Packaging molecular motors for delivery - MRC Laboratory of Molecular Biology
... driven by dynein motors. Andrew Carters group, has discovered a novel protein that packages these molecular motors for ... Shulin packages axonemal outer dynein arms for ciliary targeting. Mali, GR., Abid Ali, F., Lau, CK., Begum, F., Boulanger, J., ... This motion is known to be driven by dynein molecular motors, but it hasnt been clear how the dyneins are delivered into the ... Individual dynein particles in the background image are in their open state unbound by Shulin.. The airways in our lungs are ...
WGBS Analysis Part 35 - the responsible postdoc - Lab Notebook by Yaamini Venkataraman
Dynein heavy chain 5, axonemal: Associated with sperm (flagellar and cillar) motility). Ddynein heavy chain 1, 8, 12, ... cytoplasmic dynein 1 heavy chain 1-like, dynein heavy chain 1, and cytoplasmic dynein 2 heavy chain 1-like contained DML in C. ... 2012). Dynein does not have strict functions relating to sperm motility. Differential abundance of dynein proteins was found in ... Similar findings to dynein heavy chain 5 (see above). *Kinesin-like protein KIF23: Helps with organelle transport and required ...
Browse Rattus norvegicus ORF cDNA clones by chromosome 20, map 20p12, page 1
Precise Force Field and Bioinformatics Laboratory
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Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chain in motile cilia and sperm ... Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice ... Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice ... 2 architecture and inner dynein arm defects in the respiratory cilia and sperm flagella. Subsequently, animal models of Dnah10- ...
EFFECT OF SOLUTION COMPOSITION AND PROTEOLYSIS ON THE CONFORMATION OF AXONEMAL COMPONENTS | Journal of Cell Biology |...
In addition, proteolysis increases the specific ATPase activity of dynein and removes a portion of it from the axonemal ... Supernatant dynein had a greater specific ATPase activity than dynein extracted from axonemes. Observations on specimens ... Gel electrophoresis showed this corresponded to the appearance of dynein in the supernatant and a decrease in dynein associated ... EFFECT OF SOLUTION COMPOSITION AND PROTEOLYSIS ON THE CONFORMATION OF AXONEMAL COMPONENTS C. Richard Zobel C. Richard Zobel ...
Dyneins are large microtubule motor proteins required for mitosis intracellular transport - Small-Molecule Inhibitor of...
... of native dyneins in three conformational says were also analysed to compare the post-powerstroke axonemal dyneins and ... In sea urchin flagella two dynein heavy chains α- and β-dynein form a dimeric ODA complex. Our classification of dyneins from ... a-f) Longitudinal tomographic slices of averaged axonemal dyneins in post- (a-c) Dyphylline pre-I (d e) and pre-II (f) ... Dyneins are large microtubule motor proteins required for mitosis intracellular transport. Dyneins are large microtubule motor ...
CIL:9904, Euplotes sp., cell by organism, eukaryotic cell, Eukaryotic Protist, Ciliated Protist. CIL. Dataset
... singlets and dynein arms as well as spokes. Euplotes h... ... axonemal dynein complex plasma membrane adoral zone of ... The cilia of a membranelle of the AZM (adoral zone of membranelles) have well defined doublets, singlets and dynein arms as ...
Sperm from β1,4-galactosyltransferase I-null mice exhibit precocious capacitation | Development | The Company of Biologists
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Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal...
August 2017 - Outlook on PI3K/AKT/mTOR inhibition
... although thioredoxins have been evolutionarily conserved in axonemal dyneins, the role that these proteins play in dynein ... Outer dynein arms (ODAs) and inner arm dyneins are attached to the outer doublet microtubules of the eukaryotic flagellar ... Similar increases in enzymatic activity after thiol modification have been observed in both sea urchin sperm and dyneins (Ogawa ...
Winfield S Sale PhD - OpenEmory | Profile
Axonemal dyneins must be precisely regulated and coordinated to produce ordered ciliary/flagellar motility, but how this is ... Ciliary dyneins are classified into two general types: the outer dynein arms (ODAs) and the inner dynein arms (IDAs). While ... Here, we identify the DRC1 subunit of the nexin-dynein regulatory complex (N-DRC), an axonemal structure critical for the ... The nexin-dynein regulatory complex (N-DRC) is proposed to coordinate dynein arm activity and interconnect doublet microtubules ...
Computer modelling: A versatile tool for the study of structure and function in cilia<...
Components have been assigned mechanical properties and the distortion of a pair of linked microtubules by assemblies of dynein ... Finite element analysis is being used to interpret the functions of the axonemal components. Components have been assigned ... Components have been assigned mechanical properties and the distortion of a pair of linked microtubules by assemblies of dynein ... Components have been assigned mechanical properties and the distortion of a pair of linked microtubules by assemblies of dynein ...
Mutations in the dynein regulatory complex alter the ATP-insensitive binding sites for inner arm dyneins in Chlamydomonas...
To understand mechanisms of regulation of dynein activity along and around the axoneme we further characterized the ... "dynein regulatory complex" (drc). The lack of some axonemal proteins, which together are referred to as drc, causes the ... Components of a "dynein regulatory complex" are located at the junction between the radial spokes and the dynein arms in ... Mutations in the "dynein regulatory complex" alter the ATP-insensitive binding sites for inner arm dyneins in Chlamydomonas ...
Drosophila Regulatory factor X is necessary for ciliated sensory neuron differentiation | Development | The Company of...
Structural components of cilia such as tubulins, tektins and axonemal dynein subunits have mostly been isolated from the single ... 6B,C) clearly show the 9+0 axonemal structure in wild-type antennae, but no axoneme profiles were found in serial sections of ... have axonemal defects illustrating the importance of axoneme integrity for chordotonal organ function(Eberl et al., 2000). ... that is both rootlet apparatus and axonemal structures are absent from scolopidia in Rfx mutant antennae as observed by ...
To prove this, purified individual little airway BC (99 highly - MicroRNA-Mediated Suppression of the STAT3 and STAT5 Signaling...
Does Exercise Improve Sperm Motility? - Fertiligy Male Fertility Supplement
Sperm mitochondria must be able to shuttle ATP through the flagellum to supply energy to the flagellum and axonemal dynein ... Researchers have discovered a protein involved in their movement called dynein. This protein plays an important role in many ... Calcium is an important nutrient for sperm motility, as it regulates flagellar motility and dynein-driven microtubule sliding. ...
Flagellum - New World Encyclopedia
These proteins include dynein, a molecular motor that can cause flagella to bend, and propel the cell relative to its ... Intraflagellar transport (IFT), the process by which axonemal subunits, transmembrane receptors, and other proteins are moved ... These dynein arms produce force through ATP hydrolysis. The flagellar axoneme also contains radial spokes, polypeptide ... Each of the outer 9 doublet microtubules extends a pair of dynein arms (an "inner" and an "outer" arm) to the adjacent ...
sp|Q9NRG9|AAAS HUMAN Aladin OS=Homo sapiens GN=AAAS PE=1 SV=1
Heterotaxy Syndrome and Primary Ciliary Dyskinesia: Background, Pathophysiology, Epidemiology
... an axonemal dynein, and was named lrd, for left-right dynein (human homolog is DNAH11/DNAHC11). However, its expression at ... Bartoloni L, Blouin JL, Pan Y, Gehrig C, Maiti AK, Scamuffa N. Mutations in the DNAH11 (axonemal heavy chain dynein type 11) ... DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013 Sep. 45(9):995-1003. [QxMD MEDLINE Link ... CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in ...
Establishment of a new in vitro Culture System and functional
The left-right dynein gene (lrd) mutated in these mice codes for an axonemal dynein heavy chain, which as a motor protein is ... is provided by dynein motors anchored to the microtubule scaffold. Here, the inner and outer arm dynein complexes perform a ... The axonemal structure as the inner framework, common to all cilia consists of a circular arrangement of nine microtubule ... Subsequent studies revealed that mice mutant for several other IFT, dynein or even basal body genes show a similar loss of Shh- ...
Mytilus trossulus Iso-seq Annotation - quarter-shell - The lab notebook of Steven Roberts
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Molecules and Cells
... kinesin or dynein) and cargo IFT proteins (Ishikawa and Marshall, 2011; Rosenbaum and Witman, 2002). ... ciliary membranes and axonemal proteins are synthesized in the cytoplasmic endoplasmic reticulum-Golgi and transported to the ... kinesin or dynein) and cargo IFT proteins (Ishikawa and Marshall, 2011; Rosenbaum and Witman, 2002). ... ciliary membranes and axonemal proteins are synthesized in the cytoplasmic endoplasmic reticulum-Golgi and transported to the ...
DeCS 2010 - New terms