Mitochondrial Signals for the Nucleus | Science Signaling
What's a transcription factor of the basic helix-loop-helix leucine zipper family doing in the cytoplasm? Sans et al. explored ... why nearly all of the transcription factor MondoA and its binding partner protein called Mlx is found in the cytoplasm but the ... protein appears to function as a transcription factor in the nucleus. The authors found that in primary cultures of human ... Inhibition of nuclear shuttling of the proteins with an inhibitor of the CRM1 nuclear export factor caused MondoA (detected by ...http://stke.sciencemag.org/content/2006/342/tw221
OriGene - MITF (NM 001184967) cDNA Clone
Human microphthalmia-associated transcription factor (MITF) transcript variant 7 available for purchase from OriGene - Your ... Gene Summary: This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural ... Mitf (untagged) - Rat microphthalmia-associated transcription factor (Mitf). $480. 3 weeks. RR216850. Mitf (myc-DDK-tagged) - ... Mitf (Myc-DDK-tagged) - Mouse microphthalmia-associated transcription factor (Mitf), transcript variant 2. $390. Next day. ...http://www.origene.com/cdna/trueclone/accession/NM_001184967/SC328771.aspx
SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. -...
... is a basic-helix-loop-helix-leucine zipper-type transcription factor. The mutant mi and Mi(wh) alleles encode MITFs with ... These results indicated that SgIGSF mediated the adhesion of CMCs to fibroblasts and that the transcription of SgIGSF was ... Microphthalmia transcription factor (MITF) is a basic-helix-loop-helix-leucine zipper-type transcription factor. The mutant mi ... Inhibitory effect of the transcription factor encoded by the mi mutant allele in cultured mast cells of mice.. *A Ito. , E ...https://www.semanticscholar.org/paper/SgIGSF-a-new-mast-cell-adhesion-molecule-used-for-Ito-Jippo/e3a9095a58781264052aa1205602f52abc9ec801
The multiple roles of microRNA-155 in oncogenesis | Journal of Clinical Bioinformatics | Full Text
MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate ... It down-regulates BCL6 (B-cell lymphoma 6) protein , which is an evolutionarily conserved zinc finger transcription factor ... It does not bind DNA directly, but attaches through the transcription factors MEF2C and MEF2D. Analysis of DLBCL patient data ... Firstly, miR-155 promotes hk2 transcription by activation of signal transducer and activator of transcription 3 (STAT3), a ...https://jclinbioinformatics.biomedcentral.com/articles/10.1186/2043-9113-3-17
The human ROX gene: genomic structure and mutation analysis in human breast tumors. - The Christie Research Publications...
TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor.Authors: Bjerknes M, ... We have recently isolated a human gene, ROX, encoding a new member of the basic helix-loop-helix leucine zipper protein family ... We have recently isolated a human gene, ROX, encoding a new member of the basic helix-loop-helix leucine zipper protein family ... Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. -. dc.subject.mesh. Breast Neoplasms. - ...http://christie.openrepository.com/christie/handle/10541/92932
WikiGenes - MITF - microphthalmia-associated transcription...
... the interaction between the basic helix-loop-helix and leucine-zipper region of microphthalmia-associated transcription factor ... Synonyms: BHLHE32, CMM8, Class E basic helix-loop-helix protein 32, MI, Microphthalmia-associated transcription factor, ... ... The transcription activation domain of microphthalmia transcription factor, tested as a GAL-MITF fusion protein, remained fully ... Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human ...https://www.wikigenes.org/e/gene/e/4286.html
Basic helix-loop-helix leucine zipper transcription factors - Wikipedia
Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both ... Basic helix-loop-helix leucine zipper transcription factors at the US National Library of Medicine Medical Subject Headings ( ... Basic helix-loop-helix and leucine zipper motifs. Examples include Microphthalmia-associated transcription factor and Sterol ...https://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors
Mitf - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad
basic helix-loop-helix-leucine zipper transcription factor; may play a role in osteoclast function [RGD, Feb 2006] ...http://www.bio-rad.com/en-us/prime-pcr-assays/assay/drnocpe5175089-primepcr-ddpcr-expression-probe-assay-mitf-rat
Mitf - PrimePCR Assay and Template | Life Science | Bio-Rad
basic helix-loop-helix-leucine zipper transcription factor; may play a role in osteoclast function [RGD, Feb 2006] ... Microphthalmia-associated transcription factor Assay Type: Probe Assay Design: intron_spanning Application: Gene Expression ... Microphthalmia-associated transcription factor Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5175088 ... Microphthalmia-associated transcription factor Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5175089 ...http://www.bio-rad.com/en-us/prime-pcr-assays/gene/mitf-rat
acute promyelocytic leukemia childhood 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / ... Targeting transcription factors in acute leukemia in children.. * In many childhood acute leukemias, transcription factors are ... Berman JN, Look AT: Targeting transcription factors in acute leukemia in children. Curr Drug Targets; 2007 Jun;8(6):727-37. ... Transcription Factors / drug effects. *[MeSH-minor] Acute Disease. Arsenicals / pharmacology. Arsenicals / therapeutic use. ...http://www.bmlsearch.com/?kwr=acute+promyelocytic+leukemia+childhood+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Congenital Patterned Leukodermas: Background, Pathophysiology, Etiology
The MITF gene encodes a transcription factor containing a basic-helix-loop-helix-leucine zipper. The genes up-regulated by this ... The genes up-regulated by this transcription factor have not been identified; however, the PAX3 gene product can bind to the ... Type II Waardenburg syndrome results from mutations in the microphthalmia transcription factor (MITF) gene,  which maps to ... The PAX3 gene encodes a transcription factor with a paired box domain, an octapeptide domain, and a homeobox domain essential ...https://emedicine.medscape.com/article/1068803-overview
Biology | Free Full-Text | Transcriptional Regulation of the Mitochondrial Citrate and Carnitine/Acylcarnitine Transporters:...
The interaction with drugs of some transcription factors, such as PPAR and FOXA1, and how this interaction can be an attractive ... The contribution of tissue-specific and less tissue-specific transcription factors in activating or repressing CIC and CAC gene ... The regulation of the expression of many genes at the level of their transcription has already been analyzed. This review ... By means of this mechanism, transcription factors, nutrients, hormones and epigenetics control not only fatty acid metabolism, ...http://www.mdpi.com/2079-7737/2/1/284/htm
KEGG ORTHOLOGY: K15591
... transcription factor EC. Transcription factors [BR:ko03000]. Eukaryotic Type. Basic helix-loop-helix/leucine zipper (bHLH-ZIP) ... macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors ...https://www.genome.jp/dbget-bin/www_bget?ko:K15591
"Meiosis in Saccharomyces cerevisiae mutants lacking the centromere-bin" by Daniel C. Masison and Richard E. Baker
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Chromosomes, Fungal; DNA-Binding Proteins; Fungal Proteins; Genes ...https://escholarship.umassmed.edu/gsbs_sp/813/
PROMUS Element Japan Small Vessel Trial
Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol ... Anti-tumor necrosis factor-α therapy increases plaque burden in a mouse model of experimental atherosclerosis. ... is critically fueled by vascular inflammation through oxidized lipids and inflammatory cytokines such as tumor necrosis factor ...https://www.bioportfolio.com/resources/trial/67282/PROMUS-Element-Japan-Small-Vessel-Trial.html
The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional...
Protein family/domain name: Basic helix-loop-helix leucine zipper transcription factor. ... The Arabidopsis basic/helix-loop-helix transcription factor family.. Toledo-Ortiz G, Huq E, Quail PH., Plant Cell 15(8), 2003 ... A classification of basic helix-loop-helix transcription factors of soybean.. Hudson KA, Hudson ME., Int J Genomics 2015(), ... Basic helix-loop-helix transcription factors and epidermal cell fate determination in Arabidopsis.. Zhao H, Li X, Ma L., Plant ...https://pub.uni-bielefeld.de/publication/1867691
Spectrum of novel mutations found in Waardenburg syndrome types 1 and 2: implications for molecular genetic diagnostics | BMJ...
14 The MITF gene encodes a transcription factor with a basic helix-loop-helix leucine zipper motif. Proteins with this kind of ... AD1-3, (trans)activation domains; b, basic domain; HLH, helix-loop-helix domain; LZ, leucine zipper domain. ... 2-4 PAX3 is a member of the mammalian PAX gene family and encodes a DNA-binding transcription factor expressed in neural crest ... which is located in the basic domain of MITF, were also described in patients with Tietz syndrome (TS, MIM #103500). Compared ...https://bmjopen.bmj.com/content/3/3/e001917.long
... which belong to the basic helix-loop-helix leucine zipper transcription factors (5). SREBP-1a and -1c are encoded by a single ... Tontonoz P, Kim JB, Graves RA, Spiegelman BM: ADD1, a novel helix-loop helix transcription factor associated with adipocyte ... PPAR-γ is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily and forms a ... Because AICAR has been reported to suppress the expression of hepatocyte nuclear factor (HNF)-4α, its downstream transcription ...http://diabetes.diabetesjournals.org/content/51/suppl_3/S414
FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non...
Expression of the microphthalmia-associated basic helix-loop-helix leucine zipper transcription factor Mi in avian neuroretina ... at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein ... Kos, R., Reedy, M. V., Johnson, R. L. and Erickson, C. A. (2001). The winged-helix transcription factor FoxD3 is important for ... Dottori, M., Gross, M. K., Labosky, P. and Goulding, M. (2001). The winged-helix transcription factor Foxd3 suppresses ...http://dev.biologists.org/content/136/11/1849?ijkey=17f990c0d20aad0dae44cebf71f7f1c6e8a860fa&keytype2=tf_ipsecsha
Andres M. Lebensohn, Ph.D. | Center for Cancer Research - National Cancer Institute
Our genetic screens uncovered a basic helix-loop-helix leucine zipper transcription factor called TFAP4 as a potential ... 1) The transcription factor TFAP4 is a new limiting component of the WNT signaling pathway. ... development and in stem cell compartments depend on a second signal provided by the R-spondin family of secreted growth factors ...https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn?qt-staff_profile_tabs=4
anti-ChREBP antibody | GeneTex
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein ...http://www.genetex.com/ChREBP-antibody-GTX30679.html
"Mutations synthetically lethal with cep1 target S. cerevisiae kinetoch" by Richard E. Baker, Kendra Harris et al.
Strains lacking CP1 are defective in chromosome segregation and MET gene transcription, leading to the hypothesis that CP1 ... Amino Acid Sequence; Base Sequence; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Chromatin; Chromosomal ... Helix-Loop-Helix Motifs; Humans; Kinetochores; Molecular Sequence Data; Mutation; Nuclear Proteins; Open Reading Frames; RNA, ... Strains lacking CP1 are defective in chromosome segregation and MET gene transcription, leading to the hypothesis that CP1 ...https://escholarship.umassmed.edu/oapubs/604/
MLX (gene) - Wikipedia
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These ... a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1-2): 7-11. doi: ... Billin AN, Eilers AL, Coulter KL, Logan JS, Ayer DE (December 2000). "MondoA, a novel basic helix-loop-helix-leucine zipper ... is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617-27. doi:10.1093/hmg/10.6.617. ...https://en.wikipedia.org/wiki/MLX_(gene)
KAKEN - Research Projects | Fibroblast-dependent Proliferation of Mast Cells (KAKENHI-PROJECT-02404030)
4). The mi locus of mice encodes a transcription factor of basic helix-loop-helix leucine zipper family. We demonstrated that ... Since KIT was transcribed in erythroblasts and germ cells of Wsh/Wsh mice, the abnormality of KIT transcription appeared to be ... Moreover, we found the KIT transcription was influenced by the age in mast cells of Wsh/Wsh mice. Although an appreciable ... Mast Cell / Stem Cell Factor / W locus of mice / Ws locus of rats / Receptor Tyrosine Kinase / Mast Cell-Deficeint Animals / ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02404030/
Mouse Monoclonal anti-MiTF (Microphthalmia Transcription Factor) (MITF/915) | Biotium
MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor. It ... MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that ... BHLHE32; Class E basic helix-loop-helix protein 32 (bHLHe32); CMM8; Mi; Microphthalmia-associated transcription factor; MITF; ... Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J. Exp.Med. 1998 ...https://biotium.com/product/monoclonal-anti-mitf-microphthalmia-transcription-factor-mitf915/