... called an axonal spheroid, may result. Because axonal transport can be disrupted in a multitude of ways, axonal spheroids can ... The basic mechanism of fast axonal transport has been understood for decades but the mechanism of slow axonal transport is only ... it is likely that axonal transport is a key player in mediating pathology. Dysfunctional axonal transport is also linked to ... Intraflagellar transport Sabry J, OConnor TP, Kirschner MW (June 1995). "Axonal transport of tubulin in Ti1 pioneer neurons in ...

... if synapsin transport is indeed dependent upon fast axonal transport of vesicles, intrinsic fast-transport variations in a ... Fast Vesicle Transport Is Required for the Slow Axonal Transport of Synapsin. Yong Tang, David Scott, Utpal Das, Daniel Gitler ... Fast vesicle transport is required for slow axonal transport of synapsin. The above experiments show that the overall kinetics ... Inhibiting axonal transport of Golgi-derived vesicles in cultured neurons. A, Photoactivation strategy to evaluate slow axonal ...

A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs Abstract. Through the ... Guanine-rich sequences located in 3UTRs of axonal mRNAs increase transport efficiency and balance the access of different ... The essential components driving cytoplasmic mRNA transport in neurons and mammalian cells are not known. We report the first ... APC activates kinesin-2, and both proteins are sufficient to drive specific transport of defined mRNA packages. ...

... did not affect the axonal transport. This is the first report of an automated monitoring system for axonal transport. This ... mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for axonal transport has ... Keywords: axonal transport, automated system, chloromethylbenzamido dialkylcarbocyanine (CM-DiI), anti-cancer drug, dorsal root ... Axonal transport plays a crucial role in neuronal morphogenesis, survival, and function. Despite its importance, however, the ...

Organelle transport is vital for the development and maintenance of axons, in which the distances between sites of organelle ... The axonal transport of mitochondria Peter J Hollenbeck et al. J Cell Sci. 2005. . ... The axonal transport of mitochondria. Saxton WM, Hollenbeck PJ. Saxton WM, et al. J Cell Sci. 2012 May 1;125(Pt 9):2095-104. ... The axonal transport of mitochondria Peter J Hollenbeck 1 , William M Saxton ...

Ricaurte GA Long-Term Impairment of Anterograde Axonal Transport Along Fiber Projections Originating in the Rostral Raphe ... Along with anterograde axonal transport, we measured two 5-HT axonal markers, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA). ... These reductions were associated with lasting decrements in 5-HT axonal markers. In general, decreases in axonal transport were ... "Long-Term Impairment of Anterograde Axonal Transport Along Fiber Projections Originating in the Rostral Raphe Nuclei After ...

Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes. Friday, September 18, 2015. ... Here, we demonstrate that late endosome (LE)-loaded dynein-snapin complexes drive AV retrograde transport in axons upon fusion ... Although dynein-driven retrograde transport of AVs has been suggested, a fundamental question remains-how do autophagosomes ... Deficiency in dynein-snapin coupling impaired AV transport, resulting in AV accumulation in neurites and synaptic terminals. ...

P N Hoffman, M A Lopata, D F Watson, R F Luduena; Axonal transport of class II and III beta-tubulin: evidence that the slow ... Axonal transport of class II and III beta-tubulin: evidence that the slow component wave represents the movement of only a ... as a well-defined wave corresponding to the slow component of axonal transport. A major goal of the present study was to ... Axotomy resulted in significant increases in the labeling and transport rates of both isotypes. Immunohistochemical examination ...

Axonal Transport in Nigro-striatal Neurones Journal Articles * Chapter 5 Modeling and Competition in the Nervous System: Clues ... AXONAL TRANSPORT IN NIGRO‐STRIATAL AND NIGRO‐THALAMIC NEURONS: EFFECTS OF MEDIAL FOREBRAIN BUNDLE LESIONS AND 6‐HYDROXYDOPAMINE ... Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons Journal Articles ... Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons Journal Articles ...

Retrograde Axonal Transport. Retrograde axonal transport (Figure 4 inset) is an important process for neuronal signal ... Retrograde axonal transport of vectors internalized at neurons dendrites towards the soma94 Compacting vector sizes showed ... A) Gene delivery systems internalized at the axons or dendrites must undergo retrograde axonal transport towards the nucleus. ... A) Gene delivery systems internalized at the axons or dendrites must undergo retrograde axonal transport towards the nucleus. ...

Tag: axonal transport. Travel disruptions: transport along neurones in MND. 23 August 2022. 24 February 2023. Research ...

A SNTF blood test, either alone or combined with other markers of axonal injury, may have important utilities for research, ... They provide further evidence linking axonal injury to persisting brain dysfunction after uncomplicated mTBI. ... a surrogate marker for axonal injury after mTBI, may have potential for the rapid prognosis of lasting post-concussion syndrome ... Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury. J Neurotrauma. (2012) 29: ...

Axonal Transport * Brain / anatomy & histology* * Brain / enzymology * Choline O-Acetyltransferase / metabolism * Globus ... The anterogradely transported lectin Phaseolus vulgaris-leukoagglutinin (PHA-L) was iontophoretically injected into the PPT in ...

This study investigated effects of R-flurbiprofen (R-F) on axonal transport and AD neuropathology in Tg2576 mice. Axonal ... R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimers disease as determined by MEMRI BIBLIOGRAPHIC ... These data indicate that both Aβ42 and tau comprise a role in axonal transport rate deficits in the Tg2576 models. ... These data indicate that both Aβ42 and tau comprise a role in axonal transport rate deficits in the Tg2576 models. ...

Ubiquinase coding genes UBEA5, UBE2D3 and UBE3A (Parkin) increased with E or E+P (all ANOVA, P<0.003). Transport-related ... axon transport and NDD-specific genes in serotonin neurons. Ovx macaques were treated with placebo, E or E+P (n=3 per group) ... Duncan JE, Goldstein LS . The genetics of axonal transport and axonal transport disorders. PLoS Genet 2006; 2: e124. ... Chevalier-Larsen E, Holzbaur EL . Axonal transport and neurodegenerative disease. Biochim Biophys Acta 2006; 1762: 1094-1108. ...

Thus, the identification of this mutation provides further support for the role of the cytoskeleton and axonal transport in ALS ... This type of axonal degeneration can be seen in the brain on biopsy as atrophy and pallor of myelinated motor axons in the ... Axonal degeneration. Motor axons die by Wallerian degeneration in ALS, and large motor neurons are affected to a greater extent ... Remarkably, while reduction in TDP-43 is shown to inhibit axonal regeneration of iPSC-derived motor neurons, rescue of stathmin ...

A novel form of axonal transport?. Together they form a unique fingerprint. ... Actin-dependent anterograde movement of growth-cone-like structures along growing hippocampal axons: A novel form of axonal ...

Further, using primary neurons from BACHD mice, for the first time, we studied axonal transport of mitochondria and synaptic ... Further, using primary neurons from BACHD mice, for the first time, we studied axonal transport of mitochondria and synaptic ... Further, using primary neurons from BACHD mice, for the first time, we studied axonal transport of mitochondria and synaptic ... Further, using primary neurons from BACHD mice, for the first time, we studied axonal transport of mitochondria and synaptic ...

... and amygdaloid connections of the rodent temporal cortices were investigated by using the anterograde transport of ... Axonal Transport * Axons / ultrastructure * Brain / anatomy & histology* * Brain / physiology * Cerebral Cortex / anatomy & ... and amygdaloid connections of the rodent temporal cortices were investigated by using the anterograde transport of ...

involved_in anterograde axonal transport of mitochondrion IEA Inferred from Electronic Annotation. more info ... involved_in retrograde axonal transport of mitochondrion IEA Inferred from Electronic Annotation. more info ...

Axonal Transport and Cytoskeleton. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ... Axonal Transport and Cytoskeleton. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ... Axonal/Dendritic Growth and Circuit Formation. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ... Axonal/Dendritic Growth and Circuit Formation. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ...

Axonal Transport and Cytoskeleton. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ... Axonal Transport and Cytoskeleton. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ... Axonal/Dendritic Growth and Circuit Formation. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ... Axonal/Dendritic Growth and Circuit Formation. *Place: Poster (Hall No.1 Building, Kobe International Exhibition Hall) ...

Identification of key modulators of axonal health and degeneration. *Discoveries to explore changes in axonal transport ...

2001). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583-94. doi:10.1016/ ... "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. UNITED STATES. 103 (4): 583-94. doi: ... The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling ... 2002). "UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans". Neuron. 32 (5): 787-800. doi: ...

Retrograde transport; Axonal transport; Sciatic nerve; Neurotoxin; Neurotoxicology; Axonopathy; Neuropathy ... The inhibitory effect of acrylamide on retrograde axon transport was transient since transport deficits were not detectable 35 ... Single injection of acrylamide (1.3 mmol/kg, i.p.) inhibited retrograde axon transport of [125I]tetanus toxin in hen sensory ... Accumulated decrements in retrograde axon transport may be the underlying cause of degeneration of motor axons in acrylamide ...

A review of axonal transport of metals. Toxicology 88:1-148160191. Crossref, Medline, Google Scholar ... Uptake and retrograde axonal transport of various exogenous macromolecules in normal and crushed hypoglossal nerves. Brain Res ... Neuronal uptake of iron: somatopetal axonal transport and fate of cationized and native ferretin, and iron-dextran after ... Attiya A and Jones B (2022) Impact of Smoke Plumes Transport on Air Quality in Sydney during Extensive Bushfires (2019) in New ...

Recent advances in our understanding of axonal transport and axonal responsiveness to trophic factors may provide new ... altered axonal transport and the question of whether aggregates are pathogenic or protective. o Novel Approaches to Delivery of ... altered cytoskeletal function/axonal transport. While these hypotheses focus on motor neurons as the final common pathway of ...

In fact, autophagy and the UPS intermingle with endocytic/secretory pathways to regulate axonal homeostasis and ... Axonal transport defects consistently contribute to axonal alterations and motor neuron degeneration in ALS and also in SBMA [ ... Ström, A.L.; Gal, J.; Shi, P.; Kasarskis, E.J.; Hayward, L.J.; Zhu, H. Retrograde axonal transport and motor neuron disease. J ... Baldwin, K.R.; Godena, V.K.; Hewitt, V.L.; Whitworth, A.J. Axonal transport defects are a common phenotype in Drosophila models ...

Vis forfatter(e) (2020). Phosphorylated TH hinges with vesicular membrane proteins for axonal transport. ...

A.05.b. Axon growth and guidance - Axonal transport and trafficking. A.05.c. Axon growth and guidance - Extrinsic mechanisms. A ...