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*  Chronic Myelomonocytic Leukaemia (CMML): Leukaemia Foundation
Recently, azacitidine has been used to treat CMML.. Is there a cure?. For some people, a stem cell transplant is an option and ...
http://leukaemia.org.au/blood-cancers/myelodysplastic-syndrome-mds/cmml/chronic-myelomonocytic-leukaemia-cmml
*  Hypomethylating agents are effective in myelodysplastic syndrome | Cancer Biology
Biological mechanism of action of azacitidine (AZA) and decitabine (DAC).. (A) Structures of cytidine, azacitidine, and ... C) Azacitidine is converted to decitabine and is then incorporated into DNA in place of cytidine during replication. Both ... Notably, azacitidine, but not decitabine, can be incorporated directly into RNA, inhibiting protein synthesis. https://www.jci. ... azacitidine and decitabine inactivate DNMTs, preventing gene methylation. The resultant hypomethylation leads to the ...
https://blogs.shu.edu/cancer/2016/09/28/hypomethylating-agents-are-effective-in-myelodysplastic-syndrome/
*  Azacitidine - National Cancer Institute
This page contains brief information about azacitidine and a collection of links to more information about the use of this drug ... More About Azacitidine. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. ... MedlinePlus Information on Azacitidine - A lay language summary of important information about this drug that may include the ... Azacitidine is also being studied in the treatment of other conditions and types of cancer. ...
https://www.cancer.gov/about-cancer/treatment/drugs/azacitidine
*  Azacitidine (Vidaza®) | OncoLink
About: Azacitidine (Vidaza®) Azacitidine kills abnormal cells in the bone marrow by inhibiting a process called DNA methylation ... How to Take Azacitidine. Azacitidine is given by subcutaneous (under the skin) injections or intravenously (IV, by vein) ... There are a number of things you can do to manage the side effects of azacitidine. Talk to your care team about these ... Female partners of male patients receiving azacitidine should not become pregnant. You should consult with your healthcare team ...
https://www.oncolink.org/cancer-treatment/oncolink-rx/azacitidine-vidaza-r
*  azacitidine | Cigna
Azacitidine is used to treat certain types of bone marrow cancers and blood cell disorders. Azacitidine may also be used for ... Azacitidine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. ... What is azacitidine?. Azacitidine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. ... How is azacitidine given?. Azacitidine is injected under the skin, or into a vein through an IV. A healthcare provider will ...
https://www.cigna.com/healthwellness/hw/medications/azacitidine-d05293a1
*  Azacitidine Drug Interactions - Drugs.com
118 medications are known to interact with azacitidine. Includes Aredia (pamidronate), Ativan (lorazepam), Co-trimoxazole ( ... Show all medications in the database that may interact with azacitidine.. Check for interactions with azacitidine. Type in a ... A total of 118 drugs (351 brand and generic names) are known to interact with azacitidine. ...
https://www.drugs.com/drug-interactions/azacitidine.html
*  Azacitidine - Drug Information - Chemocare
Azacitidine (Vidaza) chemotherapy side effects, how it's given, how it works, precautions and self care tips in treatment of ... How Azacitidine Works:. Azacitidine is a member of a new class of drugs known as DNA "demethylating" agents. Methylation of DNA ... Other name: 5-Azacitidine Drug type: Azacitidine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This ... How Azacitidine Is Given:. *As a once-a-day subcutaneous (under the skin) injection or as an IV (intravenous) injection. ...
http://chemocare.com/chemotherapy/drug-info/azacitidine.aspx
*  Azacitidine (Injection Route) Proper Use - Mayo Clinic
Women receiving azacitidine injection should use an effective form of birth control to keep from getting pregnant There is also ... Azacitidine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection ... Azacitidine belongs to the group of medicines called metabolites. It interferes with the growth of cancer cells, which are ... Since the growth of normal body cells may also be affected by azacitidine, other effects will also occur. Some of these may be ...
https://www.mayoclinic.org/drugs-supplements/azacitidine-subcutaneous-route/proper-use/DRG-20062061?p=1
*  NICE recommends azacitidine for myelodysplastic syndromes | Cancer Research UK
The National Institute for Health and Clinical Excellence has approved a drug called azacitidine for people with ... "Azacitidine is an expensive drug, and this discount enabled us to recommend it as a cost-effective use of resources on the NHS ... Azacitidine is the first drug that is specifically designed to treat MDS, in which a patient's bone marrow fails to produce ... While azacitidine does not provide a cure for these conditions, clinical trials have shown that it may extend patients' life ...
http://www.cancerresearchuk.org/about-us/cancer-news/news-report/2011-03-24-nice-recommends-azacitidine-for-myelodysplastic-syndromes
*  Azacitidine | Aplastic Anemia and MDS International Foundation
An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk ... Randomized Allogeneic Azacitidine Study Recruiting 18 years to 75 years Phase 1 Study to Evaluate MEDI4736 in MDS Recruiting 18 ... Azacitidine A demethylating agent, this medicine interacts with DNA to restore normal growth of blood cells in the bone marrow ... Ibrutinib and Azacitidine for Treatment of Higher Risk Myelodysplastic Syndrome Not yet recruiting 18 years and older ...
http://www.aamds.org/treatments/drugs/azacitidine?order=field_age_group&sort=asc
*  Macmillan responds to NICE's decision on cancer drug Azacitidine
Azacitidine was rejected earlier this year because it was not deemed to be a cost-effective treatment. The drug is valued at £ ... Home , About us , Media Centre , UK-wide News , Macmillan responds to NICE's decision on cancer drug Azacitidine ... Responding to the decision by NICE to recommend Azacitidine as a treatment for myelodyplastic syndrome, chronic myelomonocytic ... The appraisal process for Azacitidine began a year ago in March 2009 and was reviewed in July 2010 ...
https://www.macmillan.org.uk/aboutus/news/latest_news/macmillansresponsetonicesdecisiononcancerdrugazacitidine.aspx
*  Azacitidine - Tapi Teva
Azacitidine is used to treat myelodysplastic syndromes (MDS), a number of disorders in which not enough healthy blood cells are ... Azacitidine was approved by the FDA in 2004 under the trade name Vidaza as "the first effective treatment for patients with ... Azacitidine is used to treat myelodysplastic syndromes (MDS), a number of disorders in which not enough healthy blood cells are ... Azacitidine reduces DNA methylation by posing as genetic material. It is incorporated into DNA, where it inhibits the enzyme ...
https://www.tapi.com/products/azacitidine/
*  AVIDA The Vidaza® (Azacitidine) Patient Registry - Tabular View - ClinicalTrials.gov
AVIDA The Vidaza® (Azacitidine) Patient Registry (AVIDA). The safety and scientific validity of this study is the ... AVIDA The Vidaza® (Azacitidine) Patient Registry. Brief Summary This registry is a prospective, multi-center, observational ... AVIDA The Vidaza® (Azacitidine) Patient Registry. Official Title ...
https://clinicaltrials.gov/ct2/show/record/NCT00481273
*  Oral Azacitidine Safe, Effective in Low-Risk MDS | Medpage Today
Oral azacitidine (Vidaza) given for up to 21 days per 4-week cycle for myelodysplastic syndrome appeared safe and effective in ... Note that currently, azacitidine is approved as an injectable drug for MDS, administered for 7 days per 4-week treatment cycle. ... Oral azacitidine (Vidaza) given for up to 21 days per 4-week cycle for myelodysplastic syndrome (MDS) appeared safe and ... ATLANTA -- Oral azacitidine (Vidaza) given for up to 21 days per 4-week cycle for myelodysplastic syndrome (MDS) appeared safe ...
https://www.medpagetoday.com/meetingcoverage/ashhematology/36454
*  Efficiency of Antibacterial Prophylaxis in Azacitidine Treated Patients
Combination of 5-Azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML) ... More From BioPortfolio on "Efficiency of Antibacterial Prophylaxis in Azacitidine Treated Patients". *Related Companies*Related ... Efficiency of Antibacterial Prophylaxis in Azacitidine Treated Patients. 2018-07-26 12:30:16 , BioPortfolio ...
https://www.bioportfolio.com/resources/trial/212257/Efficiency-of-Antibacterial-Prophylaxis-in-Azacitidine-Treated-Patients.html
*  Azacitidine | Roswell Park Comprehensive Cancer Center
Ladakamycin How is Azacitidine Administered? Azacitidine comes as a powder to be mixed with water and injected subcutaneously ( ... What is Azacitidine Used For? This medication is used to treat myelodysplastic syndrome (MDS - a group of conditions in which ... How is Azacitidine Administered?. Azacitidine comes as a powder to be mixed with water and injected subcutaneously (under the ... Azacitidine is a member of a new class of drugs known as DNA "demethylating" agents, as well as an antimetabolite, so it is ...
https://www.roswellpark.org/patients/treatment/chemo-drug-therapy/azacitidine
*  Azacitidine in Treating Patients With Myelofibrosis - Full Text View - ClinicalTrials.gov
Azacitidine in Treating Patients With Myelofibrosis. The safety and scientific validity of this study is the responsibility of ... OUTLINE: Patients receive azacitidine subcutaneously once daily on days 1-5. Treatment repeats every 4 weeks for up to 12 ... Drug Information available for: Azacitidine Genetic and Rare Diseases Information Center resources: Myelofibrosis Polycythemia ... RATIONALE: Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of abnormal cells, either ...
https://clinicaltrials.gov/show/NCT00381693
*  Azacitidine/prednisone | Springer for Research & Development
Azacitidine/prednisone. Atypical exanthem secondary to Epstein-Barr virus reactivation: case report ...
https://rd.springer.com/article/10.1007/s40278-018-44635-2
*  Randomized Allogeneic Azacitidine Study | Aplastic Anemia & MDS International Foundation
... azacitidine) will help to control the disease in patients with AML, CMML, or MDS after an allogeneic (donor) stem cell ... Randomized Allogeneic Azacitidine Study Clinical Trial: NCT00887068. For more details on this clinical trial, including contact ... Drug: Azacitidine 32 mg/m^2 given through a needle under the skin for five consecutive days of each 28 day cycle and the ... The goal of this clinical research study is to learn if Vidaza (azacitidine) will help to control the disease in patients with ...
https://www.aamds.org/treatments/clinical-trials/randomized-allogeneic-azacitidine-study
*  Safety and efficacy of azacitidine in myelodysplastic syndromes | DDDT
... and safety of azacitidine are reviewed.Summary: Azacitidine is the first drug FDA-approved for the treatment of myelodysplastic ... The recommended dosage of azacitidine is 75 mg/m2 daily for 7 days, with different treatment schedules validated. It appears to ... Several other off-label recommendations were also analyzed.Conclusion: Azacitidine is the first DNA hypomethylating agent ... approved by FDA for the treatment of myelodysplastic syndromes with demonstrated efficacy.Keywords: Azacitidine, MDS, ...
https://www.dovepress.com/safety-and-efficacy-of-azacitidine-in-myelodysplastic-syndromes-peer-reviewed-article-DDDT
*  Azacitidine and Sonidegib in Treating Patients With Myeloid Malignancies - Mayo Clinic
Azacitidine may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving azacitidine ... This phase I/IB trial studies the side effects, best dose, and efficacy of azacitidine and erismodegib in treating patients ...
http://www.mayo.edu/research/clinical-trials/cls-20111752
*  Azacitidine and Arsenic Trioxide in Treating Patients With Myelodysplastic Syndromes
... such as azacitidine and arsenic trioxide, work in different ways to stop the growth of cancer cells, either by ki ... ATO/Azacitidine, except that patients with serum erythropoietin < 200 IU/mL who. failed to respond to a trial with EPO are not ... with ATO/Azacitidine. - Absolute QT interval > 460 msec in the presence of adequate serum potassium and. magnesium values. - ... azacitidine/treatment.. - Women of childbearing potential should be advised to avoid becoming pregnant and. should be advised ...
http://www.knowcancer.com/cancer-trials/NCT00234000/
*  Study of Azacitidine to Treat Relapsed or Refractory Multiple Myeloma
... safety and tolerability to azacitidine in patients with relapsed or refractory multiple m ... the effect of azacitidine on human myeloma cell lines in the laboratory. Azacitidine was. found to prevent both cell growth and ... myeloma azacitidine prolonged their survival.. The primary aim of this study is to determine the effectiveness of azacitidine ... the number of cycles of azacitidine required to first achieve a response and to determine. how safe and tolerable azacitidine ...
http://www.knowcancer.com/cancer-trials/NCT00412919/
*  Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer - Study Results - ClinicalTrials.gov
Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal Cancer. The safety and scientific validity of this ... Patients received 40 mg/m^2 azacitidine subcutaneously days 1-5 and 8-10 and 7 mg oral entinostat on days 3 and 10 in each 28 ... Participants received 40 mg/m^2 azacitidine subcutaneously on days 1-5 and 8-10 and 7 mg oral entinostat on days 3 and 10. ... Participants received 40 mg/m^2 azacitidine subcutaneously on days 1-5 and 8-10 and 7 mg oral entinostat on days 3 and 10. ...
https://www.clinicaltrials.gov/ct2/show/results/NCT01105377?term=entinostat&
*  Azacitidine - Wikipedia
Azacitidine (INN; trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy ... Azacitidine induces tumor regression on isocitrate dehydrogenase-1 mutant glioma xenografts in mice. In research, 5-azacitidine ... since their levels of azacitidine may progressively increase. Based on animal studies and its mechanism of action, azacitidine ... Azacitidine can be used in vitro to remove methyl groups from DNA. This may weaken the effects of gene silencing mechanisms ...
https://en.wikipedia.org/wiki/Azacitidine