x(L), and Bcl-w, many cell types proved refractory to ABT-737. We show that this resistance reflects ABT-737's inability to ... Two independent progenitor B cell lymphomas (#9: A, C and #16: B, D) derived from Eμ-myc/bcl-2 bi-transgenic mice () were ... B, C: FDC-P1 cells overexpressing Bcl-2 (B) or Bcl-xL (C) were treated with ABT-737 (0-10 μM), and Etoposide (25μM) or Cytosine ...
https://www.ncbi.nlm.nih.gov/pubmed/17097561?dopt=Abstract
*  AID 1263891 - Induction of apoptosis in human HepG2 cells assessed as reduction in Bcl-2 protein level incubated for 48 hrs by...
Induction of apoptosis in human HepG2 cells assessed as reduction in Bcl-2 protein level incubated for 48 hrs by Western blot ...
https://pubchem.ncbi.nlm.nih.gov/bioassay/1263891
*  Expression profiles of p53, p21, bax and bcl-2 proteins in all-trans-retinoic acid treated primary and metastatic melanoma...
The protein expression of p53, p21, bax and bcl-2 were examined by Western blotting and immunocytochemistry. Expression of p53 ... Modification of these protein levels in the tumour cells might be beneficial for early treatment of melanoma. ... The changes of p53, p21, bax, and bcl-2 protein levels were dose- and time-dependent. The primary melanoma cells were more ... Expression profiles of p53, p21, bax and bcl-2 proteins in all-trans-retinoic acid treated primary and metastatic melanoma ...
http://liu.diva-portal.org/smash/record.jsf?pid=diva2:244043
*  apoptosis facilitator Bcl-2-like protein 14 [Mus musculus] - Protein - NCBI
LSBio BCL2L14 / BCL-G Proteins [LifeSpan BioSciences, Inc.] LSBio BCL2L14 / BCL-G Proteins. LifeSpan BioSciences, Inc. ... Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in ... Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in ... LSBio BCL2L14 / BCL-G Antibodies [LifeSpan BioSciences, Inc.] LSBio BCL2L14 / BCL-G Antibodies. LifeSpan BioSciences, Inc. ...
https://www.ncbi.nlm.nih.gov/protein/NP_080054.1
*  AID 1342855 - Fluorescence Polarisation Assay: The fluorescence polarisation tests were carried out on microplates (384 wells)....
After incubation for 2 hours, the fluorescence polarisation is measured.. ... The Bcl-2 protein, at a final concentration of 2.50A?10A inverted question mark8 M, is mixed with a fluorescent peptide ( ...
https://pubchem.ncbi.nlm.nih.gov/bioassay/1342855
*  openarchives.gr | Apoptosis and gastric carcinogenesis: Immunohistochemical analysis of Bax and Bcl-2 proteins
This highlights the major role of Bcl-2 and the contradicting role of Bax in early carcinogenesis. Key Words: apoptosis, ... Immunohistochemical methods were used for detection of Bax and Bcl-2. Results: The expression of Bax in precancerous lesions ... related proteins in the carcinogenesis of the stomach. Materials and Methods: 80 biopsy specimens and 50 surgical specimens of ... Bcl-2 expression was as follows: chronic gastritis 0%, atrophic gastritis 35% (23/65 cases), intestinal metaplasia 90% (45/50 ...
https://www.openarchives.gr/aggregator-openarchives/edm/gastro/000025-article_view_577?language=en
*  Inserm - Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: identification of conserved hot...
... recurrent interactions in the protein complexes. The calculations show that the two anti-apoptotic proteins, Bcl-xl and Bcl-w, ... Bcl-xl, an anti-apoptotic protein of this family, is known to form heterodimers with multiple pro-apoptotic proteins, such as ... A fifth protein-peptide complex composed of another anti-apoptotic protein, Bcl-w, in complex with the peptide from Bim was ... The results identified amino acids of both the anti-apoptotic proteins as well as the Bcl-2 homology 3 (BH3) domains of the pro ...
https://www.hal.inserm.fr/inserm-00420171
*  Bcl2l11 - Bcl-2-like protein 11 - Mus musculus (Mouse) - Bcl2l11 gene & protein
View protein in InterPro. IPR014771. Apoptosis_Bim_N. IPR017288. Bcl-2-like_11. IPR015040. Bcl-x_interacting_BH3_dom. IPR036834 ... View protein in InterPro. IPR014771. Apoptosis_Bim_N. IPR017288. Bcl-2-like_11. IPR015040. Bcl-x_interacting_BH3_dom. IPR036834 ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. O54918. Q542N5. UPI0003D70628. Mus musculus ( ... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ...
http://www.uniprot.org/uniprot/O54918
*  BCL2L12 - Bcl-2-like protein 12 - Homo sapiens (Human) - BCL2L12 gene & protein
... to allow unambiguous identification of a protein.,p>,a href='/help/protein_names' target='_top'>More...,/a>,/p>Protein namesi. ... Integrated resource of protein families, domains and functional sites. More...InterProi. View protein in InterPro. IPR036834 ... p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.,p>,a ... p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different ...
https://www.uniprot.org/uniprot/Q9HB09
*  Bcl-2 Family Proteins and Antibodies - Apoptosis and Cell Cycle | Sigma-Aldrich
Bcl-xL) or promote (e.g. Bax, Bcl-xS, Bak) apoptosis. Bcl-2 inhibits apoptosis by preventing the release ... If the Bcl-2 level is higher than the Bax level, apoptosis will be prohibited. The ratio of Bcl-2 to Bax in the cell can ... Some cancer cells, such as melanoma, overexpress Bcl-2 preventing apoptosis and allowing malignant growth to continue.
... Bcl-2 is a member of a large gene family encoding proteins that can either inhibit (e.g. Bcl-2, ...
https://www.sigmaaldrich.com/life-science/cell-biology/cell-biology-products.html?TablePage=110982384
*  Bcl-2 Protein Family Inhibitors Products|Active Biopharma Corp
Inhibitors,Activator,Agonist,antagonist,API,Aurora,Metabolic Disease,VEGFR-PDGFR,Other Intermediate,Others,MOF Chemicals,,Active Biopharma Corp
http://activebiopharma.com/category69/list1.html
*  c bcl 2 Proteins at Medical-dictionary.cc
Here you can find the definitions list for the word c bcl 2 Proteins. Also you can find some other opposite words using the ... Membrane proteins encoded by the bcl- 2 genes and serving as a potent inhibitor of cell death by apoptosis. The proteins are ... Overexpression of bcl- 2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. ... For example - how to explain c bcl 2 Proteins? Here you can see the medical definition for c bcl 2 Proteins. Medical-dictionary ...
http://www.medical-dictionary.cc/what-does/c%20bcl%202%20proteins-mean
*  Potassium-ATPase
... may make inaccurate datasets because of proteins insolubility, transient or weak proteins relationships, or irrelevant ... Phospholipases type A2 (PLA2s) will be the most abundant protein within December 15, 2018Potassium-ATPase Standard ... Techniques largely useful for proteins interaction research and finding of intracellular November 3, 2018Potassium-ATPase ... AAV) vectors has been shown to efficiently induce systemic immunological tolerance to a variety of proteins in various ...
http://www.techxprtz.com/category/potassium-atpase/
*  March 2016 - Inhibitors of the anti-apoptotic Bcl-2 protein
March 31, 2016Heat Shock Protein 90 Standard. RAS-GRF1 is a guanine nucleotide exchange factor with the ability to activate RAS ... The system of coat protein (COP)II vesicle fission through the endoplasmic March 29, 2016Her Standard ... The system of coat protein (COP)II vesicle fission through the endoplasmic reticulum (ER) remains unclear. such as for example ... Consistently the appearance degree of β-catenin proteins correlated with the invasiveness of Operating-system as evidenced by ...
http://www.techxprtz.com/2016/03/
*  Structure-Function Analysis of Bcl-2 Family Proteins | Springer for Research & Development
To gain better understanding of how this protein functions, we have undertaken a... ... The Bcl-2 protein blocks a distal step in an evolutionarily conserved pathway for programmed cell death and apoptosis. ... two proteins that we have shown can associate with protein complexes containing Bcl-2 and which cooperate with Bcl-2 to ... H. Zha, C. Aime-Sempe, T. Sato and J.C. Reed, Pro-apoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax ...
https://rd.springer.com/chapter/10.1007/978-1-4899-0274-0_10
*  Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types
The expression profile of 93 genes involved in apoptosis as well as the protein level of BCL-2 family proteins were then ... Finally, the modulation of the abundance and/or of the post-translational modifications of most proteins of the BCL-2 family by ... hypoxia decreased the abundance of nearly all the pro-apoptotic BCL-2 family proteins while none of them are decreased in A549 ... are important mediators of etoposide-induced cell death in HepG2 cells and the hypoxia-induced modification of these proteins ...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047519
*  Effects of droloxifene on apoptosis and Bax, Bcl-2 protein expression of luteal cells in pseudopregnant rats. - Semantic Scholar
An increased Bax/Bcl-2 ratio might be involved in the facilitation of apoptosis induced by droloxifene in corpus luteum of ... Expression of Bax and Bcl-2 protein was observed by immunohistochemistry analysis. RESULTS Apoptosis of luteal cells during the ... the expression of Bax and Bcl-2 protein was found in the cytoplasm of luteal cells. However, no obvious differences in the ... while an increase in Bax and a decrease in Bcl-2 protein expression could be induced by droloxifene treatment. CONCLUSION ...
https://www.semanticscholar.org/paper/Effects-of-droloxifene-on-apoptosis-and-Bax%2C-Bcl-2-Leng-Feng/f86c0d1fd80ead671f42230ebeb63dcc1411e99d